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8 publications mentioning hsa-mir-3065

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-3065. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 52
Other miRNAs from this paper: hsa-mir-338, hsa-mir-657, hsa-mir-761, hsa-mir-1250, hsa-mir-4739
Given that two of the top predicted targets are likely oncogenes, it is possible that the role of MIR3065 is to suppress expression of these oncogenes. [score:7]
Perhaps the most compelling support implicating MIR3065 and BC comes from a recent study by Perrson et al. in which NGS expression analysis in paired normal and breast tumor tissue demonstrates a strikingly disparate expression pattern for MIR3065 [18]. [score:5]
Additionally, AATK contains three more miRNAs in close proximity to miR-3065: miR-657, miR-338 and miR-1250 To better understand the implications of inherited susceptibility to BC that may involve BAIAP2, we examined expression of this gene in human tissues using data from the Genotype-Tissue Expression (GTEx) project portal version 6 [45]. [score:5]
While tissue MIR3065 expression was highest in breast tumors in a panel of nine human tissues, both lung and placenta demonstrated the next highest expression levels. [score:5]
Among TargetScan’s (release 6.2, June 2012) MIR3065 gene top 15 predicted gene targets are the top hit AT-rich interaction domain 4B, ARID4B (alias BRCAA1, breast cancer antigen epitope-1) and RAB22A, a member of the RAS oncogene family of small GTPases involved in signal transduction [62– 65]. [score:5]
All four SNPs reside in a genomic region that includes the first intron of the brain-specific angiogenesis inhibitor 1 -associated protein 2 (BAIAP2), as well as the predicted primary transcript for MIR3065. [score:3]
Given their genomic location within the intron of BAIAP2 and pri- MIR3065 sequence, these four SNPs have the potential to impact BAIAP2 expression, BAIAP2 gene intron 1 binding proteins, and/or MIR3065 biogenesis. [score:3]
It is also possible that the pri- MIR3065 SNP associated with BC (or a SNP in LD) impairs MIR3065 processing, leading to lower levels of mature MIR3065 and reduced inhibition of these oncogenes. [score:3]
This complex and gene-dense region contains BAIAP2, a protein-coding gene, and MIR3065, an important nonprotein coding regulatory gene, which may play key roles in BC development and heterogeneity among AA women. [score:3]
These SNPs reside in a genomic location that includes both the predicted primary transcript of the noncoding miRNA gene MIR3065 and the first intron of the gene for brain-specific angiogenesis inhibitor 1 -associated protein 2 (BAIAP2). [score:3]
Mature MIR3065 resides in a gene adjacent to BAIAP2 known as apoptosis -associated tyrosine kinase (AATK) where it is located in the seventh intron and is transcribed in the opposite direction from its host gene. [score:2]
Germline genetic variation indicates that MIR3065 may play an important role in BC development and heterogeneity among AA women. [score:2]
For example, in addition to supporting the potential role of MIR3065 in BC, Perrson et al. also uncovered a new miRNA in a very well-studied region within the intron of ERBB2/HER2, a major predictive marker in BC [18]. [score:1]
Similar to previous studies, through BAC array comparative genomic hybridization (CGH), MIR3065 was also identified as a gene encoded in a region with high-level genomic amplification in luminal B, ERBB2/HER2 -positive, ER positive, and ER negative subtypes. [score:1]
In this gene (AATK) and miRNA-rich region, mature MIR3065 and mature MIR338 share the same genomic location but are transcribed from opposite DNA strands (Fig.   2) [44]. [score:1]
