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36 publications mentioning hsa-mir-515-2

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-515-2. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 34
Upon differentiation of cytotrophoblast (CytT) to syncytiotrophoblast (SynT), there is a downregulation in expression of miR-515 family members that belong to C19MC. [score:6]
This upregulation is owing to the interaction of the proto-oncogene protein c-MYC with the E-boxes upstream of pri-miR-515-1 and pri-miR-515-2, thereby inhibiting SynT differentiation (Figure2A). [score:6]
However, expression of miR-515-5p is markedly upregulated in the placenta of PE women [71]. [score:6]
Their expression was decreased upon overexpression of miR-515-5p, thereby impairing SynT differentiation. [score:5]
This interaction increases the expression of miR-515 thus inhibiting the differentiation of cytotrophoblasts (CytT) to syncytiotrophoblast (SynT). [score:5]
miR-515-5p target genes are critical for SynT differentiation. [score:3]
This suggests that miR-515-5p plays a pivotal role in human trophoblast differentiation [71]. [score:1]
Figure 2 Functional mechanisms of some primate-specific miRNAs A. miR-515-5p resides in the C19MC. [score:1]
In preeclampsia, proto-oncogene c-MYC interacts with the E-boxes upstream of pri-miR-515. [score:1]
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2
[+] score: 25
Using qPCR, we found that miR-194 and miR-515 were highly upregulated after cytokine stimulation (Figure 5C), indicating miR-194 and -515 may take vital roles in IL-1β and TNF-α modulated CHSYs expression. [score:6]
The blue squares represent miR-194 targeted sites, while red square represents miR-515 targeted sites. [score:5]
The right panel shows the relative protein level of CHSYs, the quantification of gray scale were shown under the blot, n = 3. (A) Immunofluorescence images of CS in NP cells treated with 10 ng/ml TGF-β and miR-194 or miR-515 or scramble miRNA mimic control for 72 h. (B) Immunofluorescence images of CS in NP cells treated with 20 ng/ml IL-1β and miR-194 or miR-515 inhibitors or scramble control inhibitor for 72 h. The quantifications of relative intensity were shown in the right panel. [score:5]
Figure 7(A) Immunofluorescence images of CS in NP cells treated with 10 ng/ml TGF-β and miR-194 or miR-515 or scramble miRNA mimic control for 72 h. (B) Immunofluorescence images of CS in NP cells treated with 20 ng/ml IL-1β and miR-194 or miR-515 inhibitors or scramble control inhibitor for 72 h. The quantifications of relative intensity were shown in the right panel. [score:5]
MiR-194 and miR-515 is essential for inflammatory cytokine regulated CHSY expressions. [score:4]
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3
[+] score: 13
As a result of the specific DNA binding, miR-519d is up-regulated by p53, whereas ERα mediates both down- and up-regulated expression of miR-515-5p induced by estrogens and tamoxifen, respectively. [score:9]
Transcription factors acting in trans are essential regulators of C19MC miRNA expression as shown by direct binding of p53 and the estrogen receptor α (ERα) to presumptive promoters of C19MC miR-519d and miR-515-5p, respectively, in chromatin immunoprecipitation assays [47, 48]. [score:4]
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4
[+] score: 11
With respect to a number of studies, miR-515 and miR-136 were up-regulated in cancer tissues (Table 5). [score:4]
