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13 publications mentioning ssc-mir-215

Open access articles that are associated with the species Sus scrofa and mention the gene name mir-215. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 52
This study used high-throughput sequencing to compare miRNA expression in pigs susceptible and resistant to E. coli F18 infection and identified 12 miRNAs with differential expression, including 11 upregulated in susceptible animals, ssc-miR-143, ssc-let-7f, ssc-miR-30e, ssc-miR-148a, ssc-miR-148b, ssc-miR-181a, ssc-miR-192, ssc-miR-27b, ssc-miR-15b, ssc-miR-21, ssc-miR-215, and one down-regulated, ssc-miR-152. [score:11]
In addition, both miR-192 and miR-215 are tumor suppressors and upregulation of miR-215 inhibits the differentiation of colon cancer stem cells [28], [29]. [score:8]
Coincidentally, a comparison of the expression profile results and the miRNA – target gene network showed that target genes corresponding to miR-192 were identical to those of miR-215. [score:7]
miRNAs overexpressed in E. coli F18-sensitive individuals include ssc-miR-143 (highest expression), ssc-let-7f, ssc-miR-143, ssc-miR-192, ssc-miR-21, ssc-miR-215, ssc-miR-378, ssc-miR-145, ssc-miR-26a, and ssc-miR-30e. [score:5]
Sharbati et al. [13] conducted miRNA cDNA library sequencing on six different sections (duodenum, anterior segment of jejunum, posterior segment of jejunum, ileum, ascending colon, and transverse colon) of 31-day-old Euroc and Piétrain hybrid pig intestinal tissues, and found that miR-194 and miR-215 were highly expressed in the duodenum and posterior segment of the jejunum and that miR-19b, miR-23a, miR-24, and miR-30b expression was higher in the colon than in other sections of the intestinal tract. [score:5]
These included 11 with increased miRNA expression in E. coli F18-sensitive pigs, ssc-miR-143, ssc-let-7f, ssc-miR-30e, ssc-miR-148a, ssc-miR-148b, ssc-miR-181a, ssc-miR-192, ssc-miR-27b, ssc-miR-15b, ssc-miR-21, ssc-miR-215, and one with reduced miRNA expression, ssc-miR-152. [score:5]
As shown in Table 1, miR-215 and miR-192 expression was significantly different between E coli F18-sensitive and -resistant groups (p<0.01). [score:3]
MiRNAs with a mean value >10000 by sequence counting (i. e., expression) included ssc-miR-143, ssc-let-7f, ssc-miR-192, ssc-miR-21, ssc-miR-215 and ssc-miR-378. [score:3]
Previous results obtained using microarray found five target genes corresponding to miR-215 (ALCAM, DLG5, FRMD4B, MIPOL1, and ZFHX3). [score:3]
l Note: 1, ssc-miR-27b; 2, ssc-miR-215; 3, ssc-miR-21; 4, ssc-miR-192; 5, ssc-miR-15b; 6, ssc-miR-148a; 7, ssc-miR-143–5p; 8, ssc-let-7f; 9, ssc-miR-152. [score:1]
However, only ALCM, associated with leukocyte adhesion, corresponded to miR-215 in the miRNA – gene network. [score:1]
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2
[+] score: 48
Other miRNAs from this paper: ssc-mir-192
The TargetScan predicted that the target genes of miR-192 and miR-215 are identical, miR-192 and miR-215 both has 156 potential target genes (Supplementary Table S1). [score:7]
The general linear mo del in SPSS 20 software was used to compare the expression of miR215, the expression of target genes, and bacteria adhesion of cells before and after transfection. [score:7]
Sharbati et al. [8] found high expression levels of miR-215 and miR-192 in rat duodenum and jejunum, while Mckenna et al. [9] found that miR-192 expression was the most abundant among 453 miRNA families identified in the intestinal mucosa of Dicer1 mutated mice. [score:5]
