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1 publications mentioning tni-mir-17-1

Open access articles that are associated with the species Tetraodon nigroviridis and mention the gene name mir-17-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 48
The miRNA differential expression data also suggest that the two isoforms have separate functions; for example, miR-124b-3p and miR-17 were down-regulated after rIFN-γ1 treatment but were significantly up-regulated after rIFN-γ2 treatment. [score:9]
MiR-106a-3p may also be involved in feedback control of IFN-γ expression by targeting IL-10, and miR-17 may also participate in the IFN-γ -mediated activation of macrophages. [score:5]
The normalized read counts of the 10 selected miRNAs are shown in Figure 5. Whereas tni-miR-124b-3p and tni-miR-17 were differentially expressed after both rIFN-γ1 and rIFN-γ2 treatment, the other eight miRNAs were differentially expressed only after either rIFN-γ1 or rIFN-γ2 treatment. [score:5]
Both miR-106a and miR-17 are regulated by c-Myc [75], [76], which is a transcription factor that can be suppressed by IFN-γ [77]. [score:4]
Previous studies in mammals have indicated that miR-106a and miR-17 were up-regulated after 12 h of IFN-γ treatment [100], which is in agreement with our findings for IFN-γ2, suggesting that T. nigroviridis IFN-γ2 may be closely related to mammalian IFN-γ. [score:4]
Additionally, seven out of the 10 validated miRNAs (miR-124b-3p, miR-132-3p, miR-142-3p, miR-145b, miR-17, miR-29d-3p, and miR-346) were differentially expressed between the IFN-γ1 and IFN-γ2 treatment groups, suggesting functional segregation or synergy of the two fish IFN-γ isoforms. [score:3]
The real-time PCR validation of these 10 miRNAs is shown in Figure 6. All of the 10 selected miRNAs showed the same pattern of increase or decrease suggested by the sequencing data, although the magnitude of the change in tni-miR-106a-3p, tni-miR-17, and tni-miR-346 expression was different between the sequencing results and PCR data. [score:3]
In total, 10 differentially expressed miRNAs (tni-miR-106a-3p, tni-miR-124b-3p, tni-miR-132-3p, tni-miR-142-3p, tni-miR-145b, tni-miR-17, tni-miR-223-5p, tni-miR-29d-3p, tni-miR-346, and tni-miR-378) were selected for PCR validation. [score:3]
MiR-106a-3p, which belongs to the miR-17 family, is involved in many types of tumors [62], [63], [64]; additionally, miR-106a directly regulates Stat3 [65] and IL-10 [66]. [score:3]
0096336.g006 Figure 6 (A): expression of miR-124b-3p, miR-142-3p, miR-145b, miR-17, miR-29d-3p, and miR-346 following IFNγ1 treatment, compared to the control group. [score:2]
In addition to its oncomiR function [70], [71], miR-17 regulates macrophage differentiation [72] and macrophage inflammatory responses [73] and is also involved in Stat3 signaling [74]. [score:2]
MiR-17 is a member in the miR-17∼92 cluster and acts as a potential oncogene [69]. [score:1]
These studies indicate that miR-106a-3p, miR-17, and miR-124b-3p may be involved in Stat3 -dependent IFN-γ signaling. [score:1]
Ten miRNAs were selected for verification, including tni-miR-106a-3p, tni-miR-124b-3p, tni-miR-132-3p, tni-miR-142-3p, tni-miR-145b, tni-miR-17, tni-miR-223-5p, tni-miR-29d-3p, tni-miR-346, and tni-miR-378. [score:1]
As mentioned above, miR-124b-3p and miR-17 may be involved in Stat3 -dependent IFN-γ signaling, which suggests that IFN-γ1 and IFN-γ2 may have opposite effects on the Stat3 signaling pathway in T. nigroviridis. [score:1]
First, we focused on previous studies of miR-106a-3p, miR-17 and miR-124b-3p in mammals. [score:1]
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