In In this study, the TargetScanHuman database identified13 miRNAs (miR-1200, miR-378d,e,i,c,h,b,f, miR-422a, miR-3690, miR-619, miR-4446-3p, miR-2909, miR-4777-5p, miR-136, miR-515-5p, miR-4659a,b-3p, miR-494 and miR-593) which were conserved and similar to the CD3G gene. [score:3]
Except for miR-515 and miR-136, which were only cited once (oral squamous cell [44] and lung cancer [51] respectively), which showed an increasing number of miRNAs in tumor tissues), no other literature is available regarding the number of other miRNAs predicted for targeting CD3G in tumor tissues or blood sera of cancer patients (Table 5). [score:3]
From the first group only 6 miRNAs (miR-378, miR-422a, miR-593 and miR-494, miR-515 and miR-136), from the second group one miRNA (miR-138) and from the third group only one miRNA (miR-214) were identified and studied, based on their levels in tissues or blood sera of different cancer patients. [score:1]
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5
[+] score: 9
Primate-specific miR-515 family members inhibit key genes in human trophoblast differentiation and are upregulated in preeclampsia. [score:6]
Zhang et al[6] found that miR-515 family members were related to PE through the inhibition of key genes in human trophoblast differentiation. [score:3]
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6
[+] score: 8
Interestingly, we found miR-515-5p, miR-519c-3p, miR-520d-5p, miR-548a-3p, and miR-548c-3p specifically expressed in oocytes, and according to ExoCarta, these have not been found incorporated in exosome vesicles. [score:3]
On the other hand, miR-515-5p, miR-519c-3p, miR-520d-5p miR-548a-3p, and miR-548c-3p, specifically expressed in oocyte, are not found incorporated in exosome vesicles. [score:3]
Moreover, miR-515-5p, miR-519c-3p and miR-520d-5p, members of C19MC, which is a primate-specific cluster, seem to have a role in early embryo development during maternal-zygotic transition, when zygotic transcription starts and maternal mRNAs are degraded (Donker et al., 2012; Battaglia et al., 2016). [score:2]
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7
[+] score: 8
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-19a, hsa-mir-21, hsa-mir-31, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-105-1, hsa-mir-105-2, hsa-mir-199a-1, hsa-mir-34a, hsa-mir-187, hsa-mir-199a-2, hsa-mir-205, hsa-mir-214, hsa-mir-221, hsa-let-7g, hsa-let-7i, hsa-mir-128-1, hsa-mir-141, hsa-mir-144, hsa-mir-145, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-146a, hsa-mir-200c, hsa-mir-128-2, hsa-mir-29c, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-133b, hsa-mir-429, hsa-mir-487a, hsa-mir-515-1, hsa-mir-526b, hsa-mir-514a-1, hsa-mir-514a-2, hsa-mir-514a-3, hsa-mir-376a-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-656, hsa-mir-542, hsa-mir-378d-2, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-1275, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-2114, hsa-mir-548q, hsa-mir-548s, hsa-mir-378b, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-514b, hsa-mir-378c, hsa-mir-4303, hsa-mir-4309, hsa-mir-4307, hsa-mir-4278, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-378f, hsa-mir-378g, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-378h, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-378i, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-378j, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
The p21 as tumor inhibitor had been explored; the overexpression of has-miR-515-3p rescued human mammary epithelial cells from Ras -induced senescence by prevention of Ras -induced upregulation of p21 [29]. [score:8]
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8
