| Community annotation |
This text is a summary paragraph taken from the Wikipedia
entry entitled miR-33. miRBase and Rfam
are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...
The text in this section is taken from the free, online
encyclopedia, Wikipedia. Anyone can edit a Wikipedia page. We hope
that experts on particular microRNA sequences will use the links to
Wikipedia below to edit the annotation of individual microRNAs, to add
information about function, evolution, discovery, and literature
references, for example. Any changes that you make will be visible in
Wikipedia immediately, and in miRBase within 24 hours.
Editing Wikipedia entries is straightforward. If you haven't
edited a page before, you might like to take a look at the following
Wikipedia help pages:
You can also create new pages at Wikipedia about microRNA families
that do not currently have specific entries there. Please let us know
if you do, so we can incorporate your annotation into miRBase, and
create the appropriate links from miRBase entries to the relevant
Wikipedia pages.
Please note, we're not responsible for the content of Wikipedia pages.
You can read more about miRBase, Wikipedia and community annotation on this blog post.
Please email us for
help or with comments about this community annotation initiative.
miR-33 is a family of microRNA precursors, which are processed by the Dicer enzyme to give mature microRNAs. miR-33 is found in several animal species, including humans. In some species there is a single member of this family which gives the mature product mir-33. In humans there are two members of this family called mir-33a and mir-33b, which are located in intronic regions within two protein-coding genes for Sterol regulatory element-binding proteins (SREBP-2 and SREBP-1) respectively.
Show Wikipedia entry
View @ Wikipedia
Edit Wikipedia entry
miR-33 is a family of microRNA precursors, which are processed by the Dicer enzyme to give mature microRNAs.[1] miR-33 is found in several animal species, including humans. In some species there is a single member of this family which gives the mature product mir-33. In humans there are two members of this family called mir-33a and mir-33b, which are located in intronic regions within two protein-coding genes for Sterol regulatory element-binding proteins (SREBP-2 and SREBP-1) respectively.[2]
Function
miR-33 plays a role in lipid metabolism; it downregulates a number of ABC transporters, including ABCA1 and ABCG1, which in turn regulate cholesterol and HDL generation.[3][4] Further related roles of miR-33 have been proposed in fatty acid degradation and in macrophage response to low-density lipoprotein.[2] It has been suggested that miR-33a and miR-33b regulates genes Involved in fatty acid metabolism and insulin signalling.[5]
Potential binding sites for mir-33 have been identified in the cDNA of tumour suppressor p53.[6] Further, study has shown that miR-33 is able to repress p53 expression and p53-induced apoptosis. This function is thought to be related to hematopoietic stem cell renewal.[7]
Applications
miR-33, along with miR-122, could be used to diagnose or treat conditions related to metabolic disorders and cardiovascular disease.[2][8]
References
- ^ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ a b c Najafi-Shoushtari, SH (Jun 2011). "MicroRNAs in cardiometabolic disease.". Current atherosclerosis reports 13 (3): 202–7. doi:10.1007/s11883-011-0179-y. PMID 21461683.
- ^ Fernández-Hernando, C; Suárez, Y; Rayner, KJ; Moore, KJ (Apr 2011). "MicroRNAs in lipid metabolism.". Current Opinion in Lipidology 22 (2): 86–92. doi:10.1097/MOL.0b013e3283428d9d. PMC 3096067. PMID 21178770.
- ^ Moore, KJ; Rayner, KJ, Suárez, Y, Fernández-Hernando, C (Dec 2010). "microRNAs and cholesterol metabolism.". Trends in endocrinology and metabolism: TEM 21 (12): 699–706. doi:10.1016/j.tem.2010.08.008. PMC 2991595. PMID 20880716.
- ^ Dávalos A, Goedeke L, Smibert P, et al. (May 2011). "miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling". Proc. Natl. Acad. Sci. U.S.A. 108 (22): 9232–7. doi:10.1073/pnas.1102281108. PMC 3107310. PMID 21576456.
- ^ Herrera-Merchan, A; Cerrato, C; Luengo, G; Dominguez, O; Piris, MA; Serrano, M; Gonzalez, S (Aug 15, 2010). "miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal.". Cell cycle (Georgetown, Tex.) 9 (16): 3277–85. doi:10.4161/cc.9.16.12598. PMID 20703086.
- ^ Fuster, JJ; Andrés, V (Sep 1, 2010). "A role for miR-33 in p53 regulation: New perspectives for hematopoietic stem cell research.". Cell cycle (Georgetown, Tex.) 9 (17): 3397–8. doi:10.4161/cc.9.17.13070. PMID 20861665.
- ^ Najafi-Shoushtari, SH; Kristo, F; Li, Y; Shioda, T; Cohen, DE; Gerszten, RE; Näär, AM (Jun 18, 2010). "MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.". Science 328 (5985): 1566–9. doi:10.1126/science.1189123. PMID 20466882.
External links
|
