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In molecular biology mir-451 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.
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In molecular biology mir-451 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.[1]
[edit] Applications
A proof-of-concept experiment has shown that miR-451, as well as mir-126 and mir-150, could be using in forensic science to distinguish between blood and saliva samples.[2] This is made possible by different miRNA profiles of miRNAs in the different tissue types.[2]
[edit] References
- ^ van Jaarsveld, MT; Helleman, J, Berns, EM, Wiemer, EA (2010 Aug). "MicroRNAs in ovarian cancer biology and therapy resistance.". The international journal of biochemistry & cell biology 42 (8): 1282–90. doi:10.1016/j.biocel.2010.01.014. PMID 20083225.
- ^ a b Courts, C; Madea, B (2011 Aug 9). "Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification.". Journal of forensic sciences 56 (6): 1464–70. doi:10.1111/j.1556-4029.2011.01894.x. PMID 21827476.
[edit] Further reading
- ^ Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC (2010). "Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.". Proc Natl Acad Sci U S A 107 (34): 15163–8. doi:10.1073/pnas.1006432107. PMC 2930549. PMID 20699384. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2930549/.
- ^ Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, Paw BH, Weiss MJ (2010). "miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta.". Genes Dev 24 (15): 1620–33. doi:10.1101/gad.1942110. PMC 2912560. PMID 20679398. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2912560/.
- ^ Patrick DM, Zhang CC, Tao Y, Yao H, Qi X, Schwartz RJ, Jun-Shen Huang L, Olson EN (2010). "Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta.". Genes Dev 24 (15): 1614–9. doi:10.1101/gad.1942810. PMC 2912559. PMID 20679397. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2912559/.
- ^ Godlewski J, Bronisz A, Nowicki MO, Chiocca EA, Lawler S (2010). "microRNA-451: A conditional switch controlling glioma cell proliferation and migration.". Cell Cycle 9 (14): 2742–8. PMID 20647762.
- ^ Svasti S, Masaki S, Penglong T, Abe Y, Winichagoon P, Fucharoen S, Umemura T (2010). "Expression of microRNA-451 in normal and thalassemic erythropoiesis.". Ann Hematol 89 (10): 953–8. doi:10.1007/s00277-010-0980-7. PMID 20461517.
- ^ Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE (2010). "MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.". Mol Cell 37 (5): 620–32. doi:10.1016/j.molcel.2010.02.018. PMC 3125113. PMID 20227367. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3125113/.
- ^ Bruchova-Votavova H, Yoon D, Prchal JT (2010). "miR-451 enhances erythroid differentiation in K562 cells.". Leuk Lymphoma 51 (4): 686–93. doi:10.3109/10428191003629362. PMID 20218812.
- ^ Tsuchiya S, Oku M, Imanaka Y, Kunimoto R, Okuno Y, Terasawa K, Sato F, Tsujimoto G, Shimizu K (2009). "MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells.". Nucleic Acids Res 37 (11): 3821–7. doi:10.1093/nar/gkp255. PMC 2699527. PMID 19386621. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2699527/.
- ^ Bandres E, Bitarte N, Arias F, Agorreta J, Fortes P, Agirre X, Zarate R, Diaz-Gonzalez JA, Ramirez N, Sola JJ, Jimenez P, Rodriguez J, Garcia-Foncillas J (2009). "microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells.". Clin Cancer Res 15 (7): 2281–90. doi:10.1158/1078-0432.CCR-08-1818. PMID 19318487.
- ^ Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM, Lieschke GJ (2009). "miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2.". Blood 113 (8): 1794–804. doi:10.1182/blood-2008-05-155812. PMC 2647672. PMID 18849488. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2647672/.
- ^ Gal H, Pandi G, Kanner AA, Ram Z, Lithwick-Yanai G, Amariglio N, Rechavi G, Givol D (2008). "MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells.". Biochem Biophys Res Commun 376 (1): 86–90. doi:10.1016/j.bbrc.2008.08.107. PMID 18765229.
- ^ Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF, Pogribny IP (2008). "Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin.". Mol Cancer Ther 7 (7): 2152–9. doi:10.1158/1535-7163.MCT-08-0021. PMID 18645025.
- ^ Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM (2008). "Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells.". Biochem Pharmacol 76 (5): 582–8. doi:10.1016/j.bcp.2008.06.007. PMID 18619946.
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