sort by

21 publications mentioning hsa-mir-502

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-502. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 26
The gene expression in HIV/MDD of genes which are targets of miRNAs that show significant target bias is illustrated in Figure 4. MiR-367 (Accession Number 442912), miR-125a-3p (Accession Number 406910), miR-502-5p (574504), and miR-136 (Accession Number 406927) showed significant target bias across all four windows (asterisks in Figure 3). [score:9]
The gene expression in HIV/MDD of genes which are targets of miRNAs that show significant target bias is illustrated in Figure 4. MiR-367 (Accession Number 442912), miR-125a-3p (Accession Number 406910), miR-502-5p (574504), and miR-136 (Accession Number 406927) showed significant target bias across all four windows (asterisks in Figure 3). [score:9]
The direction of the dysregulation of the miRNA is indication by the arrow; for miR-367, miR-136, and miR-125a, the majority of targets are dysregulated in accordance with the miRNAs; while for miR-502, the majority of targets are anticorrelated. [score:8]
[1 to 20 of 3 sentences]
2
[+] score: 22
Some of the miRNAs hosted in the CLCN5 gene have also been related to cancer, e. g., high expression of miR-362 is associated to worse prognosis and apoptosis resistance in colorectal and gastric cancer [45, 46], that of miR-500a to hepatocellular carcinoma [47], and that of miR-502 to diverse types of cancer through a polymorphism in its target gene SET8 [48], and to colon cancer by inhibiting autophagy [49]. [score:7]
The ANOVA test with post hoc analysis for condition IL-4 vs conditions Pre and Ctrl identified 7 mature miRNAs regulated by IL-4 in CLL (Fig 2A and S6 Table): miR-21-3p, miR-362-3p, miR-362-5p, miR-500a-3p, miR-502-3p, miR-532-3p, and miR-532-5p, all of them higher than 10-fold up-regulated on average. [score:5]
MiR-21, miR-362, miR-500a, miR-502, and miR-532 were induced by IL-4, likely as a consequence of up-regulation of their respective host genes, vacuole membrane protein 1 (VMP1), and chloride channel, voltage sensitive 5 (CLCN5). [score:4]
We have found up-regulation of miR-21 (5p and 3p), miR-362 (3p and 5p), miR-500a-3p, miR-502-3p, and miR-532 (3p and 5p) by IL-4 in CLL. [score:4]
MiR-21 maps several hundred base pairs downstream of the last exon of VMP1, and miR-362, miR-500a, miR-502, and miR-532 within the third intron of CLCN5. [score:1]
For miRNA expression, RNA samples were retrotranscribed with the miScript II RT Kit (Qiagen) using the miScript HiSpec buffer for mature miRNA detection only, followed by qPCR with the miScript SYBR Green PCR Kit (Qiagen) in an ABI Prism 7000 Sequence Detection System, using the miScript primer assays (Qiagen) for miR-21-3p, miR-362-3p, miR-362-5p, miR-500a-3p, miR-502-3p, miR-532, miR-532-3p, and RNU6-6P, the latter used as reference for normalization (cat. [score:1]
[1 to 20 of 6 sentences]
3
[+] score: 13
A recent study on miR-502 reported its potential tumor suppressor role in colon cancer [35]; in the present study, this miR was downregulated in Exo [Hypoxic]. [score:6]
The top 20 miRNAs significantly up- or down-regulated in Exo [Hypoxic] compared to Exo [Normoxic] are listed in Table 1. Nine miRNAs were expressed at a significantly lower level in Exo [Hypoxic] compared to Exo [Normoxic]: miR-521 (Fold change = 0.0005), miR-27a (Fold change = 0.24), miR-324 (Fold change = 0.446), miR-579 (Fold change = 0.448), miR-502 (Fold change = 0.396), miR-222 (Fold change = 0.232), miR-135b (Fold change = 0.325), miR-146a (Fold change = 0.456) and miR-491(Fold change = 0.482). [score:4]
