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32 publications mentioning hsa-mir-628

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-628. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 47
c Validation of miRNA profiling was assessed by RT-qPCR, which confirmed differential expression of these miRNAs in the two groups, being hsa-miR-29a and hsa-miR-29b down-regulated and hsa-miR-513a-5p, and hsa-miR-628-3p up-regulated in MYC translocation -negative BL cases Table 2 miRNA profiling (p-value and fold change) TargetID p value Fold change (Absolute value) Regulation in MYC-neg hsa-miR-513a-5p 0,031124841 1,02109958 Down hsa-miR-628-3p 0,004815838 1,01011474 Down hsa-miR-29a 0,0142882 1,086645638 Up hsa-miR-29b 0,001516702 1,5403288 UpBy contrast, when we applied the previously described miRNA signature able to discriminate BL from diffuse large B-cell lymphomas (DLBCL) constituted by 30 miRNAs containing MYC-regulated and nuclear factor-kB pathways -associated miRNAs [36], we failed to discriminate BL cases according to the presence of MYC translocation, this ruling out bona fide the possible presence of DLBCLs morphologically mimicking classical BL in the present series (i. e. BL/DLBCL) [1]. [score:13]
c Validation of miRNA profiling was assessed by RT-qPCR, which confirmed differential expression of these miRNAs in the two groups, being hsa-miR-29a and hsa-miR-29b down-regulated and hsa-miR-513a-5p, and hsa-miR-628-3p up-regulated in MYC translocation -negative BL cases Table 2 miRNA profiling (p-value and fold change) TargetID p value Fold change (Absolute value) Regulation in MYC-neg hsa-miR-513a-5p 0,031124841 1,02109958 Down hsa-miR-628-3p 0,004815838 1,01011474 Down hsa-miR-29a 0,0142882 1,086645638 Up hsa-miR-29b 0,001516702 1,5403288 Up By contrast, when we applied the previously described miRNA signature able to discriminate BL from diffuse large B-cell lymphomas (DLBCL) constituted by 30 miRNAs containing MYC-regulated and nuclear factor-kB pathways -associated miRNAs [36], we failed to discriminate BL cases according to the presence of MYC translocation, this ruling out bona fide the possible presence of DLBCLs morphologically mimicking classical BL in the present series (i. e. BL/DLBCL) [1]. [score:13]
Interestingly, when we compared the miRNA profiling of MYC translocation -positive versus MYC translocation -negative BL cases, we identified four miRNAs differentially expressed, of which hsa-miR-513a-5p and hsa-miR-628-3p were up-regulated and two miR-29 family members (hsa-miR-29a and hsa-miR-29b) were down-regulated in BL cases lacking the MYC translocation. [score:8]
Interestingly, two of the differentially expressed miRNAs (miR-513a-5p and miR-628-3p) have been recently reported dysregulated in human neuroblastomas, in which aberrant expression of MYCN is quite common [53, 54]. [score:6]
Of note, miR-628-3p expression seems even to correlate with tumors prognosis in such cases [55]. [score:3]
Validation of the results was performed on all the dysregulated miRNAs so identified (hsa-miR-29a, hsa-miR-29b, hsa-miR-513a-5p, and hsa-miR-628-3p). [score:2]
Collectively, fold changes of hsa-miR-29a, hsa-miR-29b, hsa-miR-513a-5p, and hsa-miR-628-3p obtained by microarray results were confirmed by RT-qPCR (Fig.   4c). [score:1]
Hsa-miR-628-3p and hsa-miR-513a-5p are less referred in the literature, whereas, more is known about the miR-29 family [41]. [score:1]
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2
[+] score: 30
The results, normalized for the expression of the housekeeping Z30 small nucleolar RNA, are reported in additional file 2. Specifically, we found appreciable levels of expression for miR-335, miR-342-3p, and miR-628, whereas mir-561 and mir-559 were moderately expressed. [score:7]
