Stem-loop sequence mml-let-7a-3

AccessionMI0007572 (change log)
DescriptionMacaca mulatta let-7a-3 stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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      u   gu                ---------        
5' ggg gag  aguagguuguauaguu         uggggcu 
   ||| |||  ||||||||||||||||         |||||| c
3' ucc uuc  ucaucuaacauaucaa         gucccgu 
      u   ug                uaggguauc        
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Genome context
Coordinates (Mmul_8.0.1; GCA_000772875.3) Overlapping transcripts
chr10: 88293991-88294064 [+]
ENSMMUT00000043908 ; TBC1D22A-203; intron 6
ENSMMUT00000005326 ; TBC1D22A-201; intron 8
ENSMMUT00000005327 ; TBC1D22A-202; intron 8
Clustered miRNAs
< 10kb from mml-let-7a-3
mml-let-7a-3chr10: 88293991-88294064 [+]
mml-let-7bchr10: 88294908-88294990 [+]
Database links

Mature sequence mml-let-7a-5p

Accession MIMAT0006151

4 - 


 - 25

Get sequence
Evidence experimental; Illumina [2]
Database links
Predicted targets

Mature sequence mml-let-7a-3p

Accession MIMAT0026789

52 - 


 - 73

Get sequence
Evidence experimental; Illumina [2]
Predicted targets


PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).