Stem-loop sequence dgr-mir-281-1

Accession

MI0009128

Description

Drosophila grimshawi miR-281-1 stem-loop

Gene family

MIPF0000087; mir-46

Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-46/mir-47/mir-281_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia.

In molecular biology, mir-46 (MI0000017) and mir-47 (MI0000018) are microRNA expressed in C. elegans from related hairpin precursor sequences. The predicted hairpin precursor sequences for Drosophila mir-281 (MI0000366, MI0000370) are also related and, hence, belong to this family. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequences are expressed from the 3' arms of the hairpin precursors.

Stem-loop

      aguga           -ug     c      ccag  ua 
cgaaua     auaaagagagc   uccgu gacagu    ua  a
||||||     |||||||||||   ||||| ||||||    ||  a
gcuuau     uguuucucucg   aggua cuguca    au  u
      -agua           uua     -      --ua  uu 

Genome context

• Coordinates (dgri_r1.3_FB2010_02): scaffold_15245: 18178200-18178287 [+]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from dgr-mir-281-1

• dgr-mir-281-1: scaffold_15245: 18178200-18178287 [+]
• dgr-mir-281-2: scaffold_15245: 18178390-18178482 [+]

Mature sequence dgr-miR-281-1-5p

• Accession: MIMAT0008587
• Previous IDs: dgr-miR-281-1*
• Sequence: 15 - aagagagcuguccgucgacagu - 36
• Evidence: by similarity; MI0000366

Mature sequence dgr-miR-281-3p

• Accession: MIMAT0008588
• Previous IDs: dgr-miR-281
• Sequence: 56 - ugucauggaauugcucucuuugu - 78
• Evidence: by similarity; MI0000366

References

1. PMID:17994087 "Evolution of genes and genomes on the Drosophila phylogeny" Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markow TA, Kaufman TC, Kellis M, Gelbart W, Iyer VN, Pollard DA, Sackton TB, Larracuente AM, Singh ND, Abad JP, Abt DN, Adryan B, Aguade M, Akashi H, Anderson WW, Aquadro CF, Ardell DH, Arguello R, Artie Nature. 450:203-218(2007).