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13 publications mentioning hsa-mir-596

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-596. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 48
Regarding translocation t(4;14), three miRNAs are differentially expressed, i. e. miR-135a, miR-596, and miR-432*, being significantly down-regulated when a t(4;14) is present with a maximal FC of 1.9 (Supplementary Table S6B). [score:6]
As all GPI [high]-patients showed a high miR-596 -expression, miR-596 is not only linked to survival and high-risk disease in terms of chromosomal aberrations, tumor mass, and the UAMS-score [38], but also to proliferation, one of the strongest independent risk-factors in myeloma [3]. [score:5]
Regarding miRNA-596, all patients classified as GPI [high] showed a significantly higher expression (P =. [score:3]
For miRNA-135b and miR-596, samples with a high expression were significantly more frequent in the particular high-risk group. [score:3]
ISS-stage as surrogate of tumor mass is associated with the expression miR-135a and miR-596. [score:3]
Furthermore, a high miR-596 expression is associated with deletion 13q14 (P =. [score:3]
Although patients with a high expression of miR-596 and miR-200a show a significantly higher GPI which is in turn associated with 1q21-gain [3], no association with this aberration could be found. [score:3]
Expression of three survival relevant miRNAs (miR-135a, miR-135b, and miR-596) was validated in ten cell lines and nine primary myeloma cell samples using qRT-PCR (miQPCR). [score:3]
Those remaining significant after correction for multiple testing, i. e. miR-135a, miR-135b, miR-200a, miR-200b, and miR-596, have recently been published to play a role in solid tumors and hematologic cancers, respectively, e. g. functioning as either oncogenes or tumor-suppressors and prognostic markers [44– 48]. [score:3]
Patients with a high expression of miR-596 show a significantly higher stage (ISS stage III). [score:3]
Of the five survival relevant miRNAs, the GPI as continuous variable is significantly higher in patients with a high expression of miR-596 (P =. [score:3]
Indeed, a high expression of miR-135a, miR-135b, and miR-596 is significantly associated with a t(4;14), miR-596 also with del13q14. [score:3]
Two miRNAs, miR-135a and miR-596, show a significant association with the International Staging System (ISS) (P =. [score:1]
01) and miR-596 (P =. [score:1]
04) and miR-596 (P <. [score:1]
Corrected for multiple testing, five miRNAs remained significantly associated with EFS as continuous variable, i. e. miR-135a, miR-135b, miR-200a, miR-200b, and miR-596, and, but for miR-200b, also with OS (Figure 2). [score:1]
05) and miR-596 (P =. [score:1]
Four miRNAs are significantly positively associated and correlate with the University of Medical Sciences (UAMS) 70-gene risk-score, i. e. miR-135b, miR-432*, miR-583, and miR-596 (Supplementary Table S4, S5). [score:1]
02), and miR-596 (P =. [score:1]
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2
[+] score: 18
Interestingly, 14 of these miRNAs (miR-596, miR-630, miR-422a, miR-490-5p, miR-375, miR-708, miR-345, miR-125b-2, miR-516a-3p, miR-135a, miR-1228, miR-1915, miR-134, and miR-663) have established roles in tumor suppression and drug resistance, while 5 miRNAs (miR-630, miR-375, miR-345, miR-1228, and miR-134) are known to inhibit epithelial–mesenchymal transition and invasion in cancer cells. [score:5]
We were able to find a strong correlation of high expression of miR-596, miR-630, miR-490, miR-375, and miR-708 with overall long-term survival in breast cancer or nasopharyngeal carcinoma patients when compared to low expression of the respective miRNA in the same cohorts of patients. [score:4]
Five highly up-regulated miRNA 12 h after 8 mM ascorbate treatment (miR-596, miR-630, miR-490, miR-375, and miR-708) were analyzed using the free online MIRUMIR database (28), which is incorporated into BioProfiling. [score:4]
