Stem-loop sequence mml-mir-30d

AccessionMI0007601 (change log)
DescriptionMacaca mulatta miR-30d stem-loop
Gene family MIPF0000005; mir-30
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-30_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression. Animal microRNAs are transcribed as pri-miRNA (primary miRNA) of varying length which in turns are processed in the nucleus by Drosha into ~70 nucleotide stem-loop precursor called pre-miRNA (preliminary miRNA) and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from both the 3' (miR-30) and 5' (mir-97-6) arms of the precursor. The products are thought to have regulatory roles through complementarity to mRNA. A screen of 17 miRNAs that have been predicted to regulate a number of breast cancer associated genes found variations in the microRNAs miR-17 and miR-30c-1, these patients were noncarriers of BRCA1 or BRCA2 mutations, lending the possibility that familial breast cancer may be caused by variation in these miRNAs. Members of the miR-30 family have been found to be highly expressed in heart cells.

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   -uu  u         ccc           gua  ac 
5'    gu guaaacauc   gacuggaagcu   ag  a
      || |||||||||   |||||||||||   ||   
3'    cg cguuuguag   cugacuuucga   uc  c
   cau  u         --a           --a  ga 
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Genome context
Coordinates (Mmul_8.0.1; GCA_000772875.3) Overlapping transcripts
chr8: 134099791-134099859 [-]
Clustered miRNAs
< 10kb from mml-mir-30d
mml-mir-30dchr8: 134099791-134099859 [-]
mml-mir-30bchr8: 134094376-134094463 [-]
Database links

Mature sequence mml-miR-30d-5p

Accession MIMAT0006171

5 - 


 - 26

Get sequence
Evidence experimental; Illumina [2]
Database links
Predicted targets

Mature sequence mml-miR-30d-3p

Accession MIMAT0026806

46 - 


 - 66

Get sequence
Evidence experimental; Illumina [2]
Predicted targets


PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).