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4 publications mentioning hsa-mir-3666

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-3666. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 21
First, both miR-3666 and FOXP2 play a larger regulatory role than expected by examining the sole impact of FOXP2 on transcription: putatively downregulated targets of miR-3666 may complexify the impact of FOXP2. [score:7]
However, how defective FOXP2 expression associated with miR-3666 misexpression might promote oncogenic initiation, maintenance, or aggressiveness remains to be assessed. [score:5]
In particular, repressive role of FOXP2 on target genes may be due in part to miR-3666 and begs for a thorough analysis of the direct binding of FOXP2. [score:4]
Recently, computational evidence has been proposed for an auto-repression of FOXP2 by miR-3666 in cell lines, and uncovered a set of several hundred genes conjointly targeted by both, with a bias toward genes putatively involved in schizophrenia and/or autism spectrum disorder [50]. [score:3]
In the context of cancer progression, miR-3666 has been associated with several cancer types and displayed reduced transcripts levels in lung [51], thyroid [52] and pituitary cancer cells [53]. [score:1]
Of particular clinical interest is miR-3666 (NR_037439), a mirtron located within the FOXP2 locus at 7 [+]:114653345-114653455 (GRCh 38) in intron 9. This intronic transcript is spliced out from all FOXP2 pre-mRNAs isoforms. [score:1]
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[+] score: 5
Prediction of functions of the best matched targets of each known miRNAs revealed that targets of some miRNAs were related to energy metabolism, including NADH dehydrogenase (miR-4144-3p, miR-1837, miR-125b*, and miR-36a*) and ATPase (miR-3666, miR-4115-5p, miR-4038-3p, miR-3668, miR-3559-3p, and miR-503); some of them were related to transcription initiation factor (miR-369-3p, miR-139, miR-4082-3p and miR-4148-5p), and splicing factor (miR-23a*, miR-767-3p, miR-463, miR-598 and miR-2881). [score:5]
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[+] score: 3
We use bioinformatics analyses to screen SDF-1 targeting miRNAs, e. g. miR-301a, miR-301b, miR-3666, miR-130a, miR-130b, miR-4295, miR-454, etc. [score:3]
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[+] score: 1
org/) and have been assigned the names hsa-miR-3665 and hsa-miR-3666, respectively. [score:1]
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