Stem-loop sequence hsa-mir-299

Accession MI0000744
Symbol HGNC:MIR299
Description Homo sapiens miR-299 stem-loop
Gene family MIPF0000186; mir-299
Stem-loop 
     a                      uu 
aagaa ugguuuaccgucccacauacau  u
||||| ||||||||||||||||||||||  g
uucuu gccaaaugguaggguguaugua  a
     c                      ua
Get sequence
Deep sequencing
339 reads, 13 experiments
Comments

The sequence from the 5' arm of this miRNA precursor is the predicted human homologue of mouse miR-299, cloned from mouse embryonic stem cells [1,2], later validated in human [4]. Altuvia et al [3] report the cloning of a miRNA sequence from the 3' arm of the same precursor in human.

Genome context
Coordinates (GRCh37.p5) Overlapping transcripts
chr14: 101490131-101490193 [+]
sense
ENST00000385016 ; MIR299-201; exon 1
ENST00000385016 ; MIR299-201; exon 1
ENST00000385016 ; MIR299-201; exon 1
Clustered miRNAs
< 10kb from hsa-mir-299
hsa-mir-379 chr14: 101488403-101488469 [+]
hsa-mir-411 chr14: 101489662-101489757 [+]
hsa-mir-299 chr14: 101490131-101490193 [+]
hsa-mir-380 chr14: 101491354-101491414 [+]
hsa-mir-1197 chr14: 101491901-101491988 [+]
hsa-mir-323a chr14: 101492069-101492154 [+]
hsa-mir-758 chr14: 101492357-101492444 [+]
hsa-mir-329-1 chr14: 101493122-101493201 [+]
hsa-mir-329-2 chr14: 101493437-101493520 [+]
hsa-mir-494 chr14: 101495971-101496051 [+]
hsa-mir-1193 chr14: 101496389-101496466 [+]
hsa-mir-543 chr14: 101498324-101498401 [+]
hsa-mir-495 chr14: 101500092-101500173 [+]
Database links

Mature sequence hsa-miR-299-5p

Accession MIMAT0002890
Sequence

7 -  

ugguuuaccgucccacauacau

 - 28

Get sequence
Deep sequencing 288 reads, 12 experiments
Evidence experimental; cloned [4]
Validated targets
Predicted targets

Mature sequence hsa-miR-299-3p

Accession MIMAT0000687
Previous IDs hsa-miR-299;hsa-miR-299-5p
Sequence

39 -  

uaugugggaugguaaaccgcuu

 - 60

Get sequence
Deep sequencing 51 reads, 2 experiments
Evidence experimental; cloned [3-4]
Predicted targets

References

1
PMID:12919684 "Embryonic stem cell-specific MicroRNAs" Houbaviy HB, Murray MF, Sharp PA Dev Cell. 5:351-358(2003).
2
PMID:15634332 "New human and mouse microRNA genes found by homology search" Weber MJ FEBS J. 272:59-73(2005).
3
PMID:15891114 "Clustering and conservation patterns of human microRNAs" Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H Nucleic Acids Res. 33:2697-2706(2005).
4
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).