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miRBase |
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![]() 5 publications mentioning mml-let-7bOpen access articles that are associated with the species Macaca mulatta and mention the gene name let-7b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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Other miRNAs from this paper: mmu-mir-126a, mmu-mir-146a, mmu-let-7b, mmu-mir-21a, mmu-mir-29a, mmu-mir-100, mml-mir-21, mml-mir-29a, mml-mir-100, mmu-mir-146b, mml-mir-126, mml-mir-146a, mml-mir-146b, mmu-mir-21b, mmu-mir-21c, mmu-mir-126b
Next, we treated the hippocampal neurons with a pan-caspase inhibitor, z-VAD-fmk, which have been shown previously to the neurotoxicity resulting from let-7b treatment [25].
[score:3]
A recent study on the role of let-7b in activation of nociceptor dorsal root ganglion (DRG) neurons indicated that cell surface expression of TLR7 and another receptor (TRPV) were necessary for the effect [27].
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The results indicate a significant increase when TLR7 expressing cells were treated with miR21-WT, Let-7b and CL264; whereas, no difference was seen in DOTAP control and miR21-Mut.
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1005032.g003 Fig 3 (A) Wildtype (WT) mouse hippocampal neurons were incubated with 1 μg of synthetic miRNAs; miR-21 (miR21-WT), miR-21 containing a mutation in TLR7 binding site (miR21-Mut) and a known TLR7 activator, Let-7b, and DOTAP artificial EVs.
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miR21-WT: 5'- UAG CUU AUC AGA CUG AUG UUG A -3'; miR21-Mut: 5'- UAG CUU AUC AGA CUG AUG U GG A -3'; and let-7b, 5’- UGA GGU AGU AGG UUG UGU GGU U -3′.
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indicate a significantly higher cell death with miR-21-WT and Let-7b than with miR-21-Mut and DOTAP control.
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A number of studies have revealed that several miRNAs, such as miR-21, miR-29a and let-7b, can even serve as physiological ligands of the ssRNA-sensing [25– 27].
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However, in our cultures, we could not see significant neurotoxicity by naked let-7b (Fig 3A).
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Enclosing let-7b in DOTAP as an EV-like particle, however, resulted in neurotoxicity.
[score:1]
Previously, it was shown that “naked” let-7b synthetic oligonucleotide elicited neurotoxicity [25, 27].
[score:1]
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-98, hsa-mir-106a, hsa-let-7g, hsa-let-7i, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-149, hsa-mir-302a, hsa-mir-99b, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-367, hsa-mir-371a, hsa-mir-372, hsa-mir-373, hsa-mir-374a, hsa-mir-381, hsa-mir-383, hsa-mir-18b, hsa-mir-20b, hsa-mir-409, hsa-mir-410, mml-mir-135a-2, mml-mir-98, mml-mir-106a, hsa-mir-146b, hsa-mir-495, hsa-mir-654, hsa-mir-758, hsa-mir-874, hsa-mir-889, mml-let-7a-1, mml-let-7a-2, mml-let-7a-3, mml-let-7c, mml-let-7d, mml-let-7e, mml-let-7f-1, mml-let-7f-2, mml-let-7g, mml-let-7i, mml-mir-18b, mml-mir-20b, mml-mir-99b, mml-mir-135a-1, mml-mir-146b, mml-mir-149, mml-mir-302a, mml-mir-302b, mml-mir-302c, mml-mir-302d, mml-mir-367, mml-mir-371, mml-mir-372, mml-mir-373, mml-mir-374a, mml-mir-381, mml-mir-383, mml-mir-409, mml-mir-410, mml-mir-495, mml-mir-654, mml-mir-758, mml-mir-874, mml-mir-889, hsa-mir-371b
Down-regulation of Lin28 mRNA is accompanied with up-regulation of let-7 miRNA family, and this regulatory axis dynamics is required for ESC differentiation as well as commitment to neural fate.
[score:8]
Inversely, the expression levels of most Let-7 family members (let-7a, 7c, 7e, 7f, 7g, and miR-98) increase gradually from ESC to R-NSCP6 (Fig. 4A).
