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39 publications mentioning hsa-mir-345

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-345. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 407
Other miRNAs from this paper: hsa-mir-21, hsa-mir-93
To determine that HCV core -induced miR-345 down-regulated endogenous p21 [Waf1/Cip1] gene expression, core expressing HepG2 cells were transfected with or without miR-345 inhibitor, and then p21 [Waf1/Cip1] gene expression at protein level was determined at 24 hours after transfection. [score:12]
Moreover, HCV core -induced miR-345 suppresses p21 [Waf1/Cip1] gene expression in HepG2 cells, and inhibits curcumin -mediated apoptosis through down-regulation of p21 [Waf1/Cip1] gene expression in Huh7 cells. [score:12]
Indeed, we also demonstrated that more truncated core protein (amino acids 1–153) which deletes more residues of hydrophobic C-terminal region up-regulated miR-345 expression, indicating that the up-regulation of miR-345 expression may be associated with the nuclear localization of HCV core protein. [score:11]
MicroRNA-345 down-regulates p21 [Waf1/Cip1] gene expression in human hepatoma cellsIt has been reported that human p21 [Waf1/Cip1] gene expression can be inhibited by miR-345 and miR-93 in HEK 293 cells [33]. [score:10]
In conclusion, our study demonstrates that mature or more truncated HCV core protein (amino acids 1–173 or 1–153) can up-regulate the expression of miR-345 which then suppresses p21 [Waf1/Cip1] gene expression in human hepatoma cells. [score:10]
The HCV core -induced miR-345 suppressed endogenous p21 [Waf1/Cip1] gene expression through targeting its 3′ untranslated region (3′UTR) in HepG2 cells and curcumin-stimulated Huh7 cells. [score:9]
HCV core -induced microRNA-345 suppressed p21 [Waf1/Cip1] gene expression through targeting its 3′ untranslated region in human hepatoma cells. [score:9]
HCV core -induced microRNA-345 inhibits p21 [Waf1/Cip1] gene expression in HepG2 cells and curcumin-stimulated Huh7 cellsIt has been reported that the mature form (amino acids 1–173) of HCV core protein in the nucleus suppresses p21 [Waf1/Cip1] gene expression in HepG2 cells [27]. [score:9]
Similarly, the suppression of p21 [Waf1/Cip1] gene expression was attenuated when mature core -expressing cells were transfected with miR-345 inhibitor (Fig. 4B, upper panel, lane 3, lane 6 and lane 7). [score:9]
These results showed that miR-345 may down-regulate human p21 [Waf1/Cip1] gene expression through targeting its 3′UTR in human hepatoma cells. [score:8]
MicroRNA-345 down-regulates p21 [Waf1/Cip1] gene expression through targeting its 3′UTR but not microRNA-93 in human hepatoma cells. [score:8]
Together, these results demonstrate that miR-345 down-regulates p21 [Waf1/Cip1] gene expression through targeting its 3′UTR in human hepatoma cells. [score:8]
Together, these results demonstrate that miR-345 inhibits curcumin -induced apoptosis through down-regulation of p21 [Waf1/Cip1] gene expression in Huh7 cells. [score:8]
HCV core protein enhances the expression of microRNA-345 which then down-regulates p21 [Waf1/Cip1] expression. [score:8]
In this study, we indicated that two p21 [Waf1/Cip1] -targeting microRNAs, microRNA-345 (miR-345) and microRNA-93 (miR-93), were up-regulated in core -overexpressing Huh7 cells (Fig. 1B). [score:8]
The results showed that miR-345 and miR-93 were overexpressed with more than 3.5- and 2-fold changes, respectively, in mature core (173 a. a. ) and more truncated core (153 a. a. ) -overexpressing Huh7 cells but not in full-length core (191 a. a. ) -overexpressing cells compared to cells nonexpressing core (Fig. 1C, left upper panel). [score:8]
MicroRNA-345 inhibits curcumin -mediated apoptosis through down-regulation of p21 [Waf1/Cip1] gene expression in Huh7 cells. [score:7]
MicroRNA-345 inhibits curcumin -induced apoptosis through down-regulation of p21 [Waf1/Cip1] gene expression in Huh7 cells. [score:7]
MicroRNA-345 inhibits curcumin -induced apoptosis through down-regulation of p21 [Waf1/Cip1] gene expression in Huh7 cellsCurcumin, a potential anticancer agent, has been used in preclinical in vitro and in vivo mo dels of HCC [22]. [score:7]
In conclusion, it is the first time that HCV core protein has ever been demonstrated to inhibit human p21 [Waf1/Cip1] gene expression through miR-345 targeting. [score:7]
MiR-345 has been reported to down-regulate BAG3 gene expression, an anti-apoptosis gene, as a tumor suppressor microRNA in human colorectal cancer [38]. [score:7]
It is the first time that HCV core protein has ever been shown to suppress p21 [Waf1/Cip1] gene expression through miR-345 targeting. [score:7]
