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22 publications mentioning mmu-mir-187

Open access articles that are associated with the species Mus musculus and mention the gene name mir-187. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 288
Our previous screening study identified miR-187 up-regulation in HNSCC [7], and the present study further confirms the up-regulation of miR-187 in OSCC tissues and correlates miR-187 up-regulation with lymph node metastasis. [score:10]
With modest up-regulation of miR-187 in OSCC, and Western blot unequivocally demonstrated a drastic down-regulation of BARX2 expression in OSCC tumors relative to paired normal mucosa. [score:9]
This decreased expression could be caused by the combined effects of BARX2 deletion and the targeting effects of miR-187, since miR-187 was not greatly up-regulated in cancer cells relative to normal cells. [score:8]
Figure 1Up-regulation of miR-187 expression in OSCC(A, C) Box and whiskers plots illustrating the expression of miR-187 in tumor tissue pairs (A) and plasma (C) detected by. [score:8]
Upon treatment with an miR-187 inhibitor, endogenous and exogenous miR-187 expression was drastically suppressed (Figure 2F). [score:7]
Exogenous miR-187 expression (Figure 3F, left) was associated with decreased BARX2 mRNA expression (Figure 3F, middle) and BARX2 protein expression (Figure 3F, right) in HSC3 cells. [score:7]
miR-187 expression increased OSCC oncogenicityCell subclones expressing miR-187 were established in SAS and OECM1 cells, which have high and low endogenous miR-187 expression, respectively (Figure 2A). [score:7]
A further understanding of the signals that up-regulate miR-187 expression and downstream effectors of BARX2 is needed to clarify the role of this regulatory axis in neoplastic processes. [score:7]
Up-regulation of miR-187 expression in OSCC. [score:6]
We observed that OSCC cell lines exhibited decreased BARX2 expression compared to that of NOK cells, possibly due to allele loss or targeting by endogenously-expressed miR-187 in cancer cells. [score:6]
Increased miR-187 expression in OSCC tumors and patient plasmaTo explore the expression of miR-187, 56 OSCC tumors and their paired NCMTs were subjected to (Table S1). [score:5]
Cell subclones expressing miR-187 were established in SAS and OECM1 cells, which have high and low endogenous miR-187 expression, respectively (Figure 2A). [score:5]
Identification of BARX2 as the target gene of miR-187 in OSCC Dab2 was reported to be a target of miR-187 in ovarian cancers [17]. [score:5]
This study suggests that miR-187 may contribute to OSCC progression through suppression of BARX2 expression and indicates the clinical importance of the miR-187–BARX2 cascade in tumor metastasis. [score:5]
To test the targeting activity of miR-187, fragments of 3′ UTR sequences of BARX2, BCL6, DYRK2, FAM80B, GRIA3, and HIPK3 containing predicted miR-187 target sites were amplified by PCR (Table S3) and cloned into the pCMV-LacZ plasmid [7]. [score:5]
In animals carrying relatively smaller tumors, miR-187 expression significantly increased the neck metastasis, and this increase can be rescued by concordant BARX2 expression (Figure 6C). [score:5]
FIH, a tumor suppressor gene in HNSCC [7], was predicted to be a target of miR-187. [score:5]
Of the potential targets, BARX2 emerged as a target of miR-187, as the reporter activity decreased significantly, to 46% of control reporter activity in SAS- miR-187 cell subclones (Figure 3B). [score:5]
Although there was no significant difference in BARX2 mRNA expression on metastatic or recurrent tumors, a significant decrease in miR-187 expression was seen in tumors with advanced nodal metastasis (N2) relative to contrasting tumors (Figure 7A). [score:5]
Studies have excluded Dab2, FIH suppressors, and other predicted genes as miR-187 targets [7, 17]. [score:5]
