sort by

52 publications mentioning hsa-mir-376b

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-376b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 36
Among them, 5 (namely miR-203a-3p miR-4510, miR-548aa, miR-376b-3p and miR-548v) inhibited GPC3 expression in HCC cells and acted as tumor suppressors in liver by inhibiting HCC cell growth and proliferation. [score:9]
While miR-548aa downregulation in HCC was associated with the presence of satellite nodules, miR-376b-3p downregulation was associated with tumors harboring p53 mutations (Supplementary Table 3). [score:8]
Figure 3Five GPC3 -regulating miRNAs are downregulated in HCC (A) The relative expression of miR-4510, miR-203a-3p, miR-548aa, miR-376b-3p and miR-548v was measured by real-time quantitative RT-PCR in 19 NTL and 98 HCC. [score:5]
Altogether, our data showed that the five GPC3 -regulating miRNAs miR-4510, miR-203a-3p, miR-548aa, miR-376b-3p and miR-548v are significantly downregulated in HCC compared to NTL. [score:4]
Altogether these results demonstrate that miR-4510, miR-203a-3p, miR-548aa, miR-376b-3p and miR-548v are potent inhibitors of HCC cell proliferation. [score:3]
No inverse correlation was observed when we compared expression of other miRNAs (miR-203a-3p, miR-548aa, miR-376b-3p and miR-548v) and the amount of GPC3 mRNA or protein in patient samples (Supplementary Figure 6A-6B). [score:2]
The regulatory effect of miR-4510, miR-4460, miR-135b-3p, miR-4635, miR-4252, miR-376b-3p, miR-140-5p and miR-548aa on membrane GPC3 levels was confirmed (Figure 2B). [score:2]
Instead, miR-4510, miR-203a-3p, miR-548aa, miR-376b-3p and miR-548v were significantly decreased in HCC (Figure 3A-3B). [score:1]
MiR-4510, miR-203a-3p, miR-548aa, miR-376b-3p and miR-548v exert an antitumor effect on HCC cells. [score:1]
Therefore, miR-4510, miR-548aa, miR-376b-3p and miR-548v are new actors in liver cancer. [score:1]
[1 to 20 of 10 sentences]
2
[+] score: 29
Upregulation of TGFA expression in osteosarcoma tissues and cells and its correlation with MIR376A and MALAT1 TGFA is a direct target of MIR376C, one of the MIR376 family members that regulate OS cell growth [18]. [score:10]
Inverse correlation of MIR376A and MALAT1 expression in osteosarcoma tissues and direct interaction between MIR376A and the 3′UTR of MALAT1 in vitroAccording to previous studies, MIR376 family members play a suppressive role in OS [18, 19]. [score:6]
TGFA is a direct target of MIR376C, one of the MIR376 family members that regulate OS cell growth [18]. [score:5]
It has been reported that TGFA regulates OS cell growth as a direct target of MIR376C, one of the MIR376 family members [18]. [score:5]
According to previous studies, MIR376 family members play a suppressive role in OS [18, 19]. [score:3]
[1 to 20 of 5 sentences]
3
[+] score: 15
Either the miR-675 and miR-376 binding sites were targets for unidentified ancient microRNAs, perhaps still present in Pelodiscus and Callorhinchus, or the more recent imprinted microRNAs evolved to target sequences that were conserved for functions unrelated to binding by microRNAs. [score:5]
If the latter scenario is correct, then the VCR is likely to have been an original target of miR-675 and miR-376 which evolved to target its sequence. [score:5]
It is notable that miR-675 and miR-376 are both imprinted and maternally expressed [12, 27]. [score:3]
The miR-376 binding site occurs distal to the end of the short transcript. [score:1]
By contrast, miR-675 is known only from marsupial and eutherian mammals [35, 36] and miR-376 only from eutherian mammals [27]. [score:1]