The expression levels of the six genes are shown in Fig. 1. Table 1 Selected HG-U133A probes with average fold-change higher than two in HMCLs HG-U133A probe Host gene Host gene intron Intron length (bp) Strand direction miRNA Location Fold-change 222156_x_at CCPG1 intron 5 4,903 - miR-628 15 q21 2.3 217838_s_at EVL intron 3 25,879 + miR-342 14q32 2.7 204235_s_at GULP1 intron 1 90,649 + miR-561 2q32 4.3 204237_at GULP1 4 215913_s_at GULP1 2.5 202016_at MEST intron 2 1,632 + miR-335 7q32 4.8 201839_s_at TACSTD1 intron 5 1,874 + miR-559 2p 9.7 211828_s_at TNIK intron 21 5,584 - miR-569 3q26 3 213107_at TNIK 2.4 213109_at TNIK 2.3 Figure 1 Host gene expression levels. [score:6]
The expression levels of the six genes are shown in Fig. 1. Table 1 Selected HG-U133A probes with average fold-change higher than two in HMCLs HG-U133A probe Host gene Host gene intron Intron length (bp) Strand direction miRNA Location Fold-change 222156_x_at CCPG1 intron 5 4,903 - miR-628 15 q21 2.3 217838_s_at EVL intron 3 25,879 + miR-342 14q32 2.7 204235_s_at GULP1 intron 1 90,649 + miR-561 2q32 4.3 204237_at GULP1 4 215913_s_at GULP1 2.5 202016_at MEST intron 2 1,632 + miR-335 7q32 4.8 201839_s_at TACSTD1 intron 5 1,874 + miR-559 2p 9.7 211828_s_at TNIK intron 21 5,584 - miR-569 3q26 3 213107_at TNIK 2.4 213109_at TNIK 2.3 Figure 1 Host gene expression levels. [score:6]
For three miRNAs, miR-335, miR-342-3p, and miR-561, we demonstrated coordinated expression with their cognate protein-coding genes MEST, EVL, and GULP1; conversely, we did not find correlated expression of miR-628 and miR-559 and their host genes CCPG1 and TACSTD1. [score:5]
A regression analysis of Q-RT-PCR miRNA values and microarray expression levels of matching host genes, conducted with R packages/software, revealed a significant correlation with the corresponding host genes for miR-335, miR-342-3p, and miR-561 (R higher than 0.6 in all cases with a p value < 0.005; see Fig. 2), but not for miR-559 (R = 0.12 at p value = 0.60) or miR-628 (R = 0.32 at p value = 0.15). [score:3]
Notably, miR-335, miR-342-3p, miR-561, and miR-559, but not miR-628, are sense oriented with respect to the corresponding host gene. [score:1]
Specifically, we found the following pairs of host genes and intronic miRNAs: CCPG1 (cell cycle progression 1) and miR-628; GULP1 (engulfment adaptor PTB domain containing 1) and miR-561; MEST (mesoderm specific transcript homolog, mouse) and miR-335; EVL (Enah/Vasp-like) and miR-342-3p; TACSTD1 (tumor -associated calcium signal transducer 1) and miR-559; and TNIK (TRAF2 and NCK interacting kinase) and miR-569 (details in Table 1). [score:1]
As specified in Table 1, miR-335, miR-342-3p, miR-561, and miR-559 are all sense oriented, whereas miR-628 is in an antisense orientation with respect to its host gene. [score:1]
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3
[+] score: 22
On the contrary, the expression of downregulated miRNAs (miR-26a and miR-628-3p) differed in exosomes in comparison to cells. [score:6]
miR-628-3p was also seen to regulate DLG5 expression. [score:4]
miR-576-3p was not detectable in exosomes, while miR-26a and miR-628-3p were upregulated in exosomes. [score:4]
Correspondingly, we also observed an increase in DLG5 expression upon influenza infection and we show that DLG5 could be regulated by miR-628-3p. [score:4]
Similar to miR-26a: PAX2, miR-628-3p was observed to be an activator of DLG5 expression. [score:3]
The anti miRNAs and miRNA mimics used in this study are commercially available (Anti/Mimic miR-26a (MH/MC10249), Anti/Mimic miR-576-3p (MH/MC13069), Anti/Mimic miR-628-3p (MH/MC12299); Ambion, USA). [score:1]
