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13 publications mentioning hsa-mir-577

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-577. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 18
The relative expression levels of NDST4 in the CRC cell lines were compared with a mean expression of 52 normal mucosae, which was adjusted to 1. For the quantification of microRNA 577 (miR-577) expression in 10 pairs of randomly selected primary CRC tissues, small RNA was extracted by using the mirVana™ miRNA Isolation Kit (Ambion) according to the manufacturer's instructions. [score:6]
The expression levels of UGT8 and miR-577 in the tested tumors were compatible with their adjacent normal mucosae. [score:3]
C. Analysis of miR-577 expression in CRC tissues by qRT-PCR. [score:3]
The expression of UGT8, NDST4, and miR-577 was screened in 10 pairs of randomly selected primary CRC tissues by RT-PCR or qRT-PCR (Figure 1B and 1C). [score:3]
miR-577 (MIR577) lies in the intron of UGT8. [score:1]
As an endogenous control, RNU6B was amplified in parallel, and the Ct value of miR-577 was normalized to that of RNU6B. [score:1]
By searching in the National Center for Biotechnology Information (NCBI) database, only two protein-coding genes, UGT8 and NDST4, as well as one microRNA, miR-577, were shown to be located in the defined minimal deletion region. [score:1]
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2
[+] score: 11
Hsa-miR-24-2* and hsa-miR-577 were chosen as G1 phase lacked miRNA expression, while in G2 phase miRNA expression was detectable. [score:5]
Still, statistical analysis detected only 11 miRNAs with altered expression in HeLa cells, of which only four miRNAs (hsa-miR-146b, hsa-miR-577, hsa-miR-877 and hsa-miR-193b*) had FC > 2 expression change between cell cycle phases. [score:5]
Additionally, hsa-miR-577 was also measured in HeLa cells, but it showed no cell cycle dependent expression pattern (Panel D). [score:1]
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3
[+] score: 10
The hsa-miR-98 and hsa-miR-375 miRNAs were upregulated, whilst hsa-miR-7-5p, hsa-miR-615-3p and hsa-miR-577 were downregulated. [score:7]
The expression levels of 5 randomly selected miRNAs: hsa-miR-7-5p, hsa-miR-615-3p, hsa-miR-577, hsa-miR-98 and hsa-miR-375, were compared. [score:2]
The log [2] (MN/NC) values of hsa-miR-7-5p, hsa-miR-615-3p and hsa-miR-577 were −5.06, −2.40 and −1.12, respectively. [score:1]
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4
[+] score: 9
The same characteristic applies to the final PPL target, the HLA-DM complex targeted via miR-577, which is also only localized in the endoplasmic reticulum. [score:3]
STAT1 is responsible for the transcription of two PAGs (1) RUNX and (2) UGT8, that respectively co-express miR-802 and miR-577, responsible for the loop closure. [score:3]
The HLA-DM protein, another chaperone, finally, is targeted by both miR-802 and miR-577. [score:3]
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5
[+] score: 8
For example, miR-577 is upregulated 3.5-fold in HPV16 E6/E7 -expressing HFKs and has eight potential targets. [score:8]
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6
[+] score: 8
In contrast, it has been found that miR-577 inhibits GBM growth by decreasing the expression of LRP6 and β-catenin [123]. [score:5]
Zhang W. Shen C. Li C. Yang G. Liu H. Chen X. Zhu D. Zou H. Zhen Y. Zhang D. miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathwayMol. [score:3]
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7
[+] score: 7
Of these, 5 miRNAs (hsa-miR-296-5p, hsa-miR-577, hsa-miR-1233, hsa-miR-1267, and hsa-miR-1825) had a significantly higher expression level (lower ΔCt) in whole saliva samples from patients with a parotid gland neoplasm compared to their expression levels in whole saliva from healthy controls. [score:4]