[1 to 20 of 5 sentences]
4
[+] score: 13
Importantly, in the case of mir-376a-5p, mir-376b-5p, mir-376a-3p and mir-376-3p the edited nucleoside resides in the seed region, which is instrumental in targeting the miRNA to its target and could therefore lead to an altered target spectrum. [score:7]
In addition to known editing targets, such as mir-376b, we also identified the brain-specific mir-377 that was hitherto unknown to be edited. [score:3]
The most abundantly edited miRNA is mir-376b, in the brain (Figure 2B), fitting with the observation that in murine and human brains, mir-376a/b/c are targets of the RNA editing machinery [51, 52]. [score:3]
[1 to 20 of 3 sentences]
5
[+] score: 12
Other miRNAs from this paper: hsa-mir-101-1, hsa-mir-34a, hsa-mir-101-2
However, studies have shown that ATG4 can be regulated by miR-34a that specifically targets ATG4B, [11] miR-376b that target intracellular levels of ATG4C, [12] and the tumor suppressor miR-101 that inhibits autophagy by targeting ATG4D. [score:12]
[1 to 20 of 1 sentences]
6
[+] score: 10
Other miRNAs from this paper: hsa-mir-376c, hsa-mir-376a-1, hsa-mir-376a-2
Thus, PRPS1 expression plays a role in fetal inner ear development, and mutations to the PRPS1 gene or to miRNA-376 may result in abnormal organ development. [score:6]
The transcript levels of PRPS1 are regulated by mir-376. [score:2]
PRPS1, transcriptionally regulated by microRNA-376 [5], codes for PRS-I, which catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) from adenosine triphosphate (ATP) and ribose-5-phophate (R5P) [4, 6]. [score:2]
[1 to 20 of 3 sentences]
7
[+] score: 10
0014416.g004 Figure 4 (A) of stably expressing miR-376a, miR376abc (a polycistronic cluster of miR-376a, miR-376b and miR-376c), miR-299-5p or miR -negative and 10-87 LP cells; (B) with stably expressing miR-376a, miR-376abc, miR-299-5p or miR -negative 10-87 HP cells. [score:5]
Indeed, the overexpression of miR-376a and the polycistronic cluster of miR-376a, miR-376b and miR-376c in non-invasive 10-87 LP cells were able to recapitulate the migration and invasion phenotypes of 10-87 HP cells. [score:3]
An expression plasmid for the polycistronic gene cluster for miR-376a, miR-376b and miR-376c was generated by amplifying 200 bp up-stream and 200 bp down-stream of the genes (termed as miR-376abc) in VERO cell DNA using primers 5′-CCCTCGACGAGAGTGATGGAAGGTGAATC-3′ and 5′-CCAGATCTATACTGAGAACACAGCCTTGT-3′. [score:2]
[1 to 20 of 3 sentences]
8
[+] score: 10
miR-374 was also downregulated in older participants in an earlier study [18], but in contrast with our study, miR-376 was upregulated in older participants in another report [20]. [score:7]
Interestingly, none of the six miRNAs has previously been shown to play a mechanistic role in aging, and none has been implicated in heart disease, but many have been shown to function and/or act as biomarkers in different cancers (miR-211: melanoma cell invasive-ness; head, neck, renal cell carcinomas; pancreatic cancer; miR-374: small cell lung cancer; miR-340: osteosarcoma, colorectal cancer, breast cancer, gastric cancer; miR-376: glioblastoma, hepato-cellular carcino-ma) [24]. [score:3]
[1 to 20 of 2 sentences]
9
[+] score: 7
Recent studies indicate that during human pancreatic development miR-7, miR-9, miR-375 and miR-376 are specific islet microRNAs expressed at high levels [18, 19]. [score:4]
Please note that even though in some cases the group III colorgram suggests a change of expression throughout the gestational stages (e. g miR-376, miR-378, etc), these were found to be not statistically significant. [score:3]
