Stem-loop sequence mml-let-7g

Accession MI0007579
Description Macaca mulatta let-7g stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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Stem-loop
a   u        a            ugagg    -a  a    a 
 ggc gagguagu guuuguacaguu     gucu  ug uacc c
 ||| |||||||| ||||||||||||     ||||  || ||||  
 ccg uuccguca cggacaugucaa     uaga  ac augg c
a   -        c            -----    gg  -    c 
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Confidence
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Genome context
Coordinates (MMUL1.0) Overlapping transcripts
2: 84124916-84124999 [+]
sense
ENSMMUT00000036762 ; mml-let-7g-201; exon 1
ENSMMUT00000011508 ; WDR82P1-201; intron 2
Database links

Mature sequence mml-let-7g-5p

Accession MIMAT0006157
Sequence

5 - 

ugagguaguaguuuguacaguu

 - 26

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Evidence experimental; Solexa [23034410]
Predicted targets

Mature sequence mml-let-7g-3p

Accession MIMAT0026794
Sequence

62 - 

cuguacaggccacugccuugcc

 - 83

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Evidence experimental; Solexa [23034410]

References

1
2
PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).