A significant correlation of high expression of miR-596, miR-630, miR-490, miR-375, and miR-708 with overall long-term survival in breast cancer (GEO dataset IDs: GSE37405 and GSE37405) or nasopharyngeal carcinoma patients (GEO dataset ID: GSE36682) was observed when compared to low expression of the respective miRNA. [score:4]
The Kaplan–Meier plots as depicted in Figure 7 were automatically generated by MIUMIR upon submission of the respective miRNAs (miR-596, miR-630, miR-490, miR-375, and miR-708). [score:1]
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3
[+] score: 14
Other miRNAs from this paper: hsa-mir-34a, hsa-mir-9-3, hsa-mir-1-1, hsa-mir-663a, hsa-mir-663b
The methylation results for LINE-1 elements, hsa-mir-1-1 and the newly identified targets MAL, hsa-mir-9-3, hsa-mir-596, and hsa-mir-663, are also compiled in Table 1. Table 1 Methylation profile of all loci across the 10 HCC samples analyzed in this study. [score:3]
Our results confirm that of bisulfite treated genomic DNA provides reliable high quality quantitative methylation data and identify MAL, hsa-mir-9-3, hsa-mir-596, and hsa-mir-663 as new targets of aberrant DNA methylation in human hepatocelluar carcinoma. [score:3]
The methylation results for LINE-1 elements, hsa-mir-1-1 and the newly identified targets MAL, hsa-mir-9-3, hsa-mir-596, and hsa-mir-663, are also compiled in Table 1. Table 1 Methylation profile of all loci across the 10 HCC samples analyzed in this study. [score:3]
In order to explore the feasibility of quantitative methylation studies using, a range of genomic loci was selected for in-depth analysis: tumor-suppressor genes reported to be frequently hypermethylated in hepatocellular carcinoma (p16 [INK4a], RASSF1A, SOCS-1, GSTπ1, [12] and references therein), classical non-protein coding CIMP loci also reported to be methylated in HCC (MINT31, [13]), and microRNA genes identified by our own group to be aberrantly methylated in HCC (mir-9-3, mir-34a, mir-596, mir-663). [score:3]
RASSF1A SOCS1 MINT31 LINE1 GSTP1 P16 MAL miR596 miR663 miR9-3 miR1-1 miR34a 1 10% 8% 4% 61% 9% 3% 6% 5% 21% 10% 11% 7% 2 75% 50% 53% 20% 22% 2% 2% 7% 19% 10% 10% 5% 3 81% 79% 67% 20% 21% 52% 2% 4% 24% 8% 18% 3% 4 28% 24% 15% 54% 11% 4% 6% 12% 10% 8% 15% 6% 5 75% 62% 64% 30% 10% 46% 2% 19% 27% 4% 10% 4% 6 88% 61% 76% 54% 74% 1% 30% 50% 79% 25% 20% 2% 7 89% 71% 37% 42% 28% 1% 12% 16% 18% 28% 17% 3% 8 66% 80% 74% 54% 53% 2% 61% 81% 75% 36% 22% 4% 9 84% 8% 64% 53% 67% 1% 38% 50% N/A 58% 24% 3% 10 91% 59% 59% 38% 35% 59% 2% 55% 54% 31% 30% 2% The percentages are the mean methylation values for a given locus in an individual sample (454 sequencing result). [score:1]
To this end the methylation patterns of 12 loci (GSTπ1, p16 [INK4a], RASSF1A, SOCS1, MAL, hsa-mir-1-1, hsa-mir-9-3, hsa-mir-34a, hsa-mir-596, hsa-mir-663, MINT31, and LINE-1) were analyzed in ten primary hepatocellular carcinoma specimens. [score:1]
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4
[+] score: 7
We have shown the top TFs and its related diseases for rhesus inter-species in Table  5. Besides these, mml-miR-338-5p, mml-miR-218, mml-miR-495, mml-miR-203, mml-miR-590-3p, mml-miR-596, mml-miR-548p, and mml-miR-524-5p have connection with “an auto immune disease like SIV” [52], Huntintong’s Disease [53], Age mediated skeletal muscle contamination [54], Enhances Coxsackievirus B3 replication [55], Neuro inflammation Disorder [56], Schizophernia [57], monkey hippocampus effected [58], and Amyotrophic lateral sclerosis [59], respectively. [score:7]
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5
[+] score: 5
We have also identified three miRNAs (let7d, miR-596 and miR-367) as independent predictors for Overall Survival (Table 4). [score:1]
The let-7 family has been extensively associated with embryogenesis, pluripotency and cancers [37] Additionally, miR-596 and miR-367 were also associated to Overall Survival (Table 4). [score:1]
