Stem-loop sequence hsa-mir-208b
|Description||Homo sapiens miR-208b stem-loop|
|Gene family||MIPF0000178; mir-208|
miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. In humans, the gene for miR-208 is located in an intron of MYH7.
miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
miR-208 has been deemed a "myomiR" as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133. miR-208 is though to be dysregulated in various cardiovascular diseases.
miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development. It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.
A preliminary study has shown a potential use in the prognosis of dilated cardiomyopathy. Another application has been suggested as using plasma concentration of miR-208 as a biomarker of damaged cardiac muscle cells.
 Further reading
--c g c aa cu cucucagg aagcuuuuug ucg uuauguuu g |||||||| |||||||||| ||| |||||||| a gggagucu uuuggaaaac agc aauauaag u gac g a ag cc
This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques . Expression was later confirmed by cloning .
Mature sequence hsa-miR-208b
|Evidence||experimental; cloned |
PMID:16954537 "Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis" Genome Res. 16:1289-1298(2006).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Cell. 129:1401-1414(2007).