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9 publications mentioning hsa-mir-892a

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-892a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 38
Of previously predicted mRNA targets of the miR-888 cluster, we found that Spag8 (sperm associated antigen 8) mRNA expression encoding for a human sperm membrane protein (hSMP-1) was significantly and negatively correlated with the expression of miR-892a along the human epididymis (Tables 2 and 3, Fig. S3). [score:7]
The involvement of hSMP-1 in the testis-specific process of spermatogenesis [55] is coherent with the down-regulation of its expression by miR-892a in the epididymis but this needs to be experimentally confirmed. [score:6]
miR-205 followed the same pattern of expression as miR-890/miR-891a/miR-891b/miR-892a/miR-892b, with higher levels in the distal regions of the epididymis (Fig. 3 C). [score:3]
Overall, these results show that the levels of miR-890/miR-891a/miR-891b/miR-892a/miR-892b and miR-205, previously reported to be primarily expressed in reproductive tissues, are present at high levels in the distal region of the epididymis, suggesting a role of these microRNAs in the later stages of epididymal sperm maturation or storage. [score:3]
Among these miRNAs, miR-890, miR-892a, miR-892b, miR-891a, miR-891b belonging to the same epididymis-enriched cluster located on the X chromosome, are significantly more expressed in the corpus and cauda regions than in the caput. [score:3]
0034996.g004 Figure 4 The expression of miR-890, miR-891a, miR-891b, miR-892a and miR-892b was assessed in total RNA extracts from the human caput, corpus and cauda epididymis from three donors. [score:3]
The expression of miR-890, miR-891a, miR-891b, miR-892a and miR-892b was assessed in total RNA extracts from the human caput, corpus and cauda epididymis from three donors. [score:3]
In contrast to miR-892a, the expression of Spag8 was significantly decreased in the corpus and cauda relative to the caput epididymidis (Fig. S3). [score:3]
Of these, 5 members of the miR-888 cluster (miR-890, miR-891a/b, miR-892a/b) were significantly more abundant in the corpus/cauda regions of the epididymis, suggesting a role in the regulation of the later stages of epididymal sperm maturation. [score:2]
Both end-point and relative quantification by real time PCR of miR-890/miR-891a/miR-891b/miR-892a/miR-892b confirmed the microarray data (Fig. 4). [score:1]
For instance, Major CDK9 elongation factor -associated protein (Aff4) and Zinc finger E-box -binding homeobox 1 (Zeb1) were positively correlated with miR-891a and miR-892a respectively, while Estrogen-related receptor gamma (Esrrg), Sperm associated antigen 8 (Spag8), Glycine receptor subunit beta (Glrb), Cysteine-rich secretory protein LCCL domain-containing 1 (Crispld1), Transmembrane protein 68 (Tmem68), and Zinc finger protein 395 (Znf395), were negatively correlated with different members of the miR-888 cluster (Tables 2 and 3, Fig. S3 and S4). [score:1]
Very low signals for miR-890/miR-891a/miR-891b/miR-892a/miR-892b were observed by PCR in the caput, whereas strong signals were detected in the corpus and cauda. [score:1]
Five of six miRNAs located in the miR-888 cluster displayed changes ranging from 1.7-fold for miR-891b to 126-fold for miR-892b, between the caput and the corpus region (miR-890/miR-891a/miR-891b/miR-892a/miR-892b). [score:1]
Our results indicate that members of the miR-888 cluster (i. e. miR-890/miR-891a/miR-891b/miR-892a/miR-892b) and miR-205 exhibit significantly lower levels in the caput relative to the corpus, while the levels of the miR-371 cluster did not differ (Fig. 3 A, B and C). [score:1]