However, the suppression of p21 [Waf1/Cip1] gene expression was attenuated in the presence of increased amount of miR-345 inhibitor (Fig. 4A, lane 3, lane 6 and lane 7). [score:7]
Up-regulation of miR-345 expression may involve in cancer development. [score:7]
HCV core protein up-regulates miR-345 and miR-93 expression in human hepatoma cells. [score:6]
The up-regulation of miR-345 expression by HCV core protein may be associated with the demethylation of its promoter. [score:6]
A recent study also reveals that some tumor-related microRNAs including miR-345 are up-regulated from 28 published tumor studies by analyzing microRNA expression microarray datasets, indicating that miR-345 may be an oncomiR in human cancers including HCC [43]. [score:6]
To further verify the down-regulation of endogenous p21 [Waf1/Cip1] gene expression by miR-345, p21 [Waf1/Cip1] mRNA and protein levels were examined in HepG2 cells at 24 hours after transfection with miR-345 mimic. [score:6]
In this study, up-regulation of miR-345 expression by mature form (amino acids 1–173) of the core protein may be also associated with its nuclear localization. [score:6]
The up-regulation of miR-21 expression by mature form (amino acids 1–173) of the core protein may contribute to miR-345 promoter hypomethylation. [score:6]
The HCV core protein was able to up-regulate microRNA-345 (miR-345) expression in human hepatoma cells. [score:6]
Furthermore, we demonstrate that mature HCV core -induced miR-345 involves in anti-apoptosis through down-regulation of p21 [Waf1/Cip1] gene expression in curcumin-stimulated Huh7 cells. [score:6]
Together, these results demonstrate that truncated HCV core proteins (amino acids 1–173 and 1–153) up-regulate cellular miR-345 and miR-93 expression in human hepatoma cells. [score:6]
Our study shows that the up-regulation of miR-345 expression may be related to hepatocarcinogenesis during chronic HCV infection. [score:6]
Some studies have described the up-regulation of miR-345 expression in human cancers including oral squamous cell carcinomas and malignant mesothelioma [41], [42]. [score:6]
However, in our study, miR-345 down-regulates p21 [Waf1/Cip1] gene expression as an oncomiR in human hepatoma cells. [score:6]
MiR-345 is down-regulated in full-length HCV genome -expressing cells as reported by Braconi et al. [19]. [score:5]
Therefore, curcumin was used to induce endogenous p21 [Waf1/Cip1] gene expression to investigate the inhibition of p21 [Waf1/Cip1] gene expression by HCV-core -induced miR-345 in Huh7 cells. [score:5]
As expected, p21 [Waf1/Cip1] gene expression at protein level was suppressed by miR-345 mimic in curcumin-stimulated Huh7 cells in a dose -dependent manner (Fig. 3C, upper panel). [score:5]
Three core gene -expressing vectors for core protein with amino acids 1–191, 1–173 and 1–153, respectively, were transfected into cells, and then the relative expression of miR-345 and miR-93 was determined at 48 hours after transfection. [score:5]
MicroRNA-345 and microRNA-93 are overexpressed in HCV core -overexpressing human hepatoma cells. [score:5]
Moreover, the core protein inhibited curcumin -induced apoptosis through p21 [Waf1/Cip1] -targeting microRNA-345 in Huh7 cells. [score:5]
MicroRNA-345 down-regulates p21 [Waf1/Cip1] gene expression in human hepatoma cells. [score:5]
It has been reported that human p21 [Waf1/Cip1] gene expression can be inhibited by miR-345 and miR-93 in HEK 293 cells [33]. [score:5]
0061089.g004 Figure 4HCV core -induced microRNA-345 inhibits p21 [Waf1/Cip1] gene expression in HepG2 cells and curcumin-stimulated Huh7 cells. [score:5]
We also show that mature HCV core -induced miR-345 can suppress endogenous p21 [Waf1/Cip1] gene expression in HepG2 and curcumin-stimulated Huh7 cells. [score:5]
Together, these results demonstrate that HCV core -induced miR-345 inhibits endogenous p21 [Waf1/Cip1] gene expression in HepG2 cells and curcumin-stimulated Huh7 cells. [score:5]
In addition, the core protein inhibited curcumin -induced apoptosis through p21 [Waf1/Cip1] -targeting miR-345 in Huh7 cells. [score:5]
The relative expressions of miR-345 and miR-93 were determined by TaqMan real-time qPCR in full-length HCV replicon -expressing Huh7 cells (right lower panel). [score:5]
HCV core -induced microRNA-345 inhibits p21 [Waf1/Cip1] gene expression in HepG2 cells and curcumin-stimulated Huh7 cells. [score:5]
Additionally, the suppression of curcumin -induced apoptosis by mature core protein (amino acids 1–173) was significantly attenuated in the presence of increased amount of miR-345 inhibitor (Fig. 4B, middle and lower panels). [score:5]
