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10 publications mentioning mmu-mir-344b

Open access articles that are associated with the species Mus musculus and mention the gene name mir-344b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

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[+] score: 279
miR-344 was found downregulated in the brain of Huntington disease mouse mo dels [20] while it was upregulated in the lungs of the rat mo del for acute respiratory distress syndrome [21]. [score:9]
Predicted Target Genes of miR-344b and miR-344c To identify the genes targeted by miR-344b and miR-344c, we employed four online bioinformatics databases, namely, miRanda, miRDB, TargetScanMouse, and DIANA micro-T CDS. [score:7]
Normalized luciferase bioluminescence was not downregulated at 24, 36, 48, or 60 h when the chimeric target gene Olig2 was cotransfected with miR-344b (Figure 7(c)). [score:6]
Our subsequent attempt to validate Olig2 and Otx2 as downstream targets of miR-344b and miR-344c unexpectedly did not concur with our earlier predictions, as chimeric Olig2 and Otx2 were not suppressed by their respective miRNAs in the luciferase suppression assay. [score:6]
While miR-344b and miR-344c predicted downstream targets were Olig2 and Otx2, respectively, these target genes were not validated via luciferase suppression assay. [score:6]
As development progressed to P1, miR-344b was not expressed in any layer of the cerebellum (Figure 2(o)), nor was it expressed in the adult cerebellum. [score:6]
To identify the genes targeted by miR-344b and miR-344c, we employed four online bioinformatics databases, namely, miRanda, miRDB, TargetScanMouse, and DIANA micro-T CDS. [score:5]
Stem-Loop RT-qPCR Expression Analysis of miR-344b and miR-344c To quantify the expression of miR-344b and miR-344c (Figure 5), we performed stem-loop RT-qPCR in embryonic mouse whole brain and multiple organs of adult mice. [score:5]
In Silico AnalysisFour data mining tools, miRanda (August 2010 Release), miRDB (version 4.0, January 2012), TargetScan Mouse (Release 6.2, June 2012), and DIANA micro-T CDS (version 5.0), were used to identify the candidate target genes of miR-344b and miR-344c. [score:5]
Four data mining tools, miRanda (August 2010 Release), miRDB (version 4.0, January 2012), TargetScan Mouse (Release 6.2, June 2012), and DIANA micro-T CDS (version 5.0), were used to identify the candidate target genes of miR-344b and miR-344c. [score:5]
Spatiotemporal Expression Profiling of miR-344b and miR-344c during Mouse Brain DevelopmentTo investigate the expression profiles of miR-344b and miR-344c during mouse brain development, we performed in situ hybridization on the sagittal plane of mice at E11.5, E13.5, E15.5, E17.5, P1, and P86 (n = 2). [score:5]
Both expressions of miR-344b and miR-344c were found coexpressed with DAPI (Figures 9(g), 9(j), 10(g), and 10(j)) as opposed to Tuj1 staining where green fluorescence was only found at the periphery of the cell (Figures 9(h), 9(k), 10(h), and 10(k)). [score:5]
Subsequent study showed miR-344 inhibited cell differentiation by targeting the Wnt/ β-catenin signalling pathway [19]. [score:5]
miR-344b was lowly expressed in adult mouse testes while skeletal muscles have the lowest expression of miR-344c. [score:5]
In addition, miR-344b and miR-344c were expressed throughout the brain all sections, suggesting a wide regulatory role for these miRNAs during brain development, such as neuronal proliferation, migration, and differentiation. [score:5]
In this study, we demonstrated comprehensive spatiotemporal expression of miR-344b and miR-344c throughout mouse brain development via in situ hybridization. [score:4]
Spatiotemporal Expression Profiling of miR-344b and miR-344c during Mouse Brain Development. [score:4]