[1 to 20 of 2 sentences]
10
[+] score: 7
These included predicted binding of spliced genes to three forms of hsa-miR-376 (a–c forms), hsa-mir-544 targeted at the same spliced gene (ITGAL) and the inflammation-related hsa-mir-150 [87] predicted to target the disease spliced gene FGD4. [score:7]
[1 to 20 of 1 sentences]
11
[+] score: 7
Kawahara and colleagues demonstrated that A-to-I editing of pri-miR-376 results in the redirection of its silencing effects to a different set of target mRNAs. [score:4]
The miR-376 is edited by ADAR2 within its “seed” sequence (+4 site), an essential region for RNA duplex formation with the complementary target mRNA [95]. [score:3]
[1 to 20 of 2 sentences]
12
[+] score: 7
As a result, we selected 11 miRNAs (miR-27a, miR-27b, miR-145, miR-185, miR-197, miR-203, miR-221, miR-222, miR-338-3p, miR-376a, and miR-376b) that were potentially regulated by CD82 to target FZD2, -3, -5, -7, and -9 for further study (Table 1). [score:4]
No significant differences in miR-27a, miR-27b, miR-145, miR-185, miR-197, miR-221, miR-222, miR-376a, or miR-376b expression levels were observed between h1299/zeo and h1299/CD82 cells (Fig 1). [score:3]
[1 to 20 of 2 sentences]
13
[+] score: 7
The miRNA signatures generated for ER status (miR-342, miR-299, miR-217, miR-190, miR-135b, miR-218), for PR status (miR-520g, miR-377, miR-527-518a, miR-520f-520c) and for HER2/ neu status (miR-520d, miR-181c, miR-302c, miR-376b, miR-30e) include miRNAs that have previously been identified as dysregulated in breast cancer and other cancers [7, 9, 37- 43] and involved in the regulation of cell functions such as growth, apoptosis, migration and invasion [38, 42, 43]. [score:3]
Notably, two chromosomal locations account for a number of the dysregulated miRNAs in these predictive sets: Ch19q13 (miR-520g, miR-520d, miR-527-528a, miR-520f-520c, miR-181c) and Ch14q32 (miR-342, miR-299, miR-377, miR-376b). [score:2]
Stepwise ANN analysis identified predictive miRNA signatures corresponding with oestrogen (miR-342, miR-299, miR-217, miR-190, miR-135b, miR-218), progesterone (miR-520g, miR-377, miR-527-518a, miR-520f-520c) and HER2/ neu (miR-520d, miR-181c, miR-302c, miR-376b, miR-30e) receptor status. [score:1]
Similarly, four miRNA transcripts (miR-520g, miR-377, miR-527-518a, miR-520f-520c) were identified that predicted tumour PR status with 100% accuracy, and HER2/ neu status was predicted with 100% accuracy by a signature of five miRNAs (miR-520d, miR-181c, miR-302c, miR-376b, miR-30e) (Table 3). [score:1]
[1 to 20 of 4 sentences]
14
[+] score: 6
Biological support to this mode was given by Nachmani et al. [14] showing that hcmv-miR-UL112-1 and hsa-miR-376, which have distinct target sites on MICB mRNA, cooperate within infected cells to down-regulate MICB. [score:6]
[1 to 20 of 1 sentences]
15
[+] score: 6
The canonical version of miR-376 and its seed-altered isomiR were shown to have highly distinct target sets [29], highlighting the biological importance of 5′-isomiRs. [score:3]
Perhaps the best-studied example of this phenomenon is the A-to-I editing of the miR-376 primary transcript leading to the expression of a 5′-isomiR of miR-376 with a modified seed [29]. [score:3]
[1 to 20 of 2 sentences]
16
[+] score: 6
Future experiment will be launched to clarify whether ATM regulates ATG4C expression through p53 or via the modulation of miR-376b. [score:4]
Some observations indicated that ATG4C could be transcriptionally regulated by p53 upon DNA damage activation, and that ATG4C mRNA is modulated by miR-376b upon starvation and rapamycin -induced autophagy [33, 34]. [score:2]