As expected, p21 [Waf1/Cip1] gene expression at mRNA and protein levels was suppressed with the increased amount of miR-345 mimic in HepG2 cells (Fig. 2C, left and right panels). [score:5]
Figure S2 Curcumin has no effect on endogenous miR-345 expression. [score:3]
Because the different cell types might generate different results, the effects of miR-345 and miR-93 on human p21 [Waf1/Cip1] gene expression were examined in human hepatoma cells. [score:3]
The results showed that wild-type miR-345 mimic can significantly inhibit the luciferase activity in wild-type p21 3′UTR construct -transfected Huh7 cells but not in mutant p21 3′UTR construct -transfected cells (Fig. 2B, right panel, second and third bar pairs). [score:3]
The results showed that the treatment with miR-345 mimic led to a significant reduction of luciferase activity in p21 3′UTR Sense construct -transfected Huh7 cells, but treatment with miR-93 mimic had no significant inhibition in luciferase activity (Fig. 2A, left lower panel, second bar cluster). [score:3]
The relative expressions of miR-345 and miR-93 were determined by TaqMan real-time qPCR. [score:3]
Curcumin -induced apoptosis was inhibited with increased amount of miR-345 mimic (Fig. 3C, left middle panel). [score:3]
However, an additional experiment with mutant miR-345 mimic (Fig. 2B, left panel, mutated sites are underlined) and mutant p21 3′UTR with restoring complementarity was able to show a significant inhibition of luciferase activity (Fig. 2B, right panel, fourth bar pair). [score:3]
Curcumin had no effect on the modulation of cellular miR-345 expression in Huh7 cells (Fig. S2). [score:3]
The relative expression of miR-345 was determined by TaqMan real-time qPCR. [score:3]
At 48 hours after transfection, relative expression of miR-345 or miR-93 was determined by TaqMan real-time qPCR in Huh7 cells (left upper panel) and HepG2 cells (right upper panel). [score:3]
Human miR-345 inhibitor (MH12733) was purchased from Applied Biosystems. [score:3]
The results showed that miR-345 induction was not significantly affected in full-length HCV replicon -expressing system in Huh7 cells compared to control cells and untreated cells (Fig. 1D, right lower panel, third bar pair). [score:2]
Human microRNA-345 (hsa-miR-345, MIMAT0000772) and microRNA-93 (hsa-miR-93, MIMAT0000093) mimics were purchased from Thermo Scientific. [score:1]
Moreover, treatment with a mixture of miR-345 and miR-93 mimics also had no double reduction of luciferase activity (Fig. 2A, left lower panel, second bar cluster). [score:1]
Mutant miR-345 mimic was synthesized. [score:1]
Mutant microRNA-345 mimic was synthesized by Thermo Scientific. [score:1]
Huh7 cells and HepG2 cells were transfected with p21 3′UTR sense or antisense luciferase reporter vector in combination with miR-345 mimic, miR-93 mimic or a mixture of miR-345 and miR-93 mimics. [score:1]
Three microRNAs, miR-21, miR-345 and miR93, of thirty-one microRNAs were indicated. [score:1]
Array data were further confirmed by TaqMan real-time qPCR for miR-345 and miR-93 in Huh7 and HepG2 cells. [score:1]
The mutant p21 [Waf1/Cip1] 3′UTR in the seed sequence of hsa-miR-345 was generated by PCR and ligation of two pieces of DNA fragments, and then cloned into pGL3-Control vector to yield a pGL3-Control-p21 3′UTR Mutant vector. [score:1]
Huh7 cells were transfected with wild-type p21 3′UTR sense or mutant p21 3′UTR luciferase reporter vector in combination with wild-type or mutant miR-345 mimic. [score:1]
As expected, miR-345 and miR-93 mimics had no effect in control vector -transfected and p21 3′UTR Antisense construct -transfected Huh7 cells (Fig. 2A, left lower panel, first and third bar clusters). [score:1]
The number of apoptotic cells (early and late apoptotic cells) had a maximum reduction of about 55% when curcumin-stimulated cells were transfected with 50 nM miR-345 mimic (Fig. 3C, left lower and right lower panels). [score:1]
We further focused on miR-345 to identify the seed sequence in human p21 [Waf1/Cip1] 3′UTR by using computational tools, miRanda (http://www. [score:1]
One luciferase reporter vector, pGL3-Control-p21 3′UTR Mutant (mutated in the seed sequence of miR-345), was constructed. [score:1]
The experiment with mutant miR-345 mimic and mutant p21 3′UTR with restoring complementarity was performed (right panel). [score:1]
Tang et al. has demonstrated that miR-345 with a CpG island in the promoter is a methylation-sensitive microRNA and is highly induced by demethylating agent in human colorectal cancer cell lines [38]. [score:1]
Moreover, the introduction of miR-345 mimic enhanced cell viability in curcumin-stimulated Huh7 cells (Fig. 3C, right middle panel). [score:1]
