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5 publications mentioning mml-let-7b

Open access articles that are associated with the species Macaca mulatta and mention the gene name let-7b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 17
Next, we treated the hippocampal neurons with a pan-caspase inhibitor, z-VAD-fmk, which have been shown previously to the neurotoxicity resulting from let-7b treatment [25]. [score:3]
A recent study on the role of let-7b in activation of nociceptor dorsal root ganglion (DRG) neurons indicated that cell surface expression of TLR7 and another receptor (TRPV) were necessary for the effect [27]. [score:3]
The results indicate a significant increase when TLR7 expressing cells were treated with miR21-WT, Let-7b and CL264; whereas, no difference was seen in DOTAP control and miR21-Mut. [score:3]
1005032.g003 Fig 3 (A) Wildtype (WT) mouse hippocampal neurons were incubated with 1 μg of synthetic miRNAs; miR-21 (miR21-WT), miR-21 containing a mutation in TLR7 binding site (miR21-Mut) and a known TLR7 activator, Let-7b, and DOTAP artificial EVs. [score:2]
miR21-WT: 5'- UAG CUU AUC AGA CUG AUG UUG A -3'; miR21-Mut: 5'- UAG CUU AUC AGA CUG AUG U GG A -3'; and let-7b, 5’- UGA GGU AGU AGG UUG UGU GGU U -3′. [score:1]
indicate a significantly higher cell death with miR-21-WT and Let-7b than with miR-21-Mut and DOTAP control. [score:1]
A number of studies have revealed that several miRNAs, such as miR-21, miR-29a and let-7b, can even serve as physiological ligands of the ssRNA-sensing [25– 27]. [score:1]
However, in our cultures, we could not see significant neurotoxicity by naked let-7b (Fig 3A). [score:1]
Enclosing let-7b in DOTAP as an EV-like particle, however, resulted in neurotoxicity. [score:1]
Previously, it was shown that “naked” let-7b synthetic oligonucleotide elicited neurotoxicity [25, 27]. [score:1]
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2
[+] score: 11
Down-regulation of Lin28 mRNA is accompanied with up-regulation of let-7 miRNA family, and this regulatory axis dynamics is required for ESC differentiation as well as commitment to neural fate. [score:8]
Inversely, the expression levels of most Let-7 family members (let-7a, 7c, 7e, 7f, 7g, and miR-98) increase gradually from ESC to R-NSCP6 (Fig.   4A). [score:3]
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3
[+] score: 8
Among others, such as hsa-miR-191, hsa-miR-200b, hsa-miR-320 and several members of let-7 family we found that hsa-miR-342-3p was regulated at a late stage of disease in both, Scrapie-infected mice and BSE-infected macaques. [score:4]
We excluded those miRNAs from further analysis showing divergent endogenous expression levels as compared to human brain, e. g. hsa-miR-103 and -107 (additional file 2) and the abundantly expressed members of the let-7 family. [score:4]
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4
[+] score: 7
Additionally, some members of let-7 family were upregulated in rpESCs. [score:4]
Oncogenic miRNAs [37], [38], including let-7 family, miR-374 family, miR-138, miR-195, miR-19a and miR-200a, had more than twice expression level in rpESCs comparing with their IVF counterparts. [score:3]
[1 to 20 of 2 sentences]
5
[+] score: 1
MiRNAs reportedly unaffected by TRIzol extraction include those from the let-7 family, hsa-miR-200c-3p, -29a-3p, and -25-3p. [score:1]
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