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13 publications mentioning oar-let-7c

Open access articles that are associated with the species Ovis aries and mention the gene name let-7c. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 26
Then Reinhart et al. [2] found another small RNA that possessed a posttranscriptional regulatory function, which was named let-7. In the following years, more and more researchers have successfully discovered this kind of RNAs and named these small RNAs miRNAs, which are noncoding and have specific temporal and spatial expressions. [score:4]
Obvious differences were noted in the expression levels of the let-7 family. [score:3]
The loss of let-7 gene activity causes reiteration of larval cell fates during the adult stage, whereas increased let-7 gene dosage leads to precocious expression of adult fates during larval stages. [score:3]
The let-7 family of miRNAs comprises one of the key regulatory elements in the developmental process. [score:3]
Phylogenetic analyses have demonstrated that the let-7 family is highly conserved in both sequence and function among mammals, and it plays a critical role during animal development. [score:2]
A comparison of these eight let-7 family types between Ovis aries and 12 other mammals illustrated that the let-7 family sequences had high similarity within Mammalia (see Figure S4). [score:1]
B. Alignments of the nine kinds of sequenced let-7-3p miRNAs and the corresponding homologous let-7-3p miRNAs. [score:1]
This study also found that the let-7 family of miRNAs possessed the same seed sequence (5′-GAGGTA-3′) reported in previous studies. [score:1]
For example, let-7 was identified as a heterochronic switch gene. [score:1]
A. Alignments of the seven kinds of sequenced let-7-5p miRNAs and the corresponding homologous let-7-5p miRNAs. [score:1]
These let-7-5p miRNAs possessed the same seed sequence (the 2nd to 7th bases at 5′ end, 5′-GAGGTA-3′). [score:1]
Eight kinds of Ovis aries let-7 family genes were discovered during this research: oar-let-7a-2 (427,369.75 reads), oar-let-7a-3 (288 reads), oar-let-7b (84,793.63 reads), oar-let-7c-1 (86,997.63 reads), oar-let-7d (28,816 reads), oar-let-7e (18,198.73 reads), oar-let-7f-1 (156,359.98 reads), oar-let-7g (19 reads), and oar-let-7i (148,896.89 reads). [score:1]
This study also found that the Ovis aries let-7 family miRNAs possessed the same seed sequence (5′-GAGGTA-3′). [score:1]
Figure S4 Alignment of the let-7 family of miRNAs sequenced in this study and the corresponding homologous let-7 family of miRNAs recorded in miRBase v17.0. [score:1]
To date, nine kinds of let-7 family genes have been identified [i. e., let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, and let-7j (only identified in dogs)] in mammals. [score:1]
The let-7 family has been studied in many species, including mammals, birds, insects, and plants. [score:1]
[1 to 20 of 16 sentences]
[+] score: 17
Five highly expressed miRNAs (miR-1, miR-206, miR-133, miR-29 and let-7) and three lowly expressed miRNAs (miR-155, miR-15 and miR-146) were chosen, and their expression levels in the biceps femoris muscle of adult (12-month-old) Altay sheep were determined using qRT-PCR according to an approach called miR-Q [41]. [score:7]
To validate the accuracy of the microarray data, five highly expressed miRNAs (miR-1, miR-206, miR-133, miR-29 and let-7) and three lowly expressed miRNAs (miR-155, miR-15 and miR-146) were chosen, and their expression in the biceps femoris muscle of adult (12-month-old) Altay sheep were detected using qRT-PCR. [score:7]
We further analyzed the microarray result and found that only 22 miRNAs; let-7a, let-7c, miR-1, miR-206, miR-133a, miR-133b, miR-128–1, miR-128–2, miR-140, miR-143, miR-199a, miR-22, miR-26a, miR-27b, miR-29a, miR-29c, miR-378–1, miR-378–2, miR-486, miR-499, miR-99a and miR-101–2 have high levels of expression. [score:3]
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[+] score: 11
In addition, the apoptosis, Wnt signaling, and C21-Steroid hormone metabolism pathways, which contain target genes of the let-7 family, are important for granulosa cell proliferation, follicular growth and development, and luteinic formation and regression. [score:4]
The mir-10 (MIPF0000033), mir-143 (MIPF0000094), let-7 (MIPF0000002) and mir-26 (MIPF0000043) families were found to be preferentially expressed in ovine ovary. [score:3]
For example, the expression abundance of let-7 family members varied from 0 to 344,318 reads. [score:3]
Some of the abundant miRNAs in the anestrous ovary of Tan sheep, including miR-143, miR-26a, let-7 and miR-21, were also reported to be highly abundant in ovaries of human, cow [23– 25], pig [26], adult and neonatal mouse [27, 28] and sheep [2, 3]. [score:1]
[1 to 20 of 4 sentences]
[+] score: 11
