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In molecular biology bantam microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
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In molecular biology bantam microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
[edit] Function
In Drosophila, bantam microRNA works in the epithelial cells where it regulates the growth of dendrites in sensory neurons.[1] The Hippo signaling pathway also tends to be directly linked with the BANTAM microRNA as it regulates it to control the functionality of cell proliferation and survival.[2][3] Recent studies show that human miRNA are also related to this pathway.[3] Homothorax (Hth) and Teashirt (Tsh) are two DNA-binding transcription factors expressed in the Drosophila eye imaginal disc. Recent studies have shown that the Hth and Tsh which are found to be important in cell survival of the Drosophila anterior optimal disc participate in the regulation of the Bantam miRNA.[2]It is concluded that the miRNA has a important function in the central pacemaker of the Drosophila circadian rhythm clock. To be more precise Bantam miRNA has a important relation with the clock component clk. Thus making it an important factor of study regarding its role in the Drosophila behavior.[4]
[edit] Diseases
Fragile X syndrome disease are implicated to be regulated by the FMRP, a RNA-binding protein. Studies on Drosophila has shown that the Bantam miRNA plays an important role in the regulation of the protein dFMRP and also genetically interact with the protein in stem cell maintenance.[5] Thus implicating the possibility of an relation between the miRNA and the disease.It is also suggested that the endogenous expression of the Bantam gene in the developing eye imaginal disc contributes to controlling the level of hid-induced apoptosis, which is normally involved in reducing cell number in the pupal eye disc.[6]
[edit] See also
[edit] Further reading
- ^ a b Parrish JZ, Xu P, Kim CC, Jan LY, Jan YN (2009). "The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons". Neuron 63 (6): 788–802. doi:10.1016/j.neuron.2009.08.006. PMC 2772869. PMID 19778508.
- ^ a b c Peng HW, Slattery M, Mann RS (2009). "Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc". Genes Dev 23 (19): 2307–19. doi:10.1101/gad.1820009. PMC 2758742. PMID 19762509.
- ^ a b c Thompson BJ, Cohen SM (2006). "The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila". Cell 126 (4): 767–74. doi:10.1016/j.cell.2006.07.013. PMID 16923395.
- ^ a b Kadener S, Menet JS, Sugino K, Horwich MD, Weissbein U, Nawathean P, Vagin VV, Zamore PD, Nelson SB, Rosbash M. (2009). "A role for microRNAs in the Drosophila circadian clock.". Genes Dev. 23 (18): 2179–91. doi:10.1101/gad.1819509. PMC 2751990. PMID 19696147.
- ^ a b Yang Y, Xu S, Xia L, Wang J, Wen S, Jin P, Chen D (2009). "The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells". In Orr, Harry. PLoS Genet 5 (4): e1000444. doi:10.1371/journal.pgen.1000444. PMC 2654963. PMID 19343200.
- ^ a b Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM (2003). "bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila". Cell 113 (1): 25–36. doi:10.1016/S0092-8674(03)00231-9. PMID 12679032.
- ^ Nahvi A, Shoemaker CJ, Green R (2009). "An expanded seed sequence definition accounts for full regulation of the hid 3' UTR by bantam miRNA". RNA 15 (5): 814–22. doi:10.1261/rna.1565109. PMC 2673059. PMID 19286629.
- ^ Jaklevic B, Uyetake L, Wichmann A, Bilak A, English CN, Su TT (2008). "Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila". Dev Biol 320 (1): 122–30. doi:10.1016/j.ydbio.2008.04.043. PMC 2629399. PMID 18550049.
- ^ Nolo R, Morrison CM, Tao C, Zhang X, Halder G (2006). "The bantam microRNA is a target of the hippo tumor-suppressor pathway". Curr Biol 16 (19): 1895–904. doi:10.1016/j.cub.2006.08.057. PMID 16949821.
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