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7 publications mentioning rno-mir-323

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-323. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 17
By contrast, recent evidence points towards miR-323 as a positive regulator of Wnt/cadherin signaling to upregulate pro-inflammatory mechanisms and potentiate cell migration, proliferation and adhesion in the pathogenesis of rheumatoid arthritis [79], [80]. [score:5]
However, in line with potentially protective effects of miR-323 upregulation, mouse studies have also found that maternal stress may enhance anti-viral immunity, for example by promoting the protection against herpes simplex virus [85], [86]. [score:4]
Both miR-323 and miR-98 upregulation in brains of prenatally stressed offspring may indicate an altered pro-inflammatory state in the brain. [score:4]
Further changes in miRNA profiles included miR-323, which modulates host-pathogen interactions, such as those involved in HIV-1 [76] and H1N1 Influenza A [31]. [score:1]
miR-323 binds to the PB1 virus gene and may assist in the defense against viral replication [31] and thus have protective functions against stress -induced vulnerability to pathogens [77], [78]. [score:1]
The following miRNAs were analyzed (5′ to 3′): mirR-181 and miR-186 (dams); miR-103, miR-151, miR-323, miR-145, miR-425, miR-98 (newborns). [score:1]
Non-stress groups), as observed by microarray analyses, the following candidates were selected for verification by qRT-PCR analysis: miR-151, miR-145, miR-425 (all down) and miR-103, miR-323, miR-98 (up) (Figure 3C). [score:1]
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2
[+] score: 9
We then used a screening system based on the luciferase reporter plasmid carrying the full-length 3′UTR of the FSHb mRNA and found that 18 miRNAs, specifically miR-433-3p, miR-323-3p, miR-328a-3p, miR-3573-3p, miR-204-5p, miR-206-5p, miR-31a-5p, miR-7a-5p, miR-880-3p, miR-186-5p, miR-503-5p, miR-383-5p, miR-324-5p, miR-505-5p, miR-27b-3p, miR-221-5p, miR-320-3p and miR-21-3p, could suppress the expression of the reporter by more than 30% (Figure 1). [score:5]
Interestingly, we identified 12 other miRNAs (miR-323-3p, miR-328a-3p, miR-3573-3p, miR-204-5p, miR-206-5p, miR-31a-5p, miR-7a-5p, miR-880-3p, miR-186-5p, miR-503-5p, miR-383-5p and miR-320-3p) that might also regulate FSHb expression, and then affected FSH secretion, but their specific effects need to be verified through further experiments. [score:4]
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3
[+] score: 6
Therefore 13 miRNAs, i. e., the two strands specified by genes miR-323, −3585, −433, −485, −543, and −770 as well as the miR-547-3p strand appeared impacted by the perinatal unbalanced environment. [score:1]
Six Partner-miRNAs, i. e., miR-323-5p, −3585-5p, −433-3p, −485-3p, −543-5p, and −770-3p displayed close FCEs and padj-values = < 5.0E-2. Seven Partner-miRNAs (shaded Partner-miRNAs) displayed similar FCEs but padj-values >5.0E-2. miRNAs are listed by alphabetical order. [score:1]
In six cases, i. e., miR-323-3p, −3585-3p, −433-5p, −485-5p, −543-3p, and −770-5p, Partner-miRNAs, 323-5p, −3585-5p, −433-3p, −485-3p, −543-5p, and −770-3p, also displayed very close padj-values (<5.0E-2). [score:1]
Based on these criteria, 11 miRNAs, i. e., the two strands specified by the genes miR-323, −3585, −433, −485, and −770 as well as the 3p strand defined by the gene miR-547 defined a subset of miRNAs repeatedly impacted by the perinatal unbalanced environment. [score:1]
C-C. miRNAs and Partner-miRNAs specified by the genes miR-323,−3585,−433,−485, and−770 as well as the miRNA miR-547-3p appeared significantly impacted by the sole perinatal unbalanced environment (padj-value < 5.2E-02; see Table 3). [score:1]
The five miRNAs miR-323-3p, −3585-3p, −433-5p, −485-5p, and −770-5p, the five Partner-miRNAs, 323-5p, −3585-5p, −433-3p, −485-3p, and−770-3p and the closely linked miRNA miR-547-3p defined a subset of miRNAs repeatedly impacted by the perinatal unbalanced environment. [score:1]
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4
[+] score: 5
Seven overexpressed miRNAs (miR-20a, miR-199a-5p, miR-199, miR-323, miR-301a, miR-301b and miR-130b) showed the most target mRNAs. [score:5]
[1 to 20 of 1 sentences]
5
[+] score: 2
Compared to F0-N controls, rno-miR-138-1-3p* was significantly induced in the frontal cortex of F0-S dams whereas rno-miR-323-5p was significantly suppressed (P <0.01, n = 3). [score:2]
[1 to 20 of 1 sentences]
6
[+] score: 1
Furthermore, this cluster has a complex composition, containing other related sequences {hsa-mir-323, HP-33, HP-34, HP-35, HN-6} whereas the corresponding mouse cluster {mmu-mir-323, mmu-mir-329, MP-35, MN-7, MP-37} additionally contains a rodent-specific sequence, MN-7, which is not related to the other sequences in the cluster. [score:1]
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7
[+] score: 1
9 -45.6 mmu-miR-27b -1.8 -71.4 -462.7 mmu-miR-214* -2.6 -5.0 -43.5 mmu-let-7c-1* -73.2 -204.4 -334.1 mmu-miR-34c -9.4 -26.1 -42.7 mmu-miR-542–3p -5.9 -195.6 -319.8 mmu-miR-706 -9.3 -5.0 -38.7 mmu-miR-487b -2.0 -161.5 -263.9 mmu-miR-467b* -10.1 -2.2 -33.6 rno-miR-17–3p -1.6 -152.0 -248.5 mmu-miR-323–3p -3.7 -23.3 -29.8 mmu-miR-10b -2. 4 -136.6 -223.3 mmu-miR-202–3p -6.5 -5.9 -21.4 mmu-miR-29b -3.0 -135.1 -220.9 mmu-miR-339–5p -1.6 -9.6 -19.6 mmu-miR-297a* -2.4 -128.4 -209.8 mmu-miR-181c -2.0 -10.5 -14.6 mmu-miR-692 -41.5 -115.8 -189.2 mmu-miR-203 -4.6 -6.4 -13.8 mmu-miR-208 -40.6 -113.5 -185.5 mmu-miR-467a* -2.6 -3.9 -11.4 mmu-miR-467c -38.9 -108.6 -177. [score:1]
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