[1 to 20 of 2 sentences]
17
[+] score: 6
When applying a cut-off P-value of <0.05, twenty miRNAs showed a significant down-regulation, of up to four fold, with the exception of miR-376b whose expression seemed to be strongly induced (2.6 fold) by Aβ treatment (Fig 1C). [score:6]
[1 to 20 of 1 sentences]
18
[+] score: 6
Among the most upregulated, miR-376b has been shown to be differentially expressed in pediatric hBM-MSCs when comparing to adult hBM-MSCs [85]; miR-200a has been associated with the oxidative stress [87] and shown to be activated in stress -induced senescent cells [88]. [score:6]
[1 to 20 of 1 sentences]
19
[+] score: 5
miRNA Expressionp-value Expression fold change (log2) Survivalp-value hsa-miR-136 7.52E-14 −1.69 NS hsa-miR-145 5.88E-04 −1.04 0.005 hsa-miR-155 1.18E-21 1.94 NS hsa-miR-181b 5.44E-02 −0.22 NS hsa-miR-342 4.35E-10 −1.25 NS hsa-miR-129 1.29E-16 −3.39 NS hsa-miR-376a 4.35E-07 −0.63 NS hsa-miR-376b 7.37E-02 0.07 NS Survival p-value was calculated from miRNA expression data with Kaplan-Meier analysis. [score:5]
[1 to 20 of 1 sentences]
20
[+] score: 5
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. [score:5]
[1 to 20 of 1 sentences]
21
[+] score: 4
A recent study has reported tissue-specific editing of miR-376 cluster members and the expression of edited mature miR-376 RNAs in certain tissues [20]. [score:3]
First, in miR-376c and miR-376a, members of miR-376 cluster, specific adenosine (A) residues in the seed sequence (+6 site) were detected as guanosine (G) in the sequencing chromatogram, which suggests adenosine to inosine (I) editing [20]. [score:1]
[1 to 20 of 2 sentences]
22
[+] score: 4
In addition, 17 miRNAs (miR-136, miR-143, miR-148a, miR-15b, miR-18a, miR-181a, miR-181a*, miR-20b, miR-27b, miR-29b, miR-30d, miR-30e*, miR-301a, miR-376a, miR-376b, miR-410 and miR-7), which are differentially expressed in our retinal induction treatment, are involved in the regulation of developing mouse retina 25. [score:4]
[1 to 20 of 1 sentences]
23
[+] score: 4
According to the study conducted by Mo and colleagues, human ESCs with low MEG3 expression level (designated as MEG3-OFF) also showed significantly low expressions of DLK1-DIO3 locus-derived noncoding RNAs, including MEG8, miR-127, miR-376, miR-494, miR-495, miR-496, and miR-154, compared to its counterpart MEG3-ON [68]. [score:4]
[1 to 20 of 1 sentences]
24
[+] score: 3
It should be noted that the differential expression between grades I and II observed in deep sequencing in a few miRNAs (miR-21, miR-34a, miR-376, miR-451 and miR-99a) were not verified in RT-qPCR (Table 2 and Table 3). [score:3]
[1 to 20 of 1 sentences]
25
[+] score: 3
In this follow up study, we selected nine miRNA candidates (miR-125-3p, miR-320c, miR-320d, miR-9-1, miR-139, miR-125a-5p, miR-4792, miR-376, miR-543, miRNA-381) for validation in the independently recruited patients with early-stage (I, II) colon cancer. [score:1]
MiR-9-1, miR-125a-3p, miR-125a-5p, miR-320c, miR-320d, miR-4792, miR-376, miR-139, miR-543, and miR-381(MS00010752, MS00008554, MS00003423, MS00041867, MS00031710, MS00045087, MS00007392, MS00003493, MS00010080, MS00004116, QIAGEN, Valencia, CA) were selected for downstream validation. [score:1]
In this study, we selected miR-9-1, miR-125a-3p, miR-125a-5p, miR-320c, miR-4792, miR-376, miR-543, and miR-381 as diagnostic candidates for validation. [score:1]
[1 to 20 of 3 sentences]
26
[+] score: 3
Not all miRNA editing events are ancient: we found six cases of miRNA editing (miR-376a-1, miR-376b, miR-376c, miR-379, miR-381 and miR-411) that were limited to placental mammals and that therefore represent evolutionary novelties (Figure  1). [score:1]