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2
[+] score: 13
For instance searching for loops containing the oncogene HRAS (ENSG00000174775), identifies a coherent feedforward loop potentially suppressing HRAS where miR-892a directly suppresses HRAS and, indirectly, suppresses HRAS by suppressing the oncogene PLAG1, a putative activator of HRAS. [score:11]
miRNA deregulation of PLAG1 is already known to occur in leukemia cells [55], thus there is a possibility HRAS may in some circumstances be a downstream effector of miR-892a and PLAG1. [score:2]
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3
[+] score: 8
From the 13 cfs-miRNAs previously identified to be predominately derived from the epididymis [21], five miRNAs (miR-891b, miR-892b, miR-892a, miR-888 and miR-890), were significantly down-regulated (P=0.000, 0.001, 0.025, 0.001, 0.000, respectively) in men with UA, as compared with the normozoospermic control donors (Figure 1). [score:3]
Levels of miR-891b/miR-892b/miR-892a/ miR-888/miR-890 combination (miRNA panel) was also significantly correlated with sperm progressive motility (r=0.218, p=0.000) (F). [score:1]
The results suggested that miR-891b, miR-892b, miR-892a, miR-888 and miR-890 were correlated with sperm progressive motility separately (r=0.287, 0.395, 0.279, 0.346 and 0.301, p=0.001, 0.000, 0.001, 0.000 and 0.001 respectively) (A-E). [score:1]
We found that miRNA level of miR-891b, miR-892b, miR-892a, miR-888 and miR-890 were correlated with sperm progressive motility separately (r=0.287, 0.395, 0.279, 0.346 and 0.301, p=0.001, 0.000, 0.001, 0.000 and 0.001 respectively) (Figure 3A-3E). [score:1]
Levels of miR-891b/miR-892b/miR-892a/miR-888/miR-890 combination (miRNA panel) was also significantly correlated with sperm progressive motility (r=0.218, p=0.000) (Figure 3F). [score:1]
After identifying 5 members of miR-888 cluster (miR-891b, miR-892b, miR-892a, miR-888 and miR-890) dysregulated in UA patients, we analyzed characteristics of these 5 miRNAs dysregulation in validation set. [score:1]
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4
[+] score: 7
We selected 12 miRNAs: miR-9, miR-19b, miR-27b, miR-92a, miR-140-5p, miR-190, miR-200a, let-7a, miR-129-5p, miR-582-5p, miR-892a, and miR-1237 (Figure  1) and tested whether they downregulate FOXP2 expression in cell culture systems. [score:6]
We found that miR-9, miR-19b, miR-140-5p, miR-200a, let-7a, miR-129-5p, miR-582-5p, and miR-892a reduced FOXP2 protein levels significantly (Figure  2A). [score:1]
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5
[+] score: 5
Interestingly, in a study performed in human breast cancer cell line MCF-7 exposed to BaP leads to diminish miR-892a expression and function. [score:3]
The putative effect of miR-892a was previously predicted by an in silico study [111]. [score:1]
Based on web databases analyses, six putative micro RNAs (miRNAs), hsa-miR-125b-2, hsa-miR-488, hsa-miR-657, hsa-miR-892a, hsa-miR-511, and hsa-miR-626, with one or more binding sites to the 3′UTR region of hCYP1A1 were identified [21]. [score:1]
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6