[score:3]
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-26a-1, hsa-mir-103a-2, hsa-mir-103a-1, mmu-let-7g, mmu-let-7i, mmu-mir-145a, mmu-mir-191, mmu-mir-200b, mmu-mir-143, hsa-mir-200b, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-143, hsa-mir-145, hsa-mir-191, hsa-mir-320a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-26a-1, mmu-mir-103-1, mmu-mir-103-2, mmu-mir-342, mmu-mir-320, mmu-mir-26a-2, hsa-mir-26a-2, hsa-mir-342, mml-mir-145, mml-mir-26a-1, mml-mir-103-1, mml-mir-124a-1, hsa-mir-494, mmu-mir-494, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-103b-1, hsa-mir-103b-2, mml-let-7a-1, mml-let-7a-2, mml-let-7a-3, mml-let-7c, mml-let-7d, mml-let-7e, mml-let-7f-1, mml-let-7f-2, mml-let-7g, mml-let-7i, mml-mir-26a-2, mml-mir-103-2, mml-mir-124a-2, mml-mir-143, mml-mir-191, mml-mir-320a, mml-mir-342, mml-mir-494, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, hsa-mir-320e, mml-mir-320b, mml-mir-320c, mmu-mir-145b, mmu-let-7j, mmu-let-7k
Among others, such as hsa-miR-191, hsa-miR-200b, hsa-miR-320 and several members of let-7 family we found that hsa-miR-342-3p was regulated at a late stage of disease in both, Scrapie-infected mice and BSE-infected macaques.
[score:4]
We excluded those miRNAs from further analysis showing divergent endogenous expression levels as compared to human brain, e. g. hsa-miR-103 and -107 (additional file 2) and the abundantly expressed members of the let-7 family.
[score:4]
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-19a, hsa-mir-21, hsa-mir-93, hsa-mir-96, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-182, hsa-mir-183, hsa-mir-222, hsa-let-7g, hsa-let-7i, hsa-mir-138-2, hsa-mir-143, hsa-mir-145, hsa-mir-138-1, hsa-mir-195, hsa-mir-200a, hsa-mir-302a, hsa-mir-99b, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-371a, hsa-mir-374a, hsa-mir-378a, hsa-mir-342, mml-mir-145, mml-mir-21, mml-mir-103-1, mml-mir-182, mml-mir-19a, mml-mir-93, mml-mir-183, mml-mir-96, hsa-mir-378d-2, hsa-mir-374b, hsa-mir-302e, hsa-mir-302f, hsa-mir-103b-1, hsa-mir-103b-2, mml-let-7a-1, mml-let-7a-2, mml-let-7a-3, mml-let-7c, mml-let-7d, mml-let-7e, mml-let-7f-1, mml-let-7f-2, mml-let-7g, mml-let-7i, mml-mir-99b, mml-mir-103-2, mml-mir-138, mml-mir-143, mml-mir-195, mml-mir-200a, mml-mir-222, mml-mir-302a, mml-mir-302b, mml-mir-302c, mml-mir-302d, mml-mir-342, mml-mir-371, mml-mir-374a, mml-mir-374b, mml-mir-378a, hsa-mir-378b, hsa-mir-378c, hsa-mir-374c, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-371b, mml-mir-378d, hsa-mir-378j, mml-mir-378j
Additionally, some members of let-7 family were upregulated in rpESCs.
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Oncogenic miRNAs [37], [38], including let-7 family, miR-374 family, miR-138, miR-195, miR-19a and miR-200a, had more than twice expression level in rpESCs comparing with their IVF counterparts.
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Other miRNAs from this paper: mml-mir-200c, mml-mir-141, mml-mir-16-1, mml-mir-23a, mml-mir-93, mml-let-7a-1, mml-let-7a-2, mml-let-7a-3, mml-let-7c, mml-let-7d, mml-let-7e, mml-let-7f-1, mml-let-7f-2, mml-let-7g, mml-let-7i, mml-mir-16-2, mml-mir-205, mml-mir-423
MiRNAs reportedly unaffected by TRIzol extraction include those from the let-7 family, hsa-miR-200c-3p, -29a-3p, and -25-3p.
[score:1]
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