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12 publications mentioning dme-mir-33

Open access articles that are associated with the species Drosophila melanogaster and mention the gene name mir-33. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 12
After controlling for the generation of adventitious target sites in the luciferase vector for other microRNAs expressed in S2 cells, only six microRNAs are found to repress their targets at levels greater than expected (bantam-5p, miR-33-5p, miR-8-3p, miR-307a-3p, miR-308-5p and miR-8-3p). [score:7]
We also observe that the most abundant microRNAs (bantam-3p, bantam-5p, miR-184-3p, miR-33-5p, miR-8-3p) repress their targets by similar amounts, despite representing a more than 30-fold difference in expression. [score:5]
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2
[+] score: 11
Atf3 appears on the predicted target lists for three miRNAs whose over -expression eliminates Or47b expression (i. e., miR-2a-2, miR-33, and miR-2491). [score:7]
Combined we identified seven miRNA lines (Pictured: miR-263a, miR-2a-2, and miR-2491; Not shown: bantam, miR-33, miR-308, and miR-973/974) that reduce the expression of the Or47b reporter. [score:3]
Figure 2D indicates the positions of the miR-2a-2 and miR-33 binding sites in the Atf3 3′-UTR. [score:1]
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3
[+] score: 9
Phylogenetic analysis, target gene prediction and pathway analysis showed that, among the 13 conserved miRNAs (miR-1, miR-100, miR-10a, miR-124, miR-125, miR-184, miR-33, miR-34, miR-7, miR-9, miR-92a, miR-92b and miR-let7), several highly conserved miRNAs (miR-1, miR-7 and miR-34) targeted the same or similar genes leading to the same pathways in shrimp, fruit fly and human (Figure 3b). [score:5]
Six miRNAs (miR-279, miR-33, miR-79, miR-9, miR-S5 and miR-S12) were significantly down-regulated by more than twofold. [score:4]
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4
[+] score: 6
In the case of Drosophila mo dels particular attention should be brought to the two members of conserved mir family, mir-33, and mir-92a, that show trend toward overexpression in some mo dels, albeit not statistically significant at this early time point. [score:3]
However, when we looked more closely to the miRNAs from Table 1 corresponding to conserved miRNA families, we noticed a trend to overexpression of mir-33 and mir-92a in all ataxia mo dels (Table 2), although the statistical significance is below threshold in independent analysis. [score:3]
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5
[+] score: 6
Importantly, levels of several miRNAs, including miR-33, miR-34, miR-276a, miR-317, miR-2b, miR-184 and miR-bantam, were significantly reduced upon SmD1 knockdown (Fig 1B–1G), reminiscent of the phenotype elicited by the loss of the canonical miRNA biogenesis enzyme Drosha. [score:2]
High magnification of miR-33 precursor region. [score:1]
S9 FigHigh magnification of miR-33 precursor region. [score:1]
Interestingly, among the primary miRNA transcripts that we have examined so far, miR-33 and miR-34 are the top two highly enriched in immunopurified SmD1 complex (Figs 3C, 5C and 5D). [score:1]
A and B illustrate two SmD1-bound clusters at the miR-33 locus, corresponding read coverage and T to C conversion events are shown. [score:1]
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6
[+] score: 5
mir-995 cdc2c Yes mir-11/998 E2f Yes mir-92a jigr1 Yes mir-999 CASK Yes mir-281-1/281-2 Oda Yes mir-970 Tomosyn Yes mir-2b-2/2a-1/2a-2 spi Yes mir-13b-2 CG7033 Yes mir-9c/306/79/9b grpYes [a] mir-33 HLH106 No expression information mir-1012 Lerp No expression information mir-1010 SKIP No a Detected in the oocyte. [score:5]
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7
[+] score: 4
