sort by

37 publications mentioning hsa-mir-1207

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1207. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 31
miRNA Tissue type Mode of action Reference miR-491-5p Cervical cancerUnknown, inhibits hTERT Zhao et al., 2015 miR-1182 Gastric cancerBinds the ORF of hTERT mRNA, preventing translation Zhang et al., 2015 miR-1207-5p Gastric cancerRepresses hTERT in normal tissues Chen et al., 2014 miR-1266 Gastric cancerRepresses hTERT in normal tissues Chen et al., 2014 miR-138 Anaplastic thyroid carcinoma (ATC)Interaction with 3′UTR of hTERT to reduce protein expression Mitomo et al., 2008 let-7g Pulmonary fibrosisInteraction with 3′UTR of hTERT to reduce expression Singh et al., 2010 miR-133a Jurkat cellsInteraction with 3′UTR of hTERT to reduce expression Hrdličková et al., 2014 miR-342 Jurkat cellsInteraction with the 3′UTR of hTERT to reduce expression Hrdličková et al., 2014 miR-541 Jurkat cellsInteraction with the 3′UTR of hTERT to reduce expression Hrdličková et al., 2014 Non-coding RNAs can also target transcription factors involved in the control of hTERT. [score:17]
Long noncoding RNA BC032469, a novel competing endogenous RNA, upregulates hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer. [score:6]
miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase. [score:5]
miR-1207-5p and miR-1266 also target hTERT within gastric cancers, and are significantly repressed in gastric cancer tissue samples (Chen et al., 2014). [score:3]
[1 to 20 of 4 sentences]
2
[+] score: 23
Other miRNAs from this paper: hsa-let-7b, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-92b, hsa-mir-762
Using a mo del of corneal epithelial cells exposed to natural human tear fluid, we showed that; 1) tear fluid treatment followed by bacterial antigens upregulates miR-762 and miR-1207, and down-regulates miR-92 and let-7b compared to bacterial antigens alone, 2) miR-762 negatively regulates the expression of genes encoding the antimicrobial RNase7, the immunomodulator ST2, and the RhoGTP -binding protein Rab5a, but not the defensins hBD-2 or hBD-3, 3) over -expression of miR-762 suppresses RNase7 and ST2 mRNA levels, and increases bacterial internalization, and 4) tear fluid alone induces miR-762 expression, which negatively regulates genes encoding RNase7 and ST2. [score:16]
MiR-762 and miR-1207 were both significantly upregulated; miR-92 and let-7b were both significantly downregulated. [score:7]
[1 to 20 of 2 sentences]
3
[+] score: 22
Interestingly, we found that 116 genes of our signature are predicted targets of deregulated microRNAs; in particular, the down-regulated gene SYK is target of all up-regulated microRNAs, while LGALS1 is a putative target of miR-1207-5p, miR-1225-5p. [score:14]
Interestingly, the showed that SYK is a putative target of all up-regulated microRNAs, while LGALS1 is a predicted target only of miR1207-5p and miR1225-5p. [score:8]
[1 to 20 of 2 sentences]
4
[+] score: 20
In particular, since the colors in the heatmap showed the relative expression of the miRNA across all samples, we observed two types of expression profiles, one in which the expression was lower in the patients with a short-OS (for miR-211, miR-1207-3p, miR-326) and one in which the pattern was opposite (for miR-4321). [score:7]
With the exception of the patient S2, two groups of miRNAs can be observed, one group in which the expression is lower in the patients with short-OS (miR-211, miR-1207-3p, miR-326, miR-197, let-7b*, miR-1296, miR-4290) and one group that has an opposite expression profile (miR-4321, miR-3610, miR-1914*). [score:5]
Conversely, patients with long-OS had higher expression values for miR-211, miR-1207-3p, miR-326, and lower expression values for miR-4321. [score:5]
Highly stringent statistics identified the top 4 discriminating miRNAs (miR-211, miR-1207-3p, miR-326 and miR-4321) between patients with short vs. [score:1]
