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4 publications mentioning hsa-mir-3680-1

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-3680-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 54
Other miRNAs from this paper: hsa-mir-548b, hsa-mir-1299, hsa-mir-3680-2
Upregulation of MiR-3680-5p was significantly different (P < 0.05) between the PD patients with low and high iPTH levels, whereas upregulations of miR-1299 and miR-548b-5p were not significantly different between the low and high iPTH groups (Fig 3). [score:7]
Although the associated mechanism has not been fully described, miR-3680-5p can have a role in downregulation of ubiquitin -dependent pathway genes, which in turn can result in downregulation of PTH/PTHrP degradation via ubiquitin -dependent proteolysis. [score:7]
Among the differentially expressed candidate miRNAs, three (miR-548b-5p, miR-3680-5p, and miR-1299) were markedly upregulated (fold changes 4.85, 4.09, and 2.56, respectively). [score:6]
Variables Exp (B) 95% CI P value Hemoglobulin 0.336 0.142–0.796 0.013 miR-3680-5p 6.235 1.184–32.829 0.031 Target gene prediction was performed by using TargetScan with the 95% context percentile and conserved method (S3 Table). [score:5]
Three of those miRNAs (miR-548b-5p, miR-3680-5p, and miR-1299) had been previously reported to be related to human diseases such as cancer [39], tuberculosis [40], and rheumatic heart disease [41]. [score:5]
The results of the target gene analysis revealed that miR-3680-5p was annotated to USP 6, USP 32, USP 46, and DLT; genes associated with ubiquitin -dependent proteolysis and deubiquitination. [score:3]
In this study, miR-3680-5p was associated with the lower limit of PTH (150 pg/mL) and those results suggested that miR-3680-5p could provide a research target in the study of non-invasive biomarkers and ABD etiology. [score:3]
Variables Exp (B) 95% CI P value Hemoglobulin 0.336 0.142–0.796 0.013 miR-3680-5p 6.235 1.184–32.829 0.031 At initial enrollment, 15 patients were selected for miRNA expression microarray analysis. [score:3]
Regardless, the preliminary indications provided by the results of this study suggest that miR-3680-5p should be a research target for further study into the etiology of CKD-MBD. [score:3]
The results of the analyses indicate that miR-3680-5p can be associated with ABD, because the expression of miR-3680-5p is significantly lower in PD patients having a iPTH level less than 150 pg/mL than it is in PD patients with a iPTH level greater than 150 pg/mL. [score:3]
We could not determine the exact mechanism involved in the association between miR-3680-5p and the PTHrP coding genes; however, we were able to observe an indirect mechanism involving miR-3680-5p and the ubiquitin -dependent proteolysis pathway genes. [score:2]
Thus, further research to clarify the association between miR-3680-5p and PTH/PTHrP, and the mechanisms related to that association, is necessary. [score:1]
Univariate logistic regression results showed that phosphorous, hemoglobin, and miRNA-3680-5p levels were significantly associated with iPTH level. [score:1]
Accordingly, phosphorous, hemoglobin, and miRNA-3680-5p data were included in a multivariate logistic regression analysis. [score:1]
The multivariate logistic regression results showed that phosphorous was not significantly associated with iPTH level (P = 0.120), but both hemoglobin and miRNA-3680-5p were significantly associated with iPTH level (P < 0.05) (Table 2). [score:1]
Moreover, miR-3680-5p was associated with the USP6, USP32, USP46, and DTL genes, which have roles in the ubiquitin (deubiquitin) proteolysis system. [score:1]
The result presented that only miR-3680-5P was associated with iPTH level (P = 0.045), with r = 0.279. [score:1]
Pathways and genes predicted to be associated with miR-3680-5p. [score:1]
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2
[+] score: 46
After normalization to 1 in the control group (U937/GFP), the relative expressions of selected downregulated miRNAs (miR-27a-3p, miR-424-5p, and miR-496-5p) in the test group are shown in A; the relative expressions of upregulated miRNAs (miR-296-5p, miR-377-5p, and miR-3680-5p), and unchanged miR-191-5p in the test group are shown in B. Figure 3 qPCR validation of miRNA expression levels in samples from the latent tuberculosis infection (LTBI) group versus the healthy control group. [score:13]
After normalization to 1 in the control group (U937/GFP), the relative expressions of selected downregulated miRNAs (miR-27a-3p, miR-424-5p, and miR-496-5p) in the test group are shown in A; the relative expressions of upregulated miRNAs (miR-296-5p, miR-377-5p, and miR-3680-5p), and unchanged miR-191-5p in the test group are shown in B. Figure 3 qPCR validation of miRNA expression levels in samples from the latent tuberculosis infection (LTBI) group versus the healthy control group. [score:13]
In parallel, the levels of upregulated miR-296-5p, miR-377-5p, miR-3680-5p, and unchanged miR-191-5p were similar to the chip results as well (Figure 2B). [score:4]
As shown in Figure 3, the results of four miRNAs (miR-424-5p, miR-27a-3p, miR-377-5p, miR-3680-5p) recapitulated the microarray data, and the other two miRNAs (miR-493-5p and miR-296-5p) were not significant differentially expressed. [score:3]
Although the expressions of miR-424-5p (previous ID: miR-424), miR-27a-3p, miR-377-5p and miR-3680-5p were consistent in clinical PBMC samples, the small size of healthy controls weakened the statistical power. [score:3]
The expression level of seven miRNAs (miR-424-5p, miR-493-5p, miR-296-5p, miR-27b-3p, miR-377-5p, miR-3680-5p, miR-191-5p) were validated by qRT-PCR. [score:3]
The expression level of four miRNAs (miR-424-5p, miR-27b-3p, miR-377-5p, miR-3680-5p) in the peripheral blood mononuclear cells samples from LTBI and healthy participants reflected the altered patterns observed in the microarray profile. [score:3]
Relative expressions of miR-424-5p, miR-496-5p, miR-27a-3p, miR-377-5p, and miR-3680-5p in LTBI and healthy samples. [score:3]
The miR-424-5p (previous ID: miR-424), miR-493-5p (previous ID: miR-493*), and miR-296-5p were reported as potential to discriminate between latent TB and healthy by the previous study [12], the other four miRNAs (miR-27b-3p, miR-377-5p, miR-3680-5p, miR-191-5p) were randomly selected. [score:1]
[1 to 20 of 9 sentences]
3
[+] score: 1
The respective 16 markers include hsa-miR-1299, hsa-miR-3124, hsa-miR-4290, hsa-miR-2278, hsa-miR-32*, hsa-miR-3149, hsa-miR-877*, hsa-miR-584, hsa-miR-3148, hsa-miR-122, hsa-miR-718, hsa-miR-670, hsa-miR-3680*, hsa-miR-193b*, hsa-miR-3911 and hsa-miR-1228* (see Figure  4). [score:1]
[1 to 20 of 1 sentences]
4
[+] score: 1
The 1q21.1 CNV contains a single miRNA of unknown role (miR-5087), while the 16p11.2 paternal duplication covers 2 miRNAs: miR-3680-3p and miR-3680-5p and the de novo 16p11.2 deletion has no miRNA content (Additional file 1: Table S2). [score:1]
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