Stem-loop sequence mml-let-7f-2

AccessionMI0007578 (change log)
DescriptionMacaca mulatta let-7f-2 stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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   u      u   gu                uuagggucauac 
5'  guggga gag  aguagauuguauaguu            c
    |||||| |||  ||||||||||||||||             
3'  cacccu uuc  ucaucugacauaucaa            c
   g      -   ug                uagagguucuac 
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Genome context
Coordinates (Mmul_8.0.1; GCA_000772875.3) Overlapping transcripts
chrX: 52964085-52964167 [-]
ENSMMUT00000007642 ; WNK3-201; intron 1
ENSMMUT00000007643 ; WNK3-202; intron 1
Clustered miRNAs
< 10kb from mml-let-7f-2
mml-let-7f-2chrX: 52964085-52964167 [-]
mml-mir-98chrX: 52963138-52963217 [-]
Database links

Mature sequence mml-let-7f-5p

Accession MIMAT0006156

8 - 


 - 29

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Evidence by similarity; MI0000068
Database links
Predicted targets