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19 publications mentioning mmu-mir-147

Open access articles that are associated with the species Mus musculus and mention the gene name mir-147. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 63
Groups of mice (n = 25) were transfected with 30 ug of miRNA inhibitors (miR-147-3p, miR-151-5p, miR-155-3p, miR-223-3p) or an miRNA negative inhibitor control (miRNA negative inhibitor control #1; Bioneer Co. [score:7]
It is important to note that only 9 miRNAs (miR-100-5p, miR-130a-5p, miR-146b-3p, miR-147-3p, miR-151-5p, miR-155-3p, miR-223-3p, miR-301a-3p, and miR-495-3p) were significantly upregulated or downregulated in both lungs infected with either wild type w81 or the mouse-adapted ma81 strain at all time points (Tables  1 and 2). [score:7]
Groups of 8 (done twice, total 16) or 9 (lung viral titration) C57BL/6 mice were inoculated intranasally with ma81 H5N2 avian influenza virus (5 MLD50) 24 hours after individual transfection of 30 μg miRNA inhibitors (miR-147-3p, miR-151-5p, miR-155-3p, miR-223-3p) or an miRNA negative inhibitor control (miRNA negative inhibitor control #1; Bioneer Co. [score:7]
In addition, expression of miR-147-3p was upregulated at all times in lungs infected with either w81 or ma81. [score:6]
Even with their known immunological functions (Table  5), downregulation of miR-147-3p or miR-155-3p by each miRNA inhibitor could not alter the viral replication and mortality in infected mice. [score:6]
Twenty-seven and 20 differentially expressed miRNAs identified to be commonly presented at 1 and 3 dpi were presented in Tables  3 and 4. Of these, only miR-100-5p, miR-130a-5p, miR-146b-3p, miR-147-3p, miR-151-5p, miR-155-3p, miR-223-3p, miR-301a-3p, and miR-495-3p were commonly upregulated at both 1 and 3 dpi. [score:6]
Among the 238 differentially expressed miRNAs, we selected 4 miRNAs with greater than 2-fold differences in expression levels in the lungs of mice that were infected with either w81 or ma81 compared to mock control infections for in-depth analyses (miRNAs are miR-151-5p, miR-223-3p, miR-147-3p, and miR-155-3p) (Table  5). [score:4]
It is noteworthy that only 9 miRNAs (miR-100-5p, miR-130a-5p, miR-146b-3p, miR-147-3p, miR-151-5p, miR-155-3p, miR-223-3p, miR-301a-3p, and miR-495-3p) were significantly upregulated in both lungs infected with either wild type w81 or the mouse-adapted ma81 strain at both time points. [score:4]
Inhibition of miR-147-3p, miR-151-5p, miR-155-3p, and miR-223-3p confers viral pathogenesis in mice. [score:3]
Notably, expression levels of miR-151-5p, miR-223-3p, miR-147-3p, and miR-155-3p were higher in the lungs of mice infected with the ma81 virus than those infected with the w81 virus. [score:3]
Notably, expression levels of miR-147-3p, miR-151-5p, miR-155-3p, and miR-223-3p were higher in the lungs of mice infected with the ma81 virus than those infected with the w81 virus. [score:3]
In contrast, all the mice treated with anti-miR-147-3p and anti-miR-155-3p lost body weight as quickly as the control mice and died from influenza infection within 8 dpi. [score:1]
Specifically, these miRNAs have been implicated in immune responses (miR-223-3p and miR-147-3p), viral infection (miR-155-3p), and cell migration (miR-151-5p) [50- 56]. [score:1]
These miRNAs include miR-151-5p, miR-223-3p, miR-147-3p, and miR-155-3p (Table  5). [score:1]
A: miR-147-3p, B: miR-151-5p, C: miR-155-3p, D: miR-233-3p. [score:1]
Therefore, elucidation of the potential roles of miR-147-3p in host cells during influenza infection will require further study. [score:1]
MiR-147-3p has been shown to be associated with Toll-like receptor stimulation and regulation of murine macrophage inflammatory responses [62, 63]. [score:1]
Ten enriched immune- and cell death-related GO terms of molecular function for the miR-147-3p were detected (P < 0.05). [score:1]
[1 to 20 of 18 sentences]
2
[+] score: 39
Distinct groups of miRNAs regulated by IAV infection could be defined: (1) miRNAs (n = 39) whose expression correlated with hemagglutinin (HA) mRNA expression and represented the general response to IAV infection independent of host genetic background; (2) miRNAs (n = 20) whose expression correlated with HA mRNA expression but differed between the two strains; and (3) remarkably, miR-147-3p, miR-208b-3p, miR-3096a-5p, miR-3069b-3p, and the miR-467 family, whose abundance even in uninfected lungs differentiated nearly perfectly (area under the ROC curve > 0.99) between the two strains throughout the time course, suggesting a particularly strong association with the differential susceptibility of the two mouse strains. [score:10]