The increased cell migration associated with endogenous and exogenous miR-187 expression was decreased by miR-187 inhibition in both SAS (Figure 2G) and OECM1 cells (Figure 2H). [score:5]
To generate reporters for target screening, we cloned sequence fragments of the predicted miR-187 target genes BARX2, BCL6, DYRK2, FAM80B, GRIA3, and HIPK3. [score:5]
miR-187 was shown in our preliminary screening study as the 3rd most conspicuously up-regulated miRNA in HNSCC [7]. [score:4]
Up-regulation of miR-187 was found in 40 (71%) of OSCC tumor tissues. [score:4]
Reporter assays of SAS- miR-187 cell subclone indicated that miR-187 repressed the reporter activity by directly targeting the wild type sequence and that the mutation partially reverted the repression (Figure 3D). [score:4]
Exogenous miR-187 expression did not significantly change the proliferation (Figure 2B, upper) or AIG (Figure 2D, upper) of SAS cells. [score:3]
This study provides novel evidence that BARX2 is a target of miR-187 in OSCC. [score:3]
Establishment of cell subclones with miR-187 or BARX2 expression. [score:3]
Figure 2 miR-187 modulates oncogenicity of OSCC cells(A) miR-187 expression. [score:3]
In addition, cell subclones with exogenous miR-187 and BARX2 expression (designated miR-187/BARX2) were established after viral infection, puromycin selection and fluorescence sorting. [score:3]
In this study, we investigated the oncogenic role of miR-187 by targeting the BARX2 tumor suppressor in OSCC. [score:3]
Dab2 was reported to be a target of miR-187 in ovarian cancers [17]. [score:3]
However, our preliminary Western blot analyses have excluded these genes as miR-187 targets in OSCC cells (Figure 3A). [score:3]
OSCC cell subclones with stable miR-187 expression and controls were established by puromycin selection. [score:3]
Identification of BARX2 as the target gene of miR-187 in OSCC. [score:3]
Increased miR-187 expression was observed in patients with ovarian and gall bladder cancer [18, 19]. [score:3]
miR-187 expression also increases the metastatic rate of xenografic tumors and this is associated with worse host survival. [score:3]
The miR-187 expression in SAS- miR-187 and OECM1- miR-187 subclone increased ~11.2 and ~15.9 folds relative to respective control subclones. [score:3]
The targets and mechanisms associated with miR-187 in OSCC pathogenesis are unknown. [score:3]
BARX2 expression reverted miR-187 -induced cell migration. [score:3]
OECM1 cells expressing BARX2 were treated with miR-187 mimic. [score:3]
Increased miR-187 expression in OSCC tumors and patient plasma. [score:3]
In addition, low miR-187 expression defines the sensitivity of ovarian cancers to taxol therapy [20]. [score:3]
org/) version 6.2 was used to predict the potential targets of miR-187 [7]. [score:3]
miR-187 also represses the tumor-suppressor gene disabled homolog-2 (Dab2) in ovarian cancers [17]. [score:3]
However, studies have also revealed that miR-187 is suppressive to some malignancies, including prostate and pancreatic carcinomas as well as clear renal cell carcinoma [21– 25]. [score:3]
miR-187 targets BARX2 in OSCC. [score:3]
In addition, a significant increase in miR-187 expression was noted in tumors with nodal metastasis relative to tumors without node involvement (Figure 1A). [score:3]
ROC analyses indicated that miR-187 expression in OSCC had a predictive power of 0.68 for distinguishing metastatic from non-metastatic states (Figure 1B). [score:3]
miR-187 expression was not associated with other clinicopathological parameters. [score:3]
Establishment of cell subclones with miR-187 or BARX2 expressionA lentivirus carrying the pre-miR-187 sequence and a red fluorescence (RFP) tag was purchased from Biosetta (San Diego, CA, USA). [score:3]
Exogenous miR-187 expression levels differ between cell lines, which may underlie the differences in its potential to promote proliferation and AIG. [score:3]
To explore the expression of miR-187, 56 OSCC tumors and their paired NCMTs were subjected to (Table S1). [score:3]