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4
[+] score: 15
Other miRNAs from this paper: hsa-mir-148a, hsa-mir-152, hsa-mir-148b, hsa-mir-548q
They have also identified two additional miRNAs (miR-548q and miR-628-5p) which may regulate HLA-G expression in RCC, demonstrating a direct interaction of these miRNAs with the 3′ untranslated region (3′ UTR) of HLA-G. Stable overexpression of miR-548q and miR-628-5p caused a downregulation of HLA-G mRNA and protein, leading to an enhanced NK cell -mediated cytotoxicity. [score:12]
In addition, they found an inverse correlation between the expression of miR-628-5p and HLA-G protein in primary RCC lesions and cell lines. [score:3]
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5
[+] score: 14
6)) given that it is down-regulated in prostate cancer (Srivastava et al., 2014[150]) and the miR-15/107 family and miR-628-5p that are regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia (Favreau et al., 2012[52]). [score:5]
7) (References in Table 7: let-7b-5p: Selbach et al., 2008[145]; miR-16-5p: Balakrishnan et al., 2014[14]; miR-20a-3p: Balakrishnan et al., 2014[14]; miR-23b-5p: Balakrishnan et al., 2014[14]; miR-29a-5p: Balakrishnan et al., 2014[14]; miR-103a-3p: Balakrishnan et al., 2014[14]; miR-107: Balakrishnan et al., 2014[14]; miR-532-5p: Haecker et al., 2012[63]; miR-628-5p: Balakrishnan et al., 2014[14]; miR-522-3p: Tan et al., 2014[153]) documents ten human experimentally supported miRNA/endoglin mRNA interactions, and the methodology utilized to substantiate the interaction, the tissue and/or cell line used for experimentation, the location of the MRE if known, the type of interaction (direct or indirect), and the literature reference. [score:3]
Additional miRNAs with potential roles in regulating endoglin biology include miR-628-5p (Table 6 (Tab. [score:2]
7)), including the 3′-UTR miR-16-5p or miR-628-5p MRE. [score:1]
7) (miR-16-5p and miR-628-5p) were predicted to interact with human endoglin mRNAs by the Diana-microT-CDS algorithm. [score:1]
Interestingly, the human L-endoglin mRNA would not include the two miR-628-5p MREs harbored in the 3′-UTR because this mRNA isoform does not harbor intron 14. [score:1]
Additionally, this mRNA isoform was predicted to have three miR-628-5p MREs, two sites were identified (5′ CAGCAU 3′, 6mer “seed” region) in the 3′-UTR, 184 and 223 nts downstream from the stop codon (within the intron 14 sequence) and one additional site was identified in the CDS (5′ UGUCAGCA 3′, 8mer “seed” region), 1645 nts downstream from the start codon. [score:1]
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6
[+] score: 13
Although miR-628-3p showed upregulation in miRNA profiling, all donors used in independent validation did not show significant upregulation, thus resulting in no change. [score:7]
indicate that among the nine upregulated miRNAs tested from Table 2, all except miR-628-3p showed upregulation by independent qRT-PCR assay. [score:6]
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7
[+] score: 11
It has been reported that hsa-miR-628-5p associated with most common brain cancer glioma and acted as protective factors where their expression decreased gradually during glioma progression [42]. [score:3]
Those 3 miRNAs have shown significant sequence identity with MERS-CoV genome where seed region of hsa-miR-628-5p and hsa-miR-332-3p showed perfect identity with 3′ untranslated region of viral mRNA. [score:3]
Functional analysis of this miRNA indicates that they have critical roles in cell cycle and cell proliferation in glioblastoma malignant progression where has-miR-628-5p exhibited dominant regulatory activities [42]. [score:2]