[+] score: 8
In a previous study that profiled miRNA expression of angiosarcoma, miR-515-3p and miR-517c were proposed as diagnostic markers by comparing miRNA expression of angiosarcoma with normal tissues adjacent to tumors and other sarcomas [8]. [score:5]
After reverse transcription polymerase chain reaction (RT-PCR) validation, it was proposed that miR-515-3p and miR-517c were tissue specific and potentially may be diagnostic markers for angiosarcoma [8], but the alteration of miRNA expression associated with angiosarcoma malignancy has not been reported. [score:3]
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9
[+] score: 7
It was showed that miR-515-5p was downregulated by estrogen treatment in ER positive BC cells to regulate the BC cell proliferation through its target SK1 [1]. [score:7]
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10
[+] score: 7
NRAS is overexpressed in lung cancer cells and can be directly downregulated by miR-515-5p [45]. [score:7]
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11
[+] score: 7
Primate-specific miR-515 family members inhibit key genes in human trophoblast differentiation and are upregulated in preeclampsia. [score:6]
Bars represent standard errors Previous studies show that miRNAs (miR-210 [24], miR-181a [25], miR-126-3p and miR-126-5p [26], miR-223 [27], miR-515 [28], and miR-519d [29]) are involved in the pathogenesis of PE. [score:1]
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12
[+] score: 7
42 members of the miR-515 family (miR-515–527) and eight members of the miR-302–367 cluster (miR-302a, miR-302a*, miR-302b, miR-302b* miR-302c, miR-302d, miR-302d* and miR-367) were only up-regulated in TGCT and not in the other two cancers, and three members of the miR-105-767 cluster (miR-105, miR-105* and miR-767-5p) were ranked as the top ten up-regulated miRNAs in TGCT. [score:7]
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13
[+] score: 6
Identification of a common consensus sequence between the regulatory miR-515 and miR-203 family members (below). [score:2]
Of these, miR-302a and miR-302d are members of the miR-302 family and miR-519e, -519b, and -517a belong to the miR-515 family. [score:1]
A closer look at sequence similarity analysis of the whole miR-515 family revealed a striking consensus sequence between related Wnt-activating miRs (Fig. S8). [score:1]
Alignment to identify a functional consensus in the miR-515 family and its overlap with modulators the miR-302 family in regarding their ability to modulate the Wnt pathway. [score:1]
Figure S8 Extraction of a consensus sequence of identified miRs within the miR-515 and miR-302 family. [score:1]
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14
[+] score: 6
miR-101 and miR-515-5p target Mcl-1, which are downregulated in gastric cancer, lead to increased levels of Mcl-1 and an anti-apoptotic phenotype (Figure 2). [score:6]
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15
[+] score: 5
Although multiple miRNAs, such as miR-122 [30], miR-18b [31], miR-515-5p [32], miR-148a and miR-152 10, 14, are involved in IGF-1 regulation pathway by directly targeting IGF-1, IGF-1R, IRS-1 or FOXO3a in breast cancer, the effects of IGF-1 induced signaling cascades on miRNA expression in breast cancer has yet to be evaluated. [score:5]
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16
[+] score: 5