Before infection, host susceptibility was particularly associated with consistently higher expression of miR-208b-3p, miR-3096b-3p, and the miR-467 family and lower expression of miR-3096a-5p and the potentially anti-inflammatory miR-147-3p. [score:5]
miR-147-3p constituted an exception in that it was markedly overexpressed in C57BL/6J mice within the first 24 hpi and had a similar expression level as DBA/2J at 48 hpi. [score:5]
Most of these highly strain-specifically expressed miRNAs (except miR-147-3p and miR-3069a-5p) were expressed more highly in the DBA/2J strain. [score:5]
Taken together, the above results suggest (1) that the selective expression of several IAV-regulated miRNAs, including miR-147-3p, miR-208b-3p, miR-3096a-5p, miR-3069b-3p, and the miR-467 family, in uninfected and incipiently infected DBA/2J lungs was specifically associated with higher susceptibility of this mouse strain to IAV infection at later time points and (2) that it accurately predicted this higher susceptibility. [score:4]
In total, there were eight differentially expressed miRNAs with AUCs > 0.99 (miR-147-3p, miR-208b-3p, miR-467a-5p, miR-467c-5p, miR-467d-5p, miR-467e-5p, miR-3096a-5p, and miR-3096b-3p) whose abundance changed significantly during infection. [score:3]
Indeed, changes in expression of several of these 20 miRNAs (miR-147-3p, miR-155-3p, miR-223-3p, as well as the miR-34 and miR-449 families) correlate with IAV virulence (14, 15, 17, 64). [score:3]
miR-147-3p has been reported to negatively regulate TLR signaling in murine macrophages (69). [score:2]
Also, miR-147-3p can dampen TLR-signaling in murine macrophages (69). [score:1]
Using the ViTa Database, the human homologs of miR-135b-5p, miR-147-3p, miR-31-5p, miR-379-5p, miR-7a-5p, as well as the miR-449 (-5p) and miR-34 (-5p) families, were predicted to bind to viral RNA segments of influenza A/Puerto Rico/8/34/Mount Sinai (H1N1). [score:1]
[1 to 20 of 10 sentences]
3
[+] score: 13
By using quantitative PCR, we then showed that activation of p53 in NB4 cells increased the expression of miR-125b to nearly the same extend as did the p53 target miR-34a, but had no effect on the levels of miR-147, used here as a p53-independent miR (Figure 3B). [score:5]
Both miR-34a and miR-125b were upregulated, whereas the levels of miR-147 remained unmodified (Figure 3C). [score:4]
A known target of p53, miR34a, and the p53-unrelated miR-147, were also included as controls. [score:3]
This reduction was not observed when cells were transfected with miR-147 or when the reporter vector contained a mismatch sequence (Figure 3E). [score:1]
[1 to 20 of 4 sentences]
4
[+] score: 10
Other miRNAs from this paper: hsa-mir-147a, hsa-mir-147b
Zhang and colleagues reported that miR-147 inhibited breast cancer migration and proliferation by targeting the Akt/mTOR pathway [12]. [score:5]
Although the above data indicated that miR-147 participates in tumorigenesis, however, the role of miR-147b was largely unexplored, here we report for the first time that miR-147b was dysregulated during HCC pathogenesis and positively regulated HCC tumor cell proliferation. [score:3]
As another member of the same cluster to miR-147b, miR-147 was reported to involved in several tumor progresses, Lee et al find that miR-147b induced MET and cell cycle arrest in both colon and lung cancer cells [10]. [score:1]
Low serum level of miR-147 is correlated with tumor metastasis, LNM, and tumor size [11]. [score:1]
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5
[+] score: 9
However the paucity of SNPs around the miRNA and within the AA467197/ NMES1 gene (7 SNPs within 2 kb), where Mir147 resided, suggested that there may be no expression difference between 129 and B6. [score:3]
Mir147 is expressed in the spleen but not in normal colon and is involved with TLR4-stimulated macrophage production of TNFα and IL6 [49]. [score:2]
The regulation of miR-147B is distinct from Mir147 suggesting a different function in humans [50]. [score:2]
miR-147B is the human ortholog of Mir147. [score:1]
There were 2 validated miRNAs in the MGI databases that mapped within Gdac1; Mir674 [1a] (117 mbp) and Mir147 [111a] (122.4 mbp). [score:1]
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6
[+] score: 8
Our effort to concur in a wider description of miRNA involvement in host-pathogen interactions is in agreement with previous data showing up-regulation of cellular miRNAs such as miR-155 and miR-147, which are involved in the control of inflammatory responses [25], [26]. [score:4]
Among these upregulated miRNAs are miR-155 (4.3-fold), a well described actor in inflammatory reactions [25], and the TLR -dependent miR-147 (8-fold) [26], which has also been recently shown to be involved in the response to dengue virus [27]. [score:4]
