Stem-loop sequence mml-mir-218-1

Accession MI0007675
Description Macaca mulatta miR-218-1 stem-loop
Gene family MIPF0000026; mir-218
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-218_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-218 microRNA precursor is a small non-coding RNA that regulates gene expression by antisense binding. miR-218 appears to be a vertebrate specific microRNA and has now been predicted and experimentally confirmed in a wide range of vertebrate species. The extents of the hairpin precursors are not known. In this case the mature sequence in excised from the 5'arm of the hairpin. miR-218, along with miR-585, has been found to be silenced by DNA methylation in oral squamous cell carcinoma. It is also downregulated in Nasopharyngeal carcinoma, with artificially-induced expression serving to slow tumour growth. miR-218 has also been found to have tumour suppressing qualities in bladder cancer cells.

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Stem-loop
   -----aau  a   a   u      u         cu        gg    gag 
5'         gu gcg gau uucugu gugcuugau  aaccaugu  uugc   g
           || ||| ||| |||||| |||||||||  ||||||||  ||||   u
3'         cg cgc cug aaggua cacgaacug  uugguaca  aaug   a
   acaucuuu  a   a   c      c         cc        -a    agu 
Get sequence
Deep sequencing
5437 reads, 71.8 reads per million, 8 experiments
Confidence
Feedback: Do you believe this miRNA is real?
Genome context
Coordinates (CR_1.0) Overlapping transcripts
chr5: 15652544-15652648 [+]
antisense
ENSMMUT00000042386 ; KCNIP4-201; intron 1
ENSMMUT00000042385 ; KCNIP4-202; intron 1
Database links

Mature sequence mml-miR-218-5p

Accession MIMAT0002574
Sequence

20 - 

uugugcuugaucuaaccaugu

 - 40

Get sequence
Deep sequencing 40 reads, 5 experiments
Evidence experimental; Illumina [2]
Predicted targets

Mature sequence mml-miR-218-1-3p

Accession MIMAT0031080
Sequence

63 - 

augguuccgucaagcaccaug

 - 83

Get sequence
Evidence experimental; Illumina [2]

References

1
2
PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).