Lower, miR-187 mimic treatment does not affect the FIH expression in OSCC cells. [score:3]
However, the oncogenic role of miR-187 and its target gene in OSCC have been unknown. [score:3]
Figure 3 miR-187 targets BARX2 in OSCC(A, E). [score:3]
Overall, miR-187 expression increased the oncogenicity of OSCC cells, especially in the OECM1 cell line. [score:3]
To confirm the targeting of miR-187 on BARX2, HSC3 cells were treated with miR-187 mimic for 48 hr. [score:3]
miR-187 expression increased OSCC oncogenicity. [score:3]
Data showing that miR-187 -induced cell migration was attenuated by BARX2 (Figure 5E) support the notion that miR-187 targeted BARX2 to modulate OSCC cell migration. [score:3]
However, exogenous miR-187 expression significantly increased the migration (Figure 2C, upper) and xenografic tumor growth (Figure 2E) in SAS- miR-187 subclones. [score:3]
Paired t-test; [***] p < 0.01. miR-187 has diverse expression across malignancies and plays differential oncogenic roles in different types of tumors [15, 16, 18– 25]. [score:3]
An miR-187 mimic, miR-187 inhibitor, and scramble (Scr) control were purchased from Applied Biosystems (Foster City, CA, USA). [score:3]
Similarly, the OECM1- miR-187 cell subclone also had lower BARX2 expression (Figure 3G). [score:3]
The TaqMan miRNA assay kit was used to quantify the expression of miR-187, BARX2, and other genes according to the manufacturer's instructions (Applied Biosystems). [score:2]
In addition to its role in oncogenesis, miR-187 takes part in the regulation of inflammation, cell stemness, and insulin secretion [26– 28]. [score:2]
Our findings suggest that in addition to chromosomal deletion, epigenetic regulation by oncogenic miRNAs such as miR-187 is also able to repress BARX2 in OSCC pathogenesis. [score:2]
The survival rate of mice carrying the xenografts of SAS- miR-187 cell subclones was drastically decreased comparing to controls (Figure 6D). [score:1]
Many oncogenic miRNAs are potential serological markers of HNSCC or OSCC [2, 10, 39], and our preliminary analysis further supports that plasma miR-187 is a potential marker of OSCC. [score:1]
The results indicated that the activity of BARX2 reporters was repressed by ~55% in SAS- miR-187 cell subclone relative to control. [score:1]
It would be important to specify the enrichment of these aberrant miRNAs with miR-187 in promoting tumor metastasis in future study. [score:1]
miR-187 modulates oncogenicity of OSCC cells. [score:1]
Functional clues support the oncogenicity of miR-187 in OSCC, particularly with respect to enhancing tumor cell migration. [score:1]
Exogenous BARX2 rescued miR-187-enhanced neck metastasis of SAS cells. [score:1]
Exogenous BARX2 rescued miR-187-enhanced neck metastasis of SAS cellsThe tissue analysis revealed the primary xenografic tumor growth of SAS cell subclones in tongue and the metastatic involvement in neck lymph nodes (Figure 6B). [score:1]
Figure 3C illustrates the complementarity between the BARX2 3′UTR sequence and miR-187. [score:1]
Further study is required to confirm the efficacy of miR-187 as a non-invasive marker of oral premalignant disorders [40]. [score:1]
These subclones were designated SAS- miR-187 and OECM1- miR-187. [score:1]
In addition, the antisense sequence of miR-187 was cloned to generate miR-187asR as a positive control reporter. [score:1]
Therefore, the functional role of miR-187 in different cancers may be paradoxical. [score:1]
The miR-187 gene is located on chromosome 18q12.2. [score:1]
Few studies have investigated the relationship of miR-187 targets to tumorigenesis [7, 17, 24]. [score:1]
ROC analysis indicated that the plasma miR-187 level had a predictive power of 0.77 for distinguishing malignant from non-malignant states (Figure 1D). [score:1]
The proliferation, migration, and AIG in OECM1- miR-187 subclone was higher than control subclone (Figure 2B–2D, lower). [score:1]