miRNA ΔCt control mean(sd) ΔCt neoplasm mean (sd) Wilcoxon 2-sided p-value hsa-miR-103a-3p 14.32 (3.59) 10.00 (4.75) < 0.001 hsa-miR-211 14.91 (3.18) 8.56 (4.37) < 0.001 hsa-miR-296-5p 12.80 (4.15) 6.95 (4.66) < 0.001 hsa-miR-425-5p 9.96 (5.13) 2.54 (4.79) < 0.001 hsa-miR-577 10.19 (1.57) 9.66 (2.85) 0.650 hsa-miR-1233 15.74 (0.70) 9.17 (6.89) < 0.001 hsa-miR-1267 9.78 (5. 03) 4.39 (5.21) < 0.001 hsa-miR-1825 7.47 (7.46) -0.77 (3.95) < 0.001 Multivariate logistic regression mo dels with these miRNA biomarkers were constructed for the classification of patient samples into parotid gland neoplasm and healthy categories. [score:1]
miRNA ΔCt control mean (sd) ΔCt neoplasm mean (sd) Wilcoxon 2-sided p-value hsa-miR-103a-3p 6.34 (1.71) ND < 0.001 hsa-miR-211 9.45 (1.38) ND < 0.001 hsa-miR-425-5p 11.56 (3.72) ND < 0.001 hsa-miR-296-5p ND 7.41 (3.75) < 0.001 hsa-miR-577 ND 5.96 (3.44) < 0.001 hsa-miR-1233 19.14 (4.98) 8.93 (8.49) 0.002 hsa-miR-1267 ND 3.87 (2.79) < 0.001 hsa-miR-1825 20.94 (2.26) 5.17 (5.38) < 0.001 ND: non-detectable, assigned to samples with a Ct-value of 40 and higher. [score:1]
miRNA ΔCt control mean(sd) ΔCt neoplasm mean (sd) Wilcoxon 2-sided p-value hsa-miR-103a-3p 14.32 (3.59) 10.00 (4.75) < 0.001 hsa-miR-211 14.91 (3.18) 8.56 (4.37) < 0.001 hsa-miR-296-5p 12.80 (4.15) 6.95 (4.66) < 0.001 hsa-miR-425-5p 9.96 (5.13) 2.54 (4.79) < 0.001 hsa-miR-577 10.19 (1.57) 9.66 (2.85) 0.650 hsa-miR-1233 15.74 (0.70) 9.17 (6.89) < 0.001 hsa-miR-1267 9.78 (5. 03) 4.39 (5.21) < 0.001 hsa-miR-1825 7.47 (7.46) -0.77 (3.95) < 0.001 Samples were collected from patients with a parotid gland neoplasm (n = 46) and controls (n = 14). [score:1]
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8
[+] score: 6
Wei Z et al. 27 found that hsa-miR-577, hsa-miR-1, hsa-miR-532-3p and hsa-miR-627 could significantly down-regulate the translation efficiency of CYP3A4 mRNA in the liver. [score:6]
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9
[+] score: 4
The novel up-regulated miRNAs were miR-582-5p, miR-363, miR-577, and miR-887, which have not been previously associated with any cancer. [score:4]
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10
[+] score: 4
Chen X. Y. Li G. M. Dong Q. Peng H. MiR-577 inhibits pancreatic β-cell function and survival by targeting fibroblast growth factor 21 (FGF-21) in pediatric diabetes Genet. [score:4]
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11
[+] score: 1
01 Down 4.40E-07 hsa-miR-4488 5.95 Up 4.10E-35 hsa-miR-1269b −6.74 Down 3.15E-06 hsa-miR-296-5p 5.84 Up 3.88E-78 hsa-miR-3674 −6.74 Down 3.16E-06 hsa-miR-4454 5.19 Up 3.07E-85 hsa-miR-3910 −6.74 Down 3.17E-06 hsa-miR-4687-3p 4.37 Up 8.32E-26 hsa-miR-642a-3p −6.74 Down 5.10E-32 hsa-miR-3654 3.38 Up 1.21E-25 hsa-miR-486-5p −6.46 Down 2.81E-100 hsa-miR-577 2.94 Up 8.64E-05 hsa-miR-203 −6.30 Down 3.19E-89 hsa-miR-4508 2.9 Up 5.94E-06 hsa-miR-1277-3p −6.16 Down 3.01E-41 hsa-miR-3687 2.49 Up 2.04E-05 hsa-miR-1277-5p −5. [score:1]
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12
[+] score: 1
All miRNAs except two (miR-577 and miR-886-3p) had mouse orthologs. [score:1]
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13
[+] score: 1
miRNAlog [2]FoldChange P-value Corrected P-value hsa-mir-577 −3,28 1,46E-10 3,87E-08 hsa-mir-182-5p −2,70 6,50E-15 3,44E-12 hsa-mir-485-5p −2,12 8,79E-05 8,45E-03 hsa-mir-124-3p −1,83 1,05E-05 1,85E-03 hsa-mir-218-5p −1,68 1,54E-04 1,16E-02 hsa-mir-183-5p −1,62 3,14E-04 2,08E-02 hsa-mir-873-5p −1,58 9,80E-04 3,25E-02 hsa-mir-133a −1,53 6,05E-04 2,29E-02 hsa-mir-487b −1,45 1,56E-03 4,59E-02 hsa-mir-219-5p −1,44 9,55E-04 3,25E-02 hsa-mir-409-3p −1,34 1,12E-03 3,48E-02 hsa-mir-889 −1,23 5,71E-04 2,29E-02 hsa-mir-136-3p −1,15 1,75E-03 4,87E-02 hsa-mir-410 −1,12 4,02E-04 2,29E-02 hsa-mir-127-3p −0,95 5,61E-04 2,29E-02 hsa-mir-148a-3p 1,23 4,99E-04 2,29E-02 hsa-mir-155-5p 1,82 9,56E-05 8,45E-03 hsa-mir-221-3p 2,10 4,82E-04 2,29E-02For each differently expressed miRNA we report the standard name according to MirBase database, the log [2] fold-change, the P-value and the corresponding corrected P-value as calculated by DESeq. [score:1]
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