Using high-throughput sequencing technology, we previously identified two miRNAs (miR-192 and miR-215) differentially expressed between Escherichia coli F18 resistant and sensitive duodenum (NCBI database Gene Expression Omnibus, GEO Series accession number GSE32527) [5]. [score:5]
MiR-192 and miR-215 are highly homologous miRNAs that have been proposed as positive regulator proteins of the tumor suppressor gene p53 [6]. [score:4]
However, the regulatory mechanism of miR-192 and miR-215 in porcine disease is as yet unclear. [score:4]
Prediction and function of miR-192 and miR-215 target genes in swine. [score:3]
Related information of miR-192 and miR-215 target genes. [score:3]
As such, miR-192 and miR-215 are potential biomarkers and drug targets [7]. [score:3]
Wu et al. [10] also found that miR-192 and miR-215 are highly expressed in the duodenum and jejunum of 35-day-old Meishan piglets. [score:3]
In conclusion, the above evidence suggest a probable important regulatory function for miR-192 and miR-215 in the porcine intestine. [score:2]
In addition, the miR-192 knockout did not affect the base composition of miR-215 (Supplementary Figure S7), indicating these TALEN design were specific for miR-192. [score:2]
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3
[+] score: 38
In this study, miR-146b out of all miRNAs differentially expressed had the largest range at 4 d after weaning and had a sustaining difference at 7 d after weaning; miR-215 out of all miRNAs detected in all libraries showed the abundant expression level and was one of several downregulated expression miRNAs in the weaning groups. [score:10]
In addition, miR-215 and miR-146b out of all differentially expressed miRNAs were particularly interested, because the former had the abundant expression levels in all libraries and was one of several miRNAs that had a downregulated trend in the weaning groups, and the latter had the largest differences in expression levels between two pairs of W4 and S4, W7 and S7. [score:10]
However, the expression of miR-215 was found to be upregulated in the duodenum of E. coli F18-sensitive pigs [47]. [score:6]
In accordance with our results, miR-215 was highly expressed in the posterior segment of the jejunum of 31-d-old piglets [24]. [score:3]
The expression levels of ssc-miR-215 were significantly different between W4 and S4 (p<0.05) based on the results. [score:3]
On the other hand, the sequencing results revealed no significant differences (q >0.05) in the expression levels of ss-miR-215 between the two groups. [score:3]
Furthermore, miR-215 is thought to be involved in the pathogenesis of colon cancer as a tumor suppressor and/or candidate prognostic gene [48], [49]. [score:3]
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4
[+] score: 22
It was shown that miR-192, miR-194 and miR-215 are highly expressed in normal colon tissue while their expression is dramatically decreased in colon cancer. [score:5]
Consequently, increased expression of miR-194 and miR-215 in duodenum and proximal jejunum are probably involved in promoting epithelial differentiation in order to replace cells that differ e. g. in transport functions. [score:3]
Consistently, in distal parts of the intestine we determined diminished expression of miR-194 and miR-215, respectively pointing to a higher proliferative activity in the distal parts. [score:3]
In our microarray experiments, miR-194 and miR-215 showed the same expression pattern along the entire intestine, underlining the fact that both may derive from one transcript. [score:3]
Cluster I (Figure 3E) shown in the hierarchically clustered heatmap harbored only miR-194 and miR-215, which were highly expressed in the proximal parts of the small intestine (duodenum and proximal jejunum). [score:3]