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-18a, hsa-mir-22, hsa-mir-29a, hsa-mir-30a, hsa-mir-93, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, mmu-let-7g, mmu-let-7i, mmu-mir-1a-1, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-124-3, mmu-mir-126a, mmu-mir-9-2, mmu-mir-133a-1, mmu-mir-146a, mmu-mir-200b, mmu-mir-203, mmu-mir-204, mmu-mir-205, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-10a, hsa-mir-34a, hsa-mir-203a, hsa-mir-204, hsa-mir-205, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-221, hsa-mir-222, hsa-mir-200b, mmu-mir-34c, mmu-mir-34b, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-30b, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-126, hsa-mir-146a, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-148a, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-18a, mmu-mir-22, mmu-mir-29a, mmu-mir-29c, mmu-mir-93, mmu-mir-34a, hsa-mir-200c, hsa-mir-1-1, mmu-mir-1a-2, mmu-mir-10a, mmu-mir-100, mmu-mir-200c, mmu-mir-218-1, mmu-mir-218-2, mmu-mir-221, mmu-mir-222, mmu-mir-29b-2, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-9-1, mmu-mir-9-3, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-34b, hsa-mir-34c, hsa-mir-30e, hsa-mir-375, mmu-mir-375, hsa-mir-335, mmu-mir-335, mmu-mir-133a-2, hsa-mir-424, hsa-mir-193b, hsa-mir-512-1, hsa-mir-512-2, hsa-mir-515-1, hsa-mir-518f, hsa-mir-518b, hsa-mir-517a, hsa-mir-519d, hsa-mir-516b-2, hsa-mir-516b-1, hsa-mir-517c, hsa-mir-519a-1, hsa-mir-516a-1, hsa-mir-516a-2, hsa-mir-519a-2, hsa-mir-503, mmu-mir-503, hsa-mir-642a, mmu-mir-190b, mmu-mir-193b, hsa-mir-190b, mmu-mir-1b, hsa-mir-203b, mmu-let-7j, mmu-mir-30f, mmu-let-7k, mmu-mir-126b, mmu-mir-9b-2, mmu-mir-124b, mmu-mir-9b-1, mmu-mir-9b-3
Significant expression of miRNAs within this cluster (miR-512-3p, miR-512-5p, mir-515-5p, miR-516b, miR-517a, miR-517c, miR-518b, miR-518f, miR-519a and miR-519d) was observed in the MaSC/basal population (Fig.   3b), whereas no highly expressed luminal-specific primate miRNAs were identified. [score:5]
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17
[+] score: 5
Name Predicted targets (miRDB) 1 miR-200b ZEB1, ZEB2, BMI1, TWISTNB, PLEXINA4, DNMT3A, CDNK2B 2 miR-607 RUNX-1, RUNX-2, IGF-1, MSX1, SOCS4, CXCL6 3 miR-515-5p FGFR2, TGFBR2, NOTCH2, BMP8b, MSX2, FGF12, BMPR1B 4 miR-1245 FGF20, TBRG1, BMI1 5 miR-3919 NFAT5, ID4, HOXB13, HDAC1, RPS6KA6, TGFBR2, SEMA3A 6 miR-182 FGF9, SMAD1, IGF1R, SOX2, BMPR1B, WISP1/CCN4, EGR3 Table shows the selected possible mRNA targets related to stemness and cell differentiation. [score:5]
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18
[+] score: 4
This group showed that defined hES cells-enriched miRNA groups (miR-302, miR-17, miR-515 families, and the miR-371-373 cluster) were downregulated “rapidly” in response to differentiation. [score:4]
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19
[+] score: 4
Li J. Tang Z. Wang H. Wu W. Zhou F. Ke H. Lu W. Zhang S. Zhang Y. Yang S. CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5pBiomed. [score:4]
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20
[+] score: 3
Interestingly, a recent study demonstrates that expression levels of seven placenta-specific miRNAs (miR-518b, miR-1323, miR-516b, miR-515-5p, miR-520h, miR-519d, and miR-526b) were significantly reduced in placentas from IUGR pregnancies than in placentas from uncomplicated pregnancies [146]. [score:3]
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21
[+] score: 3
In addition, members of miR-515 subfamily restricted the formation of syncytium via suppressing the key genes of trophoblast syncytialization including hCYP19A1, GCM1, and FZD5 (7– 10). [score:3]
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22
[+] score: 3