Fig. 2Chromosome 17 position GRCh37/hg19: 79,008,947–79,105,748, encompassing breast cancer -associated SNPs, defined promoter, primary, precursor, mature and 3’-UTR, miR-3065 gene regions and other overlapping coding genes. [score:1]
Functional assessment of the BC -associated SNPs in BAIAP2 and MIR3065 are needed to identify the potential molecular mechanism behind their association with BC risk, in particular the risk of ER positive BC, the most common subtype. [score:1]
Included among these SNPs was rs73410309 within the precursor sequence of MIR4739 located on chromosome 17q25.3 (OR = 1.1; p = 0.039), which is approximately 1.5 Mb from our top hit in MIR3065 (rs9913477) and not in high LD with this SNP (D’ = 0.007 and R [2] = 0.0) based on AFR 1000 Genomes reference panel [57]. [score:1]
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2
[+] score: 36
Furthermore, a synergistic anti-TI effect of hsa-miR-3065-3p may inhibit the three viruses in a multi-target fashion, where downregulation of one virus may down-regulate the other two. [score:11]
We conclude that hsa-miR-3065-3p could be utilized as a potential target for antiviral therapeutics for TI patients and also in mono-infected patients. [score:3]
However, hsa-miR-3065-3p may indirectly be beneficial by silencing of HIV-1, which causes immunodeficiency and may be at least partially responsible for increasing the replications of and HBV (29). [score:2]
Hence, through our computational analysis, we propose the utility of hsa-miR-3065-3p in TI patients as a potential therapeutic agent infected with/HIV-1/HBV It is worth mentioning that hsa-miR-122 has been the subject of intensive investigations around the globe, and it has been fairly well established that this miRNA appears to play a crucial role in upregulating intracellular replication in hepatic cells (12, 13, 21, 22, 24). [score:2]
Here, we show via computational analysis that hsa-miR-3065-3p could be used as a therapeutic marker for treatment of triple infections (i. e., HIV-1, and HBV). [score:1]
We also performed computational analysis for 1,527 hsa-miRs to assess their alignment with all six genotypes of and found that hsa-miR-3065-3p was the only miRNA that aligned with genotype 1, as well as with HIV-1 and HBV. [score:1]
hsa-miR-3065 identity with, HIV-1, and HBV. [score:1]
As shown in Table 1, hsa-miR-3065-3p exhibited significant identity with all three viruses. [score:1]
Hsa-miR-122 shows an imperfect identity at seed residue position #4 and hsa-miR-3065-3p shows an imperfect identity at seed residue position #7 in the seed sequence (2–8 bps) to the genome (Table 1). [score:1]
Our analyses identified that hsa-miR-3065-3p shares significant mutual identity with all three viruses. [score:1]
The main focus of this study is hsa-miR-3065-3p and not hsa-miR-122, hsa-miR-99, or has-miR-548. [score:1]
We present evidence that hsa-miR-3065-3p may have a potential therapeutic application in TI patients, as well as in mono-infected individuals (12– 16). [score:1]
Here, we present evidence using essential components of bioinformatics tools, and hypothesize that utility of hsa-miR-3065-3p and perhaps miR-548 would be potential antiviral therapeutic agents in the treatment of TI patients because it shows near perfect alignment in the seed region for all three viruses. [score:1]
We analyzed the identity of hsa-miR-3065-3p through computational analysis and came to the conclusion that it is perhaps a better miRNA than hsa-miR-122 as a therapeutic agent for infection alone or for treatment of TI patients suffering from, HIV-1, and HBV. [score:1]