[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-32, hsa-mir-33a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-106a, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-30a, mmu-mir-30b, mmu-mir-126a, mmu-mir-9-2, mmu-mir-135a-1, mmu-mir-137, mmu-mir-140, mmu-mir-150, mmu-mir-155, mmu-mir-24-1, mmu-mir-193a, mmu-mir-194-1, mmu-mir-204, mmu-mir-205, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-143, mmu-mir-30e, hsa-mir-34a, hsa-mir-204, hsa-mir-205, hsa-mir-222, mmu-let-7d, mmu-mir-106a, mmu-mir-106b, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-137, hsa-mir-140, hsa-mir-143, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-126, hsa-mir-150, hsa-mir-193a, hsa-mir-194-1, mmu-mir-19b-2, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-23a, mmu-mir-24-2, mmu-mir-29a, mmu-mir-31, mmu-mir-92a-2, mmu-mir-34a, rno-mir-322-1, mmu-mir-322, rno-let-7d, rno-mir-329, mmu-mir-329, rno-mir-140, rno-mir-350-1, mmu-mir-350, hsa-mir-200c, hsa-mir-155, mmu-mir-17, mmu-mir-25, mmu-mir-32, mmu-mir-200c, mmu-mir-33, mmu-mir-222, mmu-mir-135a-2, mmu-mir-19b-1, mmu-mir-92a-1, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-7b, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-106b, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-375, mmu-mir-375, mmu-mir-133b, hsa-mir-133b, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-7b, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-17-1, rno-mir-19b-1, rno-mir-19b-2, rno-mir-23a, rno-mir-24-1, rno-mir-24-2, rno-mir-25, rno-mir-27b, rno-mir-29a, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-31a, rno-mir-32, rno-mir-33, rno-mir-34a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-106b, rno-mir-126a, rno-mir-135a, rno-mir-137, rno-mir-143, rno-mir-150, rno-mir-193a, rno-mir-194-1, rno-mir-194-2, rno-mir-200c, rno-mir-200a, rno-mir-204, rno-mir-205, rno-mir-222, hsa-mir-196b, mmu-mir-196b, rno-mir-196b-1, mmu-mir-410, hsa-mir-329-1, hsa-mir-329-2, mmu-mir-470, hsa-mir-410, hsa-mir-486-1, hsa-mir-499a, rno-mir-133b, mmu-mir-486a, hsa-mir-33b, rno-mir-499, mmu-mir-499, mmu-mir-467d, hsa-mir-891a, hsa-mir-890, hsa-mir-891b, hsa-mir-888, hsa-mir-892b, rno-mir-17-2, rno-mir-375, rno-mir-410, mmu-mir-486b, rno-mir-31b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-126b, rno-mir-9b-2, hsa-mir-499b, mmu-let-7j, mmu-mir-30f, mmu-let-7k, hsa-mir-486-2, mmu-mir-126b, rno-mir-155, rno-let-7g, rno-mir-15a, rno-mir-196b-2, rno-mir-322-2, rno-mir-350-2, rno-mir-486, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
Conversely, the 5 members of the miR-888 cluster (miR-890, miR-891a, miR-891b, miR-892a, and miR-892b) that have been reported as being highly expressed in the corpus and caudal regions of the human epididymis [12] were not detected in our analysis of the mouse epididymis or in previous work on the rat epididymis [7]. [score:3]
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7
[+] score: 3
Other miRNAs from this paper: hsa-let-7f-1, hsa-let-7f-2, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-32, mmu-mir-1a-1, mmu-mir-133a-1, mmu-mir-134, mmu-mir-135a-1, mmu-mir-144, mmu-mir-181a-2, mmu-mir-24-1, mmu-mir-200b, mmu-mir-206, hsa-mir-208a, mmu-mir-122, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-181a-1, hsa-mir-214, hsa-mir-200b, mmu-mir-299a, mmu-mir-302a, hsa-mir-1-2, hsa-mir-122, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-144, hsa-mir-134, hsa-mir-206, mmu-mir-200a, mmu-mir-208a, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-24-2, mmu-mir-328, hsa-mir-200c, hsa-mir-1-1, mmu-mir-1a-2, hsa-mir-181b-2, mmu-mir-25, mmu-mir-32, mmu-mir-200c, mmu-mir-181a-1, mmu-mir-214, mmu-mir-135a-2, mmu-mir-181b-1, mmu-mir-181c, hsa-mir-200a, hsa-mir-302a, hsa-mir-299, hsa-mir-361, mmu-mir-361, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-367, hsa-mir-377, mmu-mir-377, hsa-mir-328, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, mmu-mir-181b-2, hsa-mir-20b, hsa-mir-429, mmu-mir-429, hsa-mir-483, hsa-mir-486-1, hsa-mir-181d, mmu-mir-483, mmu-mir-486a, mmu-mir-367, mmu-mir-20b, hsa-mir-568, hsa-mir-656, mmu-mir-302b, mmu-mir-302c, mmu-mir-302d, mmu-mir-744, mmu-mir-181d, mmu-mir-568, hsa-mir-892b, mmu-mir-208b, hsa-mir-744, hsa-mir-208b, mmu-mir-1b, hsa-mir-302e, hsa-mir-302f, hsa-mir-1307, eca-mir-208a, eca-mir-208b, eca-mir-200a, eca-mir-200b, eca-mir-302a, eca-mir-302b, eca-mir-302c, eca-mir-302d, eca-mir-367, eca-mir-429, eca-mir-328, eca-mir-214, eca-mir-200c, eca-mir-24-1, eca-mir-1-1, eca-mir-122, eca-mir-133a, eca-mir-144, eca-mir-25, eca-mir-135a, eca-mir-568, eca-mir-133b, eca-mir-206-2, eca-mir-1-2, eca-let-7f, eca-mir-24-2, eca-mir-134, eca-mir-299, eca-mir-377, eca-mir-656, eca-mir-181a, eca-mir-181b, eca-mir-32, eca-mir-486, eca-mir-181a-2, eca-mir-20b, eca-mir-361, mmu-mir-486b, mmu-mir-299b, hsa-mir-892c, hsa-mir-486-2, eca-mir-9021, eca-mir-1307, eca-mir-744, eca-mir-483, eca-mir-1379, eca-mir-7177b, eca-mir-8908j
More precisely, we identified five miRNAs expressed at the level > 10 cpm solely in PSSM GM muscle: eca-miR-144, eca-miR-20b, ecaub_novel-miR-472, ecaub_novel-miR-568, and ecaub_novel-miR-892. [score:3]
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8
[+] score: 1
Among them, miR-890, miR-888, miR-892a, and miR-892b are tightly clustered within a genomic region of 3 kb and are highly similar with each other, suggesting evolution of these members as a result of tandem duplication events. [score:1]
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9
[+] score: 1
Other miRNAs from this paper: hsa-mir-17, hsa-mir-28, hsa-mir-223, hsa-mir-127, hsa-mir-188, hsa-mir-194-1, hsa-mir-155, hsa-mir-194-2, hsa-mir-30e, hsa-mir-362, hsa-mir-363, hsa-mir-367, hsa-mir-379, hsa-mir-196b, hsa-mir-450a-1, hsa-mir-431, ssc-mir-28, hsa-mir-493, hsa-mir-512-1, hsa-mir-512-2, hsa-mir-500a, hsa-mir-501, hsa-mir-502, hsa-mir-450a-2, hsa-mir-513a-1, hsa-mir-513a-2, hsa-mir-506, hsa-mir-508, hsa-mir-509-1, hsa-mir-532, hsa-mir-615, hsa-mir-660, bta-mir-127, bta-mir-30e, bta-mir-17, bta-mir-450a-2, bta-mir-532, bta-mir-363, bta-mir-660, hsa-mir-891a, hsa-mir-509-2, hsa-mir-450b, hsa-mir-892b, hsa-mir-708, hsa-mir-509-3, hsa-mir-1285-1, hsa-mir-1285-2, hsa-mir-1248, ssc-mir-17, bta-mir-155, bta-mir-188, bta-mir-194-2, bta-mir-196b, bta-mir-223, bta-mir-28, bta-mir-362, bta-mir-367, bta-mir-379, bta-mir-431, bta-mir-493, bta-mir-500, bta-mir-502a-1, bta-mir-502a-2, bta-mir-502b, bta-mir-615, bta-mir-708, bta-mir-1248-1, bta-mir-1248-2, ssc-mir-450a, bta-mir-2320, bta-mir-1388, bta-mir-194-1, bta-mir-450a-1, eca-mir-30e, eca-mir-367, eca-mir-684, eca-mir-196b, eca-mir-615, eca-mir-708, eca-mir-194-1, eca-mir-493a, eca-mir-17, eca-mir-1248, eca-mir-28, eca-mir-127, eca-mir-379, eca-mir-431, eca-mir-493b, eca-mir-155, eca-mir-194-2, eca-mir-188, eca-mir-223, eca-mir-362, eca-mir-363, eca-mir-450a, eca-mir-450b, eca-mir-450c, eca-mir-500-1, eca-mir-500-2, eca-mir-501, eca-mir-502, eca-mir-508, eca-mir-509a, eca-mir-532, eca-mir-660, ssc-mir-30e, ssc-mir-196b-1, ssc-mir-450b, ssc-mir-127, ssc-mir-532, ssc-mir-708, ssc-mir-1285, ssc-mir-500, hsa-mir-514b, ssc-mir-363-1, ssc-mir-450c, hsa-mir-500b, ssc-mir-194b, ssc-mir-155, ssc-mir-362, bta-mir-3601, ssc-mir-615, ssc-mir-2320, bta-mir-450b, ssc-mir-194a, ssc-mir-196b-2, ssc-mir-363-2, ssc-mir-493, hsa-mir-892c, eca-mir-1388, eca-mir-514b, eca-mir-506a, eca-mir-509b, bta-mir-194b, ssc-mir-1388, ssc-mir-223, ssc-mir-660, bta-mir-194b-2, bta-mir-1949
However, the six miRNAs in the mir-892 cluster on chrX in human, are conserved in a cluster on chrX in pig (See Additional file 1: Figure S20). [score:1]
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