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15 publications mentioning hsa-mir-558

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-558. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 17
Circ-Foxo3 has an inhibitory effect on tumor growth in vivo(54) Down In vitro breast cancer mo dels Potentially anti-tumorigenic, builds a ternary complex with CDF2 and p21 which inhibits cell cycle progression, decreasing cell proliferation(55) Down Breast Potentially anti-tumorigenic, blocks the interaction of MDM2 with Foxo3 and decreases the degradation of this protein, inducing cell apoptosis(56) Hsa_circ_0001649 SHPRH Down HCC Potentially anti-tumorigenic, the low expression correlates with the tumor size and occurrence of tumor embolus(57) DownGC [a] Potentially anti-tumorigenic, correlates with the histopathological differentiation level(58) Down CCA Potentially anti-tumorigenic, inhibits proliferation, invasion, migration and apoptosis(59) DownCRC [a] Potentially anti-tumorigenic, correlates with the histopathological differentiation level(60) Hsa_circ_0000284 (circHIPK3/bladder cancer-related circular RNA-2) HIPK3 Up HCC Potentially pro-tumorigenic role, by sponging miR-124, it leads to increased cell proliferation(61) Up HCC Possible pro-tumorigenic potential, by sponging miR-124, circHIPK3 indirectly induces proliferation and migration(62) Down Bladder cancerPotentially anti-tumorigenic role, by sponging miR-558 circHIPK3 inhibits cancer growth and metastasis in vivo(63) Down Bladder cancer Possible anti-tumorigenic role by sponging miR-124. [score:12]
Mechanistically, a low expression level of circHIPK3 cannot efficiently sponge miR-558, a miRNA which promotes angiogenesis by targeting heparanase. [score:5]
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2
[+] score: 15
In addition, overexpression of circHIPK3 effectively inhibited migration, invasion, and angiogenesis of bladder cancer cells in vitro and suppressed bladder cancer growth and metastasis in vivo, mainly through targeting the miR-558/heparanase axis [103]. [score:9]
Mechanistic studies revealed that circHIPK3 abundantly sponged miR-558 and suppressed heparanase (HPSE) expression, which is involved in regulating tumor invasion and metastasis. [score:6]
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3
[+] score: 11
miR-558 directly binds with its complementary site within this 5′-UTR and facilitates the binding of AGO2 to the eukaryotic translation initiation factor 4E (eIF4E) binding protein 1 and results in increased eIF4E enrichment and HIF-2α translation [139]. [score:6]
Furthermore, miR-558 provides the very interesting possibility for direct upregulation of HIF-2α levels, but this needs to be verified. [score:5]
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4
[+] score: 8
Other miRNAs from this paper: hsa-mir-127, hsa-mir-365a, hsa-mir-365b
Previously, we were able to demonstrate that miR-127-5p and miR-558, which are regulated by IL-1β in chondrocytes and downregulated in OA cartilage, are able to regulate MMP-13 and cyclooxygenase-2 (COX-2) expression, respectively 15, 16. [score:8]
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5
[+] score: 8
Li Y CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cellsEMBO Rep. [score:5]
Meanwhile, circHIPK3 was proposed to inhibit bladder cancer progression through sponging miR-558 [11]. [score:3]
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6
[+] score: 6
Of all miRNAs, seven (hsa-miR-380*, hsa-miR-106b, hsa-miR-17, hsa-miR-144*, hsa-miR-558, hsa-miR-548d-3p, and hsa-miR-222) were significantly downregulated (adjusted two-tailed t-test P <0.05) in at least 13 of 19 disease conditions, representing the most non-specific miRNAs. [score:6]
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7
[+] score: 5
For example, the precursor of miR-558, which has been previously linked with aggressive neuroblastoma [33], contained 5 in dels, and an in del (rs34385807) is located the pre-miRNA sequence of miR-141, which is involved in cancer proliferation [34], [35], [36], [37] and has been shown to target the tumor suppressor PTEN [38]. [score:5]
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8
[+] score: 5
Examples include miR-483 that binds to the promoter of IGF2 to increase its expression in Wilms’ tumors [59] and miR-558 that binds to the promoter of heparanase (HPSE) to enhance its expression, resulting in enhanced tumor growth in neuroblastoma cells [44] (Table  2). [score:5]
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9
[+] score: 4
We found several miRNAs (miR-101, miR-137, miR-145, miR-335, miR-384, miR-451, miR-545 and miR-558) upregulated in virus-transduced cells that showed resistance to 5-Aza-dC -induced senescence (Fig. 1 and Supplementary Fig. 1A,B). [score:4]
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10
[+] score: 3
We observed 4 miRNAs expressed exclusively in sALS but not in controls [miR-558 (p < 0.001); miR-16-2*, miR-146a* (p < 0.01); miR-508-5p (p < 0.05)] (Table  1). [score:3]
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11
[+] score: 3
Zheng L miRNA-558 promotes gastric cancer progression through attenuating Smad4 -mediated repression of heparanase expressionCell Death Dis. [score:3]
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12
[+] score: 3
Two of 3 genes displayed several alleles with important length variations: 6 and 15 alleles found respectively for hsa-mir-620 and hsa-mir-558 in healthy individuals (Table S1, Figure S1). [score:1]
Hsa-mir-558 with 18 repeats appeared mutated in one third of MSI cell lines (4/13; 30.8%) and MSI CRCs (12/38; 31.6%) (Table 2). [score:1]
For hsa-mir-1303 (T [13]), hsa-mir-620 ((TA) [11]) and hsa-mir-558 ((GT) [18]) genes, the polymorphic zone is determined between the smallest and the largest alleles (located between the two dashed vertical lines) observed in a large series of 40 lymphoblastoid cell lines from healthy individuals. [score:1]
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13
[+] score: 3
While most miRNAs are up to 50-fold less concentrated in CSF samples, miR-9-5p, miR-132-5p and miR-558-3p are 2–3 times more abundant than in serum samples. [score:1]
Moreover, the majority of miRNAs showed an up to approximately 50-fold higher concentration in the serum, while miR-9-5p, miR-132-5p and miR-558-3p were 2–3 times more abundant in the CSF (Figure  3; Table  3). [score:1]
Furthermore, by comparing the miRNA levels in CSF and serum of healthy controls we could show that some miRNAs, like miR-9-5p, miR-132-5p and miR-558-3p are more abundant in the CSF, while others are higher concentrated in serum. [score:1]
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14
[+] score: 3
MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1beta -induced catabolic effects in human articular chondrocytes. [score:3]
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15
[+] score: 1
rs848 included in our study was predicted to be located within the binding sites of miR-558, miR-621, and let-7i with total |ΔΔG|s of 156.5 kJ/mol. [score:1]
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