Another study also had showed that miR-344b, miR-344d, and miR-344h were downregulated in a neurotoxin -induced apoptosis in mouse MN9D cell line [14]. [score:4]
In this study, we profiled the expression of miR-344b and miR-344c in mouse brain development via in situ hybridization at both embryonic and postnatal stages. [score:4]
Studies revealed that miR-344 is expressed during mouse brain development at E15.5 [10, 15] and in the adult mouse brain [16]. [score:4]
We further compared expression of miR-344b among various adult mouse organs and found no significant difference in its expression among them (P = 0.0609; Figure 5(b)). [score:4]
Both miR-344b and miR-344c were localized to the nucleus, suggesting that these mRNAs were not direct targets of these mature miRNAs. [score:4]
Recently, miR-344-3p was reported to be expressed in neural-specific regions during mouse embryonic development [10]. [score:4]
In contrast to miR-344b, miR-344c was globally expressed throughout brain development from E11.5 to P1 and decreased in adulthood (Figures 1(g)– 1(l)). [score:4]
Bioinformatics study had predicted Olig2 and Otx2 were target genes of miR-344b and miR-344c, respectively. [score:3]
Predicted Target Genes of miR-344b and miR-344c. [score:3]
The expression profiles for miR-344b and miR-344c were generally similar with slight differences at select brain regions or time points. [score:3]
The Venn diagram summarized the number of genes targeted by miR-344b (Figure 6(a)) and miR-344c (Figure 6(b)) using the different databases. [score:3]
A high throughput microarray study revealed that miR-344 was one of the 29 miRNAs identified which inhibits adipogenesis via Wnt signally pathway [18]. [score:3]
The adult mouse pancreas had the highest expression of miR-344b, followed by the brain, skeletal muscle, skin, small intestine, large intestine, ovary and fallopian tubes, lung, thymus, kidney, heart, stomach, spleen, liver, adipose tissue, and testes (Figure 5(b)). [score:3]
Colocalization Study of miR-344b and miR-344c Bioinformatics study had predicted Olig2 and Otx2 were target genes of miR-344b and miR-344c, respectively. [score:3]
Using whole brain samples (n = 5), a significant difference in miR-344b expression was found at E11.5, E13.5, E15.5, E17.5, P1, and adult brain samples (P < 0.0001; Figure 5(a)). [score:3]
Comparison of multiple adult mouse organs showed the adult pancreas highly expressed both miR-344b and miR-344c. [score:3]
Although evidence had shown that miR-344, particularly miR-344b and miR-344c, was expressed in the developing mouse brain, the function of these miRNAs had yet to be ascertained. [score:3]
Higher magnification on these neuronal cells showed that miR-344b and miR-344c expressions were unevenly distributed in the nucleus, with an average of 5 foci per nucleus. [score:3]
To quantify the expression of miR-344b and miR-344c (Figure 5), we performed stem-loop RT-qPCR in embryonic mouse whole brain and multiple organs of adult mice. [score:3]
At P1, miR-344b was not detectable in any cortical layer of the cerebrum (Figure 2(m)) and continued to show no expression in the adult cerebral cortex. [score:3]
Our analysis provides further insight into miR-344b and miR-344c at other time points (E11.5, E13.5), as well as their expression in multiple adult mouse organs. [score:3]
Stem-Loop RT-qPCR Expression Analysis of miR-344b and miR-344c. [score:3]
Furthermore, a previous study by Ling et al. [15] showed two mature isoforms of miR-344-3p (miR-344b and miR-344c) were expressed in the whole developing mouse brain (E15.5) via Northern blot. [score:3]
Stem-loop RT-qPCR was carried out to determine the overexpression of miR-344b and miR-344c (Figure 7(b)). [score:3]
