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15 publications mentioning hsa-mir-589

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-589. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 20
There is a possibility that vitamin C treatment down-regulates miR-29b-1 and miR-589-5p and promotes Oct3/4, Sox2, Nanog and SOX2 and MAP3K8 expression respectively in hBMSCs and helps in cell proliferation and differentiation. [score:6]
Zhang X. Jiang P. Shuai L. Chen K. Li Z. Zhang Y. Jiang Y. Li X. miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinomaJ. [score:5]
Zhang et al. (2016) demonstrated that miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma [57]. [score:5]
Both miR-29b-1 and miR-589-5p are down-regulated in vitamin C- treated human BMSCs. [score:4]
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2
[+] score: 13
Another recent study shows that overexpressing proline-rich polypeptide (PRP-1) inhibited mTORC1, which resulted in upregulation of certain tumor suppressor miRNAs (miR-125b, miR-192) and downregulation of oncomiRs (miR-550, miR-589, miR-490-3p) (Galoian et al., 2014). [score:13]
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3
[+] score: 11
miR-589-5p resulted a good inhibitor of MAP3K8 and suppressor of CD90+ cancer stem cells in hepatocellular carcinoma [31]. [score:5]
For instance, the high expression of the above mentioned miR-320a and miR-589-5p were also observed in all other datasets. [score:3]
Eleven miRNAs were identified as commonly detectable in all types of specimens: miR-320a, miR-589-5p, miR-636, miR-1273a, miR-3960, miR-4419a, miR-4497, miR-4709-5p, miR-4792, miR-7641-1, and miR-7641-2. Figure 2(A) Venn diagram reporting the number of miRNAs detected in different specimens from healthy individuals and their overlap. [score:1]
miR-589-5p, miR-636, and miR-4792 have been also described previously in other studies. [score:1]
Eleven miRNAs were identified as commonly detectable in all types of specimens: miR-320a, miR-589-5p, miR-636, miR-1273a, miR-3960, miR-4419a, miR-4497, miR-4709-5p, miR-4792, miR-7641-1, and miR-7641-2. Figure 2(A) Venn diagram reporting the number of miRNAs detected in different specimens from healthy individuals and their overlap. [score:1]
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4
[+] score: 11
Other miRNAs from this paper: hsa-mir-19a
miR-589 is expressed in A549 lung cancer cells and has two seed sequence target sites at the COX-2 promoter. [score:5]
Elevated levels of miR-589 lead to increased expression of both COX-2 and PLA2G4A. [score:3]
Ago2 and TNRC6A are recruited by miR-589 to a sense transcript that overlaps the COX-2 promoter. [score:1]
When Ago2 or TNRC6A levels are depleted, the activation of COX-2 and PLA2G4A by miR-589 is reversed. [score:1]
We have recently reported a role for Ago2 and TNRC6A in endogenous control of the inflammatory pathway genes cyclooxygenase 2 (COX-2) and phospholipase 2G 4A (PLA2G4A) by miR-589 miRNA (Matsui et al., 2013). [score:1]
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5
[+] score: 9
miR-589 downregulation was confirmed in HPMCs from PD patients and HMrSV5 cells treated with TGF- β1, in which overexpression of miR-589 attenuated the EMT changes induced by TGF- β1 [34]. [score:6]
By contrast, Zhang et al. [34] used their unpublished data of miRNA expression profiles in HPMCs of PD patients and HMrSV5 cells treated with TGF- β1 to focus their studies on miR-589 [34]. [score:3]
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6
[+] score: 9
MiR-589 was identified from the microarray study with up-regulation pattern for cases over controls in CA group (Fold-Change = 6.9, p = 0.013). [score:3]
0013735.g005 Figure 5Increased plasma levels of miR-589 for patients with breast cancer versus healthy controls in CA group. [score:1]
Increased plasma levels of miR-589 for patients with breast cancer versus healthy controls in CA group. [score:1]
C–D) Data from RT-qPCR validation in an independent set of 30 participants: The fold change of miR-589 in case relative to control is 3.3 (P = 0.0009, AUC  = 0.85). [score:1]
