Stem-loop sequence mml-mir-30d

Accession MI0007601
Description Macaca mulatta miR-30d stem-loop
Gene family MIPF0000005; mir-30
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-30_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression. Animal microRNAs are transcribed as pri-miRNA (primary miRNA) of varying length which in turns are processed in the nucleus by Drosha into ~70 nucleotide stem-loop precursor called pre-miRNA (preliminary miRNA) and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from both the 3' (miR-30) and 5' (mir-97-6) arms of the precursor. The products are thought to have regulatory roles through complementarity to mRNA. A screen of 17 miRNAs that have been predicted to regulate a number of breast cancer associated genes found variations in the microRNAs miR-17 and miR-30c-1, these patients were noncarriers of BRCA1 or BRCA2 mutations, lending the possibility that familial breast cancer may be caused by variation in these miRNAs. Members of the miR-30 family have been found to be highly expressed in heart cells.

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Stem-loop
-uu  u         ccc           gua  ac 
   gu guaaacauc   gacuggaagcu   ag  a
   || |||||||||   |||||||||||   ||   
   cg cguuuguag   cugacuuucga   uc  c
cau  u         --a           --a  ga 
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Confidence
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Genome context
Coordinates (MMUL1.0) Overlapping transcripts
8: 137355275-137355343 [-]
sense
ENSMMUT00000036765 ; mml-mir-30d-201; exon 1
Clustered miRNAs
< 10kb from mml-mir-30d
mml-mir-30d 8: 137355275-137355343 [-]
mml-mir-30b 8: 137350040-137350127 [-]
Database links

Mature sequence mml-miR-30d-5p

Accession MIMAT0006171
Sequence

5 - 

uguaaacauccccgacuggaag

 - 26

Get sequence
Evidence experimental; Solexa [23034410]
Predicted targets

Mature sequence mml-miR-30d-3p

Accession MIMAT0026806
Sequence

46 - 

uuucagucagauguuugcugc

 - 66

Get sequence
Evidence experimental; Solexa [23034410]

References

1
2
PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).