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The miR-192 microRNA precursor (homologous to miR-215), is a short non-coding RNA gene involved in gene regulation. miR-192 and miR-215 have now been predicted or experimentally confirmed in mouse and human.
microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.
mir-192 and mir-215 are thought to be positive regulators of p53, a human tumour suppressor. They are also overexpressed in gastric cancer, and could potentially be used as biomarkers or therapeutic targets. It has also been suggested that mir-192 could be used as a biomarker for drug-induced liver damage.
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The miR-192 microRNA precursor (homologous to miR-215), is a short non-coding RNA gene involved in gene regulation. miR-192 and miR-215 have now been predicted or experimentally confirmed in mouse and human.[1][2]
microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.[3]
mir-192 and mir-215 are thought to be positive regulators of p53, a human tumour suppressor.[4] They are also overexpressed in gastric cancer, and could potentially be used as biomarkers or therapeutic targets.[5] It has also been suggested that mir-192 could be used as a biomarker for drug-induced liver damage.[6]
[edit] References
- ^ Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (2003). "New microRNAs from mouse and human". RNA 9 (2): 175–9. doi:10.1261/rna.2146903. PMC 1370382. PMID 12554859. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1370382/.
- ^ "miRNA gene family: mir-192". mirBASE. University of Manchester. http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000063.
- ^ Ambros V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Pichiorri, F; Suh, SS, Rocci, A, De Luca, L, Taccioli, C, Santhanam, R, Zhou, W, Benson DM, Jr, Hofmainster, C, Alder, H, Garofalo, M, Di Leva, G, Volinia, S, Lin, HJ, Perrotti, D, Kuehl, M, Aqeilan, RI, Palumbo, A, Croce, CM (2010 Oct 19). "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development". Cancer Cell 18 (4): 367–81. doi:10.1016/j.ccr.2010.09.005. PMID 20951946.
- ^ Jin, Z; Selaru, FM, Cheng, Y, Kan, T, Agarwal, R, Mori, Y, Olaru, AV, Yang, J, David, S, Hamilton, JP, Abraham, JM, Harmon, J, Duncan, M, Montgomery, EA, Meltzer, SJ (2011 Mar 31). "MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro". Oncogene 30 (13): 1577–85. doi:10.1038/onc.2010.534. PMID 21119604.
- ^ Wang, K; Zhang, S, Marzolf, B, Troisch, P, Brightman, A, Hu, Z, Hood, LE, Galas, DJ (2009 Mar 17). "Circulating microRNAs, potential biomarkers for drug-induced liver injury". Proceedings of the National Academy of Sciences of the United States of America 106 (11): 4402–7. doi:10.1073/pnas.0813371106. PMC 2657429. PMID 19246379. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2657429/.
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