In this study, we determine the effect of a mature HCV core protein on miR-345 induction in human hepatoma cells. [score:1]
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2
[+] score: 34
Among these upregulated miRNAs were miR-10a, which is a candidate tumor suppressor and suppresses apoptosis in leukemia [39], miR-409 that suppresses tumor cell invasion and metastasis in gastric cancer [40], and miR-206 and miR-345, which are frequently downregulated in various types of cancers and are believed to act as tumor suppressors [41], [42]. [score:15]
As shown in Figure 9C, there was excellent concordance in the data from the miRNA profiling and qPCR, the expression of miR-21, miR-26a, miR-24, miR-30b and miR-29a was down-regulated by EF24 treatment both in vitro and in vivo, while the expression of miR-345, miR-409, miR-10a and miR-206 was upregulated by EF24 treatment. [score:11]
Only four miRNAs (miR-10a, miR-409, miR-206 and miR-345) were upregulated both in vitro and in vivo, which reportedly act as tumor suppressors or inhibitors of cell cycle progression. [score:8]
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3
[+] score: 32
We have shown that in tumor samples compared to normal samples, the majority of miRNAs (miR-216, miR-217, miR-100, miR-345, miR-141, miR-483-3p, miR-26b, miR-150, Let-7b, Let-195 and miR-96) were downregulated, and few were upregulated (miR-146b, miR-205, miR-31, miR-192, miR-194 21, miR-379, miR-431, miR-541, and miR-199b). [score:6]
However, a recent report in colorectal cancer patient tissues has shown significantly methylated mir-345 promoter region compared to the non-cancerous, adenoma, and normal colon tissues; further, ectopic over -expression of mir-345 in colorectal cancer cells significantly reduced cell proliferation by inhibiting the translation of anti-apoptotic BAG3 gene [51]. [score:6]
Similarly, the expression of miR-345 and miR-96 were significantly downregulated during the progression of PC in the mouse mo del (Figure 2D), which is consistent with previous reports [39, 40, 50]. [score:6]
Results showed the downregulation of miR-345, miR-96, and Let-7b in the majority of the PC cell lines compared to the HPDE cells (Figure 3A), indicating that these miRNAs were expressed in ductal cells rather than in tumor stroma. [score:5]
Further, at 50 weeks of age, the expression of miR-216, miR-217, miR-345, miR-141, miR-483-3p, miR-26b, miR-96, Let-7b (p-value = 0.01), miR-100, miR-26a and miR-150 (p-value = 0.094) were further downregulated in KC animals compared to control mice (Figure 2D). [score:5]
These studies suggest a pro-apoptotic function of miR-345; its downregulation during PC progression may be associated with promoter methylation. [score:4]
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4
[+] score: 10
control Expression in case group 1 hsa-mir-1290 0.26 down 2 hsa-mir-342-5p 0.22 down 3 hsa-mir-1224-5p 0.23 down 4 hsa-mir-345 0.38 down 5 hsa-mir-1228 0.38 down 6 hsa-mir-1249 0.32 down 7 hsa-mir-1826 0.26 down 8 hsa-miR-1306 0.38 down 9 hsa-miR-188-5p 0.43 down 10 hsa-miR-320a 0.48 down 11 hsa-miR-320c 0.26 down 12 hsa-miR-365 0.31 down 13 hsa-miR-423-5p 0.35 down 14 hsa-miR-483-5p 0.25 down 15 hsa-miR-634 0.31 down 16 hsa-miR-671-5p 0.23 down 17 hsa-miR-939 0.24 down 18 hsa-miR-1246 2.22 up 19 hsa-miR-150 10.41 up 20 hsa-miR-574-5p 8.04 up Table 3 MiRNAs Target Gene Symbol hsa-miR-345PUM2, PPP2R3A, BCAT1, ZFHX4, CHSY3, ARNT, SHE, SLC7A5, SOS1,. [score:5]
control Expression in case group 1 hsa-mir-1290 0.26 down 2 hsa-mir-342-5p 0.22 down 3 hsa-mir-1224-5p 0.23 down 4 hsa-mir-345 0.38 down 5 hsa-mir-1228 0.38 down 6 hsa-mir-1249 0.32 down 7 hsa-mir-1826 0.26 down 8 hsa-miR-1306 0.38 down 9 hsa-miR-188-5p 0.43 down 10 hsa-miR-320a 0.48 down 11 hsa-miR-320c 0.26 down 12 hsa-miR-365 0.31 down 13 hsa-miR-423-5p 0.35 down 14 hsa-miR-483-5p 0.25 down 15 hsa-miR-634 0.31 down 16 hsa-miR-671-5p 0.23 down 17 hsa-miR-939 0.24 down 18 hsa-miR-1246 2.22 up 19 hsa-miR-150 10.41 up 20 hsa-miR-574-5p 8.04 up Table 3 MiRNAs Target Gene Symbol hsa-miR-345PUM2, PPP2R3A, BCAT1, ZFHX4, CHSY3, ARNT, SHE, SLC7A5, SOS1,. [score:5]
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5
[+] score: 8
With an exceedingly stringent Sidak correction, only 4 differentially regulated miRs were identified; miR-200a, 345, 376c, and 888. miR345 is a methylation-sensitive miR (down-regulated) which is involved in cell proliferation and invasion in colorectal cancer [47], while miR-376c (here up-regulated) enhances ovarian cancer cell survival and has been implicated in chemoresistance [48]. [score:8]