Other hairpins MD5, MD17, MD157, MD244, MD366, MR175, MR201, MR268, and MR282 were aligned with hsa-miR-628-5p, hsa-miR-6804-3p, hsa-miR-4289, hsa-miR-208a-3p, hsa-miR-510-3p, hsa-miR-18a-3p, hsa-miR-329-3p, hsa-miR-548ax, and hsa-miR-342-3p, respectively. [score:1]
Roles of hsa-miR-628-5p, hsa-miR-18a-3p, and hsa-miR-332-3p in Humans. [score:1]
The utility of those 13 miRNAs, that is, hsa-miR-628-5p, hsa-miR-6804-3p, hsa-miR-4289, hsa-miR-208a-3p, hsa-miR-510-3p, hsa-miR-18a-3p, hsa-miR-329-3p, hsa-miR-548ax, hsa-miR-3934-5p, hsa-miR-4474-5p, hsa-miR-7974, hsa-miR-6865-5p, and hsa-miR-342-3p, can be utilized as antiviral therapeutics against MERS-CoV infection. [score:1]
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8
[+] score: 10
severe (p<0.05) cfa-let-7d, cfa-miR-101, cfa-miR-10a, cfa-miR-1296, cfa-miR-1306, cfa-miR-1307, cfa-miR-130a, cfa-miR-136, cfa-miR-17, cfa-miR-181b, cfa-miR-196b, cfa-miR-197, cfa-miR-215, cfa-miR-22, cfa-miR-30d, cfa-miR-33b, cfa-miR-497, cfa-miR-503, cfa-miR-574, cfa-miR-628, cfa-miR-676 Comparing the miRNA differential expression analyses between disease states obtained by RT-qPCR and RNAseq, we observed discordances between the two methods. [score:5]
severe (p<0.05) cfa-let-7d, cfa-miR-101, cfa-miR-10a, cfa-miR-1296, cfa-miR-1306, cfa-miR-1307, cfa-miR-130a, cfa-miR-136, cfa-miR-17, cfa-miR-181b, cfa-miR-196b, cfa-miR-197, cfa-miR-215, cfa-miR-22, cfa-miR-30d, cfa-miR-33b, cfa-miR-497, cfa-miR-503, cfa-miR-574, cfa-miR-628, cfa-miR-676Comparing the miRNA differential expression analyses between disease states obtained by RT-qPCR and RNAseq, we observed discordances between the two methods. [score:5]
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9
[+] score: 8
detected the expression profile of miRNAs from blood samples of influenza A H1N1 virus-infected patients and then exhibited that the expression levels of 193 miRNA molecules were altered in all influenza patients, of which 16 highly dysregulated miRNAs (miR-1260, miR-1285, miR-18a, miR-185*, miR-299-5p, miR-26a, miR-30a, miR-335*, miR-34b, miR-519e, miR-576-3p, miR-628-3p, miR-664, miR-665, miR-765 and miR-767-5p) were able to provide a clear distinction between infected and healthy individuals [39]. [score:6]
In addition, six miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p and miR-362-3p) possessed the ability to discriminate patients with enterovirus infections from healthy controls [22]. [score:1]
Further analysis revealed that combined six miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p and miR-362-3p) could discriminate patients with enterovirus infections from healthy controls. [score:1]
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10
[+] score: 7
Similarly, of 46 suppressed miRNAs, we recognized 14 human-specific non-homologous miRNAs, including miR-1206, miR-548a-5p, miR-548f, miR-576-5p, miR-600, miR-639, miR-640, miR-641, miR-647, miR-662, miR-886-3p, miR-887, miR-628-3p, and miR-888. [score:3]
Evidently, except for two candidates in each up (miR-1308, miR-1908) and down (miR-639, miR-628-3p) regulated clusters, none have been reported as serum-circulating diagnostic/prognostic markers in any tumor systems thus far. [score:2]
Further, studies have recognized the regulation of serum miR-639 and miR-628-3p in bladder cancer, melanoma, and pancreatic cancer [36- 38] and, miR-1908 in nasopharyngeal carcinoma [39]. [score:2]
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11
[+] score: 6
The C→T substitution altered the predicted target site for MIR628 (hsa-miR-628-3p; miRNA binding score = −0.6; cutoff score is < −0.1), suggesting that this "apparent silent" variant may have an effect creating aberrant cis-regulatory element for miRNA (Table 1). [score:4]
