Stem-loop sequence bma-mir-281

Accession

MI0013349

Description

Brugia malayi miR-281 stem-loop

Gene family

MIPF0000087; mir-46

Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-46/mir-47/mir-281_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia.

In molecular biology, mir-46 (MI0000017) and mir-47 (MI0000018) are microRNA expressed in C. elegans from related hairpin precursor sequences. The predicted hairpin precursor sequences for Drosophila mir-281 (MI0000366, MI0000370) are also related and, hence, belong to this family. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequences are expressed from the 3' arms of the hairpin precursors.

Stem-loop

-ggu        a  -ac         -ca     u      --  u 
    gaacgcag cg   aaagagagc   ucugu gacagu  ca a
    |||||||| ||   |||||||||   ||||| ||||||  || u
    cuuguguc gu   uuucucucg   aggua cuguca  gu a
gaau        c  aca         uua     -      ac  u 

Mature sequence bma-miR-281

• Accession: MIMAT0014123
• Sequence: 53 - ugucauggaauugcucucuuua - 74
• Evidence: by similarity; MI0000366

References

1. PMID:19874857 "Cloning and bioinformatic identification of small RNAs in the filarial nematode, Brugia malayi" Poole CB, Davis PJ, Jin J, McReynolds LA Mol Biochem Parasitol. 169:87-94(2010).