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8 publications mentioning rno-mir-490

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-490. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 69
While miR-490-5p was upregulated by the UC pathological status, its expression was downregulated after the HM intervention. [score:9]
Target gene predictions for miR-184 and miR-490-5p and the pathway analysis of the target genes of these 2 small RNAs showed that potential target genes of miR-184 were involved in some pathways that were closely associated with UC, such as the TNF signaling pathway, Ras signaling pathway, pathway in cancer, NF- κB signaling pathway, miRNAs in cancer, colorectal cancer, and AMPK signaling pathway. [score:7]
Currently, studies have reported that miR-490-5p expression is decreased in tumor tissues, whereas overexpression of miR-490-5p can inhibit tumor growth [49, 50]; these results differ from the mechanism of action in our study. [score:7]
miR-490-5p was increased in the UC mo del, and moxibustion could downregulate its expression. [score:6]
The downregulated miRNAs were miR-132-5p and miR-490-5p (Figure 7). [score:4]
Among them, miRNA-490-5p was upregulated 9.44-fold, which represented the largest change. [score:4]
The miR-184 expression level decreased and the miR-490-5p expression level increased in the UC group compared to the NC group (both P < 0.05). [score:4]
Similarly, the miR-490-5p target genes were involved in pathways associated with UC, including the cGMP-PKG signaling pathway, cAMP signaling pathway, neurotrophin signaling pathway, HIF-1 signaling pathway, and endocrine and other factor-regulated calcium reabsorption. [score:4]
The miR-184 expression level increased and the miR-490-5p expression level decreased in the UCHM group compared to the UC group (both P < 0.05) (Figures 9(a) and 9(b)). [score:4]
HM altered the expression of 15 miRNAs, of which 2 were associated with UC pathological changes (miR-184 and miR-490-5p). [score:3]
There were two common differentially expressed miRNAs in the two heat maps shown in Figures 6 and 7 (miR-184 and miR-490-5p). [score:3]
miR-490-5p had 100 target genes. [score:3]
There were 8 miRNAs with fold changes in expression greater than 3 [miR-490-5p (FC = 9.44), miR-547-3p (FC = 4.77), miR-24-1-5p (FC = 3.78), miR-200a-5p (FC = 3.55), miR-139-3p (FC = 3.51), miR-139-5p (FC = 3.46), miR-676 (FC = 3.32), and miR-532-3p (FC = 3.07)]. [score:3]
The results in this study suggested that changes in miR-184 and miR-490-5p expression levels in colon tissues under the UC pathological status were reversed in the UCHM group. [score:3]
The results suggested that HM could reverse the expression of miR-184 and miR-490-5p, which changed with the UC pathological status. [score:3]
The samples were amplified, and 2 miRNAs (miR-184 and miR-490-5p) were validated using quantitative real-time PCR. [score:1]
U6, miR-184, and miR-490-5p were synthesized and purified by RiboBio (Guangzhou, China). [score:1]
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2
[+] score: 26
rno-miR-675-5p 4.143757751 Premature senescence of cardiac progenitor cells, G1 arrest, reduced cell proliferation, colony formation, migration and invasion rno-miR-183-3p 3.74730108 Regulates claudin-1 expression rno-miR-299a-5p 3.626723224 Anti-apoptotic role rno-miR-200c-3p 3.593610443 Targets the VEGF-VEGFR2 pathway and angiogenesis rno-miR-665 3.511737089 Negatively targets anti-apoptotic BCL2L1 rno-miR-291a-5p 3.457928187 VSMC migration rno-miR-490-5p 2.373358 Tumour suppressor rno-miR-1 2.505729 Suppresses cell growth rno-miR-133b 2.192279 Inhibits cell proliferation and invasion rno-miR-30c-1-3p 2.70761 Suppresses PXR expression rno-miR-294 2.010496 Promotes proliferation and differentiation rno-miR-127-5p 2.780488 A regulator of MMP-13 and suppresses cell growth rno-miR-503 2.327383 Inhibits cell proliferation and invasion Table 2 Twenty down-regulated miRNAs. [score:26]
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3
[+] score: 22
The unique miRNA expression patterns distinguishing the ASH group from the control group were composed of six downregulated (miR-199a-3p, miR-214, miR-93, miR-146a, miR-191 and let-7b) and six upregulated (miR-129, miR-490, miR-21, miR-503, miR-183 and miR-185) miRNAs. [score:9]
Similarly, the specific miRNA profile of AFL consisted of five downregulated (miR-93, miR-451, miR-221, miR-17-5p and miR-146a) and three upregulated (miR-200c, miR-490 and miR-195) miRNAs, in comparison to the control group. [score:7]