The mutation altered the binding site for MIR628. [score:2]
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12
[+] score: 6
The expression of miR-23a, miR-181c, miR-192, miR-194, miR-208, miR-337-5p, miR-338-3p, miR-502-5p, miR-542-3p, miR-628-5p, and miR-672 is upregulated in the oral mucosa of heavy smokers with lung cancer versus patients without cancer and light smokers [66]. [score:6]
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13
[+] score: 6
In addition, miRSNP rs9943 allele G, which is an eQTL associated with downregulation of the target gene COG6 (Figure 6), was predicted to create a binding site for miR-628-5p. [score:6]
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14
[+] score: 6
Six genes deregulated between cell lines are targeted by miR-548c, miR-145, miR-301b, and miR-628-5p: Anxa8, Fbn1, Ptx3, Upp1, and Usp33. [score:4]
Thirteen mRNA were specifically related to homozygous/heterozygous status of KIT mutation: miR-518f, miR-331, miR-628, miR-145, miR-139, miR-335, miR-526b, miR-190, miR-548c, miR-202, miR-339, miR-203, and miR-301b (Anova test p<0.05). [score:2]
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15
[+] score: 6
Expression level of TGFBR1 protein degraded after transfecting of miR-628-5p and differed by genotype of rs334348 (50% and 20% for GG and AA respectively, p = 0.006). [score:3]
AA, OR = 1.69, p = 0.048), whereas rs334348 located in a MRESS of miR-628-5p in 3′UTR of the TGFBR1 gene and G-allele consolidates target -binding. [score:3]
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16
[+] score: 5
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-99a, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-106a, hsa-mir-16-2, hsa-mir-197, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-10a, hsa-mir-34a, hsa-mir-182, hsa-mir-199a-2, hsa-mir-205, hsa-mir-210, hsa-mir-221, hsa-mir-223, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-140, hsa-mir-142, hsa-mir-143, hsa-mir-125b-2, hsa-mir-134, hsa-mir-146a, hsa-mir-150, hsa-mir-206, hsa-mir-155, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-130b, hsa-mir-26a-2, hsa-mir-361, hsa-mir-362, hsa-mir-363, hsa-mir-376c, hsa-mir-371a, hsa-mir-375, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-342, hsa-mir-151a, hsa-mir-324, hsa-mir-335, hsa-mir-345, hsa-mir-423, hsa-mir-483, hsa-mir-486-1, hsa-mir-146b, hsa-mir-202, hsa-mir-432, hsa-mir-494, hsa-mir-495, hsa-mir-193b, hsa-mir-497, hsa-mir-455, hsa-mir-545, hsa-mir-376a-2, hsa-mir-487b, hsa-mir-551a, hsa-mir-571, hsa-mir-574, hsa-mir-576, hsa-mir-606, hsa-mir-629, hsa-mir-411, hsa-mir-671, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-889, hsa-mir-876, hsa-mir-744, hsa-mir-885, hsa-mir-920, hsa-mir-937, hsa-mir-297, hsa-mir-1233-1, hsa-mir-1260a, hsa-mir-664a, hsa-mir-320c-2, hsa-mir-2861, hsa-mir-378b, hsa-mir-1260b, hsa-mir-378c, hsa-mir-1233-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-664b, hsa-mir-378j, hsa-mir-486-2
Further analyses showed that six of these miRNAs (miR-1260, miR-335*, miR-664, miR-26a, miR-576-3p, and miR-628-3p) had similar expression signatures in human A549 and Madin–Darby canine kidney (MDCK) cells infected with H1N1 in vitro. [score:3]
The combination of six miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) generated a biosignature that could distinguish enteroviral patients and HC. [score:1]
Levels of eight circulating serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-206, miR-140-5p, miR-455-5p, and miR-362-3p) were significantly higher in sera of patients with enteroviral infections (215). [score:1]
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17
[+] score: 5
