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1 publications mentioning hsa-mir-4274

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-4274. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

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[+] score: 43
Predicted targets for miR-4274 are BTF3, LRRC1, SOCS5, RAB10, FGR, RABGEF2 and ESRRG genes. [score:3]
Figure 3 Correlation between miRNA expression levels and genotypes for miR-3679 and miR-4274. [score:3]
In our study the AA genotype for both rs6430498 and rs12512664 showed higher expression levels of miR-3679-3p and miR-4274 in hOBs, respectively. [score:3]
Association between expression levels of mature miRNA miR-3679-3p and miR-4274 with its corresponding own genotype was analyzed. [score:3]
Two osteoblast-related microRNAs, miR-3679 and miR-4274, were found to be associated with femoral neck BMD and overexpressed in OP fractured bone. [score:3]
The A allele for both SNPs was associated with higher expression of each corresponding miRNA (miR-3674; log-additive mo del; p value = 0.015; recessive mo del; p value = 0.03, and miR-4274; recessive mo del; p value = 0.013). [score:3]
MiR-3679 and miR-4274, which harbored BMD -associated SNPs in their pre-miRNA sequence (Fig.   2), were quantified by qPCR in order to compare the expression levels between OP and non-OP bone samples. [score:3]
Once cells reached 60–70% of confluence, transient transfections were performed using mirVana mimics and inhibitors of both hsa-miR-3679-3p and hsa-miR-4274. [score:3]
Moreover, as a sensitivity test, we analyzed the miR-3679-3p and miR-4274 expression levels separated according to the exchanged genotype amongst both miRNAs (rs12512664 and rs6430498 respectively). [score:3]
In contrast, analysis of targeted genes and pathways for miR-4274 suggests that this miRNA could be involved, broadly, in vesicular and membrane trafficking, cell migration and adhesion, and cell metabolism. [score:3]
Cells were transfected with both mimics and inhibitors of miR-3679-3p and miR-4274, and their corresponding controls at day 1, and day 14 after seeding. [score:3]
Both miRNAs miR-3679-3p and miR-4274 were significantly overexpressed in the OP samples (Table  3). [score:3]
In-vitro assessment of osteoblast activity and matrix mineralizationhOBs were treated with miR-3679-3p and miR-4274 mimics or inhibitors and their respective controls for investigating their role in osteoblast function (Supplemental Fig.   1). [score:1]
Black arrows tag the corresponding allele for rs6430498 in the miR-3679 and rs12512664 in the miR-4274. [score:1]
In conclusion, two putative functional SNPs in the pre-miRNA sequence of miR-3679 and miR-4274 were associated with femoral neck BMD. [score:1]
hOBs were treated with miR-3679-3p and miR-4274 mimics or inhibitors and their respective controls for investigating their role in osteoblast function (Supplemental Fig.   1). [score:1]
Since information about these two miRNAs is very scarce, this study could be considered as a preliminary approach presenting miR-3679-3p and miR-4274 within the complex network of bone regulation. [score:1]
Once again, no differences were found in both miRNA analyzed (miR-3679-3p; rs12512664: p-value = 0.713 and miR-4274; rs6430498: p-value = 0.645). [score:1]
SNP rs6430498 in the miR-3679 was significantly associated with FN BMD in a log-additive (p value = 0.036, Beta coefficient [95% CI] = −0.008 [−0.015 to −0.001] and recessive mo del (p value = 0.021, Beta coefficient [95% CI] = −0.017 [−0.032 to −0.003]); and the SNP rs12512664 in the miR-4274 was also significantly associated with FN BMD in a log-additive (p value = 0.016, Beta coefficient [95% CI] = 0.008 [0.002 to 0.015] and recessive mo del (p value = 0.01, Beta coefficient [95% CI] = 0.015 [0.004 to 0.027). [score:1]
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