In conclusion, our study shows that miR-344b and miR-344c are spatiotemporally expressed in the developing mouse brain. [score:3]
Our study predicted Olig2 and Otx2 as the most probable targets of miR-344b and miR-344c, respectively. [score:3]
Bioinformatics analysis was employed to predict the potential downstream target genes of miR-344b and miR-344c. [score:3]
Our findings concur with previous studies that showed miR-344-3p was expressed in embryonic and adult mouse brain [10]. [score:3]
At E11.5, miR-344b expression was observed in the ventricular zone of the developing cerebral cortex (Figure 2(a)). [score:3]
Expression of miR-344b was no longer detectable at late embryonic stages, E17.5 (Figure 2(k)), and postnatal stages P1 (Figure 2(n)) and P86. [score:3]
In contrast to miR-344c, expression of miR-344b was reduced at E17.5 and P1. [score:3]
Expression of miR-344b significantly increased from E11.5 to E13.5. [score:3]
A closer look into the expression profiles revealed that both the miR-344b and miR-344c were localized in the nuclei of neuronal cells, suggesting that they may function in nuclei rather than cytosol in a noncanonical manner. [score:3]
Interestingly, miR-344-3p was also found to be primarily expressed in the olfactory bulb and cerebellar cortex of the adult mouse brain [10]. [score:3]
Both miR-344b and miR-344c had significantly increased from E11.5 to E13.5 and their expression remained in a steady state until adulthood. [score:3]
In comparison, miR-344b was not expressed in both the adult mouse olfactory bulb and cerebellum. [score:3]
miR-344b was expressed throughout the entire embryonic brain at E11.5 (Figure 1(a)) and E13.5 (Figure 1(b)). [score:3]
At E17.5, miR-344b was expressed exclusively in the cortical plate (Figure 2(j)). [score:3]
In the developing cerebellum, miR-344b was expressed in the cerebellar neuroepithelium at E11.5 (Figure 2(c)), E13.5 (Figure 2(f)), and E15.5 (Figure 2(i)). [score:3]
Similar to miR-344b, the normalized luciferase bioluminescence level was not affected by overexpression of miR-344c (Figure 7(d)). [score:3]
The expression of miR-344b and miR-344c may be wi dely diffused in the brain and it was not earlier detected via in situ hybridization, which was performed on a specific plane or section of the brain. [score:3]
Subsequently, at E17.5, expression of miR-344b decreased and was not detectable from postnatal stages (Figures 1(d)– 1(f)) onwards. [score:3]
At E17.5, miR-344b was lowly expressed in the Purkinje and granular cell layer of the developing cerebellum (Figure 2(l)). [score:3]
We chose Olig2 and Otx2 genes as potential targets of miR-344b and miR-344c, respectively, for further validation. [score:3]
Immunofluorescence staining confirmed that miR-344b and miR-344c were expressed in the nucleus of the neurons. [score:3]
miR-344b then continued to express until the adult stage (Figure 5(a)), which was in contrast with results from our in situ hybridization study. [score:3]
Moreover, miR-344 had been implicated in Huntington disease and acute respiratory distress syndrome animal mo dels. [score:3]
In the mesencephalon, miR-344b was expressed throughout the developing midbrain at E11.5 (Figure 2(b)), E13.5 (Figure 2(e)), and E15.5 (Figure 2(h)). [score:3]
Besides the brain, other studies have shown that miR-344 is expressed in the pancreas [39], lungs [21], and adipose tissue [18, 19], which concur with our findings in the current study. [score:3]
In contrast, miRNA array analysis suggested that miR-344 was expressed specifically in the brain when compared to liver and heart tissues of the adult mouse [16]. [score:2]
