Stem-loop sequence hsa-mir-203b

AccessionMI0017343
Previous IDshsa-mir-3545
Symbol HGNC:MIR203B
DescriptionHomo sapiens miR-203b stem-loop
Gene family MIPF0000108; mir-203
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled MiR-203. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology miR-203 is a short non-coding RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, such as translational repression and Argonaute-catalyzed messenger RNA cleavage. miR-203 has been identified as a skin-specific microRNA, and it forms an expression gradient that defines the boundary between proliferative epidermal basal progenitors and terminally differentiating suprabasal cells. It has also been found upregulated in psoriasis and differentially expressed in some types of cancer.

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Stem-loop
       cc  c            c  a    u    -  a  g gc 
5' gcgc  gc gggucuaguggu cu aaca uuca ca uu c  u
   ||||  || |||||||||||| || |||| |||| || || |   
3' cgcg  cg cccaggucacca ga uugu aagu gu aa g  a
       --  a            a  a    c    u  c  - ac 
Get sequence
Deep sequencing
153 reads, 15.8 reads per million, 59 experiments
Confidence
Feedback: Do you believe this miRNA is real?
Genome context
Coordinates (GRCh38) Overlapping transcripts
chr14: 104117418-104117503 [-]
antisense
OTTHUMT00000414859 ; KLC1-021; intron 1
OTTHUMT00000402947 ; KLC1-001; intron 1
OTTHUMT00000402944 ; KLC1-003; intron 1
OTTHUMT00000414860 ; KLC1-022; intron 1
OTTHUMT00000402945 ; KLC1-002; intron 1
OTTHUMT00000414861 ; KLC1-009; intron 1
OTTHUMT00000414862 ; KLC1-008; intron 1
OTTHUMT00000402946 ; KLC1-005; intron 1
OTTHUMT00000414863 ; KLC1-016; intron 1
OTTHUMT00000414864 ; KLC1-010; intron 1
OTTHUMT00000414866 ; KLC1-011; intron 1
OTTHUMT00000414867 ; KLC1-013; intron 1
OTTHUMT00000414868 ; KLC1-020; intron 1
OTTHUMT00000402950 ; KLC1-004; intron 1
OTTHUMT00000414869 ; KLC1-017; intron 1
OTTHUMT00000414871 ; KLC1-015; intron 1
OTTHUMT00000402943 ; RP11-73M18.2-001; intron 4
ENST00000557172 ; KLC1-021; intron 1
ENST00000348520 ; KLC1-001; intron 1
ENST00000380038 ; KLC1-003; intron 1
ENST00000555467 ; KLC1-022; intron 1
ENST00000389744 ; KLC1-002; intron 1
ENST00000557575 ; KLC1-009; intron 1
ENST00000553286 ; KLC1-008; intron 1
ENST00000347839 ; KLC1-005; intron 1
ENST00000555836 ; KLC1-016; intron 1
ENST00000334553 ; KLC1-010; intron 1
ENST00000246489 ; KLC1-011; intron 1
ENST00000554228 ; KLC1-013; intron 1
ENST00000557450 ; KLC1-020; intron 1
ENST00000452929 ; KLC1-004; intron 1
ENST00000554280 ; KLC1-017; intron 1
ENST00000445352 ; KLC1-015; intron 1
ENST00000472726 ; RP11-73M18.2-001; intron 4
Clustered miRNAs
< 10kb from hsa-mir-203b
hsa-mir-203bchr14: 104117418-104117503 [-]
hsa-mir-203achr14: 104117405-104117514 [+]
Database links

Mature sequence hsa-miR-203b-5p

Accession MIMAT0019813
Previous IDshsa-miR-3545-5p
Sequence

15 - 

uagugguccuaaacauuucaca

 - 36

Get sequence
Evidence experimental; Illumina [1-2]
Predicted targets

Mature sequence hsa-miR-203b-3p

Accession MIMAT0019814
Previous IDshsa-miR-3545-3p
Sequence

54 - 

uugaacuguuaagaaccacugga

 - 76

Get sequence
Deep sequencing3 reads, 1 experiments
Evidence experimental; Illumina [1-2]
Predicted targets

References

1
PMID:21199797 "Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene" Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L, Loman N, Jonsson G, Naya H, Hoglund M, Borg A, Rovira C Cancer Res. 71:78-86(2011).
2
PMID:21807764 "Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome" Joyce CE, Zhou X, Xia J, Ryan C, Thrash B, Menter A, Zhang W, Bowcock AM Hum Mol Genet. 20:4025-4040(2011).