Stem-loop sequence mml-let-7i

DescriptionMacaca mulatta let-7i stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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        u                 u   --------  u     ugu 
5' cuggc gagguaguaguuugugc guu        gg cgggu   g
   ||||| ||||||||||||||||| |||        || |||||   a
3' gaucg uuccgucaucgaacgcg caa        uc gcccg   c
        -                 u   uagaggug  -     uua 
Get sequence
Deep sequencing
97494 reads, 1.72e+03 reads per million, 8 experiments
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Genome context
Coordinates (CR_1.0) Overlapping transcripts
chr11: 60028315-60028399 [+]
ENSMMUT00000016735 ; PPM1H-201; intron 1
Database links

Mature sequence mml-let-7i-5p

Accession MIMAT0006158

6 - 


 - 27

Get sequence
Deep sequencing418 reads, 7 experiments
Evidence experimental; Illumina [2]
Predicted targets

Mature sequence mml-let-7i-3p

Accession MIMAT0026795

63 - 


 - 83

Get sequence
Deep sequencing3 reads, 2 experiments
Evidence experimental; Illumina [2]


PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).