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3 publications mentioning hsa-mir-3200

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-3200. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 29
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-mir-145, hsa-mir-2467
Real-time analysis of both undifferentiated (H1 and H9) and differentiated depletion of basic fibroblast growth factor (−bFGF) and mouse embryonic fibroblasts (MEF) induction) cells showed that miR-2467-5p, miR-3200-3p and let-7a/e-5p expression was significantly upregulated during differentiation (t-test, P<0.01 Fig. 7f), accompanied by gradual reductions in GAS5, NODAL signalling-related gene and pluripotency gene expression (Fig. 7g), indicating the existence of an inverse relationship between the expression of these miRNAs and GAS5 -mediated NODAL signalling. [score:10]
Because miR-2467-5p, miR-3200-3p and let-7a/e-5p facilitated expression of similar phenotypes resembling NODAL inhibition, we investigated whether NODAL rescues the effects of these miRNAs. [score:3]
At the same time, overexpression of miR-2467-5p, miR-3200-3p or let-7a/e-5p also promoted GAS5 turnover (Supplementary Fig. 6i). [score:3]
The pcDNA3.1-GAS5 with point mutations in the DBD mimic sequence, miR-2467, miR-3200 and let-7a/e response elements was synthesized using a QuikChange Site-Directed Mutagenesis kit (Stratagene). [score:3]
We found that miR-2467-5p, miR-3200-3p and let-7a/e-5p did not directly target these pluripotency factors, using dual luciferase assays (Supplementary Fig. 7c). [score:3]
On the basis of these data, we concluded that miR-2467-5p, miR-3200-3p and let-7a/e-5p play important roles in GAS5 -mediated NODAL regulation. [score:2]
These data suggest that the GAS5 transcript post-transcriptionally regulates the levels of miR-2467-5p, miR-3200-3p and let-7a/e-5p, and promotes their degradation. [score:2]
The biological significance of miR-2467-5p, miR-3200-3p, let-7a/e-5p and their regulatory transcripts is unknown. [score:2]
qPCR analysis showed that miR-2467-5p, miR-3200-3p and let-7a/e-5p were significantly enriched in the wild-type GAS5 and NODAL transcripts, and that no significant enrichment occurred in the relative site-mutated GAS5 transcripts or in a GAS5 transcript, in which all miRNA -binding sites were mutated (Fig. 6g). [score:1]
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2
[+] score: 8
The expression of miR-17-5p is presented as box whisker plot in Fig.   7. Likewise, this figure presents the expression of miR-3200-3p, which is most significantly down-regulated following the training period in strength and endurance athletes. [score:8]
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3
[+] score: 2
In whole blood samples of healthy controls we found nine miRNAs (hsa-miR-130b*, hsa-miR-182, hsa-miR-183, hsa-miR-3180-3p, hsa-miR-3200-5p, hsa-miR-409-3p, hsa-miR-4318, hsa-miR-501-5p, hsa-miR-942) that were detected in all whole blood samples but not in any of the separated leukocyte subsets of healthy controls. [score:1]
For the lung cancer patients five miRNAs (hsa-miR-3180-3p, hsa-miR-3200-5p, hsa-miR-4318, hsa-miR-942, hsa-miR-144*) were detected in all whole blood samples but not in any of the separated leukocyte subsets of lung cancer patients. [score:1]
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