Supplementary materials contain two tables which described the list of commonly predicted target genes of miR-344b and miR-344c (Supplemental Table 1 and 2 respectively), one figure which showed the specificity of the stem-loop RT-qPCR assay (Supplemental Figure 1), and two figures which showed negative control staining (miR-scramble) for miR-344b and miR-344c (Supplemental figure 2 and 3 respectively). [score:2]
The roles of spatiotemporally expressed miR-344b and miR-344c in brain development, however, are yet to be determined and warrant further characterization. [score:2]
We conducted a luciferase assay to determine whether Olig2 and Otx2 were targeted by miR-344b and miR-344c, respectively. [score:2]
To further profile the spatial expression of miR-344b during brain development, sagittal sections of three primary areas of the brain, namely, the telencephalon (developing cerebral cortex), mesencephalon (developing midbrain), and metencephalon (developing cerebellum), were further evaluated (Figures 2 and 3). [score:2]
To investigate the expression profiles of miR-344b and miR-344c during mouse brain development, we performed in situ hybridization on the sagittal plane of mice at E11.5, E13.5, E15.5, E17.5, P1, and P86 (n = 2). [score:2]
Transfection of plasmids with miR-344b, miR-344c, Olig2, and Otx2, purchased from GeneCopoeia ™, USA, was performed using Lipofectamine3000 (Invitrogen) as per the manufacturer's protocol. [score:1]
org/10.1155/2016/1951250) predicted in the study warrant a more extensive validation in order to elucidate with the potential functional role of miR-344b and miR-344c. [score:1]
Merged images of three different channels confirmed the locality of miR-344b and miR-344c in the nucleus of a neuronal cell (Figures 9(i), 9(l), 10(i), and 10(l)). [score:1]
Closer observations of ISH brain sections revealed that both miR-344b and miR-344c were localized to the nuclei instead of the cytoplasm of the cell (Figures 8(a) and 8(b)). [score:1]
A study by Royo et al. showed that miR-344 was one of the imprinted small RNA genes at the Prader-Willi locus of the transgenic mouse mo del. [score:1]
After 2 h of prehybridization, custom-made miR-344b, miR-344c, or miR-scrambled locked nucleic acid probes (Exiqon) were added to the hybridization buffer to a final concentration of 0.020 pmol/ µL. [score:1]
First strand cDNA contained a target site for universal reverse primer (5′-GTAGGATGCC GCTCTCAGG-3′) and Universal ProbeLibrary (UPL) probe #21 (Roche Diagnostics), which were used together with specific forward primers for miR-344b (5′-GGACCATTTA GCCAAAGCCT-3′) and miR-344c (5′-GCGTGATCTA GTCAAAGCCT-3′), respectively. [score:1]
Subsequent stem-loop RT-qPCR analysis of miR-344b and miR-344c was performed to validate our in situ hybridization findings. [score:1]
Therefore, miR-344 is a nonconserved miRNA and it is specific to rodents. [score:1]
Besides the developing brain, miR-344 had been implicated in mouse adipocyte differentiation [17, 18]. [score:1]
miR-344 is a novel miRNA that was first reported in 2004 as one of the many miRNAs found in rat cortical neurons [9]. [score:1]
Therefore, we sought to determine the localization of miR-344b and miR-344c in the cells of the developing brain. [score:1]
qPCR results for miR-344b and miR-344c were normalized against the U6 small nuclear RNA used as endogenous controls. [score:1]
However, miR-344 was not detected in homologous human Prader-Willi domain at 15q11q13 or any nonrodent genomes [11]. [score:1]
However, more studies are required to validate the potential role and mechanisms of miR-344b and miR-344c in the cell nucleus. [score:1]
miR-344 family had nine known isoforms, miR-344a to miR-344i. [score:1]
Colocalization Study of miR-344b and miR-344c. [score:1]
In addition to the whole mouse brain, we also performed similar analyses on miR-344b and miR-344c in various organs of the adult mouse. [score:1]
