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In molecular biology, mir-160 is a microRNA that has been predicted or experimentally confirmed in a range of plant species including Arabidopsis thaliana (mouse-ear cress) and Oryza sativa (rice). miR-160 is predicted to bind complementary sites in the untranslated regions of auxin response factor genes to regulate their expression. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 5' arm of the hairpin.
Specifically, 3 of A. thaliana's 23 auxin-response factor genes are thought to be post-transcriptionally regulated by mir-160. When one of these targets (ARF17) is manipulated to become miRNA-resistant, several developmental defects can be observed in the host plant. This experiment has been repeated with another mir-160 target, ARF10, and results highlighted a regulatory role in post-embryonic development and seed germination.
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In molecular biology, mir-160 is a microRNA that has been predicted or experimentally confirmed in a range of plant species including Arabidopsis thaliana (mouse-ear cress) and Oryza sativa (rice).[1] miR-160 is predicted to bind complementary sites in the untranslated regions of auxin response factor genes to regulate their expression.[2] The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 5' arm of the hairpin.
Specifically, 3 of A. thaliana's 23 auxin-response factor genes are thought to be post-transcriptionally regulated by mir-160.[3][4] When one of these targets (ARF17) is manipulated to become miRNA-resistant, several developmental defects can be observed in the host plant.[3] This experiment has been repeated with another mir-160 target, ARF10, and results highlighted a regulatory role in post-embryonic development and seed germination.[5]
[edit] References
- ^ "miRNA gene family: MIR160". mirBASE. University of Manchester. http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000032. Retrieved 5 September 2011.
- ^ Rhoades, MW; Reinhart BJ, Lim LP, Burge CB, Bartel B, Bartel DP (2002). "Prediction of plant microRNA targets". Cell 110 (4): 513–520. doi:10.1016/S0092-8674(02)00863-2. PMID 12202040.
- ^ a b Mallory, AC; Bartel, DP, Bartel, B (2005 May). "MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genes.". The Plant cell 17 (5): 1360–75. PMID 15829600.
- ^ Liu, X; Huang, J, Wang, Y, Khanna, K, Xie, Z, Owen, HA, Zhao, D (2010 May). "The role of floral organs in carpels, an Arabidopsis loss-of-function mutation in MicroRNA160a, in organogenesis and the mechanism regulating its expression.". The Plant journal : for cell and molecular biology 62 (3): 416–28. PMID 20136729.
- ^ Liu, PP; Montgomery, TA, Fahlgren, N, Kasschau, KD, Nonogaki, H, Carrington, JC (2007 Oct). "Repression of AUXIN RESPONSE FACTOR10 by microRNA160 is critical for seed germination and post-germination stages.". The Plant journal : for cell and molecular biology 52 (1): 133–46. PMID 17672844.
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