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8 publications mentioning sja-mir-10

Open access articles that are associated with the species Schistosoma japonicum and mention the gene name mir-10. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 9
These results suggested that high-abundance miRNAs such as miR-1c, miR-1a, miR-10-5p, miR-71b-5p, and let-7 were closely related to the development of 18 d-old females before pairing, whereas during the development from 18 d to 23 d, all of these high-abundance miRNAs were down-regulated not only in 23 DSI, but also in 23SSI. [score:6]
In particular, nearly all high-abundance miRNAs, such as miR-1c, miR-1a, miR-10-5p, miR-71b-5p, and let-7, were down-regulated in both, compared with 18DSI or 18SSI. [score:3]
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2
[+] score: 5
These findings demonstrated that schistosomal eggs release EVs during development in vitro and these 30–100 nm sized vesicles carry miRNAs that are both parasite-specific and homologs of mammalian (host) (e. g. mouse miR-10) miRNAs. [score:2]
Among the 13 known Sja-miRNAs identified in the egg EVs, Sja-bantam, Sja-miR-10 and Sja-miR-3479-3p were all previously detected in serum obtained from rabbits infected with S. japonicum [39]. [score:1]
We found 13 known S. japonicum miRNAs (reads >100) present in the schistosomal egg EV libraries (Table  2 and Additional file 2: Table S1), including three miRNAs (miR-10, bantam and miR-3479-3p) that were present in the plasma of S. japonicum infected host rabbits in a previous study [39]. [score:1]
Interestingly, bantam and miR-10 were significantly enriched in the libraries of EVs derived from schistosomal adult worms, whereas miR-3479-3p did not appear in those EV libraries [33]. [score:1]
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3
[+] score: 4
Schisitosoma miR-10, miR-124, miR-125, miR-192, miR-31, and let-7 were analysed by comparing all known orthologs from bilaterian animals, excluding schistosomes, as described using WebLogo described above. [score:1]
Some of the common Schistosoma miRNAs, including let-7, miR-8, miR-10, miR-31, miR-92, miR-124 and miR-125, are evolutionally conserved across bilaterian animals (Figure 5A). [score:1]
Although 21 S. japonicum miRNAs are orthologs of known miRNAs within the metazoans, some nucleotides at many positions of Schistosoma miRNAs, such as miR-8, let-7, miR-10, miR-31, miR-92, miR-124, and miR-125, are indeed significantly distinct from other bilaterian orthologs. [score:1]
Similarly, we also aligned other highly conserved miRNAs, such as let-7, miR-10, miR-31, miR-92, miR-124 and miR-125, across bilaterian animals using WebLogo tool. [score:1]
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4
[+] score: 4
Three of these (sja-bantam, sja-miR-3479-3p, sja-miR-10-5p) were further detected in the plasma of S. japonicum-infected mice by stem-loop RT-PCR analysis [22]. [score:1]
Sja-miR-10-5p was excluded from analysis due to its high sequence homology with mammalian host orthologs. [score:1]
Detection of parasite-derived miRNAs in the serum of C57BL/6 and BALB/c mice during S. japonicum infectionUsing a deep sequencing method, Cheng et al. identified the presence of five schistosome-specific miRNAs (sja-bantam, sja-miR-3479-3p, sja-miR-10-5p, sja-miR-3096 and sja-miR-8185) in the plasma of S. japonicum-infected rabbits. [score:1]
Using a deep sequencing method, Cheng et al. identified the presence of five schistosome-specific miRNAs (sja-bantam, sja-miR-3479-3p, sja-miR-10-5p, sja-miR-3096 and sja-miR-8185) in the plasma of S. japonicum-infected rabbits. [score:1]
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5
[+] score: 2
Other miRNAs from this paper: sja-bantam
Further analyses demonstrated that S. japonicum EV associated miRNAs (Bantam and miR-10) were significantly detected in the RNA isolated form cells treated with labeled S. japonicum EVs (Fig. 6b), indicating that the miRNA cargo of S. japonicum EVs can transfer to recipient cells. [score:1]
We found that 15 known S. japonicum miRNAs (cut-off reads >100) were present in S. japonicum EVs libraries (Table 2 and Supplementary Dataset 3), including two miRNAs (Bantam and miR-10) identified in the plasma of S. japonicum infected hosts in our previous study 24. [score:1]
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6
[+] score: 2
Furthermore, the 8 conserved miRNAs were identified as originating from 6 miRNA families, namely miR-124, miR-2 (miR-2b, miR-2e), bantam, miR-10, let-7 and miR-71 (miR-71, miR-71b). [score:1]
The REL of miR-10 was 2.33 fold higher in F. gigantica (2.21±0.16) than that in F. hepatica (0.95±0.05); and the let-7 was 1.14 fold higher F. gigantica (1.14±0.30) than that in F. hepatica (1.00±0.16). [score:1]
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7
[+] score: 2
Except for miR-10 that had two mature miRNAs located at the 5p and 3p arms of its precusor, all of the other miRNAs had only one mature miRNA found at 5p or 3p arms of their precursors. [score:1]
Another two miRNAs named Epa-miR-09 and Epa-miR-10 came from another scaffold named as SJC_S000254. [score:1]
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8
[+] score: 2
In some cases (such as sja-miR-10, sja-miR-36, sja-miR-61, sja-miR-133, sja-miR-277, sja-miR-310, and sja-miR-candidate-03), a presumed precursor transcript of about 80 nt was detected by northern blot in addition to the 22 nt species. [score:1]
Membranes were incubated with biotin-labeled probes complementary to candidate miRNA sequences (sja-miR-1a, sja-miR-1b, sja-miR-7, sja-miR-71b, sja-miR-71a, sja-miR-87, sja-miR-124, sja-miR-281, sja-miR-2b, sja-miR-2a, sja-miR-307, sja-miR-31, sja-miR-133, sja-miR-310, sja-miR-8, sja-miR-10, sja-miR-36, sja-miR-61, sja-miR-277, sja-miR-219, sja-miR-190, sja-miR-candidate-03). [score:1]
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