A lentivirus carrying the pre-miR-187 sequence and a red fluorescence (RFP) tag was purchased from Biosetta (San Diego, CA, USA). [score:1]
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2
[+] score: 37
miRNA gene or target mRNA Species Genome variation Molecular effect PDGFRa Human Mutation 3′UTR Altered miR-140 bindingRattanasopha et al., 2012 miR-140 Human SNP Altered miRNA-140 processingLi et al., 2010, 2011 Zebrafish Overexpression Altred Pdfra repressionEberhart et al., 2008 MSX1 Human SNP 3'UTR Altered miR-3649 bindingMa et al., 2014 FGF2/5/9 Human SNP3'UTR Altered miR-496/miR-145/miR-187 bindingLi D. et al., 2016 miR-17-92 cluster Mouse Homozygous deletion Altered Tbx113, Fgf10, Shox2 & Osr1 repressionWang et al., 2013 miR-200b Mouse Overexpression Altered Smad2, Snail& Zeb112 repressionShin et al., 2012a, b miR-133b Zebrafish Overexpression UnkownDing et al., 2016 MiRNAs are small, 19–23 nucleotide non-coding RNAs that function as post-transcriptional repressors of gene expression, either through messenger RNA (mRNA) degradation or translational repression (Bartel, 2009). [score:14]
miRNA gene or target mRNA Species Genome variation Molecular effect PDGFRa Human Mutation 3′UTR Altered miR-140 bindingRattanasopha et al., 2012 miR-140 Human SNP Altered miRNA-140 processingLi et al., 2010, 2011 Zebrafish Overexpression Altred Pdfra repressionEberhart et al., 2008 MSX1 Human SNP 3'UTR Altered miR-3649 bindingMa et al., 2014 FGF2/5/9 Human SNP3'UTR Altered miR-496/miR-145/miR-187 bindingLi D. et al., 2016 miR-17-92 cluster Mouse Homozygous deletion Altered Tbx113, Fgf10, Shox2 & Osr1 repressionWang et al., 2013 miR-200b Mouse Overexpression Altered Smad2, Snail& Zeb112 repressionShin et al., 2012a, b miR-133b Zebrafish Overexpression UnkownDing et al., 2016 Using microarray analysis, the expression profile of murine miRNAs in the developing lip and PS were analyzed from E10 to E14 (Mukhopadhyay et al., 2010; Warner et al., 2014). [score:12]
miRNA gene or target mRNA Species Genome variation Molecular effect PDGFRa Human Mutation 3′UTR Altered miR-140 bindingRattanasopha et al., 2012 miR-140 Human SNP Altered miRNA-140 processingLi et al., 2010, 2011 Zebrafish Overexpression Altred Pdfra repressionEberhart et al., 2008 MSX1 Human SNP 3'UTR Altered miR-3649 bindingMa et al., 2014 FGF2/5/9 Human SNP3'UTR Altered miR-496/miR-145/miR-187 bindingLi D. et al., 2016 miR-17-92 cluster Mouse Homozygous deletion Altered Tbx113, Fgf10, Shox2 & Osr1 repressionWang et al., 2013 miR-200b Mouse Overexpression Altered Smad2, Snail& Zeb112 repressionShin et al., 2012a, b miR-133b Zebrafish Overexpression UnkownDing et al., 2016 CS, CC, JV: Conception of the work, drafting of the manuscipt, revision of the manuscript, final approval of the manuscript. [score:10]
Similarly, altered miR-496-FGF2, miR-145-FGF5, and miR-187-FGF9 interactions were associated with clefting in 289 nsCLP and 49 nsCPO patients (Li D. et al., 2016). [score:1]
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3
[+] score: 22
The results reported in Figure 1 confirm the overexpression of miR-483-5p, miR-483-3p, miR-675-5p, miR-21-3p, and the downregulation of miR-187-3p in HMGA1P7 overexpressing MEFs in comparison with the WT ones. [score:8]
Dou C. Liu Z. Xu M. Jia Y. Wang Y. Li Q. Yang W. Zheng X. Tu K. Liu Q. miR-187-3p inhibits the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting S100A4Cancer Lett. [score:5]
Finally, in the opposite way, miR-187-3p has been reported as oncosuppressor because of its inhibitory action on metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma and non-small cell lung cancer [38, 39]. [score:5]
Sun C. Li S. Yang C. Xi Y. Wang L. Zhang F. Li D. MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6Biochem. [score:4]
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4
[+] score: 19
