Stem-loop sequence spu-mir-210

AccessionMI0010182 (change log)
DescriptionStrongylocentrotus purpuratus miR-210 stem-loop
Gene family MIPF0000086; mir-210
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-210_microRNA. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology mir-210 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-210 has been strongly linked with the hypoxia pathway, and is upregulated in response to Hypoxia-inducible factors. It is also overexpressed in cells affected by cardiac disease and tumours. MiRNA-210 in particular, has been studied for its effects in rescuing cardiac function after myocardial infarcts via the up-regulation of angiogenesis and inhibition of cardiomyocyte apoptosis.

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   cuc             a    g        -----  -  a 
5'    guuaguugcuguc cgcg cacaagag     ag ca u
      ||||||||||||| |||| ||||||||     || ||  
3'    uagucagcgacag gugc guguucuc     uc gu c
   aca             c    -        acaua  u  a 
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Genome context
Coordinates (Spur_4.2; GCA_000002235.3) Overlapping transcripts
KN917968.1: 222056-222132 [+]
Database links

Mature sequence spu-miR-210

Accession MIMAT0009646

52 - 


 - 73

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Evidence experimental; 454 [1]


PMID:19196333 "The deep evolution of metazoan microRNAs" Wheeler BM, Heimberg AM, Moy VN, Sperling EA, Holstein TW, Heber S, Peterson KJ Evol Dev. 11:50-68(2009).