In our profiling data we found important miRs, already reported to be of relevance in disease biology, [17, 18, 35] to be equally abundant in cells and exosomes while other miRs such as miR-202-3p, miR-628-3p, and miR-1290 were specifically enriched in exosomes. [score:3]
However, we found that certain candidate miRs are specifically enriched or counter-selected in exosomes including miR-202-3p, miR-1290, and miR-628-3p but are less abundant in the parental cells (Fig 4A). [score:1]
Importantly, miR-1290, miR-628-3p, and miR-202-3p were enriched within the exosomal RNA (Fig 4A). [score:1]
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18
[+] score: 5
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-25, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-92a-1, hsa-mir-93, hsa-mir-98, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-106a, hsa-mir-16-2, hsa-mir-192, hsa-mir-196a-1, hsa-mir-197, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-182, hsa-mir-183, hsa-mir-196a-2, hsa-mir-205, hsa-mir-181a-1, hsa-mir-221, hsa-mir-222, hsa-mir-200b, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-15b, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-137, hsa-mir-140, hsa-mir-141, hsa-mir-143, hsa-mir-145, hsa-mir-152, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-150, hsa-mir-194-1, hsa-mir-206, hsa-mir-200c, hsa-mir-1-1, hsa-mir-155, hsa-mir-128-2, hsa-mir-194-2, hsa-mir-106b, hsa-mir-29c, hsa-mir-200a, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-301a, hsa-mir-26a-2, hsa-mir-372, hsa-mir-374a, hsa-mir-375, hsa-mir-328, hsa-mir-133b, hsa-mir-20b, hsa-mir-429, hsa-mir-449a, hsa-mir-486-1, hsa-mir-146b, hsa-mir-494, hsa-mir-503, hsa-mir-574, hsa-mir-630, hsa-mir-449b, hsa-mir-449c, hsa-mir-708, hsa-mir-301b, hsa-mir-1827, hsa-mir-486-2
The evidence that miR-628 overexpression is associated with resistance to crizotinib treatment, since crizotinib -induced cell death occurs through activation of the caspase-3, which is a miR-628 target, is also noteworthy [208- 209]. [score:5]
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19
[+] score: 4
MiRNAs miR-324-3p (1.73x), miR-1227 (1.95x), miR-362-3p (1.85x), miR-99b-3p (2.21x), miR-19b-1-5p (4.11x), miR-628-3p (2.77x), miR-26a-1-3p (42.47x), miR-576-3p (2.49x) and miR-27a-5p (108x) were up-regulated, in OROV-infected cells relative to uninfected cells. [score:4]
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20
[+] score: 4
In contrast, 11 miRNAs (miR-9-5p, miR-184, miR-328-3p, miR-363-3p, miR-372-3p, miR-518d-3p, miR-518f-3p miR-523-3p, miR-618, miR-625-5p, and miR-628-5p) were significantly up-regulated in human oocytes (with respect to FF) (Figure 3B and Supplementary Table S1). [score:4]
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21
[+] score: 3
It was observed that in whole blood of H1N1 patients, miR-1260, miR-26a, miR-335, miR-576-3p, miR-628-3p and miR-664 are differentially expressed [57]. [score:3]
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22
[+] score: 3
However, the involvement of miR-187, miR-299-3p, and miR-628-5p in some aspects of biology, including cancer, has been reported [43]– [46]; thus these miRNAs may play roles in regulating the proliferation of iPS/ES cells. [score:2]
Note that miR-628-5p and miR-888 are primate-specific miRNAs, which makes them very useful candidate miRNAs to distinguish not only pluripotent and differentiated cells, but also human and other non-primate species. [score:1]
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23
[+] score: 3
