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5 publications mentioning eca-mir-26a

Open access articles that are associated with the species Equus caballus and mention the gene name mir-26a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 27
The overexpression of miR-26a in tumor cells strongly improved the accumulation of pyruvate and reduced the production of acetyl coenzyme A. At the same time, the inhibition of miR-26a expression developed opposite biological effects [23]. [score:7]
HGF was identified as a target of miR-26a and its activation antagonizes the effects induced by the up-regulation of miR-26a [22]. [score:6]
We have revealed common small non-coding RNA molecules (miR-26a, miR-195, miR- miR-126, miR-122, miR-21, miR-155, miR-9, miR-135b, miR-29b, miR-142-3p, miR-210, miR-181, miR- 224) in HCC and CRC, which suppress the expression of multiple genes involved in tumor- stromal interactions, immune invasion and tumor angiogenesis. [score:5]
Moreover, the miR-26 down-regulation increases the angiogenic potential of these types of cancers. [score:4]
Therefore, miR-26a partially exerted its anti-angiogenesis effect by blocking the HGF-receptor (cMet) and its signaling pathway, thus consequently suppressing VEGFA production in HCC cells and modifying vascular endothelial growth factor receptor 2 (VEGFR2)-signaling in endothelial cells. [score:3]
In multivariate analysis, it was demonstrated that miR-26a, alone or in combination with HGF, is an independent prognostic indicator for time to recurrence and overall survival in HCC patients [22] (Figure 1). [score:1]
In conclusion, HCC patients with low hepatocyte growth factor (HGF), low VEGFA, high miR-26a levels or low microvessel density in tumor cells have a better prognosis with longer overall survival and time to recurrence. [score:1]
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2
[+] score: 9
Data have been normalized to the endogenous controls miR-26a and miR-103, and are expressed as fold change from unstimulated samples at time 0 (2 [-ΔΔCT]). [score:3]
In a study of human patients with liver disease and healthy controls, miR-21 was the most abundant in PBMCs from all donors, while the second most abundant in eight of twelve samples was either let-7g or miR-26a (ranked second and third in horses) [35]. [score:3]
PCR data have been normalized to the endogenous controls miR-26a and miR-103. [score:1]
0177664.g005 Fig 5PCR data have been normalized to the endogenous controls miR-26a and miR-103. [score:1]
Data were normalized to the geometric mean of two endogenous controls, miR-26a-5p and miR-103. [score:1]
[1 to 20 of 5 sentences]
3
[+] score: 8
Other miRNAs from this paper: eca-mir-146b, eca-mir-763, eca-mir-1289
Four miRNAs were identified within 1 to 3.35 Mbp of the SNP's location on chromosomes 6, 16, 1, and 7. Some miRNAs (such as eca-miR-26a) regulate protein translation by RNA interference (by cleavage or inhibition of translation) for sets of up to several 100 genes. [score:8]
[1 to 20 of 1 sentences]
4
[+] score: 5
Gene targeted by the disease miRNA26. [score:5]
[1 to 20 of 1 sentences]
5
[+] score: 2
Other miRNAs have also been implicated in muscle development, including miR-26a (23), miR-27b (24), miR-29 (25), miR- 125b (26), miR-155 (27), miR-128a (28) and miR- 181 (29). [score:2]
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