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6
[+] score: 8
miR-345, which is downregulated in non-small cell lung cancer through promoter hypermethylation [152], targets IRF1, a downstream factor of mTOR/AKT signalling involved in the EMT process [153]. [score:6]
IGF-1R is another RTK that is also regulated by miR-214 [32] and miR-345 [33], which in turn are aberrantly methylated in cancer [34]. [score:2]
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7
[+] score: 7
After primary miRNA microarray analysis, in PCa tissues, five miRNAs (miR-345, miR-145, miR-221, miR-27b and miR-378) were down-regulated and twenty-two miRNAs were up-regulated (Figure 1). [score:7]
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8
[+] score: 7
With respect to thyroid cancer, several miRNAs (i. e., miR-220, miR-221, and miR-222) have been shown to be significantly upregulated, while several other miRNAs (i. e., let-7, miR-26, and miR-345) have been shown to be significantly downregulated in papillary thyroid carcinoma (PTC) cells [3– 6]. [score:7]
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9
[+] score: 7
In chronic hepatitis B and HBV -associated HCC, several miRNA were also found in blood, including hsa-miR-7, - 196b, -433, -511, with targets in polymerase or surface genes; hsa-miR-205, targeting X gene; and hsa-miR-345, targeting HBV preC gene [30]. [score:7]
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10
[+] score: 6
The expression patterns of miRNAs that were previously reported in adipocytes or their precursors are in agreement with published data, as summarized in Additional file 3. However, the adipogenesis -dependent regulation of many of the differentially expressed miRNAs we identified has never been described before; these include miR-642a-3p, miR-345, miR-193b, miR-29c, miR-664, miR-10b, miR-136, miR-22*, miR-181a, miR-154*, let-7a, let-7b and let-7c. [score:6]
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11
[+] score: 6
Strikingly, expression levels of 5 miRNAs shown to be increased in centenarians (hsa-miR-148a, hsa-miR-345, hsa-miR-361-5p, hsa-miR-192, hsa-miR-454) have been demonstrated to be down-regulated during cellular senescence (Table 5). [score:6]
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12
[+] score: 6
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-27a, hsa-mir-30a, hsa-mir-93, hsa-mir-96, hsa-mir-99a, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-105-1, hsa-mir-105-2, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-10a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-205, hsa-mir-212, hsa-mir-181a-1, hsa-mir-222, hsa-mir-224, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-132, hsa-mir-141, hsa-mir-145, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-146a, hsa-mir-150, hsa-mir-184, hsa-mir-188, hsa-mir-320a, hsa-mir-181b-2, hsa-mir-30c-1, hsa-mir-302a, hsa-mir-34c, hsa-mir-30e, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-371a, hsa-mir-372, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-383, hsa-mir-339, hsa-mir-133b, hsa-mir-425, hsa-mir-483, hsa-mir-146b, hsa-mir-202, hsa-mir-193b, hsa-mir-181d, hsa-mir-498, hsa-mir-518f, hsa-mir-518b, hsa-mir-520c, hsa-mir-518c, hsa-mir-518e, hsa-mir-518a-1, hsa-mir-518d, hsa-mir-518a-2, hsa-mir-503, hsa-mir-513a-1, hsa-mir-513a-2, hsa-mir-376a-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-645, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-744, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-302e, hsa-mir-302f, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, hsa-mir-548q, hsa-mir-548s, hsa-mir-378b, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-320e, hsa-mir-548x, hsa-mir-378c, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-378f, hsa-mir-378g, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-378h, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-378i, hsa-mir-548am, hsa-mir-548an, hsa-mir-371b, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-378j, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
There were some miRNAs, differently expressed between euploid and aneuploid embryos, such as miR-141, miR-27b, miR-339-3p, and miR-345 that were all upregulated in euploid embryos. [score:6]
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13
[+] score: 6
Previous studies demonstrated that loss of some tumor suppressive miRNAs leads to PARP1 up-regulation in cancer, such as miR-216b, let-7, miR-345, and miR-221 [14–17]. [score:6]
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14
[+] score: 5