Consistent with this, miR-376b, miR-381 and miR-411 are thought to be edited primarily by ADAR [12, 13]. [score:1]
Editing of miR-376b, miR-376c, miR-379, miR-381, miR-411 and miR-497 was significantly correlated with age in both species, demonstrating that the age-related increase of editing frequencies at specific sites is conserved between species (Figure  4B). [score:1]
[1 to 20 of 3 sentences]
27
[+] score: 3
Within hsa-mir-136, hsa-mir-423, hsa-mir-376b and hsa-mir-1307, their 5p arm miRNAs have higher expression level in the normal tissue; while their 3p arm miRNAs dominated in the tumor tissue. [score:3]
[1 to 20 of 1 sentences]
28
[+] score: 3
Nonetheless, the inhibition of IGF1R by mir-376a and mir-376 has not been described before. [score:3]
[1 to 20 of 1 sentences]
29
[+] score: 3
However, in rare cases, such as mir-376, RNA editing causes base substitution in the seed sequence and generates edited mature miRNAs with unique target genes and functions different from those of the unedited miRNAs (Kawahara et al., 2007). [score:3]
[1 to 20 of 1 sentences]
30
[+] score: 3
The most likely candidate miRNAs targeting the CFTR 3’UTR which overlapped in at least three prediction programs resulted miR-101, miR-144, miR-199-3p, miR-345, miR-376b, miR-377, miR-380, miR-494, miR-509-3p, miR-600 and miR-645. [score:3]
[1 to 20 of 1 sentences]
31
[+] score: 3
Among the top 50 prediction list, 47 miRNAs were verified by HMDD, dbDEMC, and miR2Disease; and only hsa-mir-151, hsa-mir-372, and hsa-mir-376b were not confirmed. [score:3]
[1 to 20 of 1 sentences]
32
[+] score: 3
[37] For example, ULK1 (unc-51 like autophagy activating kinase 1) is targeted by MIR20A and MIR106; [85] BECN1/beclin 1 by MIR30A, MIR376B and MIR519A; [86-89] RAB5A (RAB5A, member RAS oncogene family) by MIR101 and MIR630; [89,90] RB1CC1/FIP200 (RB1 inducible coiled-coil 1) by MIR224; [91] and ATGs by MIR30A, MIR181A, MIR374A, MIR630, MIR376B, MIR204, MIR224, MIR375, MIR519A, MIR885, and MIR-101. [score:3]
[1 to 20 of 1 sentences]
33
[+] score: 3
For example, miR-144, miR-937, miR-376, miR-519, and miR-548A-3P are shown to regulate a number of mRNAs, and HCK, NFKBIE, IL6, SHMT2, and MCM4 are regulated by several miRNAs. [score:3]
[1 to 20 of 1 sentences]
34
[+] score: 3
Notably, microRNAs hsa-miR-127-5p, hsa-miR-370 and hsa-miR-376 had been shown to be highly and specifically expressed in islets of developing and adult human pancreas [53, 54]. [score:3]
[1 to 20 of 1 sentences]
35
[+] score: 2
Interestingly, these two miRNAs (in addition to miR-376b) were also identified as being more highly expressed in chondrocytes from murine neonatal hind limb cartilage when compared to osteoblasts [24]. [score:2]
[1 to 20 of 1 sentences]
36
[+] score: 2
A few miRNAs, like miR-30a, miR-101, miR-376b, miR-130a, miR-375, miR-502, have been identified as the regulators of autophagy [6- 9]. [score:2]
[1 to 20 of 1 sentences]
37
[+] score: 2
In addition, a number of other miRNAs, including miR-30d, let-7e, miR-21, miR-9, and miR-376, are also implicated in human pancreatic islet differentiation and development [25, 26, 27]. [score:2]
[1 to 20 of 1 sentences]
38
[+] score: 2
From the remaining deregulated miRNAs, the most significant were hsa-miR-23/27 cluster and hsa-let-7, hsa-miR-30, and hsa-miR-376 families. [score:2]
[1 to 20 of 1 sentences]
39
[+] score: 2
A similar situation can be found in the human cluster {hsa-mir-368, HP-37, HN-7, hsa-mir-376a} which corresponds to the mouse {mmu-mir-376a, mmu-mir-376b, MP-38}. [score:1]