Among these, 15 miRNAs (miR-143, miR-146a, miR-181a, miR-204, miR-222, miR-27a, miR-335, miR-433, miR-491, miR-502, miR-521, miR-92a, miR-127, miR-135b and miR-451) target 211 mRNAs when the confidence limit was set as “Experimentally Observed” only. [score:3]
[1 to 20 of 3 sentences]
4
[+] score: 13
Thus, miR-502 may suppress EMT by inhibiting SET8 (Figure  3B). [score:5]
MiR-502 suppressed SET8 directly and promoted E-cadherin expression. [score:5]
Fengju Song et al. identified a single-nucleotide polymorphism within the miR-502 seed -binding region in the 3′-UTR of the SET8 genethat modulates SET8 expression [80]. [score:3]
[1 to 20 of 3 sentences]
5
[+] score: 11
Zhang G. Sun Y. Wang Y. Liu R. Bao Y. Li Q. miR-502–5p inhibits IL-1beta -induced chondrocyte injury by targeting TRAF2 Cell. [score:5]
Mechanistically, this involves miRNA-502-5p -mediated inhibitory targeting of tumor necrosis factor receptor -associated factor 2 (TRAF2) [85]. [score:5]
Similarly, miRNA-502-5p has also been found, through in vitro experimentation, to counteract NF-kB signaling. [score:1]
[1 to 20 of 3 sentences]
6
[+] score: 9
Of these, 14 (miR-23b, miR-28, miR-98, miR-103, miR-107, miR-193a,0, miR-324-5p, miR-324-3p, miR-331, miR-374, miR-432, miR-502, and miR-660) were upregulated and 6 (miR-31, miR-451, miR-452, miR-565, miR-594 and miR-659) were downregulated. [score:7]
[27]↓quail myoblasts diff, ↓ C2C12 diff [29] ↓ C2C12 diff [28] ↓ muscle development [32]40miR-320↓(this study)↑ pMyo diff [33]  41 miR-324-3p (n)↑↑(this study)   42 miR-324-5p (n)↑(this study)   43 miR-331 (n)↑(this study)-  44miR-339↓(this study)↑ C2C12 diff [33] ↑ pMyo diff [33]  45miR-361↑(this study)↑ pMyo diff [33]  46 miR-362↑↑(this study)↑ C2C12 diff [28]  47 miR-374 (n)↑(this study)   48 miR-432 (n)↑(this study)   49 miR-451 (n)↓↓↓(this study)   50 miR-452 (n)↓↓(this study)   51 miR-500↑↑(this study)↑ C2C12 diff [28, 33] ↑ pMyo diff [33]  52 miR-501↑↑↑(this study)↑ C2C12 diff [28, 33]  53 miR-502 (n)↑↑(this study)-  54 miR-503↑(this study)↑ C2C12 diff [19, 28, 33] ↑ pMyo diff [33]  55 miR-532↑↑(this study)↑ C2C12 diff [28, 33] ↑ pMyo diff [33]  56↓↓ pMyo diff. [score:2]
[1 to 20 of 2 sentences]
7
[+] score: 7
Notably, 5 downregulated miRNAs miR-532 and miR-362, miR-500, miR-501, miR-502 are clustered and together encoded in one intron of a renal specific gene voltage-gated chloride ion channel CLCN5, and have been reported to be downregulated in ccRCC [26]. [score:7]
[1 to 20 of 1 sentences]
8
[+] score: 7
We also found an increased expression in TBL1XR1, a gene playing an important role in the development of B-cell non-Hodgkin lymphomas [25], in concordance with the downregulation of miR-501-3p and miR-502-3p. [score:7]
[1 to 20 of 1 sentences]
9
[+] score: 6
The expression of miR-23a, miR-181c, miR-192, miR-194, miR-208, miR-337-5p, miR-338-3p, miR-502-5p, miR-542-3p, miR-628-5p, and miR-672 is upregulated in the oral mucosa of heavy smokers with lung cancer versus patients without cancer and light smokers [66]. [score:6]
[1 to 20 of 1 sentences]
10
[+] score: 6
miR-532-5p (Figure  2B; mean fold change 2.4), miR-188-3p (Figure  2C; mean fold change 2.5), miR-362-5p (Figure  2D; mean fold change 4.0), miR-501-3p (Figure  2E; mean fold change 5.3), miR-660-3p (Figure  2F; mean fold change 2.2), and miR-502-5p (Figure  2G; mean fold change 3.0) were all markedly up-regulated in the triple -negative breast cancers compared to the normal breast tissue controls. [score:3]
