Stem-loop sequence mml-mir-30c-1

Accession MI0007599
Description Macaca mulatta miR-30c-1 stem-loop
Gene family MIPF0000005; mir-30
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-30_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression. Animal microRNAs are transcribed as pri-miRNA (primary miRNA) of varying length which in turns are processed in the nucleus by Drosha into ~70 nucleotide stem-loop precursor called pre-miRNA (preliminary miRNA) and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from both the 3' (miR-30) and 5' (mir-97-6) arms of the precursor. The products are thought to have regulatory roles through complementarity to mRNA. A screen of 17 miRNAs that have been predicted to regulate a number of breast cancer associated genes found variations in the microRNAs miR-17 and miR-30c-1, these patients were noncarriers of BRCA1 or BRCA2 mutations, lending the possibility that familial breast cancer may be caused by variation in these miRNAs. Members of the miR-30 family have been found to be highly expressed in heart cells.

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Stem-loop
   a     cu    ugu u       u   aca         ---g  a 
5'  ccaug  guag   g guaaaca ccu   cucucagcu    ug g
    |||||  ||||   | ||||||| |||   |||||||||    ||  
3'  gguac  cguc   c cauuugu ggg   gagggucgg    ac c
   a     --    uuc u       u   --a         ugga  u 
Get sequence
Deep sequencing
7222 reads, 133 reads per million, 8 experiments
Confidence
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Genome context
Coordinates (CR_1.0) Overlapping transcripts
chr1: 43866484-43866572 [+]
intergenic
Clustered miRNAs
< 10kb from mml-mir-30c-1
mml-mir-30e chr1: 43863530-43863621 [+]
mml-mir-30c-1 chr1: 43866484-43866572 [+]
Database links

Mature sequence mml-miR-30c-5p

Accession MIMAT0006170
Sequence

17 - 

uguaaacauccuacacucucagc

 - 39

Get sequence
Deep sequencing 494 reads, 8 experiments
Evidence experimental; Illumina [2]
Predicted targets

Mature sequence mml-miR-30c-1-3p

Accession MIMAT0026805
Sequence

57 - 

ugggagaggguuguuuacucc

 - 77

Get sequence
Deep sequencing 2 reads, 2 experiments
Evidence experimental; Illumina [2]

References

1
2
PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).