hsa-miR-3065 identity with, HIV-1, and HBVHere, we show via computational analysis that hsa-miR-3065-3p could be used as a therapeutic marker for treatment of triple infections (i. e., HIV-1, and HBV). [score:1]
The ‘mature’ and ‘stem-loop’ sequences for hsa-miR-122 and hsa-miR-3065 were obtained from the ‘miRBase’ database (http://www. [score:1]
However, neither of the two miRNAs (i. e. hsa-miR-3065-3p and hsa-miR-122) exhibited 100% identity with. [score:1]
However, an overall high identity of hsa-miR-3065-3p to all three viruses may still make this miRNA a strong candidate against all three viruses. [score:1]
As summarized in Table 1, we also show that three hsa-miRs (miR-3065-3p, miR-99, and miR-548) exhibited a significant mutual identity to genomic sequences of these three viruses. [score:1]
We identified one unique miRNA, hsa-miR-3065-3p, that shares significant mutual identity to these three viral genomes (∼61–83%). [score:1]
Triple infection and hsa-miR-3065 identityAll TI viruses share similar modes of transmission that include blood to blood contact, sexual contact with an infected person, or vertical (mother to child) transmission. [score:1]
Triple infection and hsa-miR-3065 identity. [score:1]
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3
[+] score: 7
83 (0.13) −0.07 (1.0) hsa-miR-551b-3p ND ND ND hsa-miR-3065-5p −1.4 (0.03) −2.2 (0.002) −0.74 (1.0) hsa-miR-196a-5p 0.23 (1.0) 0.07 (1.0) −0.31 (1.0) BE, Barrett's esophagus; GERD, Gastroesophageal reflux disease; EE refers to those GERD patients with erosive esophagitis; NERD (Non-erosive reflux disease) refers to those GERD patients without erosive disease; NGS, next generation sequencing; negative numbers indicate downregulation in BE compared to GERD; 1 Fold changes by RT-PCR calculated by ΔΔCt method; 2 p-value was adjusted for false discovery rate of 5% and reported in parentheses; miRs-4253, -4776-3p, -548n and -675-3p were also significantly different but with reads <25 in each group and were not included for RT-PCR validation; ND, not detected. [score:7]
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4
[+] score: 4
Other miRNAs from this paper: hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-27a, hsa-mir-30a, hsa-mir-32, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-107, hsa-mir-129-1, hsa-mir-30c-2, hsa-mir-139, hsa-mir-181c, hsa-mir-204, hsa-mir-212, hsa-mir-181a-1, hsa-mir-222, hsa-mir-15b, hsa-mir-23b, hsa-mir-132, hsa-mir-138-2, hsa-mir-140, hsa-mir-142, hsa-mir-129-2, hsa-mir-138-1, hsa-mir-146a, hsa-mir-154, hsa-mir-186, rno-mir-324, rno-mir-140, rno-mir-129-2, rno-mir-20a, rno-mir-7a-1, rno-mir-101b, hsa-mir-29c, hsa-mir-296, hsa-mir-30e, hsa-mir-374a, hsa-mir-380, hsa-mir-381, hsa-mir-324, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-15b, rno-mir-17-1, rno-mir-18a, rno-mir-19b-1, rno-mir-19b-2, rno-mir-19a, rno-mir-21, rno-mir-23a, rno-mir-23b, rno-mir-24-1, rno-mir-24-2, rno-mir-27a, rno-mir-29c-1, rno-mir-30e, rno-mir-30a, rno-mir-30c-2, rno-mir-32, rno-mir-92a-1, rno-mir-92a-2, rno-mir-93, rno-mir-107, rno-mir-129-1, rno-mir-132, rno-mir-138-2, rno-mir-138-1, rno-mir-139, rno-mir-142, rno-mir-146a, rno-mir-154, rno-mir-181c, rno-mir-186, rno-mir-204, rno-mir-212, rno-mir-181a-1, rno-mir-222, rno-mir-296, rno-mir-300, hsa-mir-20b, hsa-mir-431, rno-mir-431, hsa-mir-433, rno-mir-433, hsa-mir-410, hsa-mir-494, hsa-mir-181d, hsa-mir-500a, hsa-mir-505, rno-mir-494, rno-mir-381, rno-mir-409a, rno-mir-374, rno-mir-20b, hsa-mir-551b, hsa-mir-598, hsa-mir-652, hsa-mir-655, rno-mir-505, hsa-mir-300, hsa-mir-874, hsa-mir-374b, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-874, rno-mir-17-2, rno-mir-181d, rno-mir-380, rno-mir-410, rno-mir-500, rno-mir-598-1, rno-mir-674, rno-mir-652, rno-mir-551b, rno-mir-344b-2, rno-mir-3564, rno-mir-3065, rno-mir-1188, rno-mir-3584-1, rno-mir-344b-1, hsa-mir-500b, hsa-mir-374c, rno-mir-29c-2, rno-mir-3584-2, rno-mir-598-2, rno-mir-344b-3, rno-mir-466b-3, rno-mir-466b-4