Relative expression levels of (B) miR-532-5p, (C) miR-188-3p, (D) miR-362-5p, (E) miR-501-3p, (F) miR-660-3p, and (G) miR-502-5p in triple -negative breast cancer tissues (n = 19) and adjacent normal tissues (n = 4) are shown. [score:3]
[1 to 20 of 2 sentences]
11
[+] score: 5
Both mir-502-3p and ZC3H4 are expressed in adipose [42]. [score:3]
In addition the minor allele of rs3810291 is predicted to create an MRE for mir-502-3p within the ZC3H4 transcript and associates with BMI. [score:1]
22 (CEPH) 7-mer-A1 2nd hsa-miR-502-5p SET8 19789321 rs111842797* 12: 123893831 A G NA 7-mer-A1 8th hsa-miR-502-5p SET8 19789321 rs76290581 12: 6760093 T C. [score:1]
[1 to 20 of 3 sentences]
12
[+] score: 4
001 hsa-miR-210 11p15.5 Up (3.23) 0.021 hsa-miR-30b 8q24.2 Down (-2.02) 0.015 hsa-miR-30c 1p34.2 Down (-2.32) 0.039 hsa-miR-494 14q32.3 Up (8.03) 0.021 hsa-miR-497 17p13.1 Down (-2.15) 0.014 hsa-miR-502 Xp11.23 Down (-2.43) 0.014 hsa-miR-532 Xp11.23 Down (-2.11) 0.049 hsa-miR-551b 3q26.2 Down (-7.30) 0.034 hsa-miR-622 13q31.1 Up (2.39) 0.015 Hierarchical clustering of 44 miRNA genes with significantly different expression (p<0.05) in tumor tissues. [score:3]
001 hsa-miR-210 11p15.5 Up (3.23) 0.021 hsa-miR-30b 8q24.2 Down (-2.02) 0.015 hsa-miR-30c 1p34.2 Down (-2.32) 0.039 hsa-miR-494 14q32.3 Up (8.03) 0.021 hsa-miR-497 17p13.1 Down (-2.15) 0.014 hsa-miR-502 Xp11.23 Down (-2.43) 0.014 hsa-miR-532 Xp11.23 Down (-2.11) 0.049 hsa-miR-551b 3q26.2 Down (-7.30) 0.034 hsa-miR-622 13q31.1 Up (2.39) 0.015 Three miRNAs (hsa-miR-494, hsa-miR-551b, and ebv-miR-BART19) were validated in an independent sample set of non-TRU- and TRU-type lung adenocarcinoma and corresponding normal lung tissue (n = 21 and 12, respectively) by qRT-PCR. [score:1]
[1 to 20 of 2 sentences]
13
[+] score: 4
In addition, qRT-PCR failed to detect the expression of hsa-miR-122 and hsa-miR-502-3p. [score:3]
1E-1653.37hsa-miR-99bCentenarian97 (15.32)276 (83.78)2.15E-244.96E-223.09hsa-miR-181a*Centenarian627 (24.30)1641 (307.63)4.5E-1231E-1202.84hsa-miR-363Centenarian4732 (260.52)11971 (2286.46)002.75hsa-miR-21*Centenarian2529 (286.89)6313 (1153.62)002.71hsa-miR-92b*Centenarian99 (11.67)245 (42.00)2.45E-185.66E-162.69hsa-miR-20b*Centenarian319 (77.91)708 (84.88)5.78E-421.33E-392.41hsa-miR-148aCentenarian11599 (1225.92)25583 (655.62)002.40hsa-miR-1975Centenarian1654 (86.54)3529 (335.65)2. 1E-1884.9E-1862.32hsa-miR-502-3pCentenarian191 (13.48)387 (14.66)4.03E-209.31E-182.20hsa-miR-181cCentenarian153 (6.46)310 (63.42)1.8E-164.15E-142.20hsa-miR-1259Centenarian106 (25.78)210 (29.26)4.01E-119.27E-092.15hsa-miR-148a*Centenarian339 (46.74)656 (14.26)3.38E-307.82E-282.10hsa-miR-192Centenarian7126 (1026.34)13754 (2446.01)002.10hsa-miR-361-5pCentenarian307 (20.35)587 (89.41)1.65E-263.81E-242.08hsa-miR-9Centenarian341 (26.37)629 (37. [score:1]
[1 to 20 of 2 sentences]
14
[+] score: 3
This gene has eight intronic miRNAs, and surprisingly, some of their transcripts may be targeted by their intronic miR-502 (see miRIAD). [score:3]
[1 to 20 of 1 sentences]
15
[+] score: 3
Other miRNAs from this paper: hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-127
A single-nucleotide polymorphism (SNP), namely polymorphism rs16917496 T>C, which is located within the binding site of another miRNA, miR-502, in SETD8 3′UTR, modulates SETD8 protein expression, and thus contributes to susceptibility to breast and ovarian cancer, and clinical outcome of small cell lung cancer and hepatocellular carcinoma [63– 66]. [score:3]
[1 to 20 of 1 sentences]
16
[+] score: 3