However, to our knowledge, this is the first study unraveling the possible prognostic role of miR-211, miR-1207-3p, miR-326 and miR-4321 in PDAC. [score:1]
The miR-1207-3p sequence is related to a group of mammalian miRNAs with overlapping seeds (rno-miR-337, mmu-miR-763, and hsa-miR-565) and has been recently detected in a panel of cancer cell lines, during the identification of MiRNAs in the genomically unstable region of human chromosome 8q24 [61] that is also frequently alterated, with high copy number gain, in PDAC [62]. [score:1]
[1 to 20 of 6 sentences]
5
[+] score: 14
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-101-1, hsa-mir-106a, hsa-mir-107, hsa-mir-16-2, hsa-mir-192, hsa-mir-196a-1, hsa-mir-199a-1, hsa-mir-129-1, hsa-mir-148a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-196a-2, hsa-mir-199a-2, hsa-mir-203a, hsa-mir-210, hsa-mir-212, hsa-mir-214, hsa-mir-215, hsa-mir-217, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-mir-200b, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-15b, hsa-mir-27b, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-130a, hsa-mir-141, hsa-mir-142, hsa-mir-143, hsa-mir-145, hsa-mir-153-1, hsa-mir-153-2, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-129-2, hsa-mir-146a, hsa-mir-150, hsa-mir-185, hsa-mir-195, hsa-mir-206, hsa-mir-200c, hsa-mir-1-1, hsa-mir-155, hsa-mir-181b-2, hsa-mir-106b, hsa-mir-29c, hsa-mir-200a, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-130b, hsa-mir-376c, hsa-mir-375, hsa-mir-378a, hsa-mir-148b, hsa-mir-338, hsa-mir-335, hsa-mir-423, hsa-mir-20b, hsa-mir-429, hsa-mir-449a, hsa-mir-433, hsa-mir-451a, hsa-mir-193b, hsa-mir-520d, hsa-mir-503, hsa-mir-92b, hsa-mir-610, hsa-mir-630, hsa-mir-650, hsa-mir-449b, hsa-mir-421, hsa-mir-449c, hsa-mir-378d-2, hsa-mir-744, hsa-mir-1266, hsa-mir-378b, hsa-mir-378c, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-4512, hsa-mir-378i, hsa-mir-203b, hsa-mir-451b, hsa-mir-378j
Moreover, GC patients with over -expression of miR-107 [28, 29, 30], miR-143 [40], miR-145 [41, 42], miR-181b/c [17, 47, 48, 55, 56], miR-196a/b [59], miR-20b [23, 66], miR-23a/b [77, 78, 79], miR-34 [17, 47, 48, 55, 56] and miR-630 [100] and decreased expression of miR-1 [111], miR-1207-5p [121], miR-125a-3p/-5p [24, 125, 126, 127], miR-185 [140], miR-193b [60], miR-20a [111], miR-206 [150, 151], miR-215 [142], miR-217 [153], miR-27a [111], miR-29c [169], miR-34a [172, 173], miR-423-5p [111], and miR-520d-3p [99] indicate advanced tumor stage or TNM stage. [score:5]
Chen L. Lu M. H. Zhang D. Hao N. B. Fan Y. H. Wu Y. Y. Wang S. M. Xie R. Fang D. C. Zhang H. miR-1207–5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase Cell Death Dis. [score:5]
miR-1207-5p and miR-1266 are significantly down-regulated in GC tissues. [score:4]
[1 to 20 of 3 sentences]
6
[+] score: 12
Alvarez et al. reported that miR-1207-5p is derived from PVT1 lncRNA and was upregulated by high glucose and TGFβ1 in kidney cells. [score:4]
This indicates that glucose and TGFβ1 regulates miR-1207-5p expression but in an independent manner of its host gene PVT1. [score:4]
Further they showed that like PVT1, miR-1207-5p also increased the expression of TGF-β1, PAI-1, and FN1 independently of PVT1. [score:3]
Taken together, these results show that miR-1207-5p and its host gene play an important role in the pathogenesis of DN (38). [score:1]
[1 to 20 of 4 sentences]
7
[+] score: 12
Amongst miRNAs with reported targeting specificity for hTERT, miR-541, miR-512-5p and miR-1207-5p were able to efficiently reduce hTERT-3’UTR reporter activity in our screen; miR-133a was not represented in our candidate miRNAs list (Supplementary Figure 1B). [score:3]
Recent studies demonstrated that miR-138, miR-133a, miR-342, miR-491-5p, miR-541, miR-1207-5p, miR-1266 and miR-1182 control hTERT expression in leukemic T-cell lymphoblasts, gastric cancer, cervical cancer, thyroid carcinoma and head and neck squamous cell carcinoma [28– 31, 33]. [score:3]