let-7c and let-7i belong to the let-7 family, which is an important tumor-suppressor miRNA, and both are downregulated. [score:6]
The expression pattern of miR-143, miR-10a, miR-199p-3a, let-7c, let-7i, NW_004080189.1_7961, NW_004080184.1_6535, NW_004080184.1_6326, NW_004080165.1_8572, NW_004080166.1_9139, NW_004080181.1_3961, NW_004080174.1_726, NW_004080166.1_10417 and NW_004080190.1_13733 showed that they may participate in the formation of hair follicles and different flower pattern. [score:3]
Research studies on miRNA -10a, let-7c, and let-7i are mainly related to cancer and their roles in animal hair follicle development are largely unknown. [score:2]
[1 to 20 of 3 sentences]
[+] score: 8
In the L4 libraries, hco-miR-5885a-3p, hco-miR-5885b-3p, hco-miR-5885c-3p, hco-miR-5908-3p, hco-lin-4-5p, hco-miR-83-3p and sequences homologous to cel-let-7-5p and asu-miR-100a-5p, not previously identified from H. contortus, are all highly expressed in the L4 EV-enriched and have lower read counts in the L4 EV -depleted libraries. [score:3]
Interestingly, some of these (let-7, miR-100) have identity within the seed region to mammalian miRNAs, implying that they could potentially regulate host genes [21], or alternatively compete in host miRNA -mediated regulation. [score:3]
Interestingly a number of these (asu- miR-100a-5p, miR-60-3p, miR-71-5p, let-7-5p, lin-4-5p and miR-5885a, b, c-3p) were also present in EV libraries prepared from H. polygyrus adult stage [9], while miR-100a-5p and let-7-5p were recently identified in adult EV of the clade I nematode Trichuris muris [21]. [score:1]
This is consistent with data on secreted miRNAs of H. polygyrus that showed enrichment of let-7, mir-100 and mir-60 in the vesicle rather than supernatant fraction [9]. [score:1]
[1 to 20 of 4 sentences]
[+] score: 7
For example, members of the let-7 family (let-7a, let-7b and let-7c) were detected to be less abundant in lambs with curly fleece than in adults with non-curling fleece, consistent with previous observation that let-7 miRNAs showed decreased expression from small waves to medium waves and medium waves to large wave in Hu sheep [32]. [score:3]
Therefore, we speculate that let-7 miRNAs may function by altering the expression profiles in hair cells, thereby changing hair cell differentiation and function and facilitating the hair curvature. [score:3]
Other studies also showed that let-7 genes are related to the growth of hair follicles and hair quality in skin tissue [33, 34]. [score:1]
[1 to 20 of 3 sentences]
[+] score: 5
MiR-let-7, which includes miR-let-7i, miR-let-7c, and miR-let-7b, is expressed in the skin of goats, sheep, and mice, and its target genes were related to the growth of hair follicles and hair quality. [score:5]
[1 to 20 of 1 sentences]
[+] score: 4
However, low expression of 12 members of another common miRNA family, let-7 (not found in T. saginata[51]), was shared among T. multiceps (17,125 counts), E. granulosus and E. multilocularis. [score:3]
Considering that T. saginata and T. multiceps belong to the same genus, Taenia, the absence of let-7 miRNAs in T. saginata, their presence in T. multiceps and their universal existence in some other species suggest that non-recovery of let-7 in T. saginata may be attributed to the specific stage of the parasite examined or experimental methods. [score:1]
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[+] score: 3
PPRV infection in spleen and lung triggered the expression of many immune-related miRNAs, including, miR-21, miR-150, miR-146b, and let-7 family as reported in Japanese encephalitis virus infection (Cai et al., 2015). [score:3]
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[+] score: 3
In the whole hair cycle, the abundance of expression of let-7a-5p, let-7f, let-7b, let-7c, let-7g, miR-199a-3p, miR-143, miR-1, and miR-320a reached their highest levels in the present study (Table  2). [score:3]
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[+] score: 1
In later years, another short RNA let-7 was identified [98], with a large number of small RNAs being revealed in 2001 [92], which subsequently opened the lid to the world of the microRNA biotechnology [93, 99- 102]. [score:1]
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[+] score: 1
These include miR-126-5p, miR-30a-5p, and miR-30d (Guay et al. 2011), as well as miR-27b, miR-21, miR-206 (Herrera et al. 2010), and let-7 family (Frost and Olson 2011), each of which is altered in the states of insulin resistance, glucose intolerance, and/or type-2 diabetes in adult life. [score:1]
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[+] score: 1
In the DU, CE, and CO libraries, miR-143 had the largest number of reads, while the miR-21, miR-148a, miR-26, and let-7 families were the next most abundant. [score:1]
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