We previously suggested that of the miRs analyzed, nine (miR-21, miR-20a, miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805 and miR-194) stand out as being differentially expressed in C57BL/6 mice undergoing IRI compared to the expression observed in mice undergoing a sham procedure [14]. [score:4]
Shown is a three-dimensional plot of the first three PCs obtained by performing PCA on expression data for miR-21, miR-20a, miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805 and miR-194 obtained for kidneys from C57BL/6 mice following IRI (blue line) or sham surgery (red lines). [score:3]
Our previous work showed that in C57BL/6 mice, expression of miR-21, miR-20a, miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805 and miR-194 is significantly different between IRI and sham control groups at all times analyzed [14]. [score:3]
Movie showing the rotation of a three-dimensional plot of the first three PCs obtained by performing PCA on all expression data obtained for kidneys from C57BL/6 mice following IRI (blue line) or sham surgery (red lines) in which we eliminated miR-21, miR-20a, miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805 and miR-194 from the analysis. [score:3]
Panel C, Shown is a three-dimensional plot of the first three PCs obtained by performing PCA on all expression data obtained for kidneys from C57BL/6 mice following IRI (blue line) or sham surgery (red lines) in which we eliminated miR-21, miR-20a, miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805 and miR-194 from the analysis. [score:3]
Shown is a three-dimensional plot of the first three PCs obtained by performing PCA on expression data for miR-21, miR-20a, miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805 and miR-194 obtained for kidneys from C57BL/6 mice following IRI (blue line) or sham surgery (red lines) (Movie S3). [score:3]
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5
[+] score: 8
Of these possible nonspecific targets, only 3 are expressed in adult dentate gyrus -miR-187, miR-218, and miR-301 (Fig. 4b). [score:5]
Only three microRNAs were both reduced in the multiplex array and expressed endogenously in the dentate gyrus – miR-187, miR-218, and miR-301. [score:3]
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6
[+] score: 8
Only the expression of miR-154 and miR-187 were found to be inhibited by dexamethasone in both the absence and presence of LPS stimulation. [score:5]
Once again we identified a number of miRNAs whose expression appeared to be repressed at a single time point including miR-187 (1 hrs), miR-27b (6 h), miR-29c (6 h), miR-100 (6 h), miR-149 (6 h), miR-150 (6 h) and miR-154 (6 h) (Table S2). [score:3]
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[+] score: 7
The top 8 downregulated (hsa-miR-200c, hsa-miR-212, hsa-miR-29a, hsa-miR-532, hsa-miR-141, hsa-miR-1, hsa-miR-363, hsa-miR-187) and 8 upregulated (hsa-miR-487, hsa-miR-452, hsa-miR-1233, hsa-miR-92a, hsa-miR-106b, hsa-miR-1290, hsa-miR-320, hsa-miR-26a) miRNAs were presented in Figure 1A. [score:7]
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8
[+] score: 6
A previous study found that miR-18a, miR-126, let-7e, miR-155, and miR-224 were down-regulated while miR-498, miR-187, miR-874, miR-143, and miR-886-3p were up-regulated in asthmatic patients compared to controls [27]. [score:6]
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9
[+] score: 4
miR-187-3p is reported to post-transcriptionally regulate S100A4 and S100A4 -mediated metastasis in hepatocellular carcinoma (HCC) [22]. [score:2]
However, to our knowledge only miR-187-3p is reported to post-transcriptionally regulate S100A4 and S100A4 mediated metastasis [22]. [score:2]
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10
[+] score: 4
MicroRNAs like miR-19a, 34b, 129, 135a, 142-3p, miR-153, miR-186, miR-187, and miR-301a were significantly downregulated in Cs1-ko mice. [score:4]
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[+] score: 4