The rest of co-expressed clusters were listed for regions at 6q13 (including mir-30a and mir-30c-2), Xp11.23 (including mir-362, mir-500, mir-501, mir-502 and mir-532), 14q32.2 (including mir-134, mir-379 and mir-382), 14q32.31 (including mir-127, mir-432 and mir-770), 9q22.32 (including let-7d, mir-23b and mir-27b) and 7q22.1 (including mir-93 and mir-106b) (Table 3). [score:3]
[1 to 20 of 1 sentences]
17
[+] score: 2
A few miRNAs, like miR-30a, miR-101, miR-376b, miR-130a, miR-375, miR-502, have been identified as the regulators of autophagy [6- 9]. [score:2]
[1 to 20 of 1 sentences]
18
[+] score: 2
Finally, among the 64 miRNAs, four (miR-28, miR-331, miR-486 and miR-502) were differently deregulated at, at least, two different time points of infection. [score:2]
[1 to 20 of 1 sentences]
19
[+] score: 1
severe (p<0.05) cfa-let-7a, cfa-let-7b, cfa-let-7c, cfa-let-7f, cfa-miR-127, cfa-miR-1271, cfa-miR-130a, cfa-miR-139, cfa-miR-17, cfa-miR-1836, cfa-miR-1837, cfa-miR-20a, cfa-miR-23a, cfa-miR-25, cfa-miR-26a, cfa-miR-29b, cfa-miR-378, cfa-miR-421, cfa-miR-502, cfa-miR-503, cfa-miR-542, cfa- miR-652, cfa-miR-653, cfa-miR-872 Normal and mild vs. [score:1]
[1 to 20 of 1 sentences]
20
[+] score: 1
Other miRNAs from this paper: hsa-mir-17, hsa-mir-28, hsa-mir-223, hsa-mir-127, hsa-mir-188, hsa-mir-194-1, hsa-mir-155, hsa-mir-194-2, hsa-mir-30e, hsa-mir-362, hsa-mir-363, hsa-mir-367, hsa-mir-379, hsa-mir-196b, hsa-mir-450a-1, hsa-mir-431, ssc-mir-28, hsa-mir-493, hsa-mir-512-1, hsa-mir-512-2, hsa-mir-500a, hsa-mir-501, hsa-mir-450a-2, hsa-mir-513a-1, hsa-mir-513a-2, hsa-mir-506, hsa-mir-508, hsa-mir-509-1, hsa-mir-532, hsa-mir-615, hsa-mir-660, bta-mir-127, bta-mir-30e, bta-mir-17, bta-mir-450a-2, bta-mir-532, bta-mir-363, bta-mir-660, hsa-mir-891a, hsa-mir-892a, hsa-mir-509-2, hsa-mir-450b, hsa-mir-892b, hsa-mir-708, hsa-mir-509-3, hsa-mir-1285-1, hsa-mir-1285-2, hsa-mir-1248, ssc-mir-17, bta-mir-155, bta-mir-188, bta-mir-194-2, bta-mir-196b, bta-mir-223, bta-mir-28, bta-mir-362, bta-mir-367, bta-mir-379, bta-mir-431, bta-mir-493, bta-mir-500, bta-mir-502a-1, bta-mir-502a-2, bta-mir-502b, bta-mir-615, bta-mir-708, bta-mir-1248-1, bta-mir-1248-2, ssc-mir-450a, bta-mir-2320, bta-mir-1388, bta-mir-194-1, bta-mir-450a-1, eca-mir-30e, eca-mir-367, eca-mir-684, eca-mir-196b, eca-mir-615, eca-mir-708, eca-mir-194-1, eca-mir-493a, eca-mir-17, eca-mir-1248, eca-mir-28, eca-mir-127, eca-mir-379, eca-mir-431, eca-mir-493b, eca-mir-155, eca-mir-194-2, eca-mir-188, eca-mir-223, eca-mir-362, eca-mir-363, eca-mir-450a, eca-mir-450b, eca-mir-450c, eca-mir-500-1, eca-mir-500-2, eca-mir-501, eca-mir-502, eca-mir-508, eca-mir-509a, eca-mir-532, eca-mir-660, ssc-mir-30e, ssc-mir-196b-1, ssc-mir-450b, ssc-mir-127, ssc-mir-532, ssc-mir-708, ssc-mir-1285, ssc-mir-500, hsa-mir-514b, ssc-mir-363-1, ssc-mir-450c, hsa-mir-500b, ssc-mir-194b, ssc-mir-155, ssc-mir-362, bta-mir-3601, ssc-mir-615, ssc-mir-2320, bta-mir-450b, ssc-mir-194a, ssc-mir-196b-2, ssc-mir-363-2, ssc-mir-493, hsa-mir-892c, eca-mir-1388, eca-mir-514b, eca-mir-506a, eca-mir-509b, bta-mir-194b, ssc-mir-1388, ssc-mir-223, ssc-mir-660, bta-mir-194b-2, bta-mir-1949
A more difficult case is the mir-532 cluster located on chrX in human (Additional file 1: Figure S14), which contains 8 known miRNAs from miRBase: mir-532, mir-188, mir-500a, mir-362, mir-501, mir-500b, mir-660, mir-502. [score:1]
[1 to 20 of 1 sentences]
21
[+] score: 1
The rs16917496 is a C/T variation located in the 3′UTR of SET8 within the miR-502 binding site, having the C allele a perfect match in the seed region of miR-502. [score:1]
[1 to 20 of 1 sentences]