Other miRNAs from this paper: hsa-mir-511, hsa-mir-515-1, hsa-mir-519e, mmu-mir-511, hsa-mir-4711
Co-transfection with miR-515-3p or miR-519e did not lead to luciferase activity reduction for either rs2734647 T or C (Fig  6B). [score:1]
Of the Renilla luciferase reporter construct (phRL-TK rs2734647C, or rs2734647T, respectively), 1 μg (per well), plus 1 μg (per well) of the reference construct pCMV-LacZ (Clontech, Mountain View, CA, USA) were co -transfected in the presence of 10 pg of mirVana miRNA mimic hsa-miR-4711-3p, hsa-miR-511, hsa-miR-515-3p, hsa-miR-519e-3p, negative control #2 (all Life Technologies, Darmstadt, Germany), or no miRNA, respectively. [score:1]
While miR-4711-3p and miR-511 are predicted to show preferential binding in case of the presence of the T-allele, miR-515-3p has a strong negative ΔΔG only in case of the C-allele, and miR-519e lacks a strong allele preference. [score:1]
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23
[+] score: 3
Our analysis shows a possible involvement of several members of the miR-515 family (such as miR-515-5p, miR-519 and miR-520a-3p/b/c-3p/d-3p/e/g/h), located at 19q13.4, in POF, since they are predicted to target FMR1 and FOXL2, two genes which are associated to POF [47], [48]. [score:3]
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24
[+] score: 2
In another study conducted in 2015 by Nagasaki University Graduate School of Biomedical Sciences in Japan, the researchers discovered that plasma concentration of cell-free pregnancy associated miRNAs—miR-323-3p, miR-515-3p, miR-517a, miR-517c, miR-518b—and the concentration of hCG have significant statistical differences in women with SA, EP and normal pregnancies (NP). [score:1]
Moreover, there was no significant statistical difference of cell-free serum concentration of miR-21 between three groups and they reported no relationship between serum levels of hCG and plasma cell free of miR-323-3p, miR-515-3p, miR-517a, miR-517c, miR-518b, and miR-21. [score:1]
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25
[+] score: 2
Other miRNAs from this paper: hsa-mir-200b, hsa-mir-301a, hsa-mir-515-1, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, mml-mir-301a, mml-mir-548a, mml-mir-548b, mml-mir-548c, mml-mir-548d, mml-mir-548e, mml-mir-548f, ptr-mir-301a, ptr-mir-515-1, ptr-mir-515-2, ptr-mir-548a-1, ptr-mir-548a-2, ptr-mir-548b, ptr-mir-548c, ptr-mir-548f-1, ptr-mir-548f-2, ptr-mir-548h, ptr-mir-548i-1, ptr-mir-548i-2, ptr-mir-548i-3, ptr-mir-548i-4, ptr-mir-548i-5, ptr-mir-548j, ptr-mir-548k, ptr-mir-548l, ptr-mir-548n, ptr-mir-548p, hsa-mir-2115, hsa-mir-548q, hsa-mir-2681, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-3065, hsa-mir-548x, ppy-mir-515-1, ppy-mir-515-2, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-4511, hsa-mir-548am, hsa-mir-548an, hsa-mir-4691, hsa-mir-203b, hsa-mir-4760, hsa-mir-4762, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, ptr-mir-548o, ptr-mir-548e, ggo-mir-548b, ggo-mir-203b, ggo-mir-548c, ggo-mir-548e, ggo-mir-548a, ggo-mir-548d, ggo-mir-548f, ggo-mir-200b, ppy-mir-548e, ppy-mir-548a, ppy-mir-548h, ppy-mir-548f, ppy-mir-548c, hsa-mir-548ay, hsa-mir-548az, mml-mir-548g, mml-mir-548h, mml-mir-548i, mml-mir-548j, hsa-mir-548ba, hsa-mir-548bb, ggo-mir-515-1, ggo-mir-515-2, ppy-mir-515-3, hsa-mir-548bc, ggo-mir-301a, ppy-mir-301a
The miR-515 family with 28 pre-miRNA members is the biggest miRNA family that was annotated by the Infernal tool in the marmoset genome (Table S2). [score:1]
In the human genome, the largest miRNA family in the current miRBase is the miR-548 family with 69 pre-miRNA members; the second largest is the miR-515 family with 42 members. [score:1]