Finally, miR-30c-2-3p, miR-101b-3p, miR-142-3p, miR-142-5p, miR-181a-1-3p, miR-374-5p, miR-466c-3p, miR-1188-3p, miR-3065-3p and miR-3582 were significantly down-regulated in the chronic stage (Supplementary Fig. S7D). [score:4]
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5
[+] score: 4
This phenomenon showed that both strands of specific genomic region could be transcribed to generate the same mature miRNAs (for example, hsa-mir-3130-1 and hsa-mir-3130-2, Figure 2C) or different mature miRNAs (for example, hsa-mir-338 and hsa-mir-3065, Figure 2A). [score:1]
For example, both hsa-miR-338-5p and hsa-miR-338-3p could be accurately mapped to the opposite strand of hsa-mir-3065 (Figure 2A). [score:1]
These two miRNA genes shared consensus sequences, in which hsa-mir-338 was a part of the opposite strand of hsa-mir-3065 (Figure 2A). [score:1]
In fact, these two miRNAs were generated from sense and antisense strands of the same genomic location according to the miRBase annotation (hsa-mir-338: chromosome 17 (−): 79,099,683–79,099,749; and hsa-mir-3065: chromosome 17 (+): 79,099,677–79,099,755). [score:1]
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6
[+] score: 3
01 Stress response, cell proliferation miR-542 ↓2.60 NA miR-574 ↑2.09 Inflammation (Tlr9 activation), cell proliferation, apoptosis miR-669j ↑3.12 NA miR-672 ↑2.40 NA miR-674 ↑2.19 NA miR-744 ↑4.35Oncogene (Tgf) suppression miR-873 ↑2.53 ↑3.22 NA miR-1930 ↑3.31 NA miR-1934 ↑2.17 ↑3.27 NA miR-1942 ↑2.49 NA miR-3064 ↑2.50 NA miR-3065 ↑3.20 NA miR-3069 ↑2.98 NA miR-3071 ↑3.51 NA miR-3073 ↓2.78 NA miR-3092 ↑3.48 NA miR-3093 ↑3.28 NA miR-3109 ↓2.07 NAAll reported variations were statistically significant (P < 0.05). [score:3]
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7
[+] score: 1
Other miRNAs from this paper: hsa-mir-200b, hsa-mir-301a, hsa-mir-515-1, hsa-mir-515-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, mml-mir-301a, mml-mir-548a, mml-mir-548b, mml-mir-548c, mml-mir-548d, mml-mir-548e, mml-mir-548f, ptr-mir-301a, ptr-mir-515-1, ptr-mir-515-2, ptr-mir-548a-1, ptr-mir-548a-2, ptr-mir-548b, ptr-mir-548c, ptr-mir-548f-1, ptr-mir-548f-2, ptr-mir-548h, ptr-mir-548i-1, ptr-mir-548i-2, ptr-mir-548i-3, ptr-mir-548i-4, ptr-mir-548i-5, ptr-mir-548j, ptr-mir-548k, ptr-mir-548l, ptr-mir-548n, ptr-mir-548p, hsa-mir-2115, hsa-mir-548q, hsa-mir-2681, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, ppy-mir-515-1, ppy-mir-515-2, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-4511, hsa-mir-548am, hsa-mir-548an, hsa-mir-4691, hsa-mir-203b, hsa-mir-4760, hsa-mir-4762, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, ptr-mir-548o, ptr-mir-548e, ggo-mir-548b, ggo-mir-203b, ggo-mir-548c, ggo-mir-548e, ggo-mir-548a, ggo-mir-548d, ggo-mir-548f, ggo-mir-200b, ppy-mir-548e, ppy-mir-548a, ppy-mir-548h, ppy-mir-548f, ppy-mir-548c, hsa-mir-548ay, hsa-mir-548az, mml-mir-548g, mml-mir-548h, mml-mir-548i, mml-mir-548j, hsa-mir-548ba, hsa-mir-548bb, ggo-mir-515-1, ggo-mir-515-2, ppy-mir-515-3, hsa-mir-548bc, ggo-mir-301a, ppy-mir-301a
While in the orangutan, the binding sites of GATA2 have been discovered in the upstream sequences of the five intergenic miRNA genes except ppy-mir-200b, ppy-mir-203b and ppy-mir-3065 (Table S6). [score:1]
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8
[+] score: 1
For example, miR-2964-3p and miR-3065-5p were detected only by the Bioo Scientific kit. [score:1]
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