Alterations in miRNA expression have been observed in CRC, and several dysregulated miRNAs, including miR-625-3p [8], miR-99-5b [9], miR-361-5p [10], miR-17-5p [11], miR-137 [12], miR-95 [13], miR-23a [14, 15], miR-155 [16], miR-150 [17], miR-191[18], miR-339-5p [19], miR-429 [20], miR-345 [21], miR-22 [22], miR-638 [23] and miR-138 [24], have been shown to regulate CRC cell growth, apoptosis and metastasis. [score:5]
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15
[+] score: 5
Other significant changes in isolated adipocytes included increased expression of miR-132, miR-17, miR-31, miR-93, and miR-345 and decreased miR-422a expression. [score:5]
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16
[+] score: 5
Out of these, miR-208b-3p, miR-467b-5p, miR-345-3p, and miR-744-3p were differentially expressed during infection in both mouse strains. [score:3]
For instance, miR-142-5p plays critical roles in lymphocyte development and homeostasis (57), and miR-106a-5p, miR-130-3p, miR-20b-5p, miR-345-3p, and the miR-15 cluster have been associated with immune or stress responses (58– 62). [score:2]
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17
[+] score: 5
MiRNAs with expression profiles closest to the mean were miR-103, miR-185, miR-532-3p, miR-194, miR-126, miR-155, let-7e, miR-345, miR-425 and miR-15b as illustrated in Table 3. The first 9 miRNAs on this list were excluded from further EC analysis on the basis of their documented roles in breast cancer (Table 3). [score:3]
MiR-16 and miR-345 were identified as the best combination of reference miRNAs by both geNorm and NormFinder, with miR-16 and miR-345 being the single best normlizers identified by NormFinder and geNorm, respectively. [score:1]
Six candidate miRNAs (let-7a, miR-16, miR-26a, miR-345, miR-425 and miR-454) and 2 small nucleolar RNAs (RNU48 and Z30) were chosen for for further validation by RQ-PCR in a larger cohort of colorectal tissues. [score:1]
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[+] score: 5
Interestingly, 14 of these miRNAs (miR-596, miR-630, miR-422a, miR-490-5p, miR-375, miR-708, miR-345, miR-125b-2, miR-516a-3p, miR-135a, miR-1228, miR-1915, miR-134, and miR-663) have established roles in tumor suppression and drug resistance, while 5 miRNAs (miR-630, miR-375, miR-345, miR-1228, and miR-134) are known to inhibit epithelial–mesenchymal transition and invasion in cancer cells. [score:5]
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[+] score: 5
The core protein of HCV normally induces miR-345 which targets and suppresses p21 [Cip-1] [152]. [score:5]
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[+] score: 4
An increased expression of miR-21, miR-181b, and miR-345 has been associated with a higher risk of malignant transformation in patients with oral leukoplakias [17]. [score:3]
On the contrary, some miRNAs act as oncogenes, such as miR-221, miR-181, miR-375, miR-345 and miR-155 [9], [15]. [score:1]
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[+] score: 4
Profiling identified expression of several miRNAs that changed significantly in human OA chondrocyte compared with normal cells targets Smad-signaling, including miR-20b, miR-146a, and miR-345. [score:4]
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[+] score: 4
Other miRNAs from this paper: hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-98, hsa-mir-99a, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-106a, hsa-mir-16-2, hsa-mir-196a-1, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-10a, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-196a-2, hsa-mir-199a-2, hsa-mir-210, hsa-mir-181a-1, hsa-mir-214, hsa-mir-222, hsa-mir-223, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-130a, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-140, hsa-mir-141, hsa-mir-142, hsa-mir-143, hsa-mir-145, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-146a, hsa-mir-150, hsa-mir-186, hsa-mir-188, hsa-mir-195, hsa-mir-200c, hsa-mir-155, hsa-mir-181b-2, hsa-mir-106b, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-34b, hsa-mir-34c, hsa-mir-301a, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-363, hsa-mir-302c, hsa-mir-370, hsa-mir-373, hsa-mir-374a, hsa-mir-328, hsa-mir-342, hsa-mir-326, hsa-mir-135b, hsa-mir-338, hsa-mir-335, hsa-mir-424, hsa-mir-20b, hsa-mir-146b, hsa-mir-520a, hsa-mir-518a-1, hsa-mir-518a-2, hsa-mir-500a, hsa-mir-513a-1, hsa-mir-513a-2, hsa-mir-92b, hsa-mir-574, hsa-mir-614, hsa-mir-617, hsa-mir-630, hsa-mir-654, hsa-mir-374b, hsa-mir-301b, hsa-mir-1204, hsa-mir-513b, hsa-mir-513c, hsa-mir-500b, hsa-mir-374c
Among the upregulated miRNAs were miR-124a, miR-155, miR-328, miR-326, miR-302c, miR-345, miR-373*, and miR-210 [54]. [score:4]
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[+] score: 3
