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4 publications mentioning hsa-mir-1245a

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1245a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 196
The results showed that the overexpression of circ_0046264 or the suppression of miR-1245 promoted the expression of BRCA2, whereas the suppression of circ_0046264 led to the suppression of BRCA2 expression (Fig. 2g, j, 3a). [score:13]
[#] P < 0.05, compared with circ264 group Overexpression of hsa_circ_0046264 or suppression of miR-1245 significantly suppressed the invasion and viability of lung cancer cells; and the suppression of hsa_circ_0046264 or the overexpression of miR-1245 significantly suppressed cell invasion and viability (Fig.   3b, 4a and b). [score:12]
Here, hsa_circ_0046264 and BRCA2 shared common target miRNA, miR-1245, and up-regulation of miR-1245 in lung cancer resulted from the low expression of hsa_circ_0046264 caused the down-regulation of BRCA2. [score:11]
The suppressive effect of hsa_circ_0046264 resulted from its combination with miR-1245, which could indirectly up-regulate miR-1245’s target gene, BRCA2. [score:9]
Overexpression of hsa_circ_0046264 could up-regulate BRCA2 expression through down -regulating of miR-1245. [score:9]
Fig. 2Hsa_circ_0046264 overexpression down-regulated miR-1245 and up-regulated BRCA2. [score:9]
Hsa_circ_0046264 overexpression down-regulated miR-1245 and up-regulated BRCA2. [score:9]
MiR-1245 was suppressed by hsa_circ_0046264, while BRCA2, the target gene of miR-1245, was up-regulated. [score:8]
Hsa_circ_0046264 induced apoptosis but inhibited proliferation and invasion of lung cancer cells through targeting miR-1245 to up-regulate BRCA2. [score:8]
Hsa_circ_0046264 could bind miR-1245, and since BRCA2 was the target gene of miR-1245, BRCA2 was indirectly up-regulated by hsa_circ_0046264. [score:7]
a The overexpression of hsa_circ_0046264 and the suppression of miR-1245 promoted BRCA2 expression. [score:7]
Meanwhile, miR-1245 expression was reduced in tumor tissues obtained from mice in hsa_circ_0046264 overexpression group, and the mRNA and protein expressions of BRCA2 were elevated. [score:7]
Hsa_circ_0046264 and BRCA2 were down-regulated in lung cancer tissues while miR-1245 was up-regulated. [score:7]
Hsa_circ_0046264 inhibited lung cancer development through acting as a ceRNA which regulated miR-1245 and indirectly activated BRCA2. [score:6]
The deletion mutation (MUT1) and point mutation (MUT2) of circ_0046264 and BRCA2 were used to be as the control of wild type vectors (WT) which showed significant suppressions of luciferase activity by miR-1245(Fig. 2c and d). [score:5]
b The overexpression of hsa_circ_0046264 and the suppression of miR-1245 promoted cell invasion. [score:5]
The tumor tissues obtained from the nude mice had an elevated expression level of hsa_circ_0046264 in circ264 group, accompanied by lower miR-1245 and higher BRCA2 expression levels (Fig. 5c and d). [score:5]
Hsa_circ_0046264 and BRCA2 were lowly expressed in lung cancer tissues while miR-1245 was high expressed. [score:5]
The regulatory effect of miR-1245on BRCA2 expression has been reported in previous study as the 3’UTR region of BRCA2 was combined with miR-1245 [15]. [score:4]
The target gene of miR-1245 was determined as BRCA2 through the database miRTarBass. [score:3]
c- d Apoptosis of A549 and 95-D cells was promoted in circ264 group and antimir1245 group but inhibited in sicirc groups and mir1245 group. [score:3]
The overexpression of miR-1245 significantly enhanced cell apoptosis as well (Fig.   4c and d). [score:3]
a The expression level of miR-1245 was higher in advanced lung cancer tissues (stage III and stage IV) than that in early-stage cancer tissues (stage I and stage II). [score:3]
We have verified the target relationship between circ_0046264 and miR-1245 as well as miR-1245 and BRCA2. [score:3]