Recent studies reported a role of miR-133a, miR-138, miR-541, miR-491-5p, miR-512-5p, miR-1182, miR-1207-5p and miR-1266 in the control of hTERT expression in various types of cancer cells [27– 33]. [score:3]
We found that among candidate miRNAs that mediate at least 50% reduction of hTERT 3’UTR reporter activity, only miR-296-5p, miR-512-5p and miR-1207-5p showed significant down-regulation in breast cancer when compared to healthy tissue (Figure 1A, 1C, Supplementary Figure 2A). [score:3]
[1 to 20 of 4 sentences]
8
[+] score: 12
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-mir-17
Long noncoding RNA BC032469, a novel competing endogenous RNA, upregulates hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer. [score:6]
Another lncRNA termed BC032469 was also shown to be upregulated in the GC tissues and to function as competing endogenous RNA (ceRNA) to antagonize the miR-1207-5p suppression of hTERT, which promotes cell growth [18]. [score:6]
[1 to 20 of 2 sentences]
9
[+] score: 9
Although these ncRNAs are coexpressed, regulation of miR-1207-5p expression by TGF-β is independent of PVT1. [score:6]
We have previously reported on the role of miRNAs in these cells after stimulation with TGF-β plus FCS, [3] and now it is known that PVT1 can express a cluster of 6 miRNAs, such as miR-1207-5p (which we discussed previously [4]). [score:3]
[1 to 20 of 2 sentences]
10
[+] score: 9
Other miRNAs from this paper: hsa-mir-197, hsa-mir-145, hsa-mir-129-2, hsa-mir-328, hsa-mir-505
The authors also showed that down-regulated targets of two miRs, miR-1207-5p and miR-129-2-3p, were enriched in PI3K and MAPK pathways and that eight of 12 enriched pathways were downregulated in individuals with metabolic syndrome. [score:9]
[1 to 20 of 1 sentences]
11
[+] score: 8
Chen et al (12) determined that miR-1207-5p and miR-1266 interact with the 3′UTR of hTERT and suppress gastric cancer growth and invasion by targeting hTERT. [score:5]
Three different miRNAs (miR138 in human anaplastic thyroid carcinoma cell lines, miR-1207 and miR1266 in gastric cancer) have been identified that may influence hTERT expression (12, 13). [score:3]
[1 to 20 of 2 sentences]
12
[+] score: 8
To more clearly understand the mechanism of CCAT2 regulated expression of miRNAs, we used bioinformatics tool LncTar [38] and predicted CCAT2 to regulate expression of some of the miRNAs related to growth and differentiation of CSC, such as miR-146a [19], miR-146b, miR-10a, miR-15a, miR-1207, miR-16. [score:7]
Various other miRNAs such as pre-miR146ab,pre-miR-15a, pre-miR-1207 and pre-miR-10a may also be affected by CCAT2 via similar mechanisms as predicted, and by our miRNA PCR array data (Fig. 7). [score:1]
[1 to 20 of 2 sentences]
13
[+] score: 7
In this respect, the miRNAs targeting telomerase directly or indirectly, might serve as tumor suppressive genes in cellular processes, such as let-7g, miR-138, miR-1207 and miR-1266, which induced tumor senescence and death eventually [15– 17]. [score:7]
[1 to 20 of 1 sentences]
14
[+] score: 7
STAT6 was found to be a novel target of PVT1-derived miR-1207-5p, and miR-1207-5p promoted breast cancer cell growth by targeting STAT6, which in turn control CDKN1A and CDKN1B [37], confirming the tumor suppressing role of STAT6 in breast cancer. [score:7]
[1 to 20 of 1 sentences]
15
[+] score: 7
Moreover, they also found that PVT1 acts as a host gene to drive the production of miR-1207-5p which can directly target glucose-6-phosphate dehydrogenase (G6PD), prostate transmembrane protein, androgen induced 1 (PMEPA1), 3-phosphoinositide dependent protein kinase 1 (PDPK1) and SMAD family member 7 (SMAD7), and increase the expression of TGF-β1, PAI-1, and FN1 to regulate the pathogenesis of DN [112]. [score:7]
[1 to 20 of 1 sentences]
16
[+] score: 6