Early manifestations of the miRNA world emerged from pervasive control of the C. elegans heterochronic pathway [67] and the D. melanogaster Notch pathway [1], [46] by miRNAs, and a few similar situations have been documented, i. e. direct targeting throughout the branched amino acid catabolism pathway by miR-277 [47] or repression of multiple components of fatty acid metabolism by miR-33 [68]. [score:4]
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8
[+] score: 4
Other miRNAs from this paper: hsa-mir-33a, hsa-mir-92a-1, hsa-mir-92a-2, dme-mir-1, dme-mir-8, dme-mir-11, hsa-mir-34a, hsa-mir-210, dme-mir-184, dme-mir-275, dme-mir-92a, dme-mir-276a, dme-mir-277, dme-mir-281-1, dme-mir-281-2, dme-mir-34, dme-mir-276b, dme-mir-210, dme-mir-92b, dme-bantam, dme-mir-309, dme-mir-317, hsa-mir-1-2, hsa-mir-184, hsa-mir-190a, hsa-mir-1-1, hsa-mir-34b, hsa-mir-34c, aga-bantam, aga-mir-1, aga-mir-184, aga-mir-210, aga-mir-275, aga-mir-276, aga-mir-277, aga-mir-281, aga-mir-317, aga-mir-8, aga-mir-92a, aga-mir-92b, hsa-mir-92b, hsa-mir-33b, hsa-mir-190b, dme-mir-190, dme-mir-957, dme-mir-970, dme-mir-980, dme-mir-981, dme-mir-927, dme-mir-989, dme-mir-252, dme-mir-1000, aga-mir-1174, aga-mir-1175, aga-mir-34, aga-mir-989, aga-mir-11, aga-mir-981, aga-mir-1889, aga-mir-1890, aga-mir-1891, aga-mir-190, aga-mir-927, aga-mir-970, aga-mir-957, aga-mir-1000, aga-mir-309, cqu-mir-1174, cqu-mir-281-1, cqu-mir-1, cqu-mir-275, cqu-mir-957, cqu-mir-277, cqu-mir-252-1, cqu-mir-970, cqu-mir-317-1, cqu-mir-981, cqu-mir-989, cqu-mir-1175, cqu-mir-276-1, cqu-mir-276-2, cqu-mir-276-3, cqu-mir-210, cqu-mir-92, cqu-mir-190-2, cqu-mir-190-1, cqu-mir-1000, cqu-mir-11, cqu-mir-8, cqu-bantam, cqu-mir-1891, cqu-mir-184, cqu-mir-1890, cqu-mir-980, cqu-mir-33, cqu-mir-2951, cqu-mir-2941-1, cqu-mir-2941-2, cqu-mir-2952, cqu-mir-1889, cqu-mir-309, cqu-mir-252-2, cqu-mir-281-2, cqu-mir-317-2, aga-mir-2944a-1, aga-mir-2944a-2, aga-mir-2944b, aga-mir-2945, aga-mir-33, aga-mir-980
We also observed changes in miR-957, miR-970, miR-980, and miR-33, among others (Additional file 2, Table S1). [score:1]
miR-33 was cross-referenced with the Cx. [score:1]
With the exception of miR-33, all Ae. [score:1]
Top group: miRNAs and miRNA* strands identified by deep sequencingMiddle group: predicted miR-33 was identified in C7/10 cells but absent from Cx. [score:1]
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9
[+] score: 2
Other miRNAs from this paper: dme-bantam
Genotypes: (A) y w hsFLP/ y w; FRT42 arm-lacZ/FRT42 lig [1]; DIAP1-GFP4.3/+ (B) y w hsFLP/ y w; FRT42 arm-lacZ/FRT42 lig [3]; MIR33 bantam reporter/+ (C) y w/ y w; UAS-lig/ +; MIR33 bantam reporter/ DE-Gal4, UAS-RFP (D) y w hsFLP/ y w; FRT42 ubiGFP/FRT42 lig [1]; pnt-lacZ/+ (E, F, G, H, I, J, K, L) y w hsFLP/ y w; FRT42 ubiGFP/FRT42 lig [1]. [score:1]
Additional fly strains used in this study were: nubbin-Gal4 [51], da-Gal4 (BDSC), DE-Gal4 [52], ey-Gal4 (insertion on 2nd chromosome) [53], UAS-CycE [54], EP-Diap1 (BDSC), P{Fmr1.14} [55], UAS-p35 (BDSC), DIAP1-GFP4.3 [56], 10xSTAT92E-GFP [57], MIR33 bantam sensor (gift from Stephen Cohen), pnt-lacZ (P{lacW}pntS0998, former stock collection of Szeged, No. [score:1]
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10
[+] score: 1
Other miRNAs from this paper: dme-mir-34, dsi-mir-34, dsi-mir-33
The seed region displays no obvious similarity to known miRNAs (although positions 5–17 are similar to dme-miR-33-5p), but a survey of potential binding sites in D. melanogaster using miRanda 3.3a [78] identified 522 genes with at least one potential binding site in the 3′-UTR (miRanda score ≥150). [score:1]
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11
[+] score: 1
In both strains, miR-184-3p miRNA was the most abundant among the means of non-normalized reads across triplicate libraries, with miR-8-3p, miR-276a-3p, bantam-3p, and miR-33-5p as the next most abundant miRNAs in both strains (Table 2). [score:1]
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12
[+] score: 1
The losses include mir-33, mir-219, mir-2001, and mir-1993, which have been commonly lost in metazoans (Tarver et al. 2013). [score:1]
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