Wnt inhibitory factor 1 (Wif1), which may be regulated by miR-490, contributes to the activation of the Wnt signaling pathway and induces carcinogenesis through dysregulation of cell proliferation and differentiation (39). [score:5]
Among the dysregulated miRNAs, miR-490 exhibited an increment in the ASH and AFL groups, while miR-140, miR-7a, miR-451, miR-93, miR-146a and miR-191 levels exhibited a decline in the ASH and AFL groups compared with the respective controls (Table II). [score:1]
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4
[+] score: 15
Other miRNAs from this paper: mmu-mir-30a, mmu-mir-101a, mmu-mir-125a, mmu-mir-125b-2, mmu-mir-132, mmu-mir-134, mmu-mir-135a-1, mmu-mir-138-2, mmu-mir-142a, mmu-mir-150, mmu-mir-154, mmu-mir-182, mmu-mir-183, mmu-mir-24-1, mmu-mir-194-1, mmu-mir-200b, mmu-mir-122, mmu-mir-296, mmu-mir-21a, mmu-mir-27a, mmu-mir-92a-2, mmu-mir-96, rno-mir-322-1, mmu-mir-322, rno-mir-330, mmu-mir-330, rno-mir-339, mmu-mir-339, rno-mir-342, mmu-mir-342, rno-mir-135b, mmu-mir-135b, mmu-mir-19a, mmu-mir-100, mmu-mir-139, mmu-mir-212, mmu-mir-181a-1, mmu-mir-214, mmu-mir-224, mmu-mir-135a-2, mmu-mir-92a-1, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-125b-1, mmu-mir-194-2, mmu-mir-377, mmu-mir-383, mmu-mir-181b-2, rno-mir-19a, rno-mir-21, rno-mir-24-1, rno-mir-27a, rno-mir-30a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-96, rno-mir-100, rno-mir-101a, rno-mir-122, rno-mir-125a, rno-mir-125b-1, rno-mir-125b-2, rno-mir-132, rno-mir-134, rno-mir-135a, rno-mir-138-2, rno-mir-138-1, rno-mir-139, rno-mir-142, rno-mir-150, rno-mir-154, rno-mir-181b-1, rno-mir-181b-2, rno-mir-183, rno-mir-194-1, rno-mir-194-2, rno-mir-200b, rno-mir-212, rno-mir-181a-1, rno-mir-214, rno-mir-296, mmu-mir-376b, mmu-mir-370, mmu-mir-433, rno-mir-433, mmu-mir-466a, rno-mir-383, rno-mir-224, mmu-mir-483, rno-mir-483, rno-mir-370, rno-mir-377, mmu-mir-542, rno-mir-542-1, mmu-mir-494, mmu-mir-20b, mmu-mir-503, rno-mir-494, rno-mir-376b, rno-mir-20b, rno-mir-503-1, mmu-mir-1224, mmu-mir-551b, mmu-mir-672, mmu-mir-455, mmu-mir-490, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-504, mmu-mir-466d, mmu-mir-872, mmu-mir-877, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-872, rno-mir-877, rno-mir-182, rno-mir-455, rno-mir-672, mmu-mir-466l, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-466j, rno-mir-551b, rno-mir-1224, rno-mir-504, mmu-mir-466m, mmu-mir-466o, mmu-mir-466c-2, mmu-mir-466b-4, mmu-mir-466b-5, mmu-mir-466b-6, mmu-mir-466b-7, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, rno-mir-466d, mmu-mir-466q, mmu-mir-21b, mmu-mir-21c, mmu-mir-142b, mmu-mir-466c-3, rno-mir-322-2, rno-mir-503-2, rno-mir-466b-3, rno-mir-466b-4, rno-mir-542-2, rno-mir-542-3
DEX treatment up-regulated the expression of miRNA-483, miRNA-181a-1, miRNA-490 and miRNA-181b-1, while it down-regulated the levels of miR-122, miR-466b, miR-200b, miR-877, miR-296, miRNA-27a and precursor of miR-504. [score:9]
The expression of miRNA-483, miRNA-181a-1, miRNA-490 and miRNA and miRNA-181b-1 was up-regulated in response to dexamethasone treatment. [score:6]
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5
[+] score: 7
Other miRNAs from this paper: rno-mir-143, rno-mir-145
In addition, Li et al. found that microRNA-490-5p inhibited the proliferation of bladder cancer by targeting the C-FOS 3’UTR and decreasing C-FOS expression at both mRNA and protein levels [39]. [score:7]
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6
[+] score: 5
According to previous bioinformatic studies, miR-153 is a predicted regulator of LAMP1, while miR-490* is a predicted regulator of TFRC (Table  3, Additional file 6). [score:3]
However, miR-490* was not listed as one of the predicted regulators for mouse-specific Tfrc. [score:2]
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7
[+] score: 5
Other miRNAs from this paper: rno-mir-216a, rno-mir-291a, rno-mir-543, rno-mir-760, rno-mir-291b
In the MHb we found that miR-490 exhibited increased expression in NLH rats, while remaining at low expression level in LH rats (Fig 4A). [score:5]
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8
[+] score: 3
Notwithstanding, the “mut” allele generates binding sites for six alternative miRNAs (Table  1) of which four, miR-143 (3p and 5p), miR-490-3p, miR-1246, and miR-1261, were expressed in the human 1.1E7 pancreatic cell line (Fig.   5a). [score:3]
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