Similarly, lncRNA-H19 also acted as a ceRNA to modulate the availability of let-7. [30] Additionally, lncRNA-BC032469 can up-regulate hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer [31]. [score:6]
[1 to 20 of 1 sentences]
17
[+] score: 6
Figure 4Although transfection of O'methylated microRNA (miR)1207‐5p (OME‐miR‐1207‐5p, a functional inhibitor of miR1207‐5p) in HCT‐116 cells caused a marked increase in the expression of miR1207‐5p (A), it resulted in a marked reduction in Vimentin and Catenin (cadherin‐associated protein)‐ β‐1 expression, compared to the control (B). [score:6]
[1 to 20 of 1 sentences]
18
[+] score: 6
This miRSNP was predicted to affect binding of four miRNAs (miR-4741 NBC Score = 0.9, miR-4763-3p NBC Score = 0.89, miR-3918 NBC Score = 0.86, miR-1207-5p NBC Score = 0.92) and is an eQTL that upregulates the target gene in whole blood (Figure 1). [score:6]
[1 to 20 of 1 sentences]
19
[+] score: 5
It was demonstrated that miR-1207-5p and miR-1266 could suppress gastric cancer growth and invasion by targeting the telomerase reverse transcriptase (hTERT) (Chen et al., 2014). [score:5]
[1 to 20 of 1 sentences]
20
[+] score: 5
Chen L. Lü M. H. Zhang D. Hao N. B. Fan Y. H. Wu Y. Y. Wang S. M. Xie R. Fang D. C. Zhang H. Hu C. J. miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptaseCell Death Dis. [score:5]
[1 to 20 of 1 sentences]
21
[+] score: 5
Allele T may achieve its function through abolishing the repression of IL15 mRNA by miR-1207-5p, thus resulting in up-regulation of IL15 protein. [score:4]
Mutant allele T interrupts binding-site of miR-1207-5p while creating new binding-sites for miR-940/4514/4692. [score:1]
[1 to 20 of 2 sentences]
22
[+] score: 5
miRNA Location Targets References miR 193b/365Chr16,14397824-14397906 (miR193b)14403142-14403228 (miR-365)TTf1 - oncogenicBCL2 – TSGCyclin D- TSG, uPa(Qi et al., 2012)(Nie et al., 2012)(Li et al., 2009) Chr7, 130562218-130562298Sp-1MCL-1 - oncogenicTCL1 – oncogenic(Amodio et al., 2012)(Mott et al., 2007)(Pekarsky et al., 2006) Chr19, 13985513-13985622SIRT1- oncogenic and TSGKRAS - oncogenicTGFβ - TSGTNF - TSGNOTCH - oncogenic and TSG(Zhang et al., 2012)(Schonrock et al., 2012)(Hashimoto et al., 2010) miR-617 Chr12, 81226312-81226408 N/A miR-592 Chr7, 126698142-126698238 N/A miR-1207 Chr8 129061398-129061484. [score:3]
While miR-1207 may be transcribed by NRF2, there have been few studies on its role in malignancies, therefore making its role in cancers elusive. [score:1]
Like miR-1207, and miR-617, little work has been done to specifically identify the role of miR-550 in malignancies. [score:1]
[1 to 20 of 3 sentences]
23
[+] score: 5
Other miRNAs from this paper: hsa-mir-218-1, hsa-mir-218-2, hsa-mir-145
miR-1207-5p suppresses lung cancer growth and metastasis by targeting CSF1. [score:5]
[1 to 20 of 1 sentences]
24
[+] score: 5
Other miRNAs from this paper: hsa-mir-483, hsa-mir-615, hsa-mir-1266
Chen L miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptaseCell Death Dis. [score:5]
[1 to 20 of 1 sentences]
25
[+] score: 4
We found that four of the six annotated miRNAs mapping to this locus, miR-1205, miR-1207-3p, miR-1207-5p, and miR-1208, were upregulated in response to hyperglycemia in human mesangial cells [109], indicating that PVT1 may affect ECM accumulation through miRNA -mediated actions. [score:4]
[1 to 20 of 1 sentences]
26
[+] score: 4
160 pmol of 3′-biotinylated pre-mir-647 and pre-mir-1207 were bound to 2 mg of streptavidin-coated magnetic beads (M-280, Invitrogen) in binding buffer (10 mM Tris HCl pH 7.5, 1 mM EDTA, 2 M NaCl), according to the manufacturers instructions. [score:1]
Due to length constraints in the oligonucleotide synthesis process, modified pre-miR-1207 and -647 were designed to have no more than 80nt while retaining predicted secondary structure features (Figures 2B,C). [score:1]
The 20 μl EMSA binding reaction included 50 ng/μg of Poly (dI [∗]dC), 1x binding buffer, 2.5% glycerol, 5 μg nuclear lysate and 20 fmol biotin-mir-647 or biotin-mir-1207. [score:1]
