Stem-loop sequence mml-mir-301a

Accession MI0007685
Description Macaca mulatta miR-301a stem-loop
Gene family MIPF0000034; mir-130
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-130_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408), and in human (MI0000448, MI0000748). miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma. It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.

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Stem-loop
a     aa  a     c    ---u          ----a       
 cugcu  cg augcu ugac    uuauugcacu     cuguac 
 |||||  || ||||| ||||    ||||||||||     ||||| u
 gacga  gu uacga acug    gauaacguga     gacauu 
g     aa  c     a    uuau          cgauc       
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Confidence
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Genome context
Coordinates (MMUL1.0) Overlapping transcripts
16: 43395599-43395684 [-]
intergenic
Database links

Mature sequence mml-miR-301a-5p

Accession MIMAT0026850
Sequence

16 - 

ucugacuuuauugcacuacu

 - 35

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Evidence experimental; Solexa [23034410]

Mature sequence mml-miR-301a-3p

Accession MIMAT0006257
Sequence

51 - 

cagugcaauaguauugucaaagc

 - 73

Get sequence
Evidence experimental; Solexa [23034410]
Predicted targets

References

1
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PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).