The critical role of several miRNAs in this malignant transformation has also been assessed, highlighting the relevance of over -expression of miR-21, miR-181b, and miR-345 in this process. [score:3]
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[+] score: 3
Other miRNAs from this paper: hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-155
At phenotype level, Huang et al. identified that underexpression of miR-345 is associated with prostate cancer [29]. [score:3]
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25
[+] score: 3
Lerman et al. observed the expression of the following miRNAs in psoriatic lesion skin: hsa-miR-149, hsa-miR-150, hsa-miR-210, hsa-miR-220, hsa-miR-326, has-miR-324-5p, hsa-miR-342, hsa-miR-326, hsa-miR-328, hsa-miR-345, hsa-miR-346, and hsamiR-197 [20]. [score:3]
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26
[+] score: 3
The most likely candidate miRNAs targeting the CFTR 3’UTR which overlapped in at least three prediction programs resulted miR-101, miR-144, miR-199-3p, miR-345, miR-376b, miR-377, miR-380, miR-494, miR-509-3p, miR-600 and miR-645. [score:3]
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[+] score: 3
Other miRNAs from this paper: hsa-mir-21, hsa-mir-181b-1, hsa-mir-181b-2
The malignant transformation might be closely related to the high -expression of microRNA-21, microRNA-181b and microRNA-345. [score:3]
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[+] score: 3
Among the most prominently expressed miRNAs were miR-10a, miR-152, miR-22, miR-26a/b, miR-29b, miR-30b/c, miR-345, and miR-532-5p. [score:3]
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29
[+] score: 3
34 hsa-miR-335 −0.35hsa-miR-345 [44], [53], [71] 1.16 hsa-miR-363 0.99 hsa-miR-371-5p 0.55 hsa-miR-421 0.50 hsa-miR-483-5p 1.33 hsa-miR-494 0.87 hsa-miR-505* −0.40 hsa-miR-513a-5p 1.06 hsa-miR-513b 1.19 hsa-miR-513c 1.22 hsa-miR-551b −0.40 hsa-miR-574-5p 0.97hsa-miR-630 [68], [73] 0.96 hsa-miR-769-5p −0.34 hsa-miR-801 0.66 hsa-miR-873 −0.64 hsa-miR-877* 0.72 hsa-miR-923 0.89 hsa-miR-940 0.49 hsa-miR-95 −0.44 hsa-miR-99a −0.64Irradiated and non-irradiated PBL of the same donors were incubated in static gravity (1 g) for 4 and 24 h, and miRNA expression profile was analyzed at the end of each incubation time. [score:3]
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[+] score: 3
Additionally, prior studies from various mo dels of retinal degeneration identified over 300 differentially expressed miRNAs 63– 90, a total of 16 common miRNAs were identified (miR-1187, miR-125b-5p, miR-331-3p, miR466d-3p, miR-467f, miR-542-3p, miR-574-5p, miR654-3p, miR669h-3p, miR-882, miR-342-3p, miR-466a-5p, miR-466d-5p, miR-706, miR-345-3p, miR532-5p). [score:3]
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[+] score: 3
In a subsequent study, the expression of 380 miRNAs using TaqMan low density arrays was evaluated in the plasma of patients with primary osteoarthritis and controls and 12 miRNAs (hsa-miR-16, hsa-miR-20b, hsa-miR-29c, hsa-miR-30b, hsa-miR-93, hsa-miR-126, hsa-miR-146a, hsa-miR-184, hsa-miR-186, hsa-miR-195, hsa-miR-345, and hsa-miR-885) were identified being over-expressed in OA patients [28]. [score:3]
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[+] score: 2
Nevertheless, two miRNAs were similarly dysregulated in our two microfluidics arrays experiments, hsa-miR-345-5p and hsa-miR-137, emphasizing a concordance of our two studies. [score:2]
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[+] score: 2
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-99a, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-106a, hsa-mir-16-2, hsa-mir-197, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-10a, hsa-mir-34a, hsa-mir-182, hsa-mir-199a-2, hsa-mir-205, hsa-mir-210, hsa-mir-221, hsa-mir-223, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-140, hsa-mir-142, hsa-mir-143, hsa-mir-125b-2, hsa-mir-134, hsa-mir-146a, hsa-mir-150, hsa-mir-206, hsa-mir-155, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-130b, hsa-mir-26a-2, hsa-mir-361, hsa-mir-362, hsa-mir-363, hsa-mir-376c, hsa-mir-371a, hsa-mir-375, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-342, hsa-mir-151a, hsa-mir-324, hsa-mir-335, hsa-mir-423, hsa-mir-483, hsa-mir-486-1, hsa-mir-146b, hsa-mir-202, hsa-mir-432, hsa-mir-494, hsa-mir-495, hsa-mir-193b, hsa-mir-497, hsa-mir-455, hsa-mir-545, hsa-mir-376a-2, hsa-mir-487b, hsa-mir-551a, hsa-mir-571, hsa-mir-574, hsa-mir-576, hsa-mir-606, hsa-mir-628, hsa-mir-629, hsa-mir-411, hsa-mir-671, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-889, hsa-mir-876, hsa-mir-744, hsa-mir-885, hsa-mir-920, hsa-mir-937, hsa-mir-297, hsa-mir-1233-1, hsa-mir-1260a, hsa-mir-664a, hsa-mir-320c-2, hsa-mir-2861, hsa-mir-378b, hsa-mir-1260b, hsa-mir-378c, hsa-mir-1233-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-664b, hsa-mir-378j, hsa-mir-486-2