The fine-grained structure of these loci has some species-specific aspects, as illustrated by Figures 2 and 3. The figures show all the validated miRNAs in these regions, including those with suboptimal prediction scores from the Additional files 7, 8, and 9. We find that some miRNAs that are related in sequence, and have presumably arisen by duplication (such as the mir-368/mir-376-related sequences) have different numbers of copies in rodents and human. [score:1]
[1 to 20 of 2 sentences]
40
[+] score: 2
Kawahara et al. showed that miR-376 transcripts were subject to RNA editing, converting adenosine to inosine in a tissue -dependent manner, leading to a change in the silenced gene set [36]. [score:1]
MiR-376c belongs to the miR-376 cluster gene family, containing miR-376a, miR-376a*, and miR-376b. [score:1]
[1 to 20 of 2 sentences]
41
[+] score: 2
In prostate cancer cells, miR-376 was shown to be involved in regulation of proliferation, apoptosis, migration and cell invasion [43]. [score:2]
[1 to 20 of 1 sentences]
42
[+] score: 2
Congruent with previous studies, A to G changes occurred in >60% of the reads for members of the miR-376 family (miR-376a, b, and c) at nucleotide position six of the mature miRNA sequence (Table 1, Fig. S3A) [36]. [score:1]
Furthermore, several of these miRNA variants (miR-376 family members, miR-411, miR-379, and miR-320a) have previously been described in deep sequencing studies performed on human brain [36], [37], and therefore, are not specific to glioblastoma. [score:1]
[1 to 20 of 2 sentences]
43
[+] score: 2
Network 3 functions in cellular growth and proliferation, endocrine system development and function, and protein synthesis, and includes the following gene products: Akt, ANGPTL1, CDKN1B, Ctla2a, DNAJB7, DUT, Dut, ERK, ERK1/2, GAST, GCNT2, HNRPDL, HRSP12, HSPE1, IFNG, IL12, IL12/23R, IL12B, INSRR, Insulin, KHSRP, KLRB1, Mcpt8, MIF, miR-376a/miR-376b/miR-376b-3p, NUTF2, Pkc(s), POMP, PPARA, SLC38A3, SLC5A2, SUMO4, TLR3/4, and VTCN1. [score:2]
[1 to 20 of 1 sentences]
44
[+] score: 1
For the two other novel bat miRNAs within this cluster (pal-can-411 and pal-can-252), the mature sequences produced non-identical BLAST hits to miR-376 and miR-377, respectively, however the star sequences were 100% identical to miR-376 and miR-377 star sequences, respectively. [score:1]
[1 to 20 of 1 sentences]
45
[+] score: 1
For example, the sequences with the highest overlap of 26.2%/48.8% (hsa-miR-376a and hsa-miR-376b) differ in only two bases (one in length and one base substitution). [score:1]
[1 to 20 of 1 sentences]
46
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-21, hsa-mir-29a, hsa-mir-96, mmu-let-7g, mmu-let-7i, mmu-mir-124-3, mmu-mir-140, mmu-mir-181a-2, mmu-mir-182, mmu-mir-183, mmu-mir-194-1, mmu-mir-200b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-183, hsa-mir-181a-1, hsa-mir-200b, mmu-mir-34c, mmu-mir-34b, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-140, hsa-mir-194-1, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-21a, mmu-mir-29a, mmu-mir-96, mmu-mir-34a, mmu-mir-135b, hsa-mir-200c, hsa-mir-181b-2, mmu-mir-17, mmu-mir-200c, mmu-mir-181a-1, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-181b-1, mmu-mir-181c, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-376c, hsa-mir-376a-1, mmu-mir-376a, hsa-mir-135b, mmu-mir-181b-2, mmu-mir-376b, dre-mir-34a, dre-mir-181b-1, dre-mir-181b-2, dre-mir-182, dre-mir-183, dre-mir-181a-1, dre-let-7a-1, dre-let-7a-2, dre-let-7a-3, dre-let-7a-4, dre-let-7a-5, dre-let-7a-6, dre