In addition, three miRNAs (let7d, miR-596 and miR-367) were identified as better predictors for Overall Survival. [score:1]
Moreover, let-7d, miR-596 and miR-367 were strongly associated to Overall Survival. [score:1]
Additionally, we have identified three miRNAs (let-7d, miR-596 and miR-367) that strongly correlate to overall survival. [score:1]
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6
[+] score: 2
Other miRNAs from this paper: hsa-mir-193b, mmu-mir-193b, rno-mir-193b
8+ works as a natural decoy for miR-596 and cooperates in the promotion and development of bladder cancer [20]. [score:2]
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7
[+] score: 1
Some miRNAs were not detected in a variety of liver cancer cells such as miR-596, miR-548i-3, miR-597, miR-4286, miR-1322, miR-598 and miR-548v. [score:1]
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8
[+] score: 1
In this work, the SVM method selected hsa-miR-146a-5p, hsa-miR-18b-5p, hsa-miR-21-3p, hsa-miR-22-3p, hsa-miR-29a-3p, hsa-miR-432-5p, hsa-miR-511-5p, and hsa-miR-596 as an EVD classifier. [score:1]
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9
[+] score: 1
In total, eight circulating miRNAs (hsa-miR-146a-5p, hsa-miR-18b-5p, hsa-miR-21-3p, hsa-miR-22-3p, hsa-miR-29a-3p, hsa-miR-432-5p, hsa-miR-511-5p, and hsa-miR-596) were selected as an EBOV classifier. [score:1]
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10
[+] score: 1
8 is able to promote bladder carcinogenesis by interacting with miR-596 [10]. [score:1]
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11
[+] score: 1
1 −2.0 −4.2 miR-410 −2.4 −1.7 −4.2 miR-424 −4.1 −2.6 −10.7 miR-424* −1.2 −4.0 −4.9 miR-431 2.2 −4.3 −1.9 miR-432 −1.9 −2.4 −4.6 miR-503 −8.6 −3.2 −27.3 miR-542-3p −3.2 −2.1 −6.9 miR-542-5p −2.0 −3.1 −6.1 miR-596 2.2 −4.4 −2.0 miR-610 1.9 −5.1 −2. [score:1]
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12
[+] score: 1
A multivariate analysis using paraffin-embedded (FFPE) ependymoma samples from patients has identified let-7d, miR-596, and miR-367 to be associated with increased overall survival [143]. [score:1]
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13
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7e, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-27a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-99a, hsa-mir-100, hsa-mir-101-1, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-106a, hsa-mir-16-2, hsa-mir-192, hsa-mir-196a-1, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-10a, hsa-mir-196a-2, hsa-mir-199a-2, hsa-mir-203a, hsa-mir-215, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-mir-200b, hsa-mir-1-2, hsa-mir-15b, hsa-mir-27b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-141, hsa-mir-143, hsa-mir-145, hsa-mir-152, hsa-mir-191, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-146a, hsa-mir-150, hsa-mir-185, hsa-mir-194-1, hsa-mir-195, hsa-mir-320a, hsa-mir-200c, hsa-mir-1-1, hsa-mir-155, hsa-mir-128-2, hsa-mir-194-2, hsa-mir-200a, hsa-mir-101-2, hsa-mir-130b, hsa-mir-302c, hsa-mir-375, hsa-mir-378a, hsa-mir-148b, hsa-mir-324, hsa-mir-451a, hsa-mir-483, hsa-mir-484, hsa-mir-486-1, hsa-mir-500a, hsa-mir-92b, hsa-mir-595, hsa-mir-421, hsa-mir-378d-2, hsa-mir-744, hsa-mir-885, hsa-mir-939, hsa-mir-940, hsa-mir-1229, hsa-mir-1233-1, hsa-mir-1290, hsa-mir-1246, hsa-mir-103b-1, hsa-mir-103b-2, hsa-mir-718, hsa-mir-378b, hsa-mir-378c, hsa-mir-4306, hsa-mir-4286, hsa-mir-500b, hsa-mir-1233-2, hsa-mir-3935, hsa-mir-642b, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-3976, hsa-mir-4644, hsa-mir-203b, hsa-mir-451b, hsa-mir-378j, hsa-mir-486-2
Shivapurkar et al. identified a panel of six informative miRNAs (miR-15a, miR-103, miR-148a, miR-320a, miR-451, and miR-596) from a miRNA array analysis and validation study [80]. [score:1]
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