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1 publications mentioning spu-mir-375

Open access articles that are associated with the species Strongylocentrotus purpuratus and mention the gene name mir-375. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 19
Other miRNAs from this paper: spu-let-7, spu-mir-125
MiR-375 negatively regulates glucose-stimulated insulin exocytosis by targeting myothrophin mRNA, a protein involved in insulin secrection in pancreatic β-cells [20]. [score:3]
Remarkably, the same cells express the evolutionary conserved pancreatic microRNA miRNA-375. [score:3]
Interestingly, the pancreatic exocrine-like cells also express the islet-specific microRNA-375. [score:3]
Figure  2f shows that miRNA-375 is strongly expressed throughout the ciliary band and in the stomach, where it is localized exclusively in the pancreatic exocrine-like cells. [score:3]
In addition, studies on mice lacking miR-375 demonstrated that it controls β- and α-cells mass by regulating genes involved in cellular growth and differentiation [22]. [score:2]
One of the most abundant and evolutionary conserved miRNA involved in pancreas development is miR-375. [score:2]
A loss of function approach in zebrafish revealed that miR-375 is essential for the formation of insulin producing β-cells because its knockdown mainly results in malformation of the endocrine pancreas [21]. [score:2]
mir375 probe has already been used by Christodoulou et al. 2010. [score:1]
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