A–B) Data from microarray profiling of 20 participants: The fold change of miR-589 in case relative to control is 6.9 (P = 0.0131, AUC  = 0.62). [score:1]
For the CA group, let-7c and miR-589 were chosen for RT-qPCR validation (Table S3, S4). [score:1]
Let-7c and miR-589 were selected to be validated in CA group and miR-425* and let-7d* were selected to be validated in AA group. [score:1]
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7
[+] score: 7
MiR-219 was described to be upregulated in AML with MLL-AF6 and MLL-AF9 versus other AML cases [41], while miR-589 was observed to be upregulated in MLL-rearranged AML versus normal controls [42]. [score:7]
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8
[+] score: 7
Conversely, expression of MIR941 (50%, p < 0.05) and MIR589-5P (69%, p < 0.05), which were predicted by RNA-Seq analysis to be down regulated, were not validated by qPCR. [score:4]
We used qPCR to confirm expression patterns predicted by RNA-Seq analysis for 8 miRNA (MIR29A-5P, MIR140-5P, MIR126P, MIR374A-3P, MIR26A-2-3P and MIR147B, MIR941 and MIR589-5P) that were induced following treatment of any eCig liquid (ANY LIQUID). [score:3]
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9
[+] score: 5
In a separate study [2], miR-1244 was again associated with cisplatin efficacy, as both miR-1244 and miR-589 were significantly downregulated in cisplatin-resistant A549 cells (A549/DDP) when compared to the parental cell line, and transfection of A549/DDP with either miRNA markedly increased sensitivity to cisplatin, indicating that miR-1244 has important tumor suppressive functions that may be vital in the treatment of NSCLC. [score:5]
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10
[+] score: 4
The fold change value for the downregulated miRNAs ranged from −14.23 (hsa-miR-217) to −1.03 (hsa-miR-589-5p). [score:4]
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11
[+] score: 4
Among the miRNAs associated with positive regulation of the EEF2 gene that showed a significant change in their abundance in plasma samples of patients with lupus nephritis class IV were: hsa-miR-584-5p [48], hsa-miR-589-3p [49], hsa-miR-145-5p [48], hsa-miR-183-5p [48], Hsa-miR-125b-5p [35] and hsa-miR-106a-5p [50]. [score:2]
In conclusion, we identified 24 novel differentially abundant miRNAs in the plasma of patients with class IV lupus nephritis (hsa-miR-589-3p, hsa-miR-1260b, hsa-miR-4511, hsa-miR-485-5p, hsa-miR-584-5p, hsa-153-3p, hsa-miR-6087, hsa-miR-3942-5p, hsa-miR-7977, hsa-miR-323b-3p, hsa-miR-4732-3p, hsa-miR-6741-3p) that are good candidates for further assessment as diagnostic biomarkers of class IV lupus nephritis. [score:1]
Alterations in the relative abundance of miR-589-3p, miR-1260b, miR-4511, miR-485-5p, miR-584-5p, miR-543, miR-153-3p, miR-6087, miR-3942-5p, miR-7977, miR-323b-3p, miR-4732-3p and miR-6741-3p, and its possible association with lupus nephritis is described for the first time. [score:1]
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12
[+] score: 3
Four miRNAs had similar altered expressions as their host genes (miR-126-5p, miR-589-3p, miR-15b-5p, miR-25-3p). [score:3]
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13
[+] score: 2
Twelve miRNAs in group 5 (miR-196b, miR-485-3p, miR-589, miR-324-3p, miR-342-3p, miR-92a1#, miR-155, miR-146b, miR-142-3p, miR-1260, miR-143, and miR-142-5p) have strong loading (absolute value ≥ 0.8). [score:1]
Twelve miRNAs in this group (miR-196b, miR-485-3p, miR-589, miR-324-3p, miR-342-3p, miR-92a-1#, miR-155, miR-146b, miR-142-3p, miR-1260, miR-143, and miR-142-5p) seem to be influential on patient prognosis. [score:1]
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14
[+] score: 1
First, those which correlate to a larger number of miRNAs of lower significance value, indicated by dark blue in the p<0.05 column, for example miR-122 (Accession Number 406906), miR-589 (Accession Number 693174), and miR-423-5p (Accession Number 494335). [score:1]
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15
[+] score: 1
On the other hand, the best predictor in Caucasians was miR-589 with an AUC of 0.85 (31). [score:1]
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