-let-7b, dre-let-7c-1, dre-let-7c-2, dre-let-7d-1, dre-let-7d-2, dre-let-7e, dre-let-7f, dre-let-7g-1, dre-let-7g-2, dre-let-7h, dre-let-7i, dre-mir-15a-1, dre-mir-15a-2, dre-mir-17a-1, dre-mir-17a-2, dre-mir-21-1, dre-mir-21-2, dre-mir-29a, dre-mir-96, dre-mir-124-1, dre-mir-124-2, dre-mir-124-3, dre-mir-124-4, dre-mir-124-5, dre-mir-124-6, dre-mir-140, dre-mir-181c, dre-mir-194a, dre-mir-194b, dre-mir-200b, dre-mir-200c, hsa-mir-181d, hsa-mir-507, dre-let-7j, dre-mir-135b, dre-mir-181a-2, hsa-mir-376a-2, mmu-mir-376c, dre-mir-34b, dre-mir-34c, mmu-mir-181d, mmu-mir-21b, mmu-let-7j, mmu-mir-21c, mmu-let-7k, dre-mir-181a-4, dre-mir-181a-3, dre-mir-181a-5, dre-mir-181b-3, dre-mir-181d, mmu-mir-124b
Analysis of miR-376 RNA cluster members in the mouse inner ear. [score:1]
[1 to 20 of 1 sentences]
47
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-20a, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-29a, hsa-mir-30a, hsa-mir-93, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-107, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-15b, mmu-mir-23b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-101a, mmu-mir-124-3, mmu-mir-125a, mmu-mir-130a, mmu-mir-9-2, mmu-mir-135a-1, mmu-mir-136, mmu-mir-138-2, mmu-mir-140, mmu-mir-144, mmu-mir-145a, mmu-mir-146a, mmu-mir-149, mmu-mir-152, mmu-mir-10b, mmu-mir-181a-2, mmu-mir-182, mmu-mir-183, mmu-mir-185, mmu-mir-24-1, mmu-mir-191, mmu-mir-193a, mmu-mir-195a, mmu-mir-200b, mmu-mir-204, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-183, hsa-mir-204, hsa-mir-181a-1, hsa-mir-221, hsa-mir-222, hsa-mir-200b, mmu-mir-301a, mmu-mir-34c, mmu-mir-34b, mmu-let-7d, mmu-mir-130b, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-30b, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-130a, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-138-2, hsa-mir-140, hsa-mir-144, hsa-mir-145, hsa-mir-152, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-136, hsa-mir-138-1, hsa-mir-146a, hsa-mir-149, hsa-mir-185, hsa-mir-193a, hsa-mir-195, hsa-mir-320a, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-20a, mmu-mir-23a, mmu-mir-24-2, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-93, mmu-mir-34a, mmu-mir-330, mmu-mir-339, mmu-mir-340, mmu-mir-135b, mmu-mir-101b, hsa-mir-200c, hsa-mir-181b-2, mmu-mir-107, mmu-mir-10a, mmu-mir-17, mmu-mir-200c, mmu-mir-181a-1, mmu-mir-320, mmu-mir-26a-2, mmu-mir-221, mmu-mir-222, mmu-mir-29b-2, mmu-mir-135a-2, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-7a-1, mmu-mir-7a-2, mmu-mir-7b, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-301a, hsa-mir-130b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-361, mmu-mir-361, hsa-mir-376a-1, mmu-mir-376a, hsa-mir-340, hsa-mir-330, hsa-mir-135b, hsa-mir-339, hsa-mir-335, mmu-mir-335, mmu-mir-181b-2, mmu-mir-376b, mmu-mir-434, mmu-mir-467a-1, hsa-mir-485, hsa-mir-146b, hsa-mir-193b, hsa-mir-181d, mmu-mir-485, mmu-mir-541, hsa-mir-376a-2, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, mmu-mir-301b, mmu-mir-674, mmu-mir-146b, mmu-mir-467b, mmu-mir-669c, mmu-mir-708, mmu-mir-676, mmu-mir-181d, mmu-mir-193b, mmu-mir-467c, mmu-mir-467d, hsa-mir-541, hsa-mir-708, hsa-mir-301b, mmu-mir-467e, mmu-mir-467f, mmu-mir-467g, mmu-mir-467h, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, mmu-mir-467a-2, mmu-mir-467a-3, mmu-mir-467a-4, mmu-mir-467a-5, mmu-mir-467a-6, mmu-mir-467a-7, mmu-mir-467a-8, mmu-mir-467a-9, mmu-mir-467a-10, hsa-mir-320e, hsa-mir-676, mmu-mir-101c, mmu-mir-195b, mmu-mir-145b, mmu-let-7j, mmu-mir-130c, mmu-mir-30f, mmu-let-7k, mmu-mir-9b-2, mmu-mir-124b, mmu-mir-9b-1, mmu-mir-9b-3