Interestingly, miR-194 and miR-215 were both duplicated and located on chromosomes X and 10 and clustered within a 353 bp chromosomal region. [score:1]
A) ssc-miR-215, B) MDM238, C) MDM392, D) ssc-miR-30a, E) ssc-miR-194, F) ssc-miR-374b, G) ssc-miR-155, H) ssc-miR-4331. [score:1]
We have identified several genomic clusters one of those including the porcine miRNAs miR-194 and miR-215. [score:1]
They identified two genomic clusters in the human genome either encoding miR-194-1 and miR-215 on chromosome 1 or encoding miR-194-2 and miR-192 on chromosome 11 [30]. [score:1]
In contrast to human, both porcine clusters are 100% identical encoding only miR-194 and miR-215. [score:1]
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5
[+] score: 16
Ssc-miR-215 was the most down-regulated microRNA at 3 dpi (log [2]FC = -5.58), 5 dpi (log [2]FC = -7.36) and ssc-miR-122 was the most down-regulated microRNA at 7 dpi (log [2]FC = -5.71) in Landraces' lungs. [score:7]
While, in the lungs of Tongcheng pigs, the most up-regulated microRNAs at 3, 5 and 7 dpi were ssc-miR-490-5p (log [2]FC = 2.15), ssc-miR-183 (log [2]FC = 2.8) and ssc-miR-215 (log [2]FC = 6.2), respectively. [score:4]
MiR-122 and miR-215, as Landrace specific DEmiRNAs, were both significantly down-regulated at 3, 5 and 7 dpi. [score:4]
Previous studies showed that miR-122 and miR-215 46 were able to enhance the replication of HCV. [score:1]
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6
[+] score: 14
As shown in Figure 6, qualitative qPCR validated that ssc-miR-146a-5p, ssc-miR-221-5p and ssc-miR-148b-3p were significantly upregulated by LPS, and ssc-miR-215 and ssc-miR-192 were downregulated. [score:7]
Similarly, five miRNAs (ssc-miR-192, 4_16129, 13_5595, ssc-miR-215 and ssc-miR-429) were significantly downregulated (Table 3). [score:4]
Differential expressions of five selected miRNAs (ssc-miR-146a-5p, ssc-miR-221-5p, ssc-miR-148b-3p, ssc-miR-215 and ssc-miR-192) were validated by quantitative polymerase chain reaction (qPCR). [score:3]
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7
[+] score: 13
Sharbati et al. (2010) conducted miRNA cDNA library sequencing on six different sections (duodenum, anterior segment of jejunum, posterior segment of jejunum, ileum, ascending colon and transverse colon) of 31-day-old healthy piglet (EUROC × Pietrain) intestinal tissues and found that miR-194 and miR-215 were highly expressed in the duodenum and posterior segment of the jejunum and that miR-19b, miR-23a, miR-24 and miR-30b expression was higher in the colon than in other sections of the intestinal tract [29]. [score:5]
Ye et al. (2012) conducted miRNA sequencing on duodenum tissues of 28-day-old Sutai (Duroc × Meishan) resistant and sensitive to E. coli F18 piglets and identified 12 candidate miRNA disease markers, especially the expressions of miR-215 and miR-192 were found to be significantly different between E. coli F18-sensitive and -resistant groups [31]. [score:5]
Tao et al. (2013) conducted miRNA sequencing on jejunum tissue of newborn litters of crossbred piglets (DYL, originating from mating Duroc boars with Yorkshire-Landrace sows) and found that the expression of miR-215 and miR-146b were significantly different at different days (P < 0.05) [30]. [score:3]
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8
[+] score: 9
Moreover, 13 miRNAs were differentially expressed: 8 were upregulated (ssc-miR-132, ssc-miR-146b, ssc-miR-215, ssc-miR-371, ssc-miR-27a, ssc-miR-331-3p, ssc-miR-432-5p and ssc-miR-199a/b-3p), while 5 were down-regulated after PRV infection (ssc-mir-10a-5p, ssc-mir-148-3p, ssc-mir-219a, ssc-mir-374b-3p and ssc-miR-532-5p) (Fig 7). [score:9]