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26
[+] score: 1
These include microRNA (miR)-92b, miR-302 cluster, miR-200c, miR-368, and miR-154* clusters, miR-371, miR372, miR-373*, miR-373, and the miR-515 cluster [21, 22]. [score:1]
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27
[+] score: 1
Besides these 9 miRNAs, we also identified 12 more miRNAs in this cluster; they were miR-515-5p, miR-517a, miR-517b, miR-517c, miR-519e, miR-520b, miR-520d, miR-520f, miR-520h, miR-521, miR-525-3p, and miR-526b*. [score:1]
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28
[+] score: 1
A. The miRNA gene family mir-515 (26 members; 172 common ss-motifs). [score:1]
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29
[+] score: 1
Seed sequence examination indicated no similarities to the known seed sequences of pluripotency-specific miRNAs such as AAGUGC in miR-302b-3p, miR-373, miR-520e, miR-519c-3p, miR-520a-3p, and miR-520b; AGUGCC in miR-515-3p and miR-519e; and AAGUG in miR-519d. [score:1]
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30
[+] score: 1
This cluster includes the family miR-515 but also miR-373 and miR-290. [score:1]
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31
[+] score: 1
These include miR-145-5p [20, 21], miR-141-3p [21, 22], miR-27b-3p [21, 81], miR-106b-5p, miR-93-5p [21] miR-148a-3p, miR-193a-3p [22, 81], miR-135a-5p, miR-374b-5p, miR-29c-3p, miR-365a-3p [22], let-7a-5p, miR-515-3p [24], and miR-34c-3p [81]. [score:1]
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32
[+] score: 1
Other miRNAs from this paper: hsa-mir-17, hsa-mir-19a, hsa-mir-29a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-198, hsa-mir-208a, hsa-mir-10a, hsa-mir-223, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-150, hsa-mir-155, hsa-mir-29c, hsa-mir-99b, hsa-mir-296, hsa-mir-196b, hsa-mir-515-1, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-550a-1, hsa-mir-550a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-640, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-550a-3, bta-mir-29a, bta-mir-125b-1, bta-mir-126, bta-mir-10a, bta-mir-124a-1, bta-mir-17, bta-mir-29b-2, bta-mir-29c, bta-mir-150, bta-mir-122, bta-mir-125b-2, bta-mir-19a, bta-mir-99b, hsa-mir-208b, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, bta-mir-124a-2, bta-mir-124b, bta-mir-146a, bta-mir-155, bta-mir-196b, bta-mir-208a, bta-mir-208b, bta-mir-223, bta-mir-296, bta-mir-29d, bta-mir-9-1, bta-mir-9-2, bta-mir-29e, bta-mir-29b-1, hsa-mir-548q, bta-mir-2284i, bta-mir-2285a, bta-mir-2284s, bta-mir-2285d, bta-mir-2284l, bta-mir-2284j, bta-mir-2284t, bta-mir-2285b-1, bta-mir-2284d, bta-mir-2284n, bta-mir-2284g, bta-mir-2284p, bta-mir-2284u, bta-mir-2284f, bta-mir-2284a, bta-mir-2284k, bta-mir-2284c, bta-mir-2284v, bta-mir-2285c, bta-mir-2284q, bta-mir-2284m, bta-mir-2284b, bta-mir-2284r, bta-mir-2284h, bta-mir-2284o, bta-mir-2284e, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, bta-mir-2284w, bta-mir-2284x, hsa-mir-548y, hsa-mir-550b-1, hsa-mir-550b-2, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, bta-mir-2284y-1, bta-mir-2285e-1, bta-mir-2285e-2, bta-mir-2285f-1, bta-mir-2285f-2, bta-mir-2285g-1, bta-mir-2285h, bta-mir-2285i, bta-mir-2285j-1, bta-mir-2285j-2, bta-mir-2285k-1, bta-mir-2285l, hsa-mir-548ay, hsa-mir-548az, bta-mir-2285o-1, bta-mir-2285o-2, bta-mir-2285n-1, bta-mir-2285n-2, bta-mir-2285p, bta-mir-2285m-1, bta-mir-2285m-2, bta-mir-2284y-2, bta-mir-2285n-3, bta-mir-2285n-4, bta-mir-2284y-3, bta-mir-2285o-3, bta-mir-2285o-4, bta-mir-2285m-3, bta-mir-2284y-4, bta-mir-2284y-5, bta-mir-2284y-6, bta-mir-2285m-4, bta-mir-2285o-5, bta-mir-2285m-5, bta-mir-2285n-5, bta-mir-2285n-6, bta-mir-2284y-7, bta-mir-2285n-7, bta-mir-2284z-1, bta-mir-2284aa-1, bta-mir-2285k-2, bta-mir-2284z-3, bta-mir-2284aa-2, bta-mir-2284aa-3, bta-mir-2285k-3, bta-mir-2285k-4, bta-mir-2284z-4, bta-mir-2285k-5, bta-mir-2284z-5, bta-mir-2284z-6, bta-mir-2284z-7, bta-mir-2284aa-4, bta-mir-2285q, bta-mir-2285r, bta-mir-2285s, bta-mir-2285t, bta-mir-2285b-2, bta-mir-2285v, bta-mir-2284z-2, bta-mir-2285g-2, bta-mir-2285g-3, bta-mir-2285af-1, bta-mir-2285af-2, bta-mir-2285y, bta-mir-2285w, bta-mir-2285x, bta-mir-2285z, bta-mir-2285u, bta-mir-2285aa, bta-mir-2285ab, bta-mir-2284ab, bta-mir-2285ac, bta-mir-2285ad, bta-mir-2284ac, bta-mir-2285ae, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc, bta-mir-2285ag, bta-mir-2285ah, bta-mir-2285ai, bta-mir-2285aj, bta-mir-2285ak, bta-mir-2285al, bta-mir-2285am, bta-mir-2285ar, bta-mir-2285as-1, bta-mir-2285as-2, bta-mir-2285as-3, bta-mir-2285at-1, bta-mir-2285at-2, bta-mir-2285at-3, bta-mir-2285at-4, bta-mir-2285au, bta-mir-2285av, bta-mir-2285aw, bta-mir-2285ax-1, bta-mir-2285ax-2, bta-mir-2285ax-3, bta-mir-2285ay, bta-mir-2285az, bta-mir-2285an, bta-mir-2285ao-1, bta-mir-2285ao-2, bta-mir-2285ap, bta-mir-2285ao-3, bta-mir-2285aq-1, bta-mir-2285aq-2, bta-mir-2285ba-1, bta-mir-2285ba-2, bta-mir-2285bb, bta-mir-2285bc, bta-mir-2285bd, bta-mir-2285be, bta-mir-2285bf-1, bta-mir-2285bf-2, bta-mir-2285bf-3, bta-mir-2285bg, bta-mir-2285bh, bta-mir-2285bi-1, bta-mir-2285bi-2, bta-mir-2285bj-1, bta-mir-2285bj-2, bta-mir-2285bk, bta-mir-2285bl, bta-mir-2285bm, bta-mir-2285bn, bta-mir-2285bo, bta-mir-2285bp, bta-mir-2285bq, bta-mir-2285br, bta-mir-2285bs, bta-mir-2285bt, bta-mir-2285bu-1, bta-mir-2285bu-2, bta-mir-2285bv, bta-mir-2285bw, bta-mir-2285bx, bta-mir-2285by, bta-mir-2285bz, bta-mir-2285ca, bta-mir-2285cb, bta-mir-2285cc, bta-mir-2285cd, bta-mir-2285ce, bta-mir-2285cf, bta-mir-2285cg, bta-mir-2285ch, bta-mir-2285ci, bta-mir-2285cj, bta-mir-2285ck, bta-mir-2285cl, bta-mir-2285cm, bta-mir-2285cn, bta-mir-2285co, bta-mir-2285cp, bta-mir-2285cq, bta-mir-2285cr-1, bta-mir-2285cr-2, bta-mir-2285cs, bta-mir-2285ct, bta-mir-2285cu, bta-mir-2285cv-1, bta-mir-2285cv-2, bta-mir-2285cw-1, bta-mir-2285cw-2, bta-mir-2285cx, bta-mir-2285cy, bta-mir-2285cz, bta-mir-2285da, bta-mir-2285db, bta-mir-2285dc, bta-mir-2285dd, bta-mir-2285de, bta-mir-2285df, bta-mir-2285dg, bta-mir-2285dh, bta-mir-2285di, bta-mir-2285dj, bta-mir-2285dk, bta-mir-2285dl-1, bta-mir-2285dl-2, bta-mir-2285dm
These include the majority of miRNAs numbered from miR-550 to miR-640; some 200 miRNAs, which include the hsa-miR-515 cluster (11 miRNAs), and interestingly, the miR-548 family. [score:1]
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33
[+] score: 1
Also C19MC cluster was represented by 20 moRNAs, which all derived from miR-515 family of hairpins. [score:1]
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34
[+] score: 1
-25.00 ERB B3 254 hsa-miR-515-3p. [score:1]
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35
[+] score: 1
qPCR (e) and representative denaturing PAGE (12%) of the amplified products (f) of miR-302c, miR-367, miR-498, miR-515, miR-519e, miR-19b, miR-92a, miR-24-2, miR-126-3p, miR-126-5p, and miR-887. [score:1]
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[+] score: 1
001 miR-493 92.40058 <0.001 miR-515-3p 97.85771 <0.001ER = estrogen receptor. [score:1]
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