50E-0367mmu-miR-339-5pmir-3390.206.807.92E-037.53E-028mmu-miR-34c-5pmir-340.246.689.54E-066.88E-0477mmu-miR-34a-5pmir-340.179.541.17E-029.66E-0245mmu-miR-340-5pmir-3400.178.511.71E-032.45E-0217mmu-miR-361-5pmir-3610.247.887.74E-052.90E-0319mmu-miR-376b-3pmir-3680.268.451.05E-043.50E-0356mmu-miR-376a-3pmir-3680.1910.215.63E-036.40E-0223mmu-miR-434-3pmir-4340.2210.461.76E-044. [score:1]
[1 to 20 of 1 sentences]
48
[+] score: 1
Using stepwise artificial neural networks (ANN) analysis, Lowery et al. identified a predictive miRNA signature (miR-520d, miR-181c, miR-302c, miR-376b, miR-30e) corresponding with Her2/neureceptor status [30]. [score:1]
[1 to 20 of 1 sentences]
49
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-33a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-96, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, hsa-mir-16-2, hsa-mir-196a-1, hsa-mir-198, hsa-mir-129-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-183, hsa-mir-196a-2, hsa-mir-199b, hsa-mir-203a, hsa-mir-204, hsa-mir-210, hsa-mir-211, hsa-mir-212, hsa-mir-181a-1, hsa-mir-214, hsa-mir-215, hsa-mir-216a, hsa-mir-217, hsa-mir-219a-1, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-mir-224, hsa-mir-200b, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-15b, hsa-mir-23b, hsa-mir-30b, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-130a, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-137, hsa-mir-138-2, hsa-mir-140, hsa-mir-141, hsa-mir-142, hsa-mir-143, hsa-mir-145, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-129-2, hsa-mir-138-1, hsa-mir-146a, hsa-mir-150, hsa-mir-184, hsa-mir-185, hsa-mir-195, hsa-mir-206, hsa-mir-320a, hsa-mir-200c, hsa-mir-1-1, hsa-mir-155, hsa-mir-181b-2, hsa-mir-128-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-101-2, hsa-mir-219a-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-301a, hsa-mir-99b, hsa-mir-296, hsa-mir-130b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-365a, hsa-mir-365b, hsa-mir-375, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-382, hsa-mir-383, hsa-mir-151a, hsa-mir-148b, hsa-mir-338, hsa-mir-133b, hsa-mir-325, hsa-mir-196b, hsa-mir-424, hsa-mir-20b, hsa-mir-429, hsa-mir-451a, hsa-mir-409, hsa-mir-412, hsa-mir-483, hsa-mir-146b, hsa-mir-202, hsa-mir-181d, hsa-mir-499a, hsa-mir-376a-2, hsa-mir-92b, hsa-mir-33b, hsa-mir-151b, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-301b, hsa-mir-216b, hsa-mir-103b-1, hsa-mir-103b-2, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, hsa-mir-378b, hsa-mir-320e, hsa-mir-378c, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-219b, hsa-mir-203b, hsa-mir-451b, hsa-mir-499b, hsa-mir-378j
For instance, A-to-I editing inside the seed sequence has been observed in some miRNAs, such as miR-151, miR-376a, miR-376b, and miR-368 (Kawahara et al. 2007; García-López et al. 2013). [score:1]
[1 to 20 of 1 sentences]
50
[+] score: 1
Other miRNAs from this paper: hsa-mir-376a-1, hsa-mir-376a-2
Moreover, no sites for the mouse orthologue of miR-376a(e) (mmu-miR-376b(e)) were predicted in the 3′UTR of the mouse orthologue of HLA-E, Qa-1b. [score:1]
[1 to 20 of 1 sentences]
51
[+] score: 1
Five possible miRs (miR-200c-3p, miR-200b-3p, miR-429, miR-376a-3p, and miR-376b-3p) were identified, using the Starbase human Pan cancer tool, that could interact with the hsa-circ-0001358 [92]. [score:1]
[1 to 20 of 1 sentences]
52
[+] score: 1
We checked the reference suggested by the reviewer and found that they have talked about only one family within the cluster of miR-376 (miR-376a, -b or-c). [score:1]
[1 to 20 of 1 sentences]