[1 to 20 of 2 sentences]
7
[+] score: 7
Other miRNAs from this paper: hsa-mir-147a, hsa-mir-147b
Importantly, the part of our candidate hairpin that aligned with miR-147 was within a 26 nt region predicted to contain a mature miRNA by our method. [score:1]
Mouse miR-147 had not been deposited in miRBase because it did not have a sufficiently good match to the mouse genome assembly. [score:1]
Further analysis of the candidate that only had BLAST hits in chicken revealed that it was highly similar to mouse miRNA miR-147 cloned by Lagos-Quintana et al. [9]: 19/21 bases from the clone match. [score:1]
Our novel human and mouse candidates are also similar to hsa-mir-147 (81% identity over 72 bases, although BLAST only found a 26-base HSP), but more similar to gga-mir-147-1/2 (87–89% identity over 70 bases). [score:1]
The chicken miRNAs gga-mir-147-1 and gga-mir-147-2, which have not been experimentally validated, were annotated based on similarity (76% identity over 72 bases) to hsa-mir-147. [score:1]
Experimental validation is required to show whether the mir-147 entries in miRBase, as well as our novel human and mouse candidates, represent true pre-miRNAs. [score:1]
This region was subsequently deposited in miRBase as hsa-mir-147 based on the evidence from the mouse clone. [score:1]
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8
[+] score: 5
Other miRNAs from this paper: hsa-mir-147a, hsa-mir-147b
IL-10 inhibits LPS -induced expression of miR-147 in murine macrophages. [score:5]
[1 to 20 of 1 sentences]
9
[+] score: 4
Liu G. Friggeri A. Yang Y. Park Y. J. Tsuruta Y. Abraham E. miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses Proc. [score:2]
miR-147 is induced upon TLR stimulation and negatively regulates murine macrophage inflammatory responses [20]. [score:2]
[1 to 20 of 2 sentences]
10
[+] score: 4
Let-7a and miR-147 are directly induced upon LPS stimulation due to NF κB binding sites in their promoter regions, which induces the expression of proinflammatory cytokines including TNF- α and IL-6 [29, 75]. [score:4]
[1 to 20 of 1 sentences]
11
[+] score: 4
Inflammatory stimuli, such as Toll-like receptor, interleukin (IL)-1β, or IL-13, can stimulate the upregulation of miR-147, miR-146a, or miR-21, respectively. [score:4]
[1 to 20 of 1 sentences]
12
[+] score: 3
A further 6 of these were not appreciably expressed in the other tissues (<10 tags in all tissues; miR-147*, miR-463*, miR-1943*, miR-1933-3p, miR-883-3p and miR-2145-1*, the latter removed from miRbase 17) and thus their unusual strand biases have not previously been highlighted. [score:3]
[1 to 20 of 1 sentences]
13
[+] score: 2
mmu-miR-147 was found to be activated during the inflammatory response in mice where it functions as a negative regulator of toll-like receptor (TLR) -associated signaling events [30]. [score:2]
[1 to 20 of 1 sentences]
14
[+] score: 2
The microglial cell-line enriched cluster contained 20 miRNAs including miR-146a and a number of other miRNAs reportedly involved in inflammation, such as miR-155, miR-221 [23] and miR-147, a microRNA that is induced upon Toll-like receptor (TLR) stimulation and regulates murine macrophage inflammatory responses [24]. [score:2]
[1 to 20 of 1 sentences]
15
[+] score: 1
Interestingly, Listeria -induced miRNAs included miR-155, miR-146a and miR-147, which are known modulators of the inflammatory response upon TLR ligation in macrophages [15]– [16], [26]. [score:1]
[1 to 20 of 1 sentences]
16
[+] score: 1
Only miRNA-147 had a nominal P-value < 0.001 and a FDR q-value < 0.25 (0.17). [score:1]
[1 to 20 of 1 sentences]
17
[+] score: 1
Other miRNAs from this paper: mmu-mir-21a, mmu-mir-671, mmu-mir-21b, mmu-mir-21c
We were able to find small RNA reads to three of these exonic miRNAs (mmu-miR-21, mmu-miR-671, mmu-miR-147). [score:1]
[1 to 20 of 1 sentences]
18
[+] score: 1
In particular, miR-155, miR-21, miR-146a, miR-132, miR-9, and miR-147 have all been significantly implicated in the immune response initiated by IL-1R or TLRs (Bazzoni et al., 2009; Nahid et al., 2011; Quinn and O’Neill, 2011). [score:1]
[1 to 20 of 1 sentences]
19
[+] score: 1
Other miRNAs from this paper: mmu-mir-142a, mmu-mir-142b
These genes include members of the SPEER -family (4930572o03rik, Speer7-ps1, Speer4b, Speer4c, Speer4e, Gm5862, Gm9758), chloride channel calcium activated channels (Clca1, Clca3, Clca4), microRNAs (Mir142, Mir147, Mir5117), a transcription factor (Akna), and X-linked lymphocyte-regulated genes (Xlr4a, Xlr4b). [score:1]
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