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-18a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-21, hsa-mir-23a, hsa-mir-31, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-96, hsa-mir-98, hsa-mir-99a, hsa-mir-106a, mmu-let-7g, mmu-let-7i, mmu-mir-23b, mmu-mir-99a, mmu-mir-127, mmu-mir-128-1, mmu-mir-136, mmu-mir-142a, mmu-mir-145a, mmu-mir-10b, mmu-mir-182, mmu-mir-183, mmu-mir-193a, mmu-mir-195a, mmu-mir-200b, mmu-mir-206, mmu-mir-143, hsa-mir-139, hsa-mir-10b, hsa-mir-182, hsa-mir-183, hsa-mir-187, hsa-mir-210, hsa-mir-216a, hsa-mir-217, hsa-mir-219a-1, hsa-mir-221, hsa-mir-222, hsa-mir-224, hsa-mir-200b, mmu-mir-302a, mmu-let-7d, mmu-mir-106a, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-128-1, hsa-mir-142, hsa-mir-143, hsa-mir-145, hsa-mir-127, hsa-mir-136, hsa-mir-193a, hsa-mir-195, hsa-mir-206, mmu-mir-19b-2, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-18a, mmu-mir-21a, mmu-mir-23a, mmu-mir-31, mmu-mir-92a-2, mmu-mir-96, mmu-mir-98, hsa-mir-200c, mmu-mir-17, mmu-mir-139, mmu-mir-200c, mmu-mir-210, mmu-mir-216a, mmu-mir-219a-1, mmu-mir-221, mmu-mir-222, mmu-mir-224, mmu-mir-19b-1, mmu-mir-92a-1, mmu-mir-128-2, hsa-mir-128-2, mmu-mir-217, hsa-mir-200a, hsa-mir-302a, hsa-mir-219a-2, mmu-mir-219a-2, hsa-mir-363, mmu-mir-363, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-371a, hsa-mir-18b, hsa-mir-20b, hsa-mir-452, mmu-mir-452, ssc-mir-106a, ssc-mir-145, ssc-mir-216-1, ssc-mir-217-1, ssc-mir-224, ssc-mir-23a, ssc-mir-183, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-128-1, ssc-mir-136, ssc-mir-139, ssc-mir-18a, ssc-mir-21, hsa-mir-146b, hsa-mir-493, hsa-mir-495, hsa-mir-497, hsa-mir-505, mmu-mir-20b, hsa-mir-92b, mmu-mir-302b, mmu-mir-302c, mmu-mir-302d, hsa-mir-671, mmu-mir-216b, mmu-mir-671, mmu-mir-497a, mmu-mir-495, mmu-mir-146b, mmu-mir-708, mmu-mir-505, mmu-mir-18b, mmu-mir-493, mmu-mir-92b, hsa-mir-708, hsa-mir-216b, hsa-mir-935, hsa-mir-302e, hsa-mir-302f, ssc-mir-17, ssc-mir-210, ssc-mir-221, mmu-mir-1839, ssc-mir-146b, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-128-2, ssc-mir-143, ssc-mir-10b, ssc-mir-23b, ssc-mir-193a, ssc-mir-99a, ssc-mir-98, ssc-mir-92a-2, ssc-mir-92a-1, ssc-mir-92b, ssc-mir-142, ssc-mir-497, ssc-mir-195, ssc-mir-127, ssc-mir-222, ssc-mir-708, ssc-mir-935, ssc-mir-19b-2, ssc-mir-19b-1, ssc-mir-1839, ssc-mir-505, ssc-mir-363-1, hsa-mir-219b, hsa-mir-371b, ssc-let-7a-2, ssc-mir-18b, ssc-mir-187, ssc-mir-218b, ssc-mir-219a, mmu-mir-195b, mmu-mir-145b, mmu-mir-21b, mmu-let-7j, mmu-mir-21c, ssc-let-7d, ssc-let-7f-2, ssc-mir-20b-1, ssc-mir-20b-2, ssc-mir-31, ssc-mir-182, ssc-mir-216-2, ssc-mir-217-2, ssc-mir-363-2, ssc-mir-452, ssc-mir-493, ssc-mir-671, mmu-let-7k, ssc-mir-7138, mmu-mir-219b, mmu-mir-216c, mmu-mir-142b, mmu-mir-497b, mmu-mir-935, ssc-mir-9843, ssc-mir-371, ssc-mir-219b, ssc-mir-96, ssc-mir-200b
Ssc-miR-182, ssc-miR-187, ssc-miR-136, ssc-miR-210, ssc-miR-217 and ssc-miR-10b participate in regulation Neurotrophin signaling pathway by targeting corresponding genes, including BNDF, SHC4, KRAS and FOXO3. [score:4]
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[+] score: 3
However, the involvement of miR-187, miR-299-3p, and miR-628-5p in some aspects of biology, including cancer, has been reported [43]– [46]; thus these miRNAs may play roles in regulating the proliferation of iPS/ES cells. [score:2]
In the case of miR-187, 299-3p, 499-5p, 628-5p, and 888, these miRNAs showed nearly negligible values or were not examined in previous studies [13], [14]. [score:1]
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[+] score: 3
Other miRNAs from this paper: mmu-mir-26a-1, mmu-mir-26a-2, mmu-mir-146b
Nikiforove et al. (4) used a ‘miRNACHIP’ micro-array approach to demonstrate that miR-187, −221, −222, −146b, −155, −122a, −31, −205 and −224 are up-regulated in PTCs compared with normal thyroid tissue. [score:3]
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14
[+] score: 3