Next, to further explore the functions of these miRNAs in HCC, we selected miRNAs with a fold change >5, namely hsa-miR-636, hsa-miR-671, hsa-miR-489, hsa-miR-26a, hsa-miR-320, hsa-miR-628, hsa-miR-505, hsa-miR-100, hsa-miR-664, hsa-miR-942, hsa-miR-192, hsa-miR-99b, hsa-miR-125b, hsa-miR-10b, hsa-miR-30b, and hsa-miR-145, for GO (Gene Ontology) enrichment analysis [21] of their target genes using the web -based software WebGestalt 2.0 [22]. [score:3]
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24
[+] score: 3
An encouraging report has identified another FOXP2 -targeting microRNA, miR-628, as an efficient tool to damper the aggressiveness of prostate epithelial cancer cell lines [145]. [score:3]
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25
[+] score: 3
Functionally, it was shown that the G allele of rs334348 is targeted with higher efficiency by miR-628-5p than the A allele. [score:3]
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26
[+] score: 2
To validate the differential expression of the selected 20 miRNAs, reverse-transcribed and pre-amplified miRNA fractions from 10 additional BM-infiltrating and 10 primary tumors were amplified in a 96 well plate in triplicate using the specific TaqMan [©] human microRNA assays (hsa-miR-324-3p, catalog #002161; hsa-miR-516-3p, catalog #001149; hsa-miR-628-5p, catalog #002433; hsa-miR-659-3p, catalog #001514; hsa-miR-10b, catalog #002218; hsa-miR-128, catalog #002216; mmu-miR-137, catalog #01129; mmu-miR-140, catalog #001187; hsa-miR-16, catalog #000391, hsa-miR-191, catalog #002299; hsa-miR-301, catalog #000528; hsa-miR-361-3p, catalog #002116; hsa-miR-365, catalog #001020; hsa-miR-548d-3p, catalog #001605; hsa-miR-572, catalog #001614; hsa-miR-576-5p, catalog #002350, hsa-miR-616, catalog #001589; hsa-miR-628-3p, catalog #002434; hsa-miR-873, catalog #002356; hsa-miR-98, catalog #000577; U6 snRNA, catalog #001973, Life Technologies). [score:2]
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[+] score: 2
There were 333 co -regulating pairs formed by 41 miRNAs (Figure  2) in the network, such as hsa-miR-342-5p, hsa-miR-628-3p, hsa-miR-600, and hsa-miR-647. [score:2]
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Despite the fact that this fetus has a similar number of D4Z4 contractions as the FSHD 14.1, they share only four modulated miRNAs (Fig. 4); miR-195, miR-451, miR-1260 and miR-628–5p. [score:1]
miR-628–5p was modulated in FSHD1 at all 3 different fetal ages. [score:1]
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Overall, the 40 combinations consisted of 15 different miRNAs (miR-20b, miR-24, miR-28-3p, miR-132-3p, miR-140-3p, miR-146b-5p, miR-155, miR-191, miR-193a-5p, miR-328, miR-331, miR-381, miR-532, miR-628-5p, and miR-660) that were used for further analysis. [score:1]
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Among them, miR-628-3p and RNU44 (detectable in SN at the basal level but not after treatment with LPS) and miR-1243, miR-193b*, and miR-597 (detectable in SN upon inflammation, Figure  2) changed their detection levels after stimulation. [score:1]
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Six miRNAs (miR-601, miR-628-3p, miR-320e, miR-508-3p, miR-598, and miR-563) have been previously linked to PCa [36, 39, 46– 48, 62, 75, 85] and of those, only miR-320e has shown functional relevance in in vitro studies [46, 47]. [score:1]
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964.00E-04 hsa-miR-376a−1.831.00E-03 hsa-miR-2101.877.00E-04 hsa-miR-628−1.871.00E-03 hsa-miR-17-3p1.879.00E-04 hsa-miR-487b−1.951.00E-03 hsa-miR-302b*1.769.00E-04 hsa-miR-410−1.811.00E-03 hsa-miR-2241.599.00E-04 hsa-miR-140−1.792.00E-03 hsa-miR-1831.789.00E-04 hsa-miR-801−1.342.00E-03 hsa-miR-1381.791.00E-03 hsa-miR-376a*−1.802.00E-03 hsa-miR-1881.632.00E-03 hsa-miR-154−1.763.00E-03 hsa-miR-92b1. [score:1]
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