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9
[+] score: 6
Other miRNAs from this paper: ssc-mir-122, ssc-mir-135-1, ssc-mir-135-2, ssc-mir-148a, ssc-mir-19a, ssc-mir-20a, ssc-mir-224, ssc-mir-24-1, ssc-mir-323, ssc-mir-140, ssc-mir-183, ssc-mir-214, ssc-mir-27a, ssc-mir-325, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-107, ssc-mir-136, ssc-mir-153, ssc-mir-18a, ssc-mir-186, ssc-mir-196a-2, ssc-mir-204, ssc-mir-21, bta-mir-18b, bta-let-7f-2, bta-mir-101-2, bta-mir-103-1, bta-mir-148a, bta-mir-18a, bta-mir-20a, bta-mir-21, bta-mir-221, bta-mir-27a, bta-mir-27b, bta-mir-107, bta-mir-140, bta-mir-20b, bta-mir-215, bta-let-7d, bta-mir-17, bta-mir-186, bta-mir-199b, bta-mir-210, bta-mir-214, bta-mir-450a-2, bta-let-7g, bta-mir-24-2, bta-let-7a-1, bta-let-7f-1, bta-mir-122, bta-let-7i, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-15a, bta-mir-19a, bta-mir-204, ssc-mir-15a, ssc-mir-17, ssc-mir-199b, ssc-mir-210, ssc-mir-221, bta-mir-101-1, bta-mir-133a-2, bta-mir-133a-1, bta-mir-135a-2, bta-mir-135a-1, bta-mir-135b, bta-mir-136, bta-mir-146b, bta-mir-153-1, bta-mir-153-2, bta-mir-183, bta-mir-24-1, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-224, bta-mir-323, ssc-mir-101-1, ssc-mir-101-2, ssc-mir-133a-1, ssc-mir-450a, ssc-mir-146b, bta-mir-1343, bta-mir-2320, bta-mir-2326, bta-mir-2366, bta-mir-2411, bta-mir-2483, bta-mir-450a-1, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-103-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-196b-1, ssc-mir-450b, ssc-mir-450c, ssc-mir-133a-2, ssc-let-7a-2, ssc-mir-18b, ssc-mir-1343, ssc-mir-2320, bta-mir-450b, ssc-let-7d, ssc-let-7f-2, ssc-mir-20b-1, ssc-mir-20b-2, ssc-mir-196a-1, ssc-mir-196b-2, ssc-mir-2366-1, ssc-mir-2366-2, ssc-mir-2411, ssc-mir-2483
The results showed that 9 miRNAs were significantly different between the two libraries, such as the expression of miR-215, miR-135 and miR-146b was higher in Large White pigs, opposite to the patterns shown by miR-1a, miR-133a, miR-122, miR-204 and miR-183 (Table 1), suggesting that these miRNAs may have effects on the development of backfat tissue. [score:4]
For example, ssc-miR-153, miR-325, miR-135-1*, miR-135-2*, miR-146b*, miR-15a*, miR-215* and miR-323* were only identified in Large White, contrary to the patterns displayed by ssc-miR-101a-1*, miR-103*, miR-183*, miR-1a* and miR-210*, indicating that these miRNAs may function in the physiology or development of the backfat tissue. [score:2]
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10
[+] score: 6
Ten miRNAs, such as miR-215, miR-411, miR-487b and miR-30c, are represented by category D. The expression levels of a large proportion of miRNAs (categories A and B) were differentially expressed between gestational days 15 and 26, suggesting these miRNAs may regulate embryo implantation and placentation in porcine endometrium. [score:6]
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11
[+] score: 5
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-99a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-16-2, hsa-mir-192, hsa-mir-148a, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181a-1, hsa-mir-215, hsa-mir-223, hsa-mir-224, hsa-mir-200b, hsa-mir-15b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-141, hsa-mir-143, hsa-mir-152, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-184, hsa-mir-200c, hsa-mir-155, hsa-mir-29c, hsa-mir-200a, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-342, hsa-mir-148b, hsa-mir-451a, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-15b, ssc-mir-184, ssc-mir-224, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