Markers for liver fibrosis in HBV-infected patients have also been examined, with miR-345-3p, miR-371a-5p, and miR-2861 reported as positive indicators of fibrosis, whereas miR-486-3p and miR-497-5p exhibited lower expression at all stages of fibrosis when compared to non-fibrosis CHB patients (173). [score:2]
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[+] score: 2
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-23a, hsa-mir-25, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-33a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-96, hsa-mir-99a, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-16-2, hsa-mir-198, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-203a, hsa-mir-204, hsa-mir-210, hsa-mir-212, hsa-mir-181a-1, hsa-mir-214, hsa-mir-215, hsa-mir-216a, hsa-mir-217, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-219a-1, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-mir-224, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-27b, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-130a, hsa-mir-132, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-142, hsa-mir-145, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-134, hsa-mir-146a, hsa-mir-150, hsa-mir-186, hsa-mir-188, hsa-mir-193a, hsa-mir-194-1, hsa-mir-320a, hsa-mir-155, hsa-mir-181b-2, hsa-mir-128-2, hsa-mir-194-2, hsa-mir-106b, hsa-mir-29c, hsa-mir-219a-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-99b, hsa-mir-130b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-362, hsa-mir-369, hsa-mir-375, hsa-mir-378a, hsa-mir-382, hsa-mir-340, hsa-mir-328, hsa-mir-342, hsa-mir-151a, hsa-mir-148b, hsa-mir-331, hsa-mir-339, hsa-mir-335, hsa-mir-196b, hsa-mir-424, hsa-mir-425, hsa-mir-20b, hsa-mir-451a, hsa-mir-409, hsa-mir-484, hsa-mir-486-1, hsa-mir-487a, hsa-mir-511, hsa-mir-146b, hsa-mir-496, hsa-mir-181d, hsa-mir-523, hsa-mir-518d, hsa-mir-499a, hsa-mir-501, hsa-mir-532, hsa-mir-487b, hsa-mir-551a, hsa-mir-92b, hsa-mir-572, hsa-mir-580, hsa-mir-550a-1, hsa-mir-550a-2, hsa-mir-590, hsa-mir-599, hsa-mir-612, hsa-mir-624, hsa-mir-625, hsa-mir-627, hsa-mir-629, hsa-mir-33b, hsa-mir-633, hsa-mir-638, hsa-mir-644a, hsa-mir-650, hsa-mir-548d-1, hsa-mir-449b, hsa-mir-550a-3, hsa-mir-151b, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-454, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-708, hsa-mir-216b, hsa-mir-1290, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, hsa-mir-378b, hsa-mir-3151, hsa-mir-320e, hsa-mir-378c, hsa-mir-550b-1, hsa-mir-550b-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-219b, hsa-mir-203b, hsa-mir-451b, hsa-mir-499b, hsa-mir-378j, hsa-mir-486-2
Expression of miR-126, miR-345, miR-222, and miR-551a were reduced in ALL patients with central nervous system (CNS) relapse compared to non-CNS-relapsed ALL patients [76]. [score:2]
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[+] score: 2
Five miRNAs were enriched in WJ-MSCs, including hsa-miR-345, hsa-miR-106a, hsa-miR-17-5p, hsa-miR-20a and hsa-miR-20b (Figure 1B). [score:1]
Five miRNAs were enriched in WJ-MSCs, including miR-345, miR-106a, miR-17-5p, miR-20a and miR-20b. [score:1]
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[+] score: 2
The miRNAs differentially regulated by prenatal stress includes miR-23a (up), miR-129-2 (up), miR-361 (down), let-7f (up), miR-17-5p (down), miR-98 (up), miR-425 (down), miR-345-5p (down), miR-9 (up), miR216-5p (up), miR-667 (up), and miR-505 (down) (Figure 3A). [score:2]
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37
[+] score: 1
Many of the human pri-miRNAs detected are for miRNAs that have been previously identified in liver cells, such as let-7b, miR-16, miR-92, miR-93, miR-122a, miR-125a, miR-125b, miR-150, miR-151, and miR-345 [33- 35]. [score:1]
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[+] score: 1
The analysis revealed 6 miRNAs that presented stress -induced change: hsa-let-7b, miR-342-3p, hsa-miR-20b, hsa-miR-345, hsa-miR-30c, hsa-miR-29c. [score:1]
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[+] score: 1
We identified 71, 96, 69, and 30 DE miRNAs (P-value <0.01) in the 60/120, 120/150, 150/180, and 180/210 dpn comparisons, respectively, in LW pig (Table 1 and S7 Table), among which four miRNAs (ssc-miR-127, ssc-miR-331-3p, ssc-miR-new-304, and ssc-miR-345-3p) were common (S3 Fig and S7 Table). [score:1]
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