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4 publications mentioning mmu-mir-1192

Open access articles that are associated with the species Mus musculus and mention the gene name mir-1192. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 33
miR-1192 is the only miR locus that is located within any of the NR2F1 target genes; it is found in the Klf9 gene which is up-regulated in the inner ear of Nr2f1 [–/–] mouse [12] and is targeted by miR-140 (Table 1 ). [score:8]
Tissue-Dependent Co-regulation of Klf9 by NR2F1 and miR-140We found it intriguing that miR-1192 expression was not altered whereas the gene Klf9, which harbors the miR-1192 locus, was up-regulated in the Nr2f1 [–/–] [12], suggesting that Klf9 is regulated independently in the inner ear. [score:8]
We found it intriguing that miR-1192 expression was not altered whereas the gene Klf9, which harbors the miR-1192 locus, was up-regulated in the Nr2f1 [–/–] [12], suggesting that Klf9 is regulated independently in the inner ear. [score:7]
Of all the NR2F1 target genes inspected, only one miRNA gene intersection was found in the human genome–the Klf9 gene, which contains the gene encoding miR-1192, was previously validated to be up-regulated and inner ear of Nr2f1 [–/–] mice [12]. [score:6]
With these criteria a set of 11 miRNAs (miR-17, miR-33, miR-96, miR-140, miR-181b, miR-183, miR-191, miR-194, miR-199b, miR-341, and miR-1192) were selected that might participate to coordinate with NR2F1 to regulate inner ear gene expression. [score:4]
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2
[+] score: 31
As miR-199a, miR-455 and miR-1192 were up-regulated in PPARγ DN animals this may indicate that PPARγ normally inhibits their expression directly (e. g. by recruiting transcriptional inhibitors to those promoters) or indirectly (by the PPARγ specific transctivation of a transcriptional inhibitor). [score:14]
Interestingly, only four of the 21 regulated miRNAs (miR-199a, miR-455, miR-592, and miR-1192) were solely dependent on the genotype; independent of diet, the expression of miR-199a, miR-455 and miR-1192 was up-regulated in PPARγ DN animals whereas miR-592 was down-regulated in these mice compared to wt. [score:9]
The expression of four miRNAs was only dependent on the PPARγ expression status of the animals; miR-199, miR-455 and miR-1192 were upregulated in mice with dominant -negative PPARγ irrespective of the diet given to the animals, the fourth, miR-592, was reduced in mutant animals (“a” in Fig. 5C). [score:8]
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3
[+] score: 10
In this study we discovered three key known AMD genes, Fms related tyrosine kinase 1(Flt1), the receptor for vascular endothelial growth factor (VEGF) (putative miR1192 target), ATP binding cassette subfamily A member 1 (Abca1) (putative miR673-5p target), and Activated leukocyte cell adhesion molecule(Alcam) (putative miR188-3p target) are regulated by Nr2e3 and Rora and their potential corresponding miRNAS that are differentially expressed in Nr2e3 rd7/ rd7 retinas. [score:10]
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4
[+] score: 9
Treatment days miRNAExpression change [#] Predicted mRNA target(s)Expression change [#]GD 8/11 [†] miR-1192 ↑ Atf1, Gng4, Map3k1, Rpe, Setd2, Stxbp6, Zc3h6 ↓ miR-532-5p ↑ Atf1, Itpripl2, Stxbp6 ↓GD 14/16 [*] miR-10b ↓ Aak1 ↑ miR-184 ↓ Myl9 ↑ miR-302c ↑ Ccdc6, Mfap3, Ptpro, Rnd3, Rpl36a/r, Sema3c, Stoml3, Supt3h ↓ miR-342-5p ↓ Aak1, Cables2, Rhog ↑ miR-343 ↑ Asic4, Dcn, Gpr116, Ptpro, Stoml3 ↓ miR-449b ↓ Ina ↑PD 4/7 [†] miR-26b ↑ Adam9, Chsy1, Cnr1, Exoc8, Hs6st1, Lingo1, Map3k7, Mras, Pfkfb3, Ppm1b, Rhou, Sema6d, Shank2, Tab3, Tdrd7, Ube2j1 ↓ miR-34b-5p ↓ Kitl ↑ miR-184 ↑ Ncor2, Prkcb ↓ miR-721 ↑ Akap11, B4galt, Cnr1, Efnb2, Fam20b, Ino80, Irf1, Lrrk2, Ncoa3, Pfkfb3, Ppargc1a, Rbm9, Shank2, Spen, Sphk2, Tsc1, Wdfy3 ↓ miR-1970 ↓ Arhgap6 ↑ # Significance for expression change was 1.2-fold, p < 0.05. [score:9]
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