miR-344 is located on mouse chromosome 7, which contains 19 mature sequences [10]. [score:1]
It was used as a preliminary study to understand the functional role of miR-344b and miR-344c. [score:1]
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[+] score: 26
As shown in Figure 4, miR-181d and miR-872 were down-regulated with a 0.5-fold change in the infarct region of the MCAO mice, while miR-106b and miR-344 were up-regulated with two fold changes in the infarct region of the MCAO mice. [score:7]
Another study found that miR-344 was commonly down-regulated in Huntington’s disease mo dels [22]. [score:6]
Additionally, one study found that miR-344 inhibited the adipocyte differentiation via targeting GSK3β, and subsequently activating the Wnt/β-catenin signaling pathway [21]. [score:5]
Chen H. Wang S. Chen L. Chen Y. Wu M. Zhang Y. Yu K. Huang Z. Qin L. Mo D. MicroRNA-344 inhibits 3T3-L1 cell differentiation via targeting GSK3β of Wnt/β-catenin signaling pathway FEBS Lett. [score:4]
Four differentially expressed miRNAs (miR-181d, miR-872, miR106b, and miR-344) were validated using the miRCURY LNA™ Universal RT microRNA PCR (Exiqon A/S, DK-2950 Vedbaek, Denmark). [score:3]
To further confirm the accuracy of the miRNA microarray results, the miR-181d, miR-872, miR-106b, and miR-344 of 30 miRNAs were verified by qRT-PCR. [score:1]
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[+] score: 6
Profiling of miRNAs expression was also performed in the YAC128 and R6/2 mice, showing that nine miRNAs (miR-22, miR-29c, miR-128, miR-132, miR-138, miR-218, miR-222, miR-344, and miR-674*) are commonly down-regulated in 12-month-old YAC128 mice and 10-week-old R6/2 mice (100). [score:6]
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[+] score: 3
In fact, a couple of miRNAs (miR-27a and miR-133a), targeting inflammation and cell proliferation, had been found to be modulated by the same NSAID in A/J mice aged 10 weeks, whereas other miRNAs (miR-30, miR-101 and miR-344b) affecting later stages of pulmonary carcinogenesis were able to distinguish the mice according to the yield of both microadenomas and adenomas. [score:3]
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[+] score: 3
They suggested miR-22 and miR-125 as possible master regulators, and miR-344-5p/484 and miR-488 as possible master coregulators that may influence the genes involved in one-carbon metabolism. [score:3]
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[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-26b, hsa-mir-29a, hsa-mir-30a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-106a, mmu-let-7g, mmu-let-7i, mmu-mir-15b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-125a, mmu-mir-125b-2, mmu-mir-130a, mmu-mir-138-2, mmu-mir-181a-2, mmu-mir-182, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-10a, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-181a-1, mmu-mir-297a-1, mmu-mir-297a-2, mmu-mir-301a, mmu-mir-34c, mmu-mir-34b, mmu-let-7d, mmu-mir-106a, mmu-mir-106b, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-130a, hsa-mir-138-2, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-138-1, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-34a, rno-mir-301a, rno-let-7d, rno-mir-344a-1, mmu-mir-344-1, rno-mir-346, mmu-mir-346, rno-mir-352, hsa-mir-181b-2, mmu-mir-10a, mmu-mir-181a-1, mmu-mir-29b-2, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-125b-1, hsa-mir-106b, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-34b, hsa-mir-34c, hsa-mir-301a, hsa-mir-30e, hsa-mir-362, mmu-mir-362, hsa-mir-369, hsa-mir-374a, mmu-mir-181b-2, hsa-mir-346, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-10a, rno-mir-15b, rno-mir-26b, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-34b, rno-mir-34c, rno-mir-34a, rno-mir-106b, rno-mir-125a, rno-mir-125b-1, rno-mir-125b-2, rno-mir-130a, rno-mir-138-2, rno-mir-138-1, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-181a-1, hsa-mir-449a, mmu-mir-449a, rno-mir-449a, mmu-mir-463, mmu-mir-466a, hsa-mir-483, hsa-mir-493, hsa-mir-181d, hsa-mir-499a, hsa-mir-504, mmu-mir-483, rno-mir-483, mmu-mir-369, rno-mir-493, rno-mir-369, rno-mir-374, hsa-mir-579, hsa-mir-582, hsa-mir-615, hsa-mir-652, hsa-mir-449b, rno-mir-499, hsa-mir-767, hsa-mir-449c, hsa-mir-762, mmu-mir-301b, mmu-mir-374b, mmu-mir-762, mmu-mir-344d-3, mmu-mir-344d-1, mmu-mir-673, mmu-mir-344d-2, mmu-mir-449c, mmu-mir-692-1, mmu-mir-692-2, mmu-mir-669b, mmu-mir-499, mmu-mir-652, mmu-mir-615, mmu-mir-804, mmu-mir-181d, mmu-mir-879, mmu-mir-297a-3, mmu-mir-297a-4, mmu-mir-344-2, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-493, mmu-mir-504, mmu-mir-466d, mmu-mir-449b, hsa-mir-374b, hsa-mir-301b, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-879, mmu-mir-582, rno-mir-181d, rno-mir-182, rno-mir-301b, rno-mir-463, rno-mir-673, rno-mir-652, mmu-mir-466l, mmu-mir-669k, mmu-mir-466i, mmu-mir-669i, mmu-mir-669h, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-466j, mmu-mir-1193, mmu-mir-767, rno-mir-362, rno-mir-504, rno-mir-582, rno-mir-615, mmu-mir-3080, mmu-mir-466m, mmu-mir-466o, mmu-mir-466c-2, mmu-mir-466b-4, mmu-mir-466b-5, mmu-mir-466b-6, mmu-mir-466b-7, mmu-mir-466p, mmu-mir-466n, mmu-mir-344e, mmu-mir-344c, mmu-mir-344g, mmu-mir-344f, mmu-mir-374c, mmu-mir-466b-8, hsa-mir-466, hsa-mir-1193, rno-mir-449c, rno-mir-344b-2, rno-mir-466d, rno-mir-344a-2, rno-mir-1193, rno-mir-344b-1, hsa-mir-374c, hsa-mir-499b, mmu-mir-466q, mmu-mir-344h-1, mmu-mir-344h-2, mmu-mir-344i, rno-mir-344i, rno-mir-344g, mmu-let-7j, mmu-mir-30f, mmu-let-7k, mmu-mir-692-3, rno-let-7g, rno-mir-15a, rno-mir-762, mmu-mir-466c-3, rno-mir-29c-2, rno-mir-29b-3, rno-mir-344b-3, rno-mir-466b-3, rno-mir-466b-4
1Proliferation, Invasion, Tumor suppression [63– 66] miR-344 ↓2.0 ↓3.2 NA miR-346 ↓2.4Proliferation [67, 68] miR-362 ↓2.3Proliferation, Invasion, Apoptosis [69– 76] miR-369 ↓2.8 ↓2.6 ↓2.1Aerobic glycolysis [77] miR-374 ↑3.0 ↓2.2 NA miR-449 ↑2.7 ↑2.4Proliferation [78– 81] miR-463 ↓2.7 NAmiR-466 [°] ↑2.4 ↑2.1 ↓3.5 NA miR-483 ↓3.2Apoptosis [82] miR-493 ↑2.1 ↓2.2Proliferation [83– 85] miR-499a ↓5.0 ↑2.3Proliferation [86] miR-504 ↓2.6 ↑2.0Proliferation, Apoptosis [87, 88] miR-579 ↑2.8 NAmiR-582 [^] ↑2.4Proliferation [89] miR-615 ↓2.1Proliferation, Invasion [90, 91] miR-652 ↑2.4Proliferation, EMT [92, 93] miR-669b ↓2.1 NA miR-669h ↓3.6 ↑2.3 NA miR-669i ↓2.3 NA miR-669k ↓7.2 ↓5. [score:3]
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Specifically, miR-19a-3p, miR-344-3p, miR-34b-3p and miR-497-5p were all detected only in samples from RML infected mice (Figure S7A). [score:1]
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For example, the members of miR-344 family were all produced from shRNAs (Table S4). [score:1]
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[+] score: 1
S7 7. Nrf2 -dependent effect of 5 mg / kg PQ Nrf2(+/+) PQ5—Nrf2(–/–) PQ5 miR-135a, miR-376c, miR-31, miR-let-7i*, miR-669b*, miR-344, miR-15b, miR-700*, miR-3099, miR-377, miR-338-5p, miR-382, miR-219-3p and miR-310a S8 8. Nrf2 -dependent effect of 10 mg / kg PQ Nrf2(+/+) PQ10—Nrf2(–/–) PQ10 miR-495*, miR-154*, miR-let-7b, miR-1983, miR-103 and miR-26a S9 The miR-380-3p / Sp3 mRNA pathway is worth to mention here. [score:1]
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Three miRNAs in FCx (miR-128, miR-129-5p, and miR-344) and one miRNA in HP (miR-7a) map to two chromosomal loci (Table S1). [score:1]
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