FIGURE 2MAZ binds to pre-miR-1207 and -647 in the nucleus. [score:1]
[1 to 20 of 4 sentences]
27
[+] score: 4
Specifically, miR-1182, miR-1207-5p, miR-1266, miR-532 and miR-3064, which bind within the h TERT 3’UTR, are downregulated and associated with a poor clinical outcome in bladder, gastric and ovarian cancer [169– 171]. [score:4]
[1 to 20 of 1 sentences]
28
[+] score: 4
Whether PVT1-derived miRNAs act in concert with, or independent from, those previously identified miRNAs remains to be seen; however, our preliminary findings suggest that miR-1205, miR-1207-3p, miR-1207-5p, and miR-1208 are up-regulated by high glucose in mesangial cells (data not shown). [score:4]
[1 to 20 of 1 sentences]
29
[+] score: 4
Nineteen of the downregulated miRNAs in chronic patients were found to be associated with carcinogenesis in various organs and tissues, such as miR-1207 [40], miR-3162-5p [41, 42], miR-3196 [43, 44], miR-371b-5p [45], miR-574-5p [46, 47], miR-1225-5p [48], miR-4485 [49], miR-572 [50], miR-4299 [51], miR-3679-5p [52], miR-3940-5p [53], miR-638 [54, 55], miR-1202 [56], miR-5787 [57], miR-1973 [58], miR-4532 [59], miR-1275 [60], miR-4728-5p [61], and miR-1915-3p [62]. [score:4]
[1 to 20 of 1 sentences]
30
[+] score: 3
Using a step-wise approach, we selected five exosomal miRNAs (miR-320c, miR-1202, miR-1225-5p, miR-1207-5p, and miR-7270) and validated miR-320 and miR1225-5p expression in the PLF of 18 CG patients by qRT-PCR. [score:3]
[1 to 20 of 1 sentences]
31
[+] score: 3
Other miRNAs from this paper: hsa-mir-34a, hsa-mir-150, hsa-mir-331, hsa-mir-3923
LncRNA BC032469 expresses highly in gastric cancer, and promotes cells proliferation by function as competing endogenous RNA for miR-1207-5p and antagonizing its repression on hTERT [17]. [score:3]
[1 to 20 of 1 sentences]
32
[+] score: 3
Additionally, miR-1207 appears to target energy metabolism (most likely involving glucose metabolism). [score:3]
[1 to 20 of 1 sentences]
33
[+] score: 2
Other miRNAs from this paper: hsa-mir-30c-1, hsa-mir-3157
Using the RegRNA2.0 tool [39] we predicted binding sites for microRNAs hsa-miR-30c-1-3p, hsa-miR-1207-5p, and hsa-miR-3157-5p in the 3’UTR from the longer transcript variant. [score:1]
Only one binding site for hsa-miR-1207-5p was predicted in the transcript variant with truncated exon 23 (Fig 5A). [score:1]
[1 to 20 of 2 sentences]
34
[+] score: 2
We found that certain miRNAs (miR-203, miR-511, miR-590-3p, miR-346*/miR-1207-5p/miR-4763-3p) serve as organizational hubs of several signal transduction pathways in one of our IPA networks (Figure 5D). [score:1]
Nexus genes in complex networks Several “nexus” genes, including the components of a multi-subunit complex involved in the terminal stages of cholesterol synthesis, miRNAs (e. g. miR-203, miR-511, miR-590-3p, miR- 346*/miR-1207-5p/miR-4763-3p), members of the GPCR family of proteins (e. g. GPR1, GPR64, GPRC5A,GPR171, GPR176, GPR32, GPR25, and GPR124) and signal transduction pathways were observed. [score:1]
[1 to 20 of 2 sentences]
35
[+] score: 1
Indeed, its locus gives rise to over 20 different variants of the lncRNA according to the Ensembl annotations of the human genome (release 75) and also produces a cluster of six annotated microRNAs (i. e. miR-1204, miR-1205, miR-1206, miR-1207-5p, miR-1207-3p, and miR-1208) [96– 101]. [score:1]
[1 to 20 of 1 sentences]
36
[+] score: 1
Scare bar = 50 μm To explore whether circHIPK3 can function as “miRNA sponge” in CRC cells, we selected the top ten (miR-599, miR-93-3p, miR-365a-5p, miR-365b-5p, miR-421, miR-570-3p, miR-597-5p, miR-7, miR-1207-3p, miR-124-5p) candidate miRNAs through CircNet database [21]. [score:1]
[1 to 20 of 1 sentences]
37
[+] score: 1
Results showed that both PVT1 lncRNA and miR-1207-5p were induced by high glucose independently and they both contributed to ECM accumulation in the kidney [66]. [score:1]
[1 to 20 of 1 sentences]