-let-7f-1, ssc-mir-103-1, ssc-mir-21, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-671, hsa-mir-378d-2, bta-mir-26a-2, bta-mir-29a, bta-let-7f-2, bta-mir-103-1, bta-mir-148a, bta-mir-16b, bta-mir-21, bta-mir-499, bta-mir-99a, bta-mir-125b-1, bta-mir-126, bta-mir-181a-2, bta-mir-27b, bta-mir-31, bta-mir-15b, bta-mir-215, bta-mir-30e, bta-mir-148b, bta-mir-192, bta-mir-200a, bta-mir-200c, bta-mir-23a, bta-mir-29b-2, bta-mir-29c, bta-mir-10b, bta-mir-24-2, bta-mir-30a, bta-mir-200b, bta-let-7a-1, bta-mir-342, bta-let-7f-1, bta-let-7a-2, bta-let-7a-3, bta-mir-103-2, bta-mir-125b-2, bta-mir-15a, bta-mir-99b, hsa-mir-664a, ssc-mir-99b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-15a, ssc-mir-16-2, ssc-mir-16-1, bta-mir-141, bta-mir-143, bta-mir-146a, bta-mir-152, bta-mir-155, bta-mir-16a, bta-mir-184, bta-mir-24-1, bta-mir-223, bta-mir-224, bta-mir-26a-1, bta-mir-296, bta-mir-29d, bta-mir-378-1, bta-mir-451, bta-mir-486, bta-mir-671, bta-mir-29e, bta-mir-29b-1, bta-mir-181a-1, ssc-mir-181a-1, ssc-mir-30a, bta-mir-2318, bta-mir-2339, bta-mir-2430, bta-mir-664a, bta-mir-378-2, ssc-let-7a-1, ssc-mir-378-1, ssc-mir-29a, ssc-mir-30e, ssc-mir-499, ssc-mir-143, ssc-mir-10b, ssc-mir-486-1, ssc-mir-152, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-99a, ssc-mir-148b, ssc-mir-664, ssc-mir-192, ssc-mir-342, ssc-mir-125b-1, oar-mir-21, oar-mir-29a, oar-mir-125b, oar-mir-181a-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-296, ssc-mir-155, ssc-mir-146a, bta-mir-148c, ssc-mir-126, ssc-mir-378-2, ssc-mir-451, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-451b, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-664b, hsa-mir-378j, ssc-let-7f-2, ssc-mir-29b-2, ssc-mir-31, ssc-mir-671, bta-mir-378b, bta-mir-378c, hsa-mir-486-2, oar-let-7a, oar-let-7f, oar-mir-103, oar-mir-10b, oar-mir-143, oar-mir-148a, oar-mir-152, oar-mir-16b, oar-mir-181a-2, oar-mir-200a, oar-mir-200b, oar-mir-200c, oar-mir-23a, oar-mir-26a, oar-mir-29b-1, oar-mir-30a, oar-mir-99a, bta-mir-664b, chi-let-7a, chi-let-7f, chi-mir-103, chi-mir-10b, chi-mir-125b, chi-mir-126, chi-mir-141, chi-mir-143, chi-mir-146a, chi-mir-148a, chi-mir-148b, chi-mir-155, chi-mir-15a, chi-mir-15b, chi-mir-16a, chi-mir-16b, chi-mir-184, chi-mir-192, chi-mir-200a, chi-mir-200b, chi-mir-200c, chi-mir-215, chi-mir-21, chi-mir-223, chi-mir-224, chi-mir-2318, chi-mir-23a, chi-mir-24, chi-mir-26a, chi-mir-27b, chi-mir-296, chi-mir-29a, chi-mir-29b, chi-mir-29c, chi-mir-30a, chi-mir-30e, chi-mir-342, chi-mir-378, chi-mir-451, chi-mir-499, chi-mir-671, chi-mir-99a, chi-mir-99b, bta-mir-378d, ssc-mir-378b, oar-mir-29b-2, ssc-mir-141, ssc-mir-200b, ssc-mir-223, bta-mir-148d
Ye et al. (2012) examined miRNA expression in the duodenum of E. coli F18-sensitive and -resistant weaned piglets and identified 12 candidate miRNA (ssc-miR-143, ssc-let-7f, ssc-miR-30e, ssc-miR-148a, ssc-miR-148b, ssc-miR-181a, ssc-miR-192, ssc-miR-27b, ssc-miR-15b, ssc-miR-21, ssc-miR-215, and ssc-miR-152) disease markers. [score:5]
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12
[+] score: 4
MiR-215-5p (FC 3.1; p value 0.02) and miR-1285 (FC 2.9; p value 7.35x10 [-5]) were the most upregulated miRNAs. [score:4]
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13
[+] score: 3
Other small molecules were more slightly over-expressed (between 1.8 and 4.0 folds) and included another snoRNA of the box C/D class (D81, homologous to human U81) involved as well in guiding 20-O-ribose methylation of 28S rRNA [34], four miRNAs (miR-192, miR-194, miR-215, and let-7b) and four mitochondrial tags. [score:3]
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