miRNA p-value Fold-Change miR-146a 1.15E-09 −4.82 miR-31 9.66E-08 −4.95 miR-155 1.97E-07 −3.82 miR-2134 2.13E-07 −2.05 miR-711 1.63E-06 −4.10 miR-3473 1.95E-06 −5.62 miR-574-3p 3.32E-06 −2.55 miR-1195 6.59E-06 2.26 miR-27a* 6.89E-06 14.92 miR-27b* 7.35E-06 2.92 miR-34c 1.80E-05 −3.43 miR-1931 3.34E-05 −2.30 miR-874 4.07E-05 −2.01 miR-196b 7.99E-05 2.59 miR-181a-1* 8.02E-05 4.15 miR-187 8.11E-05 2. 02List of miRs whose expression is altered, identified from microarray analysis by comparison of levels in TM [+] and TM [−] DCs which change >2 fold with p<0.0001. [score:3]
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[+] score: 3
Moreover, Bar and colleagues [33] found that the most overexpressed miRNAs in undifferentiated human ES cells are miR-302b, miR-302c, miR-302d, miR-92b, miR-20b, miR-519d, miR-302a, miR-324-3p, miR-187, and miR-18b. [score:3]
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[+] score: 2
The predicted structure of pre-miR-342 with the addition of the in del (rs261236356) is shown at rightSeven other miRNAs had local eQTL: miR-146b, miR-181d, miR-187, miR-203, miR-221, miR-322, and miR-503. [score:1]
The predicted structure of pre-miR-342 with the addition of the in del (rs261236356) is shown at right Seven other miRNAs had local eQTL: miR-146b, miR-181d, miR-187, miR-203, miR-221, miR-322, and miR-503. [score:1]
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[+] score: 2
Several editing events within the seed were found to be much more ancient than previously recognized: editing of miR-27a was found in placental mammals and platypus, thus presumably dating back at least 220 million years, while editing of miR-187*, miR-497 and miR-1251 was shared between placental mammals and marsupials, whose last common ancestor lived 180 million years ago [20]. [score:1]
Human Macaque Mouse Opossum Platypus Chicken Human SNP Opossum SNP Known ValidatedmiR-27a6>1%>1%  >1% No-Human [e]---miR-99b*2 >1%>1%   No-Human [c]-Mouse [c]Mouse [c]miR-140*16   >5% >5%NoNo----miR-187*5  >1%>1%  NoNo----miR-301a20 >1% >5% >5%NoNo----miR-376a-13>1%>1%>1%   No-Human [b,c,d]-Mouse [b,c,d,e,f]Mouse [b,c]miR-376b6>5% >5%   No-Human [b,c,d]-Mouse [b,c,d,f,g]Mouse [b,c]miR-376c6>5% >5%   No-Human [e]-Mouse [b,d,e,f]Mouse [b]miR-3795 >5%>5%   No-Human [a,c,e]-Mouse [c,d,e,f]Mouse [c]miR-3814>5%>5%>5%   No-Human [e]Human [e]Mouse [d,f,g]-miR-4115>5%>5%>5%   No-Human [b,d]-Mouse [c,d,e]Mouse [c]miR-45517 >1%   >1%No-Human [e]Human [e]--miR-4972>5%>5%>5%>5%  NoNoHuman [e]Human [e]Mouse [d,e]-miR-497*20>5%>5%    NoNoMouse [d]---miR-12516 >5%>5%>1%  NoNoMouse [d,e]-                     - -Summary of the output from the miRNA editing detection pipeline, run with a 5% or 1% frequency cutoff. [score:1]
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[+] score: 2
Specifically, we have detected out some regulators for lung non-specific genes, i. e., TF: ATF6, DBP (early), and TBP (late); miRNAs: mmu-mir-152, mmu-mir-187, mmu-mir-320, mmu-mir-326, mmu-mir-451 (early), and mmu-mir-494 (late). [score:2]
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[+] score: 2
Zhang F MicroRNA-187, a downstream effector of TGFbeta pathway, suppresses Smad -mediated epithelial-mesenchymal transition in colorectal cancerCancer Lett. [score:2]
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20
[+] score: 1
The LPS -induced microRNA signature was formed by a large cluster of miRs, including miR-155 and miR-187, as can be seen in the third panel, Figure 1A. [score:1]
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[+] score: 1
Among these, six miRNAs (miR-138, miR-187, miR-375, miR-204, miR-210 and miR-672) are consistently and significantly detected at a lower intensity level (i. e., elevated Cq value or Cq values below the detection threshold) in Dicer1 c KO vs. [score:1]
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[+] score: 1
miR-187, miR-202, and miR-299-3p were not significantly correlated with any of the four markers. [score:1]
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