f, i The relative expression of miR-1245 in lung cancer cells decreased in circ264 group and antimir1245 group but increased in sicirc groups and miR-1245 group. [score:3]
In addition, the influence of modulation of circ_0046264 and miR-1245 expression on BRCA expression was investigated. [score:3]
We confirmed the target relationship between miR-1245 and BRCA2, and further uncovered their associations with hsa_circ_0046264. [score:3]
Therefore, miR-1245 and its target gene BRCA2 might affect the progression of lung cancers. [score:3]
These results implied that miR-1245 is a potential tumor promotor and BRCA2 is a suppressor. [score:3]
The concentration of miR-1245 mimics or miR-1245 inhibitor was 30 nM–50 nM. [score:3]
d The relative expression of miR-1245 decreased while that of BRCA2 increased in tumor tissues of circ264 group. [score:3]
The simultaneous transfection of hsa_circ_0046264 and miR-1245 did not result in significant change of BRCA2 expression. [score:3]
MiR-1245 was considered as an oncogene because it was demonstrated as a potent negative regulator of the tumor suppressor protein BRCA2 [13]. [score:2]
MiR-1245 attenuated the expression of NKG2D, an activating receptor involved in tumor immunosurveillance, in natural killer cells [14]. [score:2]
HEK293 cells (Thermo Fisher Scientific) transfected with miR-1245 mimics or miR-con were seeded in 24-well plates and co -transfected with empty pmirGLO or recombinant pmirGLO for 48 h by using Lipofectamine™ 2000 (Invitrogen). [score:1]
The influence of miR-1245 in lung cancer has not been identified yet. [score:1]
d The dual luciferase activity decreased in HEK293 cells co -transfected with BRCA2 3’UTR WT and miR-1245 mimics, but almost not changed in cells co -transfected with BRCA2 3’UTR MUT and miR-1245 mimics. [score:1]
c The dual luciferase activity decreased in HEK293 cells co -transfected with hsa_circ_0046264 WT and miR-1245 mimics, but almost did not change in cells co -transfected with hsa_circ_0046264 MUT and miR-1245 mimics. [score:1]
The simultaneous transfection of hsa_circ_0046264 and miR-1245 did not result in significant change of cell invasion. [score:1]
The transfection efficiency of circ264, sicirc, miR-1245 and antimiR-1245 were tested in both A549 and 95-D cell lines (Fig. 2e and f, h and i). [score:1]
hsa_circ_0046264 Hsa-miR-1245 BRCA2 Lung cancer Lung cancer mortality ranks the highest in cancer-related death, and the five-year survival rate is only about 20% [1]. [score:1]
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2
[+] score: 6
Our results demonstrate that a) two miRNAs, miR-193a-3p and miRPlus-E1245 (a proprietary sequence of Exiqon Inc, Denmark and named as such to differentiate from miR-1245) were commonly regulated among all 4 cell types infected with XMRV used in the study, and b) while miR-193a-3p is down regulated, miRPlus-E1245 exhibited varied expression profile in the four cell types infected with XMRV. [score:5]
The miRPlus-E1245 is a recently discovered miRNA and proprietary sequence of Exiqon Inc, Denmark and named as such to differentiate it from miR-1245. [score:1]
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3
[+] score: 5
Name Predicted targets (miRDB) 1 miR-200b ZEB1, ZEB2, BMI1, TWISTNB, PLEXINA4, DNMT3A, CDNK2B 2 miR-607 RUNX-1, RUNX-2, IGF-1, MSX1, SOCS4, CXCL6 3 miR-515-5p FGFR2, TGFBR2, NOTCH2, BMP8b, MSX2, FGF12, BMPR1B 4 miR-1245 FGF20, TBRG1, BMI1 5 miR-3919 NFAT5, ID4, HOXB13, HDAC1, RPS6KA6, TGFBR2, SEMA3A 6 miR-182 FGF9, SMAD1, IGF1R, SOX2, BMPR1B, WISP1/CCN4, EGR3 Table shows the selected possible mRNA targets related to stemness and cell differentiation. [score:5]
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4
[+] score: 3
Other miRNAs from this paper: hsa-mir-34a, hsa-mir-223, hsa-mir-155, hsa-mir-1245b
The levels of other lymphocyte-expressed miRNAs such as miR-1245 [31] and